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      • 휘발성 유기용매의 In vitro 대사속도 측정 장치의 개발

        황인영,이윤,Hwang, In-Young,Lee, Yoon 환경독성보건학회 1997 환경독성보건학회지 Vol.12 No.3

        Species, doses and routes extrapolation can be sucessfully carried out by using a physiologically-based pharmacokinetic (PBPK) approach. And PBPK approach to assess risk of hazardous chemicals is reasonable whatever the exposure scenarios are happened. Both partitioning coefficients of chemical between tissue and blood and enzymatic metabolic rate constants are key parameters to build up the PBPK model. In this study, we tried to estimate in vitro metabolic rate constants using a special apparatus instead to measure the in vivo constants which are used to PBPK simulation since the in vitro tests are less expensive and more convenient than in vivo tests. For the purpose, we designed and tested the new system to measure continuously the headspace concentration of VOC. The newly designed system is composed with a diffusion chamber which generates gaseous substrate, a reaction vessel with a recirculating pump to establish a closed system, an autbmatic sampler from a gas phase, a gas chromatography to analyze the headspace. In addition, a cold water condenser is attached between the reaction vessel and pump to reduce the content of gaseous moisture which interferes with chemical analysis. To validate the newly developed methodology, in vitro metabolic rate constants of trichloroethylene (TCE) as a prototype VOC were estimated by simulating observed results with an ACSL program. The simulated results are consistent to those estimated by the other research groups. This finding suggests that our newly designed closed system may be a useful apparatus to estimate in vitro metabolic rate constants for VOC.

      • KCI등재

        원전 조직 내 안전문화 준수에 관한 연구

        황인영,박정훈 한국시스템다이내믹스학회 2019 한국시스템다이내믹스 연구 Vol.20 No.3

        The purpose of this study is 1) to explore the cyclical causal relationship among safety culture principles in nuclear power plant organization and 2) to analyze the effects of determinants of safety culture compliance. This study conducted a survey to identify stock variables and developed a stock-flow diagram (SFD) based on eight safety principles. After that, a simulation was conducted using the SFD. The results indicate that an approach that expanding workers' understandings of duties and responsibilities regarding the safety culture is most effective in improving safety culture compliance.

      • 생물학적 방법에 의한 도시생활폐기물 매립지의 침출수 독성특성 평가

        황인영,류경무 한국환경독성학회 1996 환경독성보건학회지 Vol.11 No.1

        Leachate from municipal solid waste (MSW) landfill, effluent from leachate treatment plant, and ground water sample from a monitoring well near landfill site were tested for an acute toxicity. Microtox toxicity test was used for testing the acute toxicity of leachate and other samples. EG_(50) values which a concentration of pollutant for reducing 50% light output from luminescent bacteria, Phtobacterium phosphoreum were determined to assess the toxicity of pollutants as well as the relative toxicity. In addition, characteristics of leachate were studied and compared to those of phenol and pentachlorophenol(PCP) which are typical aquatic toxic pollutants. For leachate, EC_(50) for 30min incubation was 10.8%, while for phenol and PCP, 46ppm and 1.2 ppm, respectively, the relative toxicity of treated leachate by in 냐셔 aeration with activated sludge was reduced to more than 75% of toxicity the untreated leachate. Microtox toxicity test was failed to figure out EC_(50) values for groundwater from a monitoring well since the relative toxicity of the unconcentrated sample was too low to estimate EC_(50). Addition of activated carbon to leachate was reduced the relative toxicity. The reduction Pattern of the relative toxicity of leachate by mechanical aeration was similar to that of PCP, but different from that of phenol. These findings suggest that the toxicity of leachate may come from PCP-like toxic compounds rather than phenol-like one. In conclusion, the process of aeration with activated sludge might be very important to reduce the environmental toxicity of leachate. And Microtox test could be a reasonable bioassay for screening and monitoring the environmental toxicity of leachate from municipal solid waste landfill as well as for determining the reduction efficiency of the leachate toxicity by various treatment processes in leachate treatment plant.

      • 휘발성 유기용매의 In Vitro 대사속도 측정 장치의 개발

        황인영,이윤 한국환경독성학회 1997 환경독성보건학회지 Vol.12 No.2

        Species, doses and routes extrapolation can be sucessfully carried out by using a physiologically-based pharmacokinetic (PBPK) approach. And PBPK approach to assess risk of hazardous chemicals is reasonable whatever the exposure scenarios are happened. Both partitioning coefficients of chemical between tissue and blood and enzymatic metabolic rate constants are key parameters to build up the PBPK model. In this study, we tried to estimate in vtlro metabolic rate constants using a special apparatus instead to measure the in vivo constants which are used to PBPK simulation since the in nitro tests are less expensive and more convenient than in vivo tests. For the purpose, we designed and tested the new system to measure continuously the headspace concentration of VOC. The newly designed system is composed with a diffusion chamber which generates gaseous substrate, a reaction vessel with a recirculating pump to establish a closed system, an automatic sampler from a gas phase, a gas chromatography to analyze the headspace. In addition, a cold water condenser is attached between the reaction vessel and pump to reduce the content of gaseous moisture which interferes with chemical analysis. To validate the newly developed methodology, in vitro metabolic rate constants of trichloroethylene (TCE) as a prototype VOC were estimated by simulating observed results with an ACSL program. The simulated results are consistent to those estimated by the other research groups. This finding suggests that our newly designed closed system may be a useful apparatus to estimate in vitro metabolic rate constants for VOC.

      • KCI등재
      • Microtox^TM를 이용한 펜타클로로벤젠과 펜타클로로페놀 환경독성 평가

        황인영 인제대학교 1995 仁濟論叢 Vol.11 No.2

        Microtox toxicity of pentachlorobenzene (PeCB) and its major metabolite, pentachlorophenol (PCP) was determined by measuring the reduction of light output from luminescent bacteria, Photobacterium phosphoreum. EC50, the concentration at 50% inhibition of light emmission, of PeCB was 42mg/L, while PCP, 1.2mg/L. The result that EC50 of PCP was smaller than that of PeCB means that PCP a degraded compound is more toxic than PeCB, a parent compound. Therefore, environmental toxicity tests for degraded chemicals or mixtures of parent pollutant and its major metabolites should be done to estimate realistically the risk for a toxic pollutant. In addition, the water solubility of PeCB was determined and calculated n-ocatnol-water partition coefficient (Kow), since Kow plays generally an important role to estimate environmental toxicities, such as the bioaccumulation factor and so on.

      • 해상 유류 유출 사고 후, 유류 해양 오염에 따른 주요 해산 어ㆍ패류내 PAHs 추적

        황인영,박정규,박관하,김정상,정흥배,배철한 한국환경독성학회 2001 환경독성보건학회지 Vol.16 No.2

        Marine organisms such as fish (Sebastes schlegeli) and mussels were cultured in sea water tanks placed at Dukpo area which was contaminated by the two oil spill accidents. Results showed that PAHs concentrations in fish tissue were higher than in fish liver. This was explained by the cytochrome P450 IA induction in fish liver after PAHs exposure. Other studies showed that higher PAHs levels were detected in mussels cultures in oil contaminated area than in control site. From these results, we concluded that Dukpo area is still polluted by oil including PAHs and it takes a long time to recover of oil contamination after the oil spill accidents.

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