열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

림프관종

배재문,한호성,김영우 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.2

목적: 림프관종은 흔한 질환이 아니므로 보고된 례들도 많지 않아 그 임상적 특성이 매우 다양하게 보고되어 있다. 저자들은 최근 2년 6개월간 14례의 림프관종을 경험하였기에 림프관종의 임상적 특성을 분석하는 것이 의의가 있을 것으로 판단하였다. 방법: 1993년 9월부터 1996년 3월까지 이화여자대학교 의과대학부속 목동병원에서 치료받았던 14례의 림프관종에 대하여 임상기록을 통한 후향적 분석을 하였다. 임상적 특성은 증상, 종양의 위치, 지난방법, 종양의 크기, 치료방법 그리고 합병증 및 재발여부에 관하여 분석을 하였다. 결과: 1) 림프관종 발견 연령분포는 4주 이내가 4명, 4주 이상 2세 이하가 4명이었고 2세 이상 10세 이하가 3명이었으며 남자가 6명, 여자가 8명으로서 남녀비가 1 : 1.3 이었다. 2) 증상으로는 신체 각 부위의 종괴로 나타나는 경우가 71.4%로서 가장 많았다. 3) 발생부위는 전흉벽과 액와부에 가장 많이 발생하였다. 4) 림프관종의 진단방법으로는 초음파가 유용한 진단적 가치가 있었다. 5) 림프관종의 크기는 5cm 이하가 6례(42.9%), 5cm 이상 10cm 이하가 6례(42.9%), 10cm 이상 15cm 이하가 2례(14.2%)였다. 6) 치료방법의 주류는 완전절제이며 수술후 합병증이나 재발의 례는 없었다. 결론: 림프관종은 종괴의 감별진단에서 꼭 염두를 두어야 하며 특히 소아의 종괴일 경우 림프관종을 감별하여야 한다. Objectives : Lymphangioma is an infrequent disease. Few cases of lymphangioma has been reported, so its clinical characteristics are variale. We had experienced fourteen patients of lymphangioma during relatively short period, two and half years. It was worth to analyze the clinical characteristics of the lymphangioma. Methods : A clinical analysis was made in fourteen patients with lymphangioma who had been admitted to Ewha Womans University Mokdong Hospital from September, 1993 to March, 1996 retrospectively by the review of clinical records. The characteristics were about the symptoms, locations, diagnostic methods, sized of tumor, treatment, and complications. Results : were summerized as following 1) The sex ratio was 1 to 1.3(male to female) and the most prevalent age group was less than 10 years(78.6%) 2) The most common presenting symptom was a mass(71.4%) 3) The locations were trunk and axillary(35.7%), retroperitoneum(21.4%), extremity(21.4%), neck and mesentery in decreasing order. 4) The ultrasonogram was a useful disgnostic method of lymphangioma(71.4%). 5) The size distribution of tumors were 42.9% in less than 5cm, 42.9% in 5 to 10cm, and 14.2% in 10.1 to 15cm. 6) The treatment of choice was complete excision. There was no complication, or recurrence. Conclusion : lymphangioma should be considered as differential diagnosis in patients with mass, especially children.

Development of Cultivar-Specific DNA Markers Based on RAPD Products in Orchid Plants

Jae-il Lyu,Hyo-Shim Han,Jae-Sung Jung,Jong-Suk Lee,Young il Lee,Hyo-Yeon Lee,Chang-Hyu Bae1 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

비강 및 비인두에 발생한 도립유두종과 편평상피암종의 p53단백 및 세포증식능에 관한 연구

한주호,윤기중,이재규,신대균,박근호,조향정,문형배 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.2

