문진 방법에 따른 연관련 자각증상과 연노출 지표들과의 관련성

김용배,이병국 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

Objectives: this study was carried out to investigate the relationship between lead related symptoms and lead exposure indices by self-administrered questionnaire and direct review questionnaire in lead workers. Method: The study design was cross-sectional and research subjects were 172 workers in storage battery industries as lead exposed group and 84 workers who were not exposed to lead as control group. Lead related symptoms(15 items) were obtained by self-administered questionnaire. After then investigator asked workers about each items and completed drect interview questionnaire. Blood lead(PbB), zinc protoporphyrin(ZPP), δ-aminolevulinic acid in urine(ALAU), hemoglobin(Hb) were selected as indicators of lead exposure. Results: There was significant correlation between lead related symptoms and lead exposure index(blood ZPP) in direct review questionnaire, whereas there was no significant correlation in self-administered questionnaire. Conclusions: Our results supported current self-administered questionnair should be reassessed sensitivity and specificity. Also, if necessary, direct review questionnaire was highly recommended for the effective health management of lead workers.

탄도적인 손가락의 신전움직임에 있어서 신근과 굴근의 협조

이정범,민영기,양훈모 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

In this investigation the temporal-spatial characteristics of muscle isometric contraction of shouting in ballistic movement of the musclus biceps brachii flexion was compared between trained kendo athletes and untrained control subjects by surface electromyographic(EMG) analysis Surface EMG from the mid-point of the triceps muscle and biceps muscle, and a hand wrist flesion signal of the wrist were recorded with a personal computer through AD- conversion (1KHz of sampling frequncy). premotor tiem (PMT), motor time (MT), reaction tiem (RT), Max0tension and integrated electromyogram(I-EMG), during 500msec from the were analyxed by bio-information multi-task analyxing program (BIMUTAS Kissei comtec). In the kendo athletes, reaction time was significantly shorter tham that of control group. The shortening of reaction time in kendo athletes was mainly attributed to the shortening of motor time. In the kendo athletes, motor time was significantly shorter than that of control group. In the kendo athletes, I-EMG was significantly high frequency discharge than that of control group. From these results, it is suggested that motor learning is achieved in kendo trained and the maximal is metirc contraction may play an important role in heghtenning the efficiency of ballistic movement in coordination with the shouting.

자궁 경부의 상피내암, 침윤이 있는 상피내암과 침윤성 편평상피암에서 p53, Ki-67 및 HER-2/neu의 표출 양상

장우섭,오미혜,양승하,김의한 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

To observe the expression of p53, Ki-67 and HER-2/neu in uterine cervical lesions, such as 10 cases of carcinoma in situ(CIS), 7 cases of carcinoma in situ with stromal invasion and 8 cases of invasive squamous cell carcinoma without carcinoma in situ, and to evaluate the corrleationship between results, the author has been carried out immunohistochemical staining with monoclonal antibodies to p53, Ki-67 and HER-2/neu. So, following results are obtained. 1. The p53 show negative reaction in all cases of CIS, and similar patterns in CIS with stromal invasion and invasive squamous cell carcinoma. 2. Ki-67 show high proliferation pattern in all cases and the basal cell show proliferating activity. 3. HER-2/neu show higher score in area of CIS than invasive area in stroma. 4. The stain pattern of HE-2/neu and p53 appeared to be inverse proportion to each other

대장선암에서 Metallothionein과 p53의 표출

강동하,양승하 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

Colonic adnocarcinoma is common malignant tumor in Korea. Many oncogenes have been found in malignant tumor cells. Among these oncogenes, MT has high affinity for metals such as copper and zinc. The fuction of MT is metabolism and detoxification of copper and zinc. The relation between the expression of MT and prognosis of patients in various cancers are reported but is controversial. p53 is a regulator of cellular proliferation, and the over expression of p53 relates to malignant trasformation and prognosis. To evaluate the expression of MT and p53 according to histopathologic features in colonic adenocarcinoma, we have performed immune staining, using mouse anti-MT and mouse anti-p53. The results were as follow; 1) The expression rates of MT in hyperplastic polyp, adenoma, and adenocarcinoma of colon were 100%, 64.1%, and 46.6%, p53 were 0%, 64.1%, and 48.9%, respectively. 2) MT and p53 in colonic adnoma showed increased espressionrat according to severity of dysplasia 3) MT incolonic adenoarcinoma showed statisfically significant higher expressionrates in female9P=0.04), in cases showing lymph node metastasis(P=0.012), and in stage C(P=0.0001), but there is no significant difference according to age, site, differentiation, and invasion depth. 4) p53 in colinic adenocarcinoma showed statisfically significant higher expression rates rates in cases showing lymph node metastasis(P=0.047), but there is no statisfically significant difference in age, sex, site, invasion depth, stage. 5) In colonic adenocarcinomas expressing MT(+)p53(+) there is more many cases in carcinomas within the wall, in carcinoma showing lymph node metastasis, and stage C, but no statisfically significant difference. 6) Correlation between MT and p53 in colonic adenocarcinoma were not seen.

