한국인 알코올 의존 환자에서 알코올 대사 효소 유전자형 빈도의 남녀 차이

김성곤,김철민,이덕기,황인복,이현숙,김성연,전은숙,송영상,박제민,최병무,김명정 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : There are a number of preceding epidemiological studies reporting gender differences in the genetic etiology of alcohol dependence. The author investigated gender difference in the frequencies of ADH2 and ALDH2 genoypes between the patients with alcohol dependence and normal control. Methods : The subjects were 141 alcohol dependent patients (104 males, 37 females) and 138 normal control (79 males, 59 females). The frequencies of 1/1 and 1/2+2/2 (2+ afterward) genotypes for ADH2 and ALDH2 were investigated in male and female between alcohol dependence and normal control group. DNA was extracted from WBC in peripheral venous blood and PCR-RFLP method was used out for genotyping. Results : First, the frequency of ADH2 1/1 genotype was significantly higher in alcohol dependent patients than normal control in both genders. Second, while there was no gender difference in the frequency of ADH2 1/1 genotype in normal controls, in the patient group however, the frequency was significantly higher in females than males. Third, in male subjects with alcohol dependence, the frequency of ALDH2 1/1 genotype was significantly higher than in male normal control subjects. On the other hand, in female subjects with alcohol dependence, the frequency of ALDH2 2+ genotype was significantly higher than in female normal control subjects. Conclusion : These results suggest that while the risk of alcohol dependence is predominantly affected by ALDH2 1/1 geno-type in male, the female ADH2 1/1 genotype is mainly associated with the risk of alcohol dependence. This means that there are gender differences in the genetic etiology of alcohol dependence.

파킨슨씨병에서 Selegiline HCI (MAO-B^(�))의 효과 및 안전성

조기현,김명규,김태선,김병채,이승한,황인용,김준태,김종기 全南大醫大 2000 전남의대학술지 Vol.36 No.2

THE EFFECT OF PRIMING ETCHED DENTIN WITH SOLVENT ON THE MICROTENSILE BOND STRENGTH OF HYDROPHOBIC DENTIN ADHESIVE

박은숙,배지현,김종순,김재훈,이인복,김창근,손호현,조병훈 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.1

장기적인 상아질 접착의 내구성 악화는 접착층과 혼성층의 친수성 부위에서의 가수분해에 의해 일어나는 것으로 보고 되고 있다. 본 연구의 가설은 콜라겐 망상체를 유기용매로 프라이밍하면 콜라겐 조직을 붕괴시키지 않고 수분을 밀어내고 소수성 단량체와 유기용매로 이루어진 접착제가 침투하여 접착강도를 얻을 수 있다는 것이다. 두 소수성 단량체인 Bisphenol-A-glycidylmethacrylate (Bis-GMA)와 triethyleneglycol dimethacrylate (TEGDMA)를 아세톤, 에탄올 또는 메탄올에 용해시켜 세 가지의 실험용 접착제를 준비하였다. 산 부식과 수세과정 후에, 접착제를 습윤 상아질 표면(습윤 접착)이나 동일한 용매로 프라이밍 된 상아질 표면(용매 프라이밍 접착)에 적용하였다. 48시간 후와 1개월 후, 및 10.000회의 열순환 후에 미세인장결합강도를 측정하였다 접착계면은 주사전자현미경을 이용하여 관찰하였다. 접착방법에 무관하게 대부분의 시편의 접착계면예서 잘 발달된 혼성층을 관찰할 수 있었고 가장 높은 평균 미세인장결합강도는 에탄올을 포함하는 접착제의 48시간 후 시편에서 관찰되었다. 용매를 이용하여 프라이밍하는 접착 방법에서는 에탄올이나 메탄올을 포함하는 접착제에서 열순환 후에 미세인장접착강도가 증가하는 경향을 보였다. 그러나 습윤 접착의 경우에는 시효처리 후 미세인장결합강도의 증가가 관찰되지 않았다. 본 연구에서 에탄올을 이용한 상아질 프라이밍으로 우수한 접착력을 얻을 수 있었고. 열순환 후 접착력이 더욱 증가하였다 Deterioration of long-term dentin adhesion durability is thought to occur by hydrolytic degradation within hydrophilic domains of the adhesive and hybrid layers. This study investigated the hypothesis that priming the collagen network with an organic solvent displacc water without collapse and thereby obtain good bond strength with an adhesive made of hydrophobic monomers and organic solvents. Three experimentaladhesives were prepared by dissolving two hydrophobic monomers bisphenol-A-glycidylmethacrylate (Bis-GMA) and triethyleneglycol dimethacrylate (TEGDMA), into acetone, ethanol or methanol. After an entching and rinsing procedure, the adhesives were applied onto either wet dentin surfaces (wet bonding) or dentin .surfaces primed with the same solvent (solvent-primed bonding). Microtensile bond strength (MTBS) was measured at 48 hrs, 1 month and after 10,000 times of thermocycles. The bonded interfaces were evaluated using a scanning electron microscope (SEM) Regardless of bonding protocols, weIl-developed hybrid layers were observed at the bonded interface in most specimens. The highest mean MTBS was observed in the adhesive containing ethanol at 48 hrs. With solvent-primed bonding increased MTBS tendencies were seen with thermocycling in the adhesives containing ethanol or methanol. However in the case of wet bonding, no increase in MTBS was observed with aging.

