ORiginal Article : Gastroprotective Effects of PMK-S005 against Ethanol-Induced Acute Gastric Damage in Rats

( Yoon Jeong Choi ),( Nayoung Kim ),( Ju Yup Lee ),( Ryoung Hee Nam ),( Ji Hyung Seo ),( Seonmin Lee ),( Hee Jin Kim ),( Yoon Jin Choi ),( Hye Seung Lee ),( Dong Ho Lee ) 대한간학회 2016 Gut and Liver Vol.10 No.3

Background/Aims: This study aimed to examine the gastroprotective effects of PMK-S005, which is a synthetic S-allyl-Lcysteine (SAC; a sulfur-containing amino acid), against acute ethanol-induced gastric damage in rats. Methods: Sprague- Dawley rats were divided into six groups, including a nonethanol group, groups treated with absolute ethanol 1 hour after pretreatment with various doses of PMK-S005 (1, 5, and 10 mg/kg) or rebamipide (50 mg/kg), and an absolute ethanolonly group. Ethanol-induced gross ulcer and mucus levels were measured. Myeloperoxidase, tumor necrosis factor a, interleukin 1β, PGE2, LTB4, cPLA2, COX-1, and COX-2 levels were estimated by enzyme-linked immunosorbent assay or Western blot analysis. Furthermore, the protein expression levels of antioxidant enzymes, including heme oxygenase-1 (HO-1), NAD(P)H:quinine oxidoreductase 1 (NQO-1), GCLC, and GCLM, were assessed. Results: PMK-S005 significantly attenuated the ethanol-induced gastric damage; it reduced mucosal inflammatory cytokine production and increased mucus levels. The expression levels of cPLA2, COX-1, and COX-2 were decreased by PMK-S005. PMK-S005 did not affect PGE2 synthesis, but LTB4 production was significantly suppressed. In addition, long-term administration of PMKS005 significantly increased the expression of HO-1, NQO-1, GCLC, and GCLM. Conclusions: These results strongly suggest that PMK-S005 prevents gastric mucosal damage and that these gastroprotective activities are due to anti-inflammatory effects and enhancement of the gastric defense system, including antioxidant enzymes. (Gut Liver 2016;10:348- 355)

현행 중등학교 과학 실험 , 실습 교육 실태 조사 및 그 운영 진단 (Ⅱ) : 고등학교 과학 실험 , 실습 교육을 중심으로

김영호,이윤종,정원우,강용희,양승영,윤성효,안병호,윤일희,권용주,임성규,오철한,기우항,전명남,김중욱 한국과학교육학회 1998 한국과학교육학회지 Vol.18 No.3

본 연구는 96년도에 실시한 우리 나라 중학교 과학 실험·실습 교육의 실태 조사 연구에 따른 계속 연구의 일환으로 고등학교 과학 실험·실습 교육의 실태를 조사하기 위한 것이다. 연구내용은 고등학교 과학 교과서의 분석, 실험·실습 실시 현황 분석, 현행 실험·실습 교육의 문제점 분석, 현행 학교 구성원들의 실험·실습 교육 운영 실태 조사 및 현행 실험·실습 교육의 개선을 위한 연구과제 도출을 주요 연구내용으로 다루었다. 연구방법은 전국의 고등학교 80개교를 대상으로 이들 학교의 학생 1,977명, 교사 165명, 학교장 80명에게 적용하였다. 본 연구에서 밝혀진 결과를 중심으로 우리 나라 고등학교 과학 실험 실습 교육의 정상화를 위한 실험 내적인 연구과제를 제시하면 다음과 같다. (1)교재 개발에 대한 연구, (2)실험 킷트 개발에 대한 연구, (3)교사교육 및 재교육 프로그램 개발에 대한 연구, (4)교실 밖 실험·실습 활동 프로그램 개발에 대한 연구, (5)과학 실험·실습 소재의 개발에 대한 연구. This study was accomplished to analysis and survey on the experimental and practical science education of high school in korea for the consecutive study of the an analysis and survey on the experimental and practical science education of middle school in korea(Lee, Yoon-Jong et al., 1997). The status of facilities, management for the experiment, practices, teaching methods in high schools have been investigated. The present status and reasonable management of the high school science education have been grasped from the questionaires. To do this 165 high school science teachers, 1977 students and 80 principals of high schools in Korea are administered questionaires of Science Education Research Institute of Kyungpook National University(1997). The results of this study are as follows : The reasonable management for experiments and practices of science education were scanty in the high school around the urban and rural school owing to the shortage of facilities and equipments, crowded class, excessive class works for teacher, excessive contents of present textbooks and insufficiency of the administrative supports etc. The current teaching method of high school science has emphasized knowledge. This fact does not satisfy the objective of learning due to lack of the teaching method. Desirable directions for the improvement of present status of high school science education were proposed in this paper.

