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김은희,김철규,이순교,김순덕,이혜옥,권정순,이경미,이민미,심순미,유용만,신종식,강은희,이상일,김병식,오성태,육정환,박수길 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.2
Background : Gastric cancer is the most common malignant tumor in Korea. surgical operation is one of the major treatment modalities for gastric cancer patients. Therefore, gastrectomy is one of the most common procedures in General Surgery. There were variation in length of hospital stay and medical treatment for gastrectomy between three surgeons at Asan Medical Center. Clinical pathways have received considerable attention as a tool for recucing the medical practice variation, increasing the efficiency of care process, and improving the quality of care. The aim of this study was to evaluate the effect of a clinical pathway for gastrectomy in gastric cancer patients. Methods : The clinical pathway for gastrectomy was developed and implemented by a multidisciplinary group in Asan Medical Center. A computerized clinical pathway program was developed and revised after a pilot test. A total of 145 patients underwent gastrectomy by three surgeons at Asan Medical Center. We compared the length of hospital stay, patient satisfaction, and unplanned readmission rate between the pre-pathway group(n=67) and the post-pathway group(n=78). We also investigated the degree of satisfaction among the physicians and nurses who were main end-users of the clinical pathway. Results : The clinical pathway was applied to all target patients. The average length of hospital stay was shortened from 12.7days to 10.6days(p<0.01). The degree of patient satisfaction with the care process changed from 90.3% to 89.2% after the implementation of the clinical pathway, but the difference was of satistically significant(p=0.761). Unplanned readmission rate was 2.9% in the pre-pathway group. More than 90% of physicians and nurses answered that the clinical pathway had been a useful tool in their medical practice. Conclusions : The findings of the study demonstrated that implementation of the clinical pathway for gastrectomy produced substantial reduction in the length of hospital stay while improving the quality of patient outcomes. The computerized clinical pathway program can be used as one of the powerful patient management tools for reducing the practice variations and increasing the efficiency of care process in Korea hospital settings.
진소연,심기현,이은지,구혜진,김명현,한영실,박정수,김용훈,Jin, So-Yeon,Sim, Ki Hyeon,Lee, Eun Ji,Gu, Hae Jin,Kim, Myung Hyun,Han, Young Sil,Park, Jung Su,Kim, Yong-Hoon 한국식품영양학회 2014 韓國食品營養學會誌 Vol.27 No.6
$20^{\circ}C$에서 15일 동안 저장기간별 사과의 변화를 살펴본 결과는 다음과 같다. 사과의 중량과 수분은 저장기간 경과에 따라 점차적으로 감소하는 결과를 보였으며, 사과의 저장 중 가용성 고형물 함량은 저장 4일차까지 최고치로 증가하였다가 서서히 낮아지는 경향을 나타냈다. 사과의 저장 중 유기산 산도는 저장 5일차에 급격히 감소하다가 완만히 감소하였으며, pH는 저장기간에 따라 완만히 증가하는 경향을 나타내었다. 저장 중 사과 껍질의 색상을 측정한 결과, L값은 저장기간에 따라 서서히 증가하였으며, a값은 저장 3일까지 감소하였고, 저장 5일에 증가되었다가 그 이후 점진적으로 감소하였다. b값은 저장 6일에 최저치를 보인 후 서서히 증가하는 경향을 보였다. 사과의 조직감을 측정한 결과, 저장기간이 증가됨에 따라 사과의 경도는 전반적으로 감소하였다. 저장 기간에 따른 사과의 총 페놀과 총 플라보노이드 함량을 측정한 결과, 총 페놀 함량은 저장 기간이 길어질수록 감소하는 경향이 나타났으며, 저장 3일차에서 저장 4일차에 큰 폭 감소하였다. 총 플라보노이드의 변화 결과, 1일차에 비교적 크게 감소하였고, 실험 7일차에서 8일차 사이에 급격히 감소하였다. 저장 기간에 따른 사과의 DPPH 전자공여능 측정결과, 저장기간이 증가할수록 DPPH 전자공여능은 감소하였으며, Vit. C 함량의 경우 저장 기간이 길어질수록 감소하였는데, 특히 저장 4일차에 비교적 크게 감소하였다. 