이주호 교육과학기술부 장관 인터뷰

이주호,편집부 한국교육과정평가원 2012 교육광장 Vol.43 No.-

현장이야기 : 탐방기 ; 봄내호스피스 - 소양제일교회 / 이주호 목사 -

이주호 기독교대한성결교회 활천사 2001 활천 Vol.568 No.-

이주호 교육과학기술부 장관 인터뷰

이주호,편집부 한국교육과정평가원 2010 교육광장 Vol.38 No.-

제69차 국제수역 사무국 총회에 다녀와서

이주호 대한수의사회 2001 대한수의사회지 Vol.37 No.7

일반적인 내시경적 담도배액법이 어려운 경우의 Soehendra Stent Retriever를 이용한 담도배액법

이주호,최철웅,이상용,강진욱,허정,김광하,강대환,송근암,조몽,양웅석 대한소화기내시경학회 2003 Clinical Endoscopy Vol.26 No.1

Background/Aims: Endoscopic biliary drainage (EBD) has been used effectively as the palliative treatment for malignant biliary obstruction. In high grade strictures, endoscopic stenting can be achieved by dilating devices such as dilating or balloon catheters. Subgroup of malignant biliary obstructions are too stenotic to allow passage of plastic or metal stents. In cases of failure of conventional stenting, we evaluated the efficacy and safety of the 7-Fr Soehendra stent retriever (SSR) used as a dilator. Methods: From January 1999 to September 2001, 14 patients with malignant pancreaticobiliary stirictures (2 pancreatic, 12 biliary) that could not be traversed with plastic or metal stents, underwent stricture dilation with SSR. An endoscopic sphincterotomy was performed and a guide wire was inserted beyond the stricture. Then the SSR was introduced over the guide wire via duodenoscope. Then the stricture was traversed by torquing the SSR clockwise while pushing it. The SSR was removed and then the plastic or metal stents were inserted above the stricture. Results: Of the 14 patients, 13 patients (93%) underwent successful stenting using SSR. Symptom relief was observed in all patients after endoscopic biliary stenting. One patient (7%) went on to percutaneous biliary drainage because we failed to insert the metal stent into the stenotic left hepatic duct after traversing the stricture with SSR. There were no significant complications such as bile duct or duodenal perforation and bleeding. Conclusions: The Soehendra stent retriever is useful and safe for dilation with subsequent stent placement of malignant pancreaticobiliary stirictures resistant to conventional stenting. However, this device may be difficult to pass a tortuous or small-diameter hilar stricture. (Korean J Gastrointest Endosc 2003;26:15-20) 목적: 수술이 불가능한 악성 담도 협착 환자에서 내시경적 역행성 담관배액법은 비수술적 감황법의 하나로 널리 이용되고 있다. 담관의 악성 협착은 일반적으로 확장 도관이나 풍선 도관을 사용하여 확장하지만, 고도의 협착에서는 이러한 방법으로도 해결되지 않는다. 저자들은 일반적인 내시경적 담도배액법이 불가능한 환자에서 Soehendra 담도배액관 회수기구의 유용성을 평가하였다. 대상 및 방법: 1999년 1월부터 2001년 9월까지 담도암, 췌장암으로 수술이 불가능한 환자 14명을 대상으로 하였다(남:여=8:6, 연령: 42~81세, 평균연령: 65.6세). 0.025 inch Jag wire가 협착부위를 관통하기 어렵거나, ERCP 카테터가 협착부위를 통과하지 못하는 경우, 또는 10 Fr 플라스틱 배액관이 삽관되지 않는 경우에 유두부 절제술을 시행하고 유도선 유도하에 Soehendra 담도배액관 회수기구를 협착부위 상부로 시계방향으로 돌리면서 전진하여 관통시킨 다음, 금속배액관 및 플라스틱 배액관을 삽입하였다. 결과: 14명의 환자 중 13명에서 Soehendra 담도배액관 회수기구를 이용하여 내시경적 담도배액법에 성공(93%)하였으며 Klatskin 종양 환자 1명에서 실패하였다. 경미한 출혈과 동통 이외에 의미있는 합병증은 없었다. 결론: 일반적인 내시경적 담도배액법이 어렵거나 불가능한 경우 Soehendra 담도배액관 회수기구를 이용한 협착부위 확장으로, 경피 경간적 담도배액법으로 전환하지 않고 내적배액법을 달성하여 환자의 삶의 질 향상에 많은 도움을 줄 것으로 생각한다.

