한국비서자격시험의 개선점과 비교연구

남자현,이미정,이미영,이아영,정해금,최유정,이미숙,전인선,정혜림 이화여자대학교 법정대학 비서학과 1997 비서학연구 Vol.- No.17

GML 기반 통합 맵서버 설계 및 구현

이혜진,이현아,김동호,김진석 한국지리정보학회 2003 한국지리정보학회지 Vol.6 No.4

본 연구에서는 통합된 하나의 맵을 작성하기 위하여 통합 맵서버를 설계하고 구현한다. 제안된 통합 맵서버는 다음과 같은 두 가지 특징을 가진다. 첫째, 웹 환경에서 사용자의 요구를 반영하기 위하여 메타데이터를 개별화한다. 맵서버는 클라이언트에 필요한 정보를 메타데이터에 설정하기 때문에 메타데이터를 개별화하면 사용자는 자신이 원하는 형태의 통합 데이터를 얻을 수 있게 된다. 둘째, 융합 서비스 개념을 도입하여 공간 데이터 뿐만 아니라 공간 데이터와 비공간 데이터와의 통합도 지원한다. 융합 서비스는 링킹의 개념을 사용하여 실체화한다. 본 연구에서 제안한 통합 맵서버는 사용자의 요구에 따른 높은 수준의 맵 통합 결과를 제공함으로써 웹 매핑 환경에서 융합의 질을 높일 수 있으며, 사용자 응답 시간도 줄일 수 있다는 것을 실험을 통하여 증명하였다. This paper designs and implements an integrated map server to produce an integrated map. Two requirements for the proposed map server are as follows. Fist, the system should support a customization of metadata to meet user's requirements. The map server designed here will predefine information such as representations, regions required for client-side processing in the metadata. This will allow users easily acquire and integrated map in the required form of clients. Second, the system should be able to support not only the integration of spatial data but also their non-spatial data. Fusion service is realized by using the concept of linking. The integrated map server suggested in the paper can improve the quality of the fusion service by integrating the results of the map servers according to user's requests. Our experiments shows that the integrated map server reduces the response time in web mapping environments.

초산모의 분만유형과 모성관련지식에 관한 연구

김혜란,노진아,손은정,이명아,김증임 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

Purpose: This study was to know primipara's general characteristics, delivery type, delivery characteristics, maternity related knowledge level, and relation of delivery type and maternity related knowledge level. Method: This is a survey. Subjects were sixty primiparas who had admitted to a pediatric outpatient clinic at general hospital in Seoul. Subject's age was ranged from 15 to 44 and it was lapsed 10 weeks after delivery of their first baby. Maternity related knowledge level was measured by "primipara's maternity related knowledge level". Data was nalyzed using frequency. percentage, mean, standard deviation, ANOVA, t-test by SPSS 11.0. Result: Relation of delivery type and maternity related knowledge in primipary did not show a statistically significant. But the relation of natural delivery and maternity related knowledge in primipara was a littlehig than that of caesarean section. Conclusion: There is no significant diference of maternity related knowledge between natural delivery and caesarean section. We suggest for randomized clinical trials with a larger sample size.

Helicobacter pyloir 양성 소화성 궤양에서 lansoprazole 포함 삼제요법의 제균율 및 제균판정에 있어서 요소호기검사의 유용성