만성 간질환에 대한 DDB(Biphenyl Dimethyl Dicaboxylate)의 임상적 효과

이헌영,임의혁,김성걸,김진희,육은주,성자원,김병호,정형용,강대영,김영건 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

To investigate the effects of short-term administration of DDB(Biphenyl Dimethyl Dicarboxylate) for decreasing elevated serum aminotransferase levels in chronic liver diseases, authors applied 3 capsules of DDB per day at each meal time for 35 patients and compared with 35 patients treated with other conservative management. The following results were obtained. 1. Serum alanine aminotransferase (ALT) levels significantly decreased from 247.1± 180.0 IU/L of pretreatment level to 96.6±126.0 IU/L, 61.1±62.7 IU/L and 38.0±26.8 IU/L after 1, 3 and 6 months of treatment(p<0.05) and effective rates were observed in 60.0%, 71.4% and 88.6% of patients after 1, 3 and 6 months of treatment. 2. Serum aspartate aminotransferase (AST) levels decreased also significantly from 167.8±96.9 IU/L of pretreatment levels to 124.4±155.0 IU/L, 77.9±49.6 IU/L, 60.6± 46.9 IU/L after 1, 3 and 6 months of treatment(p<0.05), but decreasing pattern of serum AST was less significant than that of serum ALT. 3. No significant difference were observed in the serum ALT and AST changes according to the cause and duration of hepatitis. 4. No significant adverse effects were observed in whole patients treated with DDB. It is suggested that small dose administration of DDB is effective for decreasing serum aminotrans ferase levels in chronic liver disease in which other conservative management was not effective.

정상 면역 성인에서 발생한 거대세포바이러스 위염 1예

김갑현,박병배,백현정,이준행,백승운,백경란,장기택 대한내과학회 2004 대한내과학회지 Vol.66 No.3

거대세포바이러스 감염은 주로 면역기능이 저하된 환자에서 치명적인 기회감염으로 잘 나타나는 질환이다. 한편 면역 상태가 정상인 사람에서 발생되는 경우는 매우 드물다. 저자들은 심와부 동통과 구토를 주소로 내원한 정상면역의 27세 남자 1예를 보고한다. 상부위내시경상위 점막 결절상과 궤양소견을 보였고, 위 점막 결절과 궤양부위 조직검사상 거대세포바이러스 봉입체의 관찰로 거대세포바이러스 위염을 진단하였다. 최근 감염과 일차감염을 나타내는 거대세포바이러스 Ig M 항체는 양성이었다. Ganciclovir와 proton pump 억제제를 병용하여 치료하였고 증상 호전과 거대세포바이러스 seroconversion을 확인하였다. 저자들은 거대세포바이러스가 정상면역 성인에서 위 궤양을 일으킬 수 있는 경우를 경험하여 보고하는 바이다. Cytomegalovirus (CMV) infections are usually reported in immunocompromised patients. However, it occurs rarely in immunocompetent individuals. A case of CMV associated with stomach ulcers and mucosal nodules is reported in a immunocompetent host. A previously healthy 27-year-old man visited our hospital with a thirty-day history of epigastric pain and a nine-day history of vomiting. The demonstration of intranuclear inclusion bodies in a few gastric glandular epithelial cells contributed to the diagnosis of CMV gastritis. Treatment with a proton pump inhibitor and ganciclovir was successful to mitigate the epigastric pain and vomiting.

