In vivo study for the hemostatic efficacy and foreign body reaction of a new powder-type polysaccharide hemostatic agent

Yoonhyeong Byun,Eun Jin Kim,Areum Lee,Young-Ah Suh,Hee Ju Sohn,Jung Min Lee,Jae Seung Kang,Yoo Jin Choi,Youngmin Han,Hongbeom Kim,Wooil Kwon,Jin-Young Jang 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.102 No.2

Purpose: Various hemostatic agents have been introduced in therapy as postoperative bleeding is a poor prognostic factor for postoperative outcomes. These products can be divided into those that directly promote the hemostatic cascade and those that physically form a barrier by absorbing blood. The latter, powder-type hemostatic agents have the advantages of being inexpensive and more absorbable with less foreign body reactions (FBRs) and are applicable to a relatively wide area. This study was conducted to verify the safety and efficacy of a newly invented polysaccharide product (OOZFIX, Theracion Biomedical), which improves blood absorption and hemostatic effects. Methods: Two separate animal experiments were performed. The first evaluated FBRs histologically at 3 days, 2 weeks, and 4 weeks, after implantation of OOZFIX in rats, and the second compared hemostatic performance of OOZFIX and Arista AH (Bard) in the porcine liver punch biopsy model. Results: We found minimal FBRs in the 3-day group and no reactions in both the 2-week and 4-week groups after implantation of hemostatic agents. The time to hemostasis of OOZFIX was not significantly different from that of Arista AH (median [interquartile range]: 9 [6–10] minutes vs. 8 [6–10] minutes, respectively; P = 0.522). When comparing the serial bleeding grade tendency, there was no statistical difference between OOZFIX and Arista AH (P = 0.656). Conclusion: OOZFIX caused a minimal FBR that disappeared within 2 weeks in vivo, and its hemostatic performance was comparable with that of an existing agent, Arista AH. Further clinical studies are required in the future.

成人 女性의 水泳服 購買行動에 관한 硏究 : Focused on Procuct Evaluation Criteria 製品評價基準을 中心으로

徐美亞,이영아 服飾文化學會 1999 服飾文化硏究 Vol.7 No.6

The purpose of this study was analyze how korean adult women's swimming suit buying behavior varied according to consumer characteristics. Especially, it was intended to provide basic materials for swimming suit product development and quality improvement appropriate to consumer characteristics with a focus on product evaluation criteria. Questionnaire research was conducted for 850 adult women resudent in Seoul, to whom questionnaire were distributed and who were asked to complete their questionnaires. 1. As for buying motive, of swimming suit buying behavior, it was shown that the highest proportion of adult women bought their new swimming suit because their old swimming suit was wornout and most adult women tended to buy their new swimming suit or their own will rather than at others' suggestion. 2. As for the source of information at a time, of swimming suit puchase, adult women collected information from the product on display most and bought their swimming suit in a planned way in relation to the degree of purchase planning. 3. As for product evaluation criteria, adult women showed the high scores in order of the type and quality of material, activity and functionalism, dimensions and fitness. 4. In many cases actual swimming sult purchasers were the adult women who bought their swimming sult, and they used the department store or the large shopping center as the place of purcasing the swimming sult. Its reason was that the department store or the large shopping center had a diverse assortment of products. As for the degree of their travelling companion's influence, it was found that most adult women were influenced by their travelling companions when purchasing their swimming sults. 5. As for the level of satisfaction with swimming sult purchase, it was shown that adult women were generally satisfied with their swimming sult purchase.It was found that their level of satisfaction was higher in order of activity and functionalism, the type and quality of swimming sult materials, and ease in washing management while they showed the low level of satisfaction with price, the fastness of color to washing, light and detergents and durability.

근적외분광분석법을 이용한 참기름 정량 분석 및 진위 판별

서은정,백주현,우영아,김효진 동덕여자대학교 종합약학연구소 2002 동덕약학연구지 Vol.6 No.-

In this study, sesame oil have been analyzed by near infrared spectroscopy (NIRS). Sesame oil was mixed with the other edible oil. NIR transmittance spectra of sesame oil mixtures were acquired by using a dip probe. Partial least squares regression (PLSR) was applied to develop a calibration model over the spectral range 1100-1750nm. The calibration model predicted the content of sesame oil for validation set with a standard errors of prediction (SEP) of 0.3871%. Soft Independent Modeling of Class Analogy (SIMCA) was used to identify sesame oil and adulteration. This model identified the sesame oil and adulteration for validation set with 100% accuracy. This study showed that the rapid and non-destructive the determination of the quantitative analysis of sesame oil, the identification of sesame oil and adulteration was successfully performed by portable NIR system.