불리언 질의 재구성에서 의사결정나무의 학습 성능 감도 분석

윤정미,김남호,권영식 한국경영과학회 1998 한국경영과학회지 Vol.23 No.4

One of the difficulties in using the current Boolean-based information retrieval systems is that it is hard for a user, especially a novice, to formulate an effective Boolean query. One solution to this problem is to let the system formulate a query for a user from his relevance feedback documents. In this research, an intelligent query reformulation mechanism based on ID3 is proposed and the sensitivity of its retrieval effectiveness, i.e., recall, precision, and E-measure, to various input settings is analyzed. The parameters in the input settings is the number of relevant documents. Experiments conducted on the test set of Medlars revealed that the effectiveness of the proposed system is in fact sensitive to the number of the initial relevant documents. The case with two or more initial relevant documents outperformed the case with on initial relevant document with statistical significances. It is our conclusion that formulation of an effective query in the proposed system requires at least two relevant documents in its initial input set.

관상동맥 스텐트 내 재협착의 발생에 미치는 임상적 관동맥 조영술적 요인들

윤혁준,김기식,박형섭,이영수,현대우,한성욱,허승호,김윤년,김권배,박남희,원경숙 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.12

체내 납부담의 지표로서 누적 혈중 납량과 누적 혈중 ZPP가 납 관련 신기능에 미치는 영향

윤강호,김남수,김진호,김화성,이병국 대한산업의학회 2006 대한직업환경의학회지 Vol.18 No.4

목적: 체내 납부담의 지표로서 누적 혈중 납량과 누적 혈중 ZPP가 납관련 신기능에 미치는 영향을 알아보기 위하여 678명의 납 작업자들을 대상으로 본 연구를 시도하였다. 방법: 누적 혈중 납량과 누적 혈중 ZPP는 입사시부터 매 1년간의 혈중 납량과 혈중 ZPP를 누적하여 구하였다. 입사시기가 1983년 이전인 납 작업자의 경우는 최초 혈중 납량과 최초 혈중 ZPP를 그 이전의 값으로 추정하여 구하였다. 체내 납부담의 지표로서 골중 납량과 DMSA착화납량을 측정하였으며, 최근의 납 노출 지표로서는 혈중 납량과 혈중 ZPP를 측정하였다. 신기능을 평가하는 지표로서는 임상 신기능 지표로서 BUN과 혈청 creatinine을 측정하였고, 신기능 조기지표로는 NAG (N-acetyl-D- glucosamide)와 RBP (Retinol binding protein)를 측정하였다. 결과: 혈중 납량과 혈중 ZPP의 누적지수와 골중 납량과는 결정계수(r²)는 각각 0.72와 0.567로서 유의한 상관이 있었으며 이들 누적지수와 골중 납량은 곡선형적 모델이 더 적합하였다. 신기능 지표들을 종속변수로 하고 성, 연령, 직력 및 음주와 흡연을 통제한 후 혈중 납량과 혈중 ZPP를 독립변수로 한 중회귀분석에서 혈중 납량은 4개의 신기능 지표들 중 지수 변환한 NAG와만 유의한 관련이 있는 반면, 혈중 ZPP는 지수변환한 NAG를 제외한 신기능 지표들과 유의한 관련이 있었다. 한편 신기능 지표들을 종속변수로 하고 연령 및 직력과 음주와 흡연을 통제한 후 체내 납 부담노출지표들을 독립변수로 한 중회귀분석에서 골중 납량과 혈중 ZPP 누적지수는 4개의 신기능 지표들과 유의한 관련이 있는 반면, DMSA 착화납량과 혈중 납량 누적지수는 BUN을 제외한 신기능 지표들과 유의한 관련이 있었다. 결론: 상기한 결과로 보아 혈중 납량과 혈중 ZPP의 누적지수는 체내 납부담의 지표로서 효용성이 입증되었으며, 특히 혈중 ZPP의 누적지수가 혈중 납량의 누적지수보다 체내 납부담의 대리지표로서 더 좋은 것으로 나타났다. Objective: To evaluate the possibility of cumulative blood lead and blood ZPP as surrogates of lead body burden and to investigate their association with renal function as an index of lead body burden. Methods: The study subjects comprised 678 lead workers with past blood lead and blood ZPP data from their employment. Cumulative blood and ZPP were calculated by accumulating the every year mean value of both indices from the new employment since 1983. To assess the cumulative data of lead workers who started their lead work before 1983, the years before 1983 were simulated with the first available data from 1983. Study variables for lead body burden were tibia bone lead and DMSA chelatable lead, whereas those for current lead biomarkers were blood lead and blood ZPP. BUN and serum creatinine were selected as clinical renal biomarkers, while NAG (N-acetyl-D-glucosamine) and RBP (Retinol binding protein) were selected as early renal biomarkers. Results: The association between cumulative blood lead and blood ZPP with tibia bone lead was statistically significant with determinant coefficients (r²) of 0.72 and 0.567, respectively, and their relationships were better explained by the curvilinear regression model. In multiple regression analysis of current lead biomarkers on the renal biomarkers after controlling for possible confounders (age, sex, job duration, smoking and drinking status), blood lead was associated only with log-transformed NAG, whereas blood ZPP was associated with 3 other renal biomarkers. On the other hand, in multiple regression analysis of biomarkers of lead body burden on renal biomarkers after controlling for possible confounders (age, sex, job duration, smoking and drinking status), cumulative blood ZPP and tibia bone lead were associated with all 4 renal function biomarkers, whereas cumulative blood lead and DMSA chelatable lead were associated with 3 renal biomarkers except BUN. Conclusion: Cumulative blood and ZPP were demonstrated to be good surrogates of lead burden. Furthermore, the cumulative blood ZPP was confirmed to have a better association than the cumulative blood lead.