The inverted papilloma and squamous cell carcinoma are common neoplasia in the sinonasal cavity and nasopharynx, but the incidence of these tumors are very low and the study on the oncogenesis or biological activity of the tumor cells are not well known. This study was designed to evaluate the oncogenic roles of the p53 gene and the proliferative activity of the tumor cells in the inflammatory polyp, inverted papilloma and squamous cell carcinoma. The experiment was carried by the immunohistochemical stains about the p53 protein, PCNA and Ki-67, histochemical stain about the AgNORs. and flow cytometric analysis about the DNA ploidy using the formalin fixed paraffin embedded tissues. The frequency of the expression of p53 protein was 0%(0/16 cases) in the inflammatory polyps, 18.8% (3/16 cases) in the inverted papillomas, and 87.5%(14/16 cases) in the squamous cell carcinomas. The labelling index(%) of the PCNA and Ki-67 was 5.3% and 3.3% in the inflammatoy polyps, 29.6% and 25.2% in the inverted papillomas, and 51.9% and 36.8% in the squamous cell carcinoma. The expression of the PCNA and Ki-67 was distributed in the periphery of the tumor islands of the inverted papilloma and was distributed in the both of center and periphery of the tumor islands of the squamous cell carcinoma. The number of nuclear AgNORs was increased in the order of inflammatory polyps (0.96), inverted papillomas(1.34) and squamous cell carcinoma(2.09). The frequency of the DNA aneuploidy was 0%(0/16 cases) in the inflammatory polyps, 18.8%(3/16 cases) in the inverted papillomas. and 12.5%(2/16 cases) in the squamous cell carcinomas. Above results indicates that the changes of the p53 gene and proliferative activity of the tumor cells are involved on the oncogenesis and the biological activity of the inverted papilloma or squamous cell carcinoma in the nasopharynx and sinonasa cavity.

사의료비 지출 특성과 행태에 관한 연구

박재원,서수교,배중한 대구보건대학 2005 대구보건대학 論文集 Vol.25 No.-

The purpose of this study is to estimate the magnitude and to characterize the "Quasi-Medical Expenses" of Korea, which are defined as the monetary costs that are used to improve health or to heal disease but are not captured by the official medical expense statistic. The quasi-medical expenses includes the monetary expenditure associated with the underground transactions of medical good and service as well as traditional treatment which is not yet scientifically proven effective including "alternative medical treatment". The data used in this study was collected by the survey on 734 individual in Daegu area. There is a tendency that the oder people becomes the more dependent they are on the quasi-medical treatment. The result of analysis indicates that the experience of having been hospitalized, sex, and income are the significant factors that explain how much people would spend on the quasi-medical treatment. The result suggests that a policy measure is needed to accomodate part of the quasi-medical expenses in the national medical insurance system to alleviate the burden of medical cost.

자궁경부 상피종양에서 human papillomavirus 감염과 survivin 발현

윤재호,정동준,이정은,박동명,배동한,선우재근,백무준,김창진 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Human papillomavirus (HPV) has been considered a causative agent of uterine cervical carcinoma. HPV is a DNA oncogenic virus, which is well known as a causative virus in uterine cervical carcinoma. The virus is classified into two groups genotypically, low risk and high risk, according to the carcinogenic potentiality, and the determination of the viral genotype is important in clinical practice. Recently, numerous genotypes can be determined by high throughput method using DNA chip. Survivin is a recently characterized inhibitor of anti-apoptosis (IAP) protein, which is abundantly expressed in most solid and hematological malignancies, but undetectable in normal adult tissues. In this study, HPV genotypes are determined by DNA chip and the expression of survivin was examined by immunohistochemistry in 80 cases of uterine cervical intraepithelial neoplasia (CIN) and invasive carcinoma to see the roles of HPV and survivin in the carciogenesis of uterine cervical epithelial neoplasia. The results were as follows: 1. HPV positive rate was 72.5%, while negative rate was 27.5% in 80 cases of CIN and invasive carcinoma. The CIN and invasive carcinoma showed higher HPV positive rate (p <0.05). 2. HPV positive rate according to the histologic grade were 60%, 65%, 77% and 90% in CINI, CINII, CINII and invasive carcinoma, respectively. HPV positive rate showed increasing tendency according to the histologic grade, though there was no statistical significance. 3. The most frequent genotype was type 16 and the next were 58, 52, 18 and 33 in order of frequency. 4. Survivin was expressed in 96.3% of CIN and invasive carcinoma. The expression rate of survivin showed no significant difference between the histologic grade of CIN and invasive carcinoma, but showed tendency of increased expression rate in invasive carcinoma. 5. Survivin was expressed in HPV positive and in HPV negative each as in 95.5% and 96.6% respectively. There was no significant difference of survivin expression between HPV positive and negative cases. The above results suggest that HPV has no effect on the regulation of survivin expresson level in the uterine cervical intraepithelial neoplasia and invasive carcinomas.