치면열구전색제 도표 후 광중합 할 때까지의 경과시간이 전색제 침투에 미치는 영향

최선아,이창섭,이상호,이난영 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.3

치면열구전색제 도포 후 시간에 따른 열구 내 침투율을 알아보고자 발치된 소구치 192개를 이용하여 전색제 도포 후 광중합 할 때까지 경과시간 3초, 5초, 10초, 20초별로 침투율을 비교 분석하였다. 여기에 추가적으로 상악과 하악, filled sealant와 unfilled sealant군으로 나누어 시간대별로 침투율에 차이가 있는지도 비교분석하였다. 그 결과 시간이 경과할수록, filled sealant군보다 unfilled sealant군에서, 상악보다는 하악에서 전색제의 침투율이 증가하였다. 이상의 결과에서 임상에서 치면열구전색을 시행할 때 이 결과를 임상적 지침으로 적용하면 유용하리라고 여겨진다. Occlusal fissures and pits are ideal places for the development of caries. Pit and fissure sealants are now considered as a very effective means to prevent dental caries. The purpose of this investigation was to examine the effect on the sealant penetration of the elapse of time from the application of sealant until exposure to visible light, and to examine the effect of the filler content and tooth position on the sealant penetration. 192 extracted human premolars were used to this experiment. Following enamel conditioning, a light-polymerized sealant was applied and 4 different periods of time(3, 5, 10, 20 seconds) were allowed until exposure to the light source. The results obtained were as follows: 1. According to time, in both unfilled sealant and filled sealant penetration increases deeply through mindfulness. 2. Sealant that apply to mandiblar premolar penetrated deeply through than to maxillay teeth. 3. Penetration difference according to filler content, unfilled sealant penetrated deeply through than filled sealant. The result from this study indicated that unfilled sealant penetrated most deeply in mandible when at least 20s time elapsed.

Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells.

Suh, Young-Ah,Jo, Se-Young,Lee, Hwa-Young,Lee, Chuhee Lychnia 2015 International journal of oncology Vol.46 No.3

<P>Ovarian cancer is the number one cause of death from gynaecological malignancy. Platinum-based and taxol-based chemotherapy has been used as a standard therapy, but intrinsic and acquired resistance to chemotherapy is a major obstacle to treat the disease. In the present study, we found that in the chemoresistant ovarian cancer SKOV3/TR cells, interleukin-6 (IL-6), IL-6 receptor and signal transducers and activators of transcription 3 (STAT3) expression as well as STAT3 phosphorylation were upregulated compared to those in parental cells. Silencing of IL-6 using IL-6 siRNA was found to suppress IL-6 production, STAT3 and phosphoSTAT3 levels, which eventually reduced proliferation and clonogenicity of taxol-resistant SKOV3/TR cells. In addition, stattic, a STAT3 inhibitor, was found to result in decrease of cell viability and clonogenicity of these cells, indicating that the elevated IL-6 and STAT3, phosphoSTAT3 levels are associated with the development of taxol resistance. Next, we found anti-proliferative effect of apigenin on both SKOV3 and SKOV3/TR cells. RT-PCR and western blot results showed that apigenin significantly reduced the expression of Axl and Tyro3 receptor tyrosine kinases (RTKs) at mRNA and protein level, which account for its cytotoxic activity. We further found that apigenin decreased Akt phosphorylation and the level of B-cell lymphoma-extra large (Bcl-xl or BCL2-like 1 isoform 1), an inhibitor of apoptosis. On the contrary to these results, apigenin had no effect on IL-6 production, STAT3 and phosphoSTAT3 protein levels, suggesting that apigenin exerts its anti-proliferative activity via downregulation of Axl and Tyro3 expression, Akt phosphorylation and Bcl-xl expression, but not modulation of IL-6/STAT3 axis. Taken together, our data suggest that inhibition of IL-6/STAT3 signaling pathway and downregulation of Axl and Tyro3 RTKs expression might be a therapeutic strategy to overcome taxol resistance in ovarian cancer cells.</P>

Large Signal Modeling of High Power HBT including Thermal effects

Ah-Ram Suh(서아람),Young-Seok Suh(서영석),Bumman Kim(김범만) 대한전자공학회 1994 대한전자공학회 학술대회 Vol.1994 No.11

Generation of apancreatic pigs by CRISPR/Cas9 microinjection

Young June Kim,Young Kyu Kim,Ju-Young Lee,Goo Hwa Kang,Han Na Suh,Hyung Sun Kim,Kyung Tai Kim,Jeong Ah Song,Jeongsik Park,Chang Woo Song,Jeong Ho Hwang 한국실험동물학회 2020 한국실험동물학회 학술발표대회 논문집 Vol.2020 No.2

Multicenter Validation of the Baveno VI Criteria for Screening High-Risk Varices in Patients with Compensated Advanced Chronic Liver Disease