계열별 고등학생집단의 뇌기능특성화 경향에 대한 연구

윤규태,최기수,안의태,고정식,양남길,박경호 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

본 연구에서는 계열에 따른 고등학생들의 대뇌반구기능의 특성화 또는 편재화의 경향을 알아보고, 전공분야에 대한 적응력과의 상관관계를 검토하고자 했다. 일반고등학교 인문계열 학생 359명, 자연계열 학생 371명, 음악과 미술전공 학생을 포함한 예능계열 196명, 체육특기자를 포함한 체육계열 학생 151명 등 1,077명을 대상으로 각 계열별, 남녀별, 성적별 고등학생 집단들의 대뇌반구의 특성화, 편재화 경향을 시나가와(품川)질문지법을 이용하여 분석하였으며, 다음과 같은 결과를 얻었다. 1. 인문계열 고등학생의 뇌기능의 편재화 경향은 우뇌형 54.3%, 양쪽뇌형 32.6% 및 좌뇌형 13.1%였다. 남녀별로는 남학생은 우뇌형 62.9% 양쪽뇌형 27.9% 및 좌뇌형 9.5%로 나타났으며, 여학생은 각각 43.7%, 38.6% 및 17.7%로서 여학생이 남학생에 비하여 죄뇌화 경향을 보였다. 2. 자연계열 고등학생의 경우는 우뇌형 56.9%, 양쪽뇌형 29.9% 및 좌뇌형 13.2%로서 인문계열 고등학생과 비슷한 분포를 보였다 이를 남녀별로 구별하여 보면 남학생은 62.2%, 27.1% 및 10.2%, 여학생은 51.5%, 32.5%및 16.0%의 분포를 보여, 역시 여학생의 좌뇌화 경향이 뚜렷했다. 3. 예능계열 고등학생의 경우는 우뇌형 56.1%, 양쪽뇌형 35.2% 및 좌뇌형 8.7%의 분포를 보였으며, 이를 전공별로 세분해서 살펴보면 음악전공학생의 경우 53.7%, 35.5% 및 10.7%로서 전체 평균과 거의 비슷한 분포를 보였으나, 미술전공학생의 경우 60.0%, 34.7% 및 5.3%로서 , 특히 좌뇌형의 경우 음악전공에 비해 절반수준에도 못 미치는 경향을 보였다. 4. 체능계열 고등학생 집단의 경우 우뇌형 50.3%, 양쪽뇌형 37.7% 및 좌뇌형 11.9% 분포를 보였다. 5. 성적별로 보면 일반고등학교 학생 가운데 성적 우수 집단은 뚜렷하게 좌뇌형 경향(25.6% 및 25.0%)을 보였다. 6. 예능계열의 우수집단은 양쪽뇌형의 분포비율(50.0% 및 44.4%)이 특히 높았다. 7. 체육계열의 우수집단은 좌뇌형 분포(21.6%)가 높았다. According to the advanced study on differential theory of brain function, the left hemispheric functions are concerned more on the verbal, logical, sequential and arithmetic abilities, whereas the right hemisphere has characteristics of non-lingual, general, creative and aesthetic abilities. The authors compared the tendency of hemispheric specialization in high school students with different educational condition and facilities. Sinakawa's questionnaire method was the instrument for this study. The results obtained were as follows: Among 1,077 of whole subjects, right hemispheric dominant type was 55.0% (59.1% in male, 51.0% in female), bilateral type was 32.9% (10.6% in male, 35.1% in female) and left hemispheric dominant type was 12.2% (10.4% in male, 13.9% in female). 1. Of the 359 subjects in the field of humanity science, right hemispheric dominant type was 54.3% (62.9% in male, 43.7% in female), bilateral type was 32.6% (27.9% in male, 38.6% in female) and left hemispheric dominant type was 13.1% (9.5% in male, 17.7% in female). 2. Of the 371 subjects in the field of natural science, right hemispheric dominant type was 56.9% (62.2% in male, 51.5% in female), bilateral type was 29.9% (27.1% in male, 32.5% in female) and left hemispheric dominant type was 13.2% (10.2% in male, 16.0% in female). 3. Of the 196 art school students, 56.1% was regraded as right hemispheric dominant type, students majoring music was 53.7%, 35.5% and 10.7%, respectively, whereas the frequency for students majoring find art was 60.0%, 34.7% and 5.3%. 4. In students majoring physical education, 50.3% were shown in right hemispheric dominant type, 37.7% were bilateral type and 11.9% were left hemispheric dominant type. 5. Laterality patterns of students who adapt more successfully to their specific studying fields show following characteristics; Successful students of general high school show pronounced left shift in their laterality pattern, whereas successful students of art school exhibit more bilateral type. And successful students of physical education school show left shift in their laterality patterns.