밤의 유통마진 및 유통체계에 관한 연구

김병택,김의경,정병헌,김대현 慶尙大學校 地域開發硏究所 1999 地域開發硏究 - 慶尙大學校 地域開發硏究所 Vol.10 No.-

경부 종괴의 초음파 소견

김진환,김충현,이병철 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.1

The 48 sonograms of 46 patients with neck masses were retrospectively reviewed to assess the superiority of ultrasonography. Neck masses were divided into salivary glands, thyroid gland, cervical lymph node origin masses, and others. The salivary gland masses(16 cases), included pleomorpic adenoma(5 cases), sialadenitis (9 cases), and abscess (2 cases). The thyroid gland masses(7 cases), included thyroiditis(2 cases), goiter(4 cases) and malignant tumor(1 case). The cervical lymphadenopathy(10 cases) included Inflammatory(7 cases) and neoplastic(3 cases). The other masses included branchial cleft cyst(2 cases), thyroglossal duct cyst(2 cases), cystic hygroma(2 cases), abscess(2 cases) etc. Real-time ultrasonography with water bag adapted linear array 5.00 MHz transducer enabled us to ascertain mass character in detail. Sonography is very useful for differentiating a soild lesion from a cystic one, for differentiating an intraglandular lesion from a superficially located lesion extrinsic to the gland. On the other hand, CT is the method of choice for seperating lesions of the deep portion of the neck from adjacent structures. The sonography does not visualize the entire deep portion at the neck but it is not a major drawback of the method because majority of lesion originate from the superficial portion

레슬링 스타일에 따른 부상유형에 관한 연구

김정현,김창환,김병완 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.4

This study aims to investigate what types of injury frequently occur when wrestlers perform their exercise and what cause their injury and propose an efficient scheme to prevent injury. The subjects consist of 59 Greco-Roman and 53 Free-style wrestlers. The results are as follows: (1) Locations of Sports Injury In the case of Greco-Roman wrestlers, the most frequent locations of injury were in the following order: the knee joints, the wrist joints, followed by the neck, the ankle joints, the hands, the shoulder, the head, the elbow joints, the face, the breastbone, ribs, the waist, hip joints, the upper arms, the abdomen, the head, the hip, the forearms, the femoral region and trunk. In the case of Free-style wrestlers, they were in the following order: the head, the wrist joints, the face, the knee joints, the neck, the waist, the elbow joints, the ankle joints, the breastbone, ribs, the hands, hip joints, the forearms, the shoulder, the abdomen, the upper arms and trunk. (2) Types of Sports Injury In the case of Greco-Roman wrestlers, the most frequent injury types were in the following order: scratch, muscle contusion(96.6%), muscle stiffness(94.9%), muscle sprain(93.2%), sprain(91.5%), fracture(88.1%), aural hematoma(86.4%), fissure(84.7%), bone contusion(83%), incised wound or cut, collateral ligament tension and fracture(79.6%), joint sprain(76.2%), tendon fracture(64.4%), dislocation(59.3%), arthritis, disc(57.6%), cerebral concussion(50.8%), proliferous bone change(49.1%), chronic joint change(45.7%), periostitis(38.9%), nerve contusion(37.2%) and cerebral contusion(27.1%). In the case of Free-style wrestlers, they were in the following order: scratch(98.1%), muscle contusion(96.6%), muscle sprain(92.4%), sprain(91.5%), collateral ligament tension and fracture(88.6%), muscle stiffness(86.7%), joint sprain(84.9%), fissure(81.1%), fracture(79.2%), incised wound or cut, aural hematoma(71.6%), disc(69.8%), tendon fracture(56.6%), chronic joint change(49%), arthritis(47.1%), dislocation, proliferous bone change(45.2%), periostitis(41.5%), nerve contusion(37.7%), cerebral concussion(33.9%) and cerebral contusion(30.1%). (3) Times of Sports Injury According to 96.6% of Greco-Roman wrestlers and 98.1% of Free-style wrestlers, the most frequent time of injury occurrence was exercise time. While 38.9% of Greco-Roman wrestlers reported the experience of an injury on defense, 37.7% of Free-style wrestlers reported the experience of an injury both on offense and defense. While 100% of Greco-Roman wrestlers reported the experience of an injury on a cloudy day, 94.3% of Free-style wrestlers reported the experience of an injury on cloudy or raining days. The experience of an injury in the winter season was reported by 54.2% and 39.6% of Greco-Roman and Free-style wrestlers, respectively. The experience of an injury during afternoon exercise time was reported by 71.1% and 81.1% of Greco-Roman and Free-style wrestlers, respectively. (4) Causes of Sports Injury 'carelessness', 'an excessive desire to win' and 'the inability of coaches' were cited as the major causes of sports injury by 67.9%, 33.8% and 25.4 % of Greco-Roman wrestlers, respectively. Meanwhile, 'an excessive desire to win', 'lack of warm-up' and 'the inability of coaches' were cited as the major causes of sports injury by 64.1%, 37.7% and 30.1% of Free-style wrestlers, respectively. (5) Treatment of Sports Injury Both Greco-Roman and Free-style wrestlers reported that, when they had an injury, the emergency treatment was given by coaches and subsequent treatments were administered in hospital and that hot fomentation was applied as an emergency treatment. (6) Psychological state at time of sports injury Both Greco-Roman and Free-style wrestlers reported that, in case of an injury, they were thinking "I'm going to get better soon." Greco-Roman wrestlers' psychological reaction to injury was "What if I can't do as well as before? while that of Free-style wresters was "I'm afraid I will get hurt again." The most frequently recommended by both Greco-Roman and Free-style wrestlers as a solution to reduce injury was 'enough warm-up and finishing'. (7) To the question how many times they had an injury on the same location after treatment, 55.9% of Greco-Roman wrestlers and 47.1% of Free-style wrestlers answered "two to five times". Most of them reported they had experienced an injury in the same location after treatment. (8) Greco-Roman and Free-style wrestlers reported they participated in national tournaments 67 and 70 times respectively and they have ever given up an important match at least once due to injury.