대장암종에서 암관련 유전자들의 Promoter Methylation과 암종 발생 및 진행과의 관게에 대한 연구

정동준,이정은,민영기,조성우,백무준,양승하,김의한,김창진 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

The colorectal corcinoma is one of the most common malignant tumor in Korea and its carcinogenic mechanism has not been elucidated exactly yet. So far, the most common carcinogenic mechanism has been known to be multiple genetic changes. But, the CpG island hypermethylation has been revealed to be one of the most important carcinogenic mechanism second to the genetic changes. The epigenetic changes characteristically imprint and transfer to the next generation without changes of nucleotide sequences. When the CpG island of promoter or 5'- exon 1 of a specific gene is methylated by DNA methyltrasferases (DNMTs), the gene expression is inhibited. Carcinogenic mechansisms by promoter methylation has been well known, but the progression of the cancer has not been elucidated yet. The molecular researches on the carcinogenic mechanisms largely depended on the tumor tissue containing various components of cell, due to difficulties in harvesting pure homogeneous tumor cells. Promoter methylatonof the cancer related genes as APc, hMLH2, p16, DAP-K and MGMT in 50 cases of sporadic colorectal carcinoma was studied. The pure normal colorectal epithelial cells, and cancer cells from superficial and deep invasive portion were harvested respectively by laser captured microdissection(LCM), and DNA was extracted from them. The promoter methylation was studied by methylation specific poymerase reaction (MSP) after bisulfite modification of the DNA and the expression of the genes by immunohistochemistry. The results suggests that promoter methylation of the cancer related genes are closely related with the colorectal carcinogenesis and it occurrs from early phase of carcinogenesis, progressing constantly to the late stage. And the promoter methylation of normal epithelial cells increased by age. The p15, known to be the genes related to hematologic malignancy, was closely related to the colorectal carcinoma as well.

그람음성 세균에 대한 나노실버의 항균효과

송호연,고광균 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

Silver is one of the most universal anti-microbial substances. To improve the anti-microbial activity of silver, we successfully produced nanosilver by nano-technology. We examined the anti-microbial activity of nanosilver for several Gram negative pathogenic bacteria(Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi). Most bacteria were controlled within 1 ppm of nanosilver witin 1 hour. The mechanism of anti-microbial effects was explored by SEM and TEM. The severe morphologic changes, irregular cell wall, increased electron density of cytoplasm, and plasmolysis, were observed. From the result, nanosilver will be available as an antibiotics alternative.

전정 자극이 미숙아의 생리적 지수에 미치는 효과

유경희 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

Purpose : This study was to evaluate the effects of providing vestibular simulation of heart rate and respiratory rate in preterm infants. Methods: The design of this study was nonequivalent control group pretest-posttest design in quasi experimental study. Thirty two preterm infants were randomly assignes to experimental and control group : 15 in the vestibular stimulation group and 17 in the control group. The criteria for inclusion in this study were 1)gestational age less than 37 week, 2) a birth weight less than 2,500g, 3) the absence of congenital anomalies, and specific diseases, 4) a recovering physiological weight loss, and 5) weraned from venitilatory assiistance or oxygen. In date analysis. SPSSWIN 10.0 program was utilized for descriptive statistics, t-test. Results: General characteristics of the two groups showed no significant difference, thus two groups were found to be homogenous. The heart rate and respiratory rate of vestibular stimulation group were not significantly reduced than control group after 10 days.

색소성 양진 1예

이성열,이종석 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

prurigo pigmentosa is a chronic pruritic inflammatory dermatosis characterized by erythematous papules in a reticalated pattern that resolve leaving a reticulated, mottled hyperpigmentation. Most cases have been reported from Japan. We report a case of prurigo pigmentosa in a Korean man of 19 years of age.

유방외 Paget 병 1예

이성열,이종석 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

Extramammary Paget's disease is a rare cutaneous adenocarcinoma, usually of epidermal origin and glandular differentiation and frequently associated with and underlying adnexal carcinoma and perhaps with underlying internal malignancy. We report a case of extramammary Paget's disease on the right scrotum and penile shaft.

토마스 쿤의 「과학적 혁신 구조」의 이해

제갈 욱 순천향대학교 교수학습개발센터 2004 순천향 사회과학연구 Vol.10 No.2

본 논문은 Thomas S. Kuhn이 지은 「The Structure of Scientific Revolution」의 내용을 소개한 것이다. 이 저서르 ㄹ통해 과학혁신이라는 개념을 도입하여 사회 paradigm을 새로운 시각으로 설명함으로써 사회현상의 이해의 폭을 넓혀나가는데 공헌하엿다. 이러한 과학혁신의 개념을 다시 한번 체게화함으로써 공공부분의 혁신을 이해하는데 도움을 줄 수 있을 것으로 판단된다.