정혜경,곽재진,유민아,배기선,권정미,이종수,김도영,문일환 대한감염학회 2003 감염과 화학요법 Vol.35 No.3

목적 : 본 연구는 Helicobacter pylori (이하 H. polyri) 양성인 소화성 궤양 환자에서 lansoprazole 포함 삼제요법의 제균율을 알아보고, 제균 치료 후 제균 판정에 있어서 요소 호기 검사(Urea breath test, 이하 UBT) 및 신속요소분해(rapid urease test, 이하 RUT test)와의 일치율에 대하여 알아보고자 하였다. 방법 : 상부위장관내시경 검사에서 H. polyri 양성인 소화성 궤양환자에서 lansoprazole 60㎎+amoxicillin 2g+clarithromycin 1g의 약제를 2회 분복하여 1주간 복용하는 삼제요법을 실시하였다. 최소 4주후 추적 상부위장관내시경을 실시하였고, 전정부와 체부에서 각각 RUT를 실시하였으며 UBT(5분, 20분)를 시행하였다. 결과 : 대상환자는 총 46명으로 남자 34명(48±13세), 여자 12명(53±14세)이었다. LAC 삼제요법의 제균율은 40/46명(87.0%)이었고, 궤양의 치유율도 42/46명(91.3%)이었다. RUT와 20분 UBT 결과가 모두 음성이었던 경우는 41예, 모두 양성이었던 경우는 4예로 RUT와 UBT는 97.8% (45/46)의 일치율을 보였고, 1예는 UBT는 음성이었으나 체부에서 시행한 RUT가 양성이었다. 5분 UBT 검사가 양성이었던 예는 14/34 (41.2%) 이었고, 이 14예 중 12예(85.7%)는 20분 UBT 검사 음성, RUT 음성이었다. 결론 : Lansoprazole과 amoxicillin, clarithromycin 1주일 병합요법은 H. polyri 양성인 소화성 궤양 환자에서 87.0%의 제균율을 나타내어 우수한 효과를 보였고, 요소호기검사는 제균 치료 후 제균 판정에 유용한 비침습적인 방법임을 확인할 수 있었다. Background : There are only a few studies on Helicobacter pylori (H. pylori) for its eradication rates of lansoprazole-based triple therapy in Korea, and the results are controversial. Therefore, we undertook to investigate the eradication rate of lansoprazole-based triple therapy, and compare the concordance rate of urea breath test (UBT) and rapid urease test (RUT) in evaluating H. pylori eradication. Methods : Patients with acute peptic ulcer who were H. pylori-positive were recruited by prospective, consecutive manner. They received lansoprazole 30 ㎎ b.d., amoxicillin 1 g b.d. and clarithromycin 500 ㎎ b.d. for 1 week. Upper endoscopy was performed after 4 weeks to check for ulcer healing, and UBT and RUT were performed to evaluate H. pylori eradication status. Results : A total of 46 patients were recruited, and they were all compliant. H. pylori eradication rate was 87.0% (40/46) and ulcer healing rate was 91.3% (42/46). Forty one patients showed negative in both UBT and RUT, and 4 patients revealed positive in both tests, therefore, the concordance rate of UBT and RUT was 97.8% (45/46). Conclusion : Our study showed that 1-week lansoprazole-based triple therapy was effective in H. pylori eradication and ulcer healing. UBT can be an effective, noninvasive method for evaluating H. pylori status after H. pylori eradication.

난소 기형종에 동반된 직장후방 기형종

오보영,이령아,구혜수,문혜성 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.2

6-(3,4-디클로로페닐)아미노-7-클로로-5,8-퀴놀린디온의 항진균작용 및 안전성 평가

윤여표,김동현,이병무,허문영,정해문,강혜영,최정아,김도희,유충규 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

6-(3.4-Dichlorophenyl)amino-7-chloro-5.8-quinolinedione (RCK50) was tested for antifungal activities in mice systemically infected with Candida albicans. The therapeutic potential of RCK50 was also assessed in comparison with ketoconazole. RCK50 had ED_50 0.22±0.01 ㎎/㎏. Ketoconazole as a positive control had ED_50 6.00±1.70 ㎎/㎏. Intraperitoneally administered RCK50 at the ED_50 for 7 days and 14 days reduced Candida albicans colony count in the kidneys and liver. And administered RCK50 at the ED_50 for 14 days improved survival rates. The genotoxicities of RCK50 had been evaluated. RCK50 was negative in Ames test with Salmonella typhimurium and chromosomal aberration test in CHL cells. RCK50 did not show any clastogenic effect in mouse peripheral blood and was negative in mouse micronucleus assay. These results indicate that RCK50 has no genotoxic potential under these experimental conditions. Acute oral toxicity studies of RCK50 were carried out in ICR mice of both sexes. RCK50 did not show acute oral toxicities and LD_50 values were over 2.850 ㎎/㎏ in ICR mice.

