정신분열병과 Neurotensin 수용체 유전자 다형성의 연합 연구

이유상,김형배,한진희,채영규,이정식,이혜순,주연호,김형섭,최인근,양병환 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: Neurotensin(NT)은 NT수용체와 결합하여 그 효과를 나타내는 neuromodulator 혹은 neurotransmitter로서 대뇌에서 도파민의 분비를 조절하는데 중요한 역할을 한다. 근래의 연구에 의하면 NT와 그 수용체는 대뇌에서 항정신병 약물의 효과를 매개하는 것으로 생각되고 있으며 약물치료를 받지 않은 정신분열병 환자의 뇌척수액에서 NT의 양이 적으로 보고되고 있어 이들은 정신분열병과 깊은 관련을 가지고 있을 것으로 추정된다. 최근 NT수용체의 유전자의 3`인접영역에서 정보가치가 높은 4 염기반복 다형성이 발견되어 이를 유전 표지자로 하여 정신분열병과의 연합을 알아보았다. 방 법: 서로 혈연관계에 있지 않은 정신분열병 환자 120명(남자 91명, 여자 29명)과 정상 대조군 106명(남자 84명, 여자 22명)을 대상으로 하였다. PANSS를 사용하여 양성 및 음성을 알아보았다. 말초혈액에서 DNA를 분리한 후에 중합효소연쇄반응을 사용하여 3`인접영역에 있는 4 염기 반복 다형성을 증폭하였고 silver staining한 후에 유전자형을 관찰하였다. chi-square 검증과 Bonferroni`s correction을 사용하여 환자군과 정상 대조군간의 대립유전자 빈도의 차이를 알아보았다. 또한 양성 및 음성 환자군으로 나누어 차이를 알아보았다. 결 과: 총 23개의 대립유전자가 관찰되었으며, 399bp의 대립유전자(A10)의 빈도가 환자군보다 정상대조군에서 통계적으로 유의하게 높았다(χ²=16.49, df=1, p<0.001). 음성 정신분열병 환자군과 정상대조군 사이의 비교에서는 정상대조군의 A10의 빈도가 환자군보다 유의하게 높았다(χ²=21.33, df=1, p<0.001). 성별 비교에서 남자 정신분열병 환자군은 대조군에 비하여 A10의 분포가 유의하게 적었다. (χ²=13.71, df=1, p<0.001) 결 론: NT 수용체 유전자와 정신분열병사이에 음성연합이 관찰되었다. NT 수용체 유전자가 일부 정신분열병의 발병과정에서 확실하지는 않지만 어떤 종류의 보호기능을 할 수도 있다는 것을 암시한다. Objectives: Neurotensin(NT), of which functions are evoked by its interaction with neurotensin receptors(NTR), coexists with mesolimbic dopamine and regulates endogenous dopamine release. Recent studies have shown that NT with NTR exerts neuroleptic-like activity within the central nervous system and may play an important role in the pathogenesis and in the treatment of schizophrenia. We have examined the gentic association between schizophrenia and tetranucleotide repeat polymorphism in the 3-flanking region of the NTR gene to investigate the possible contribution of the NTR gene to the schizophrenia susceptibility. Methods: Among 23 alleles identified, the subjects were 120 patients(male 91, female 29)with schizophrenia and 106 normal healthy controls(male 84, female 22). They were unrelated native Korean. PANSS was used to determine positive or negative subgroup in the schizophrenic patients. Using polymerase chain reaction and polyacrylamide gel electrophoresis, tetranucleotide repeat polymorphism(CCTT and CTT) in the 3`-flanking region of NTR gene was observed. For a comparison of NTR gene`s allelic frequencies between patients with schizophrenia and normal healthy controls, chi-square test and Bonferroni`s correction was performed. Results: The frequency of A10 allele(base pair size=399)was significantly higher in normal healthy controls than schizophrenia(χ²=16.4902, df=1, p<.000). In the comparison between schizophrenic patients with negative symptoms and normal controls, the frequency of A10 allele was significantly higher in normal healthy control subjects than patients with schizophrenia(χ²=21.33, df=1, p<0.001). In the case of male, the frequency of A10 allele of schizophrenia was significantly higher than normal controls(χ²=13.71, df=1, p<0.001). Conclusions: NTR gene was negatively associated with schizophrenia. NTR gene`s tetranucleotide repeat polymorphism may provide some protective function against schizophrenia.