하악골 골절 환자에 있어 수술후 합병증으로 발생한 골수염의 치험례

윤규호,전인성,신용길,박준호,허남오,방석준 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.4

The term osteomyelitis literally means inflammation of bone marrow. It is described as an inflammatory condition of bone primarily engaging the medullary Following circulatory collapse and ischemia, the involved portions of the bone become necrotic. Cellulitis and osteomyelitis are the most frequent complications of fractures of the mandible and maxilla, because there is an abscessed tooth in the line of fracture. Since most fractures are compound fractures, infection may develop because of contact with oral secretions or outside air. The treatment of chronic osteomyelitis is still under debate. Some authors rely on antibiotics alone, while others advocate combination with surgery. But when infection occurs, establish proper drainage and administer antibiotics. Author treated a case of infected mandibular fracture with mandibular osteotomy, sequestrectomy, iliac bone graft and hyperbaric oxygen therapy, who had suffered suppurative osteomyelitis and mandibular nonunion following the open reduction of the mandibular fracture.

요관경하 배석술 후 발생한 요관외벽에 함몰된 잔석 치료 경험

이창호,전윤수,이남규 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Fifty-four years old woman complained right lower quadrant and flank pain. She was done uretroscopic removal of stone 8-weeks ago. Ultrasongraphy showed high echo suspicious ureter stone at pelvic cavity. Antegrade urography also showed radio-opaque density suspicious ureter stone, but the density was stray from the right ureter course. Ureteroscopy was done. Yellowish glittering stone which was impacted at ureter wall was found. That was removed using foreinbody forcep and by assisted maneuver.

청소년의 식이행태 조사 : 서울·양평 두 지역간 비교 The Comparison of Urban and Rural Areas

최준호,안동현,최보율,강윤주,백영석,조연규,고복자,남정현 漢陽大學校 精神健康硏究 1998 精神健康硏究 Vol.17 No.-

급성전골수성백혈병에서 백혈구성분채집술에 이은 치명적인 뇌출혈 2예

오윤정,박소윤,김윤정,한동석,김현수,최진혁,남동기,임호영,김효철,주희재 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.1

The aim of this study is to report 2 cases of acute promyelocytic leukemia who died from intracranial hemorrhage following leukapheresis and to provide proper preventive measures against hemorrhage following leukapheresis. From 1994 to 1997, a total of twenty-six patients with leukemia underwent leukapheresis to control hyperleukocytosis at Ajou University Hospital. Two patients with acute promyelocytic leukemia received all-trans retinoic acid but developed drug-induced hyperleukocytosis. Shortly after leukapheresis, they died from intracranial hemorrhage. The risk factors for fatal hemorrhage are thought to be coexisting disseminated intravascular coagulation(DIC), thrombocytopenia aggravated by leukapheresis, exacerbated coagulopathy related to mechanical trauma through leukapheresis and the excess use of citrate during leukapheresis. To reduce the risk of the bleeding associated with leukapheresis, it is necessary to replace platelet sufficiently before and after leukapheresis and to give calcium to correct coagulopathy induced by excess citrate which is used as anticoagulant as well as the correction of disseminated intravascular coagulation.