EGFR 돌연변이와 ROS1 전위를 동시에 가진 폐선암 환자의 Erlotinib 치료 1예

김민환,박예현,박혜정,지아영,송창호,진무년,김영주,김선욱,이중희,김인수,김혜련,김주항,조병철 Ewha Womans University School of Medicine 2014 EMJ (Ewha medical journal) Vol.37 No.1

The rearrangement of c-ros oncogene 1 (ROS1) has been recently identified as an important molecular target in non small cell lung cancer (NSCLC). ROS1 rearrangement and epidermal growth factor receptor (EGFR) mutation were mutually exclusive each other in previous studies, and the clinical implication of co-existence of the two genetic alterations has not been determined. We report a case of 46-year-old female never-smoker NSCLC patient whose tumor harbored ROS1 rearrangement and EGFR mutation concomitantly. She had undergone curative surgery for stage IIIA NSCLC, and the recurrence in left pleura and brain occurred at 2 years after the surgery. She received several lines of chemotherapy including docetaxel plus carboplatin, erlotinib, pemetrexed, and gemcitabine. Erlotinib therapy showed a favorable treatment response with progression-free survival of 9.5 months and partial response of tumor on radiologic evaluations. This case represents a successful erlotinib treatment in a NSCLC patient with concurrent ROS1 rearrangement and EGFR mutation.

임부의 연령에 따른 보완대체요법에 관한 인식 태도 경험 비교 연구

김연진,김지연,노경민,신혜리,유예지,이지민,장희조,정아인,최소정,강숙정,이향연,민혜영 이화여자대학교 간호과학대학 2016 이화간호학회지 Vol.- No.50

Purpose: This study aims to test if the age of pregnant women affects the perception, experience, and attitude towards complementary alternative therapy (CAT), by investigating the perception, experience, and attitude of pregnant women under the age of 35, and above 35 (Advanced Maternal Age). The study will 1) find the general characteristics of pregnant women under and over the age of 35 2) compare the perception, behavior, and experience of pregnant women under and over the age of 35, and 3) find the comparison of the perception, behavior, and experience according to the general characteristics of pregnant women under and over the age of 35. Method: The subjects of this study are composed of 44 women under the age of 35 and 44 women above the age of 35, totaling 88 pregnant women visiting midwiferies, obstetrics and gynecology, and baby fairs in Seoul and Gyeong-Gi area. Data for this study was collected from November 28, 2015 to January 6, 2016 for 40 days. The collected data analyzed mean, standard deviation, t test, ANOVA, and chi-square by using SPSS 23.0. Result Results show that there is a significant difference in the perception, attitude, and experience of the two-sample groups in the use of CAT. The question of “what is most necessary when applying CAT in a hospital clinical environment” for the perception criteria came out with the results of t=9.980, p<.05. For the attitude, results showed that the answers of pregnant women under the age of 35 displayed a more positive attitude towards CAT. (t=2.421, p<.05) Lastly, in the experience section, pregnant women under the age of 35 showed more CAT use than the other sample group. Conclusion Results have shown that there is a difference in the perception, behavior, and experience between the two sample groups. Therefore further research on the efficacy and the adverse effects of CAT needs to be done.

Editor’s Highlight: A Genome-wide Screening of Target Genes Against Silver Nanoparticles in Fission Yeast

Lee, Ah-Reum,Lee, Sook-Jeong,Lee, Minho,Nam, Miyoung,Lee, Sol,Choi, Jian,Lee, Hye-Jin,Kim, Dong-Uk,Hoe, Kwang-Lae ACADEMIC PRESS 2018 TOXICOLOGICAL SCIENCES Vol.161 No.1