( Han Ah Lee ),( Seung Up Kim ),( Hyung Joon Yim ),( Yeon Seok Seo ),( Young-sun Lee ),( Sang Jun Suh ),( Ki Tae Suk ),( Soung Won Jeong ),( Young Kul Jung ),( Moon Young Kim ),( Ji Hoon Kim ),( Sang 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: The Baveno VI consensus recommended that screening endoscopy can be safely avoided in patients with a liver stiffness (LS) < 20 kPa and platelet count >150x10⁹/L. Also, the Expanded Baveno VI criteria was proposed to spare more endoscopies. We aimed to validate and revise these criteria with other non-invasive markers in ruling out high-risk varices. Methods: Patients with compensated advanced chronic liver disease (cACLD), which is defined as LS ≥10 kPa, and who had endoscopy within 6 months of the transient elastography in 8 centers were included. Patients with hepatocellular carcinoma and those with Child-Pugh score >6 was excluded. Varices needing treatment (VNT) were defined as ≥F2 varices or varices with red color sign. Results: A total of 1218 patients with cACLD were included. Age was 56.0±11.5 years and 778 patients (63.9%) were men. Chronic hepatitis B was the most frequent underlying liver disease (479 patients, 39.3%), followed by alcoholic liver disease (359 patients, 29.5%). VNT were noted in 249 patients (20.4%). With Baveno VI criteria, VNT loss rate was only 1.9%, while sparing endoscopy rate was only 25.7%. With the Expanded Baveno VI criteria, 43.5% of endoscopies were avoided, but VNT loss rate was 5.8%. We explored various other parameters and cutoff values in ruling out VNT. Platelet >110x109/L and LS <20 kPa spared 39.1% of endoscopy with 4.4% of low VNT loss rate. When the LS-spleen diameter to platelet ratio score (LSPS) was applied, LSPS < 14.5 could spare more endoscopies (44.2%) with low VNT loss rate (4.5%). Conclusions: Combination of platelet >110x10⁹/L and LS <20 kPa has VNT loss rate less than 5%, and high endoscopic sparing rate in patients with cACLD. This study also showed LSPS <14.5 as a better strategy with increased number of spared endoscopies while maintaining excellent VNT loss rate.

Surgical Resection versus Radiofrequency Ablation in Single Small Hepatocellular Carcinoma: Data from Korea Central Cancer Registry for Hepatocellular Carcinoma Database

( Han Ah Lee ),( Yoo Ra Lee ),( Tae Hyung Kim ),( Sun Young Yim ),( Young-sun Lee ),( Sang Jun Suh ),( Young Kul Jung ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Dong-sik Kim ),( Hyung Joon Yim ),( Jong Eun 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: This study compared the survival benefits between surgical resection and radiofrequency ablation (RFA) in single small hepatocellular carcinoma (HCC). Methods: Patients registered in the database of Korea central cancer registry for HCC between 2008 and 2014 who received surgical resection or RFA for a single HCC of maximum size 3cm were reviewed. The cumulative overall survival (OS) and retreatment-free survival (RFS) were compared according to the type of treatment. Results: A total of 1426 patients were included, 662 (46.4%) in the resection group and 764 (53.6%) in the RFA group. The 5-year OS rates were 91.8% for resection, and 84.9% for RFA, respectively (P<0.001). The 5-year RFS rates were 77.8% for the resection and 70.5% for RFA, respectively (P=0.002). In patients with maximum tumor size <2cm, there was no significant difference in 5-year OS rates between the two groups (91.8% for resection, and 87.5% for RFA, respectively; P=0.094), while resection was superior to RFA in the 5-year RFS rates (81.0% for resection, and 72.3% for RFA, respectively; P=0.017). Resection was superior in both 5-year OS and RFS rates in those with maximum tumor size ≥2cm and <3cm (91.9% for resection, and 80.2% for RFA, respectively; P<0.001; 76.2% for resection, and 67.2% for RFA, respectively; P=0.007). In the entire cohort, type of treatment (HR 1.457, P=0.032), age (HR 1.031, P<0.001), serum albumin (HR 0.466, P<0.001), and serum creatinine level (HR 1.282, P<0.001) were independently associated with survival. Type of treatment (HR 1.544, P<0.001) and maximum size of tumor (HR 1.353, P=0.002) were independent predictors of RFS. Conclusions: In patients with maximum tumor size <2cm, OS is comparable between resection and RFA groups, while RFS is better in resection group. Surgical resection is superior in both OS and RFS in patients with maximum tumor size ≥2cm and <3cm.

진동 및 정치 해석 시 소음메커니즘 판단을 위한 스퀵/래틀 알고리즘 연구

송아영(Ah Young Song),김배영(Bae Young Kim),정충민(Choong Min Jeong),백우경(Woo Kyung Baik),송종원(Jong Won Song),최성욱(Sung Wook Choi),서명원(Myung Won Suh) 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.5-2