위암에서 CD44s와 CD44v6 발현과 임상병리학적 상관관계에 관한 연구

이주호,임정화,전호종 대한병리학회 2003 Journal of Pathology and Translational Medicine Vol.37 No.5

Background : The aim of this study is to elucidate the relationship between the CD44s and CD44v6 expression level and the biological characteristics of a gastric carcinoma. Methods : CD44s and CD44v6 expression was investigated in 56 gastric carcinomas, 18 dysplasias, and 22 normal mucosae by immunohischemical staining. Results : The CD44s and CD44v6 expression rates in gastric carcinomas, dysplasia, and normal mucosae were 80.3% and 83.9%, 72.2% and 77.8%, and 13.6% and 4.5%, respectively. Statistical analysis showed significant difference after comparing a gastric carcinomas and dysplasia to the normal mucosae (p<0.001). The CD44s and CD44v6 expression rates in the cases with invasion to the muscle proper and serosa were 60.7% and 57.1%, and 82.4% and 88.2%, respectively. Both showed a significant statistical difference compared to the expression rates in the cases with invasion to the mucosae and submucosae. The CD44s and CD44v6 expression rates in gastric carcinomas with a lymph node metastasis showed a statistically significant difference compared to those without a lymph node metastasis (p<0.001 and p<0.01, respectively). CD44s and CD44v6 were also expressed in the normal basal cells around gastric carcinomas. Conclusions : The CD44s and CD44v6 expression showed a significant relationship with gastric carcinogenesis, toward an aggressive biologic behavior.

갑상샘 종양에서 p53, cyclin D1 및 c-myc 발현의 의의

이주호,전호종,이미자 대한병리학회 2004 Journal of Pathology and Translational Medicine Vol.38 No.1

Background : Elafin is a potent anti-elastase in human saliva, and is supposed to play a role in preventing oral ulceration. The expression of elafin was observed in the oral lichen planus (OLP), one of the most common noninfectious oral mucosal diseases, which frequently manifests as extensive ulceration on the involved oral mucosa. Methods : 50 OLP, 10 oral leukoplakia, 3 inflammatory oral ulcers, and 3 normal oral mucosa cases were fixed with 10% buffered formalin, and immunohistochemically stained with monoclonal elafin antibody. Representative specimens were fixed with 4% paraformaldehyde, and RNA in situ hybridization, with an elafin RNA probe, was performed. Results : With both the immunohistochemistry and RNA in situ hybridization the expression of elafin was more decreased in the OLP compared to the normal mucosa, while in the hyperplastic epithelium of the leukoplakia and inflammatory ulcers the expressions of elafin was more intense. In the thin epithelia of the reticular and atrophic OLPs the expressions of elafin were reduced compared to the normal mucosa, and became almost negative in the epithelium of the erosive OLP. Conclusions : These data suggested that the extensive ulceration of the OLP was closely relevant to the reduced expression of elafin in the involved epithelium.

Hypofractionated three-dimensional conformal radiotherapy for medically inoperable early stage non-small-cell lung cancer

이주호,우홍균,허대석,김학재,박찬일,이세훈,김동완 대한방사선종양학회 2013 Radiation Oncology Journal Vol.31 No.1

Purpose: The purpose of this study was to assess the clinical outcomes of hypofractionated radiotherapy (HFRT) with three-dimensional conformal technique for medically inoperable patients with early stage non-small-cell lung cancer (NSCLC) and to evaluate prognostic factors. Materials and Methods: We performed a retrospective review of 26 patients who underwent HFRT for early stage NSCLC between September 2005 and August 2011. Only clinical stage T1-3N0 was included. The median RT dose was 70 Gy (range, 60 to 72 Gy) and the median biologically equivalent dose (BED) was 94.5 Gy (range, 78.0 to 100.8 Gy). In 84.6% of patients, 4 Gy per fraction was used. Neoadjuvant chemotherapy with paclitaxel and cisplatin was given to 2 of 26 patients. Results: The median follow-up time for surviving patients was 21 months (range, 13 to 49 months). The overall response rate was 53.9%, and the initial local control rate was 100%. The median survival duration was 27.8 months. Rates of 2-year overall survival, progression-free survival (PFS), local control (LC), and locoregional-free survival (LRFS) were 54.3%, 61.1%, 74.6%, and 61.9%, respectively. Multivariate analysis showed that BED (>90 vs. ≤90 Gy) was an independent prognostic factor influencing PFS, LC, and LRFS. Severe toxicities over grade 3 were not observed. Conclusion: Radical HFRT can yield satisfactory disease control with acceptable rates of toxicities in medically inoperable patients with early stage NSCLC. HFRT is a viable alternative for clinics and patients ineligible for stereotactic ablative radiotherapy. BED over 90 Gy and 4 Gy per fraction might be appropriate for HFRT.

"수의공중보건의 미래"

이주호,Lee, Ju-Ho 대한수의사회 2008 대한수의사회지 Vol.44 No.10

사중복음 설교_성결 : 성결의 꽃

이주호 기독교대한성결교회 활천사 2014 활천 Vol.733 No.12