Ti-6Al-4V 합금의 피로특성-열처리, 온도, 주파수의 영향을 중심으로

김승한,김현철,임병수 成均館大學校 科學技術硏究所 1995 論文集 Vol.46 No.1

The effect of temperature, frequency and microstructure on fatigue crack propagation property of Ti-6Al-4V alloy has been investigated. The temperatures employed were room temperature, 200℃ and 400℃. The frequencies were 20Hz and 8Hz. The microstructures tested were equiaxed and bimodal microstructures. The bimodal microstructure was obtained by heat treatment of aging the quenched specimen for 1 hour at 500℃ which was solutionized in β-field at 971℃. Mechanical properties, fatigue crack growth rates were measured in different test conditions. From the experimental results, following conclusions were obtained. (1) Bimodal microstructure showed superior strength and fatigue crack growth resistance to equiaxed microstructure. (2) In all test conditions, fatigue crack growth rate increased with test temperature. (3) With the frequency decreasing from 20Hz to 8Hz, fatigue crack growth rate increased.

급성 및 만성 간질환에서 C형 간염바이러스 항체(anti-HCV)양성률

김삼용,성자원,김병호,이기천,허승식,길준영,정현용,이헌영,김영건 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

The prevalence of antibody against hepatitis C virus (anti-HCV) was investigated in 331 patients with various liver diseases from April 1992 to September 1992. The presence of anti-HCV was detected by Lucky HCD EIA test in 331 cases and by (Ortho HCV Antibody ELISA test 148 patients) The results are summarized as follows: 1. Overall, antibody to HCV(anti-HCV) was positive in 37(11%) of 331 patients with various liver diseases. 2. 16(11%) of 144 patients with chronic hepatitis, 2(5%) of 37 patients with alcoholic liver disease, 17(22%) of 76 patients with liver cirrhosis and 2(5%) of 38 HBsAg carriers were positive for anti-HCV.None of 12 patients with acute hepatitis, 11 patients with drug induced hepatitis and 13 patients with hepatocellular carcinoma was anti-HCV positive. 3. HBsAg positivity in patients who had anti-HCV was 24%(9/37). 4. A positive correlation was found between Lucky HCD and Ortho HCV test. Of 128 Lucky HCD negative cases, 124 cases were negative for Ortho HCV ELISA and 4 cases were positive for Ortho HCV ELISA Of 20 Lucky HCD positive cases, 11 cases were positive for Ortho HCV ELISA and 9 cases were negative for Ortho HCV ELISA. These results suggest that hepatitis C virus has an important etiologic role in HBsAg negative chronic hepatitis and liver cirrhosis in Korea. The diagnostic value of Lucky HCD EIA test may be slightly better or equivalent to Ortho HCV ELISA test in the diagnosis of Hepatitis C virus infection.