섬유종류 및 잔골재용적비에 따른 HPFRCC의 공학적 특성에 관한 실험적 연구

이의배,이동혁,나철성,조봉석,김재환,김무한 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

In general, concrete showed brittle fracture but HPFRCC(High Performance fiber reinforced cementitious composite) showed ultra high ductile behavior in the hardened state, because of the fiber bridging properties. So a variety of experiments have being performed to access the performance of HPFRCC recently. In this study, to develope HPFRCC with high ductility and strain capacity, effects of fiber types and sand volume fraction were investigated. And results of this study were as follows; · HPFRCC reinforced with PVA or hybrid fiber were superior to PP or singleness. · Effect of sand volume fraction on HPFRCC reinforced with PP was insignificant.

대구지역 금호강 및 주요 지천 퇴적물의 시·공간적 독성변화

정홍배,문성환,정진애,김재현,박정규,배철한,황인영 한국환경독성학회 2001 환경독성보건학회지 Vol.16 No.4

1. 사전에 선정된 공통 조사 정점들 가운데 KㆍH4(금호대교)이후의 퇴적물 독성이 상부의 것보다 크게 나타났다. 즉, 정점 KH3과 KH4, 그리고 KH4와 KH5 사이에 독성물질 유입원이 있는 것으로 판단되었다. 2. 하천 퇴적물의 독성 수준에 영향을 주고 있는 물질의 종류와 배출원 파악이 필요하였다. 이러한 내용을 향후 계속적 연구 및 조사를 통하여 수행되어야 하는 과제라 사료된다. 3. 퇴적물 시료의 채취 시점에 따라서 동일 정점의 독성 변화가 심하였다. 유해화학물질에 의한 오염 수준과 하천 생태계의 영향을 예측하기 위해서는 하천 퇴적물을 대상으로 경시적으로 독성의 변화를 계속 관측하는 것이 필요하다고 판단되었다. In aqueous ecosystems, the level of toxicity is highly responsive dependant to multiple variables, including rainfall, sunlight, pH, adhesion, etc. Because Korea has particularly distinct wet and dry seasons, the toxicity of pollutants in rivers or streams is dependant on the sampling season and time. In order to examine the effects of rainfall on toxicity, sediment samples were collected from five sites along the Keumho river. It was found that Microlox toxicity levels were generally higher during the dry season than the wet season. It indicated that river pollutants are carried off more quickly by the water during the wet season. As a result, it was recommended that the point sources of pollutants of the Keumho river would be placed between KH3 (Paldalgyo) and KH4 (Keumhogyo), KH4 (Keumhogyo) and KH5 (Dasa).

생산량을 고려한 부품-기계 셀 형성에서의 퍼지이론 이용

김홍배,김재한 慶星大學校 1994 論文集 Vol.15 No.2

This paper deals with Machine-Part Group Formation in Group Technology. In order to consider uncertainty and impreciseness in Machine-Part Group Formation, this paper introduces Fuzzy Theory. In this paper we consider production volume in determination of fuzzy similarity coefficient. Although there is no proper performance measure, Fuzzy similarity coefficient proposed in this paper consider production volume and the result of this study can applicable to real life cell formation.

Siloxane-Epoxy(s) Copolymer合成에 관한 硏究

梁在乾,韓貞璉,裵長淳 단국대학교 1981 論文集 Vol.15 No.-

Oligosiloxane prepared which has moleculae weight 900∼1,000 was prepared from O.M.C.S. and epoxy(S) resine was prepared from pisphenol(S) and epichlorohydrin. The siloxane-epoxy(S) copolymer was synthesized through the copolymerization of oligosiloxane and epoxy(S) resine under alkaline acetone solution at 50∼55℃ for 5 hours. Thermal properties of epoxy(S) resine and siloxane-epoxy(S) copolymer was measured by thermogravimetric analysis, copolymer with 8.2% silicon content had the higher degradation temperature 300℃ than epoxy(S) reine which degradation at 250℃.