기술교과 교육 제도 및 연구의 국제적 동향 : ICTES '95 발표 논문을 중심으로 through Analyzing of Papers Presented at the ICTES '95

이재원,김진순,류창렬,노태천,최완식,최유현,송일민 충남대학교 공업교육연구소 1995 論文集 Vol.18 No.1

The purposes of this study were: (a) to analyze the papers presented at the ICTES according to the papers' representing countries and their main subjects, (b) to analyze the educational systems of the countries in technology education, and (c) to review the international trends of technology education through the papers presented at the conference. The papers(64 total) presented at the ICTES could be classified into eight countries of papers representing Japan(37), Taiwan(8), Korea(6), U. S. A.(3), India(3), Philippines(3), China(2), Singapore(2). The main subjects the papers dealt with could also be classified into educational system/history(9). curriculum/objectives and contents(9), international activities(9), methods/teaching-learning process and teaching materials and new media(40). Followings were the major and new issues presented at the ICTES: (a) Introduction of each country's technology education system. (b) Proposition of a new framework for technology education and a world core curriculum in technology education. (c) Creativity and problem-solving for the instructional method of technology education. (d) Methods and utilization of high technology media in technology education. (e) Necessity of engineering concept in technology education in technology oriented society. (f) Proposition of philosophical direction of technology education based on famous Asian philosophers.

안면부, 유방 및 상완부에 발생한 홍반성 루푸스 지방층염 1예

송유근,손두식,명형준,이현정,임중규,김순호,김윤아 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2

Lupus erythematous panniculitis is a chronic inflammatory disease of subcutaneous fat that occurs in 2-3% of patients with systemic lupus erythematosus. Lupus erythematous panniculitis typically presents with firm, indurated subcutaneous nodules or plaques commonly developed in proximal extremities, trunks, head and neck. Face, breast and upper extremities involvement with lupus erythematous panniculitis has been infrequently reported. We report a case of lupus erythematous panniculitis developed in a 27-year-old female confirmed by histologic features and laboratory findings.

진균성 부비동염 환자의 상악동내 농성 분비물에 대한 세균 배양 및 항생제 감수성 결과

이윤식,김용재,김재호,정유삼,이봉재 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.10

수정 몬테칼로법에 의한 鐵筋콘크리트 보의 離散形 最適設計

김유식,이해은,박경현 大田産業大學校 1999 한밭대학교 논문집 Vol.16 No.1

In this study, our effort has been made to review the economics design for the discrete optimum design of the R. C. beam section by modified Monte carlo method. In this discrete optimum formulation, the design variables are the overall depth, width and effective depth of beams and area of longitudinal reinforcement. Total weight has been used as the objective function. The constraints include the code requirements such as flexural strength and steel ratio. The proposed algorithm is applied to a test problem for reliability, and the results are compared with the Monte carlo optimum design and the modified Monte carlo optimum design by strength design method As a result of calculation, In the optimum convergence by the each method, it was very earlist on the case of 5cm unit. Optimum weight was very light in the case of 2cm unit. In the study, Our know to possible of design by the optimum design based on modified Monte carlo method.

AE기법 이용한 JLF/STS304이종재료의 최적 마찰용접조건에 관한 연구

윤한기,이진경,이상필,공유식 한국비파괴검사학회 2003 한국비파괴검사학회지 Vol.23 No.2

저방사화 페라이트강인 JLF는 핵융합로의 블랑켓과 같은 열교환기의 재료로써 유용한 재료이다. 이 재료의 광범위한 적용을 위해서는 JLF강과 다른 재료와의 접합기술의 개발이 중요하다. 최근 두 이종재료간의 접합에는 마찰용접이 많이 이용되고 있으며 본 연구에서도 JLF강과 STS304 간의 마찰용접에 의한 용접특성을 평가하였으며 특히 비파괴기법중의 하나인 음향방출 기법을 이용하여 두 이종재료간의 용접특성 및 최적의 용접조건을 평가하였다. 음향방출 파라미터중의 하나인 카운트와 사상수 등이 최적용접조건 및 용접품질을 평가하는데 유효한 파라미터들이었다. Japanese low activation ferritic steel(JLF) is a good material for the parts of heat exchanger such as blanket and diverter. At first, JLF was developed as a candidate for structural materials in nuclear fusion applications. However, the development of the jointing technique of JLF steel to other materials is important for wide applications of this material to the industry fields. Recently the jointing technologies including diffusion bonding, brazing, roll bonding, explosive bonding and hot iso-static pressing have been studied for the heterogeneous materials of JLF-1 steel(Fe-9Cr-2W-V-Ta) and stainless steel(STS304). Friction welding is one of the most popular welding methods for two different kinds of materials. In this paper, the JLF-1 steel was jointed to STS304 by friction welding method and the optimal conditions of the friction welding discussed. Acoustic emission was used as a nondestructive technique to evaluate the weld quality in processing.