사과의 관능평가 수행 결과, 저장기간이 경과함에 따라 외관의 좋은 정도는 0일차에 6.75에서 15일차 2.83으로 크게 감소하였으며, 신맛의 좋은 정도는 저장 기간에 따라 유의적인 차이를 보이지 않았으나, 전반적으로 감소하는 경향이었다. 단맛의 좋은 정도와 아삭함의 좋은 정도에서는 0일차에 각 6.25, 5.33으로 가장 높았으며, 15일차에 각 3.92, 2.83으로 유의적으로 감소하였다. 종합적인 기호도에서는 7일차와 8일차 사이에 5.00에서 3.50으로 비교적 큰 폭 감소하였으며, 15일차에 2.00으로 저장 기간에 지남에 따라 유의적으로 감소하였다. 이상의 실험결과, 사과 저장 시 3~4일차에 유의적인 차이를 보였으며, 저장 8일 이후에는 모든 항목에 있어 측정감이 크게 변화하는 경향을 나타내었다. 따라서 $0{\sim}1^{\circ}C$에서 장기 저장한 사과를 $20^{\circ}C$ 전후에서 저장 및 판매할 경우, 최고의 품질을 위해서는 3일 내에 판매할 것을 권장하며, 8일 이내에 재고를 소진할 수 있도록 유통 기간을 조정하는 것이 바람직할 것으로 사료된다. This study was performed in order to compare the changes in Korean apples' qualities and antioxidant activity when stored at room temperature, $20^{\circ}C$, for fifteen days. The results showed that the weight, moisture content, soluble solid content, acidity, and hardness levels decreased as the storage period increased. However, pH and color value L increased as the storage period increased. Total phenol contents, total flavonoids contents, DPPH free radical scavenging activity, and vit. C contents of apples significantly decreased with increased storage period. Sensory parameters, such as appearance, sweetness, sourness, crunchiness, and overall acceptability of apples, also decreased as the storage period increased. Based on these results, if, the apple are being stored around $20^{\circ}C$, then, to have the highest quality, the apples should be sold within three days, We also suggested that it is desirable not to store the apples fore more than eight days.
Sim, Sung-Eun,Ko, Eun-Sung,Kim, Duk-Kyung,Kim, Hae-Kyoung,Kim, Yong-Chul,Shin, Hwa-Yong The Korean Pain Society 2011 The Korean Journal of Pain Vol.24 No.1
Background: Nucleoplasty is a minimally invasive spinal surgery using a $Coblation^{(R)}$ technique that creates small voids within the disc. The purpose of this study was to evaluate the efficacy of cervical nucleoplasty in patients with cervical disc disorder. Methods: Between March 2008 and December 2009, 22 patients with cervical disc disorders were treated with cervical nucleoplasty after failed conservative treatment. All procedures were performed under local anesthesia, and fluoroscopic guidance and voids were created in the disc with the $Perc^{TM}$ DC Spine $Wand^{TM}$. Clinical outcomes were evaluated by the Modified Macnab criteria and VAS score at preprocedure, postprocedure 1 month, and 6 months. Results: Six patients had one, eight patients had two and eight patients had three discs treated; a total of 46 procedures was performed. Mean VAS reduced from 9.3 at preprocedure to 3.7 at postprocedure 1 month and to 3.4 at postprocedure 6 months. There was no significant complication related to the procedure within the first month. Outcomes were good or excellent in 17/22 (77.3%) cases. Postprocedure magnetic resonance imaging was acquired in two patients after two months showing morphologic evidence of volume reduction of protruded disc material in one patient but not in the other. Conclusions: Percutaneous decompression with a nucleoplasty using a $Coblation^{(R)}$ technique in the treatment of cervical disc disorder is a safe, minimally-invasive and less uncomfortable procedure, with an excellent short-term clinical outcome.