<P><B>Abstract</B></P><P>To identify target genes against silver nanoparticles (AgNPs), we screened a genome-wide gene deletion library of 4843 fission yeast heterozygous mutants covering 96% of all protein encoding genes. A total of 33 targets were identified by a microarray and subsequent individual confirmation. The target pattern of AgNPs was more similar to those of AgNO<SUB>3</SUB> and H<SUB>2</SUB>O<SUB>2</SUB>, followed by Cd and As. The toxic effect of AgNPs on fission yeast was attributed to the intracellular uptake of AgNPs, followed by the subsequent release of Ag<SUP>+</SUP>, leading to the generation of reactive oxygen species (ROS). Next, we focused on the top 10 sensitive targets for further studies. As described previously, 7 nonessential targets were associated with detoxification of ROS, because their heterozygous mutants showed elevated ROS levels. Three novel essential targets were related to folate metabolism or cellular component organization, resulting in cell cycle arrest and no induction in the transcriptional level of antioxidant enzymes such as Sod1 and Gpx1 when 1 of the 2 copies was deleted. Intriguingly, <I>met</I>9 played a key role in combating AgNP-induced ROS generation via NADPH production and was also conserved in a human cell line.</P>

가시 근적외선 분광법을 이용한 참외 숙도 판별 모델 개발

이혜인 ( Hye-in Lee ),김민지 ( Min-jee Kim ),이보영 ( Bo-young Lee ),이정은 ( Jeong-eun Lee ),이홍구 ( Hong-gu Lee ),박수환 ( Soo-hwan Park ),양하은 ( Ha-eun Yang ),유우형 ( Woo-hyeong Yu ),이아영 ( Ah-yeong Lee ),모창연 ( Changye 한국농업기계학회 2023 한국농업기계학회 학술발표논문집 Vol.28 No.2

참외는 한국의 여름철 대표 과일 중 하나로 후숙하지 않는 과일이다. 최근에는 수확에서 출고까지의 회전이 빨라 저장고를 거치지 않고 수확 즉시 유통하고 있다. 그러므로 참외의 수확 시기와 수확 직후의 상태는 참외 품질에 중요한 영향을 미친다. 특히 참외의 숙도는 상품성과 직결되는 당도에 가장 큰 영향을 주는 인자로써 미숙과일수록 당도가 낮아진다. 현재 참외를 재배하는 농가에서는 참외의 숙도를 외관 색깔만으로 판단하고 있다. 참외가 미숙에서 적숙으로 넘어가기 직전 시기에는 적숙과와 같은 노란색을 띠기 때문에 작업자는 수확 적기를 구분하기 어려워진다. 따라서 수확 후 품질 균일화를 위해서는 작업자의 주관적인 육안 판별보다 객관적인 품질 판정 기술이 필요하다. 본 연구에서는 참외의 숙도 판별을 위하여 가시 근적외선(VNIR) 분광 기법의 적용 가능성을 평가하고자 한다. 본 연구의 목적은 참외의 당도, 숙도 간의 상관관계와 VNIR 분광 스펙트럼 특성을 구명하고 참외 숙도 판별모델을 개발하는 것이다. 시료는 성주에서 수확한 참외로 미숙과 100개, 적숙과 132개를 이용하였다. 이는 착과 시기와 색도에 따라 미숙과-초록(stage 1), 미숙과-노랑(stage 2), 적숙과(stage 3)의 3단계로 분류하였다. 색도를 기준으로 더 익은 면을 앞면으로 설정하여 장축을 2부분으로 나누었으며, 단축은 꼭지부, 중앙부, 배꼽부 3부분으로 나누어 한 개체당 총 6 부위의 스펙트럼을 획득하였다. 분광 스펙트럼은 100W의 할로겐 광원과 USB4000 분광기(Ocean Optics, USA)를 이용하여 투과식으로 측정하였다. 참외 숙도 판별을 위하여 부분최소제곱 판별분석(Partial Least Squares-Discriminant Analysis, PLS-DA)모델을 개발하였으며, 분석에는 472~1,100nm의 파장 대역을 사용하였다. 그 결과, 판별 정확도 0.80의 우수한 성능을 보였다. 따라서 VNIR 분광 스펙트럼을 이용한 참외의 숙도 판별이 가능할 것으로 판단된다. 본 연구의 결과는 향후 참외의 수확 후 품질 균일화 및 품질 정보 제공 기술로 활용할 수 있을 것으로 기대된다.