동종 조혈모세포이식 후 발생한 치명적 홍역 폐렴 1예

백창렬,이동건,최정현,정현화,조유경,박훈준,이승훈,박윤희,이교영,민우성,김춘추,신완식 대한감염학회 2001 감염 Vol.33 No.4

As a result of the enlarging pool of unvaccinated children and young adults, there has been an increase in measles in our countries. In these situation, it has been reported that measles associated pneumoinia is easily complicated with fatal respiratory failure, espycially in immunocompromised patients. Herein we report the case of lethal measles pneumonia after allogenic hematopoietic stem cell transplantation in adults proven by autopsy. Recently, one case of measles was encountered in 39-year-old female patients after allogenic bone marrow transplanted case (chronic myelogenous leukemia), who progressed into interstitial pneumonia pattern, despite treatment including antibiotics, immunoglobulin. The patient died of giant cell pneumonia compatible with that of measles which was comfirmed in the section of necropsy lung specimen. (Korean J Infect Dis 33:301∼309, 2001)

현장환경의 원격제어를 위한 센서신호처리 및 전송시스템의 개발

박종식,유상대,김항준,이종국,윤태수 경북대학교 센서기술연구소 1991 센서技術學術大會論文集 Vol.2 No.1

여러 분야에 걸쳐서 각종 센서의 개발과 센서신호 처리 시스템의 개발이 활발히 이루어지고 있다. 본 논문에서는 산업 현장 및 대형 건물내에서 입력되는 환경에 대한 센서 신호를 신호처리하여 최적 환경 상태를 유지하는 시스템을 개발하였다. Locall controller는 각각 독립된 마이크로 컴퓨터를 내장한 인텔리전트 형식으로 구성되고 이들이 전용 LAN을 통해 중앙통제 장치와 통신한다.

수도 단간 수수형 도입품종에 대한 시비량 및 시비방법에 관한 연구

문태만,이유식 진주산업대학교 1970 論文集 Vol.4 No.-

본 시험포장이 사양토로써 질소의 유실이 많았다고 생각되나 단간수수형인 시라누이는 보통수준의 시비보다는 다비재배에서 그 수량이 나았고 질소비료 시비방법으로서는 기비 20%, 분열비 30%, 출수전 25일 20%, 출수전 18일 15%, 수전기 15%로 분시한 것이 가장 높은 수량을 나타내었다. 본 품종은 줄무늬 잎마름병 및 오갈병등의 바이러스병에 약하므로 이의 방제에 철저를 기할 것이며, 수수형 품종으로서 수수확보가 용이하므로 분얼비까지의 시비량을 가급적 억제하여 유효경비율을 높이고 추비중점으로 시비하여 등숙율을 높이면 성숙안전한 본도 남부 해안도서 지대에서는 증수될 것으로 기대된다. This experiment was conducted to clear the amount of fertilizer and techniques of fertilization for a newly introduced short stemed and numorous panicled variety "Siranuii". The results obtained in this experiment were as follows: Short-stemed and numorous panicled variety "Siranuii" showed fairy higher harvested yield under the condition of heavy fertili er application than common fertilization. Nitrogen application for "Siranuii" should be practiced mainly on split application as follows: 20%, 30%, 20%, 15%, 15% of the total nitrogen for the basal application, accelerate effective tillers and at 25 days before heading. 18 days before heading and top dressing for heavy panicle, respectively, since that method contributed to the highest yield. "Siranuii" becomes susceptible to leaf-sheath blight and dwarf disease. On the other hand, this variety may be induced many sufficient effective tillers with low nitrogen fertilizer application untill top dressing for accelerate tillers. Practicing low basal nitrogen application and heavy top dressing for good ripening of grains, "Siranuii" may be recommended as a highly yielding variety for the diseases, Islands of southern part in Kyung-nam province.

파종시기가 다른 일미찰의 등숙 중 호화 특성 비교

김미정, 박효진, 이유영, 김선림, 김정태, 우관식, 권영업, 정일민 忠北大學校 農業科學硏究所 2014 農業科學硏究 Vol.30 No.2

This study was conducted to investigate the pasting properties of waxy corn ‘