심은영 ( Eun-yeong Sim ),박혜영 ( Hye Young Park ),김미정 ( Mi-jung Kim ),이춘기 ( Choon-ki Lee ),전용희 ( Yong Hee Jeon ),오세관 ( Sea Kwan Oh ),원용재 ( Yong Jae Won ),이정희 ( Jeong Heui Lee ),안억근 ( Eok Keun Ahn ),우관식 ( K 한국식품영양학회 2017 韓國食品營養學會誌 Vol.30 No.5
본 연구는 가공밥용으로 적합한 품종을 선정하기 위하여 국립식량과학원에서 육성한 9개 쌀 품종의 단백질 함량, 수분관련 특성, 아밀로오스 함량, 호화점도 특성 분석 및 취반식미, toyo 윤기치, 식감 특성을 분석하였다. 쌀가루의 용해도는 선품과 친들이 6.98, 6.51%로 상대적으로 높았고, 총 전분함량은 90% 내외를 나타났으며, 아밀로오스 함량은 월백이 12.74%로 가장 낮았고, 중생골드가 17.2%로 낮았다. 치반점도는 월백과 선품이 ―89.94 및 ―36.97 RVU로 쌀가루 반죽의 노화가 가장 느릴 것으로 생각되며, 월백, 친들, 하이아미의 최종점도가 각각 152.06, 160.66 및 191.03 RVU로 식은 밥의 노화가 가장 느릴 것으로 판단된다. Toyo 윤기치는 친들, 삼광, 하이아미가 좋게 나타났으며, 식미치는 친들(80.03)>삼광(76.21)>중생골드(74.08) 순으로 나타났다. 식감특성은 중생골드, 친들, 일품이 탄력성이 높으면서 부착성이 컸으며, 일품, 하이아미는 경도가 낮으면서 부착성과 찰기가 높았다. 전체적인 취반 식미 및 식감관련 평가 결과, 친들이 가공용으로 좋은 특성을 나타낼 것으로 판단되었다. Palatability and texture analysis of nine Korean rice cultivars were investigated to select the most appropriate rice variety for the cooked-rice processing. The rice cultivars studied consisted of Samkwang, Seonpum, Wolbaek, Andabyeo, Dasan-1, Ilpum, Haiami, Jungsanggold and Chindle. They revealed the moisture, protein, amylose and starch contents of 10~12, 5~6, 12~19, and approximately 90%, respectively. Among the evaluated rice varieties, WB exhibited the lowest amylose content (12.7%) and Jungsanggold the next (17.2%). In the rapid-visco analyzer test, Jungsanggold, Chindle, Wolbaek and Seonpum revealed a low value of final and setback viscosities than other varieties. Using a toyo meter analyzer, Chindle, Haiami, Samkwang were selected as having high toyo palatability values, while Dasan-1, Wolbaek and Andabyeo revealed low values. Toughness and adhesiveness of all nine cooked rice varieties were highest in Jungsanggold, Chindle and Ilpum. Also, palatability of cooked rice was highest in the following order: Chindle (80.03) > Samkwang (76.21) > Jungsanggold (74.08). The results of this study suggest that Chindle may be effectively used to produce processed cooked rice.
Deok Yong Sim,Hyo-Jung Lee,Eunji Im,Ji Eon Park,Chi-Hoon Ahn,Ju Eun Baek,Kyung Seok Kim,Dae-Yong Lee,Sung-Hoon Kim,Bum Sang Shim 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Though Cornin is known to induce angiogenic, cardioprotective and apoptotic effects, there is no report on antitumor effect of Cornin in prostate cancers yet. Thus, in the present study, the apoptotic mechanism of Cornin was investigated in androgen-dependent prostate cancer cells in association with STAT3/AR signaling axis. Cornin exerted significant cytotoxicity, induced sub-G1 population, and decreased the PARP and caspase3 in LNCaP cells. Consistently, Cornin downregulated the expression of AR, PSA and 5α-Reductase in LNCaP cells. Furthermore, Cornin inhibited phosphorylation of STAT3 and also disrupted the binding of STAT3 and AR in LNCaP cells. Notably, Cornin upregulated the level of miR-193a-5p in LNCaP cells. Consistently, miR-193a-5p mimic exerted cytotoxicity, suppressed AR, STAT3 and pro-PARP and suppressed the expression of AR and 5α-Reductase at mRNA level, whereas miR-193a-5p inhibitor reversed the ability of Cornin to attenuate AR, PSA and STAT3 in LNCaP cells. Overall, our findings provide scientific evidence that miRNA-193a- 5p mediated inhibition of STAT3/AR signaling axis is critically involved in Cornin induced apoptosis in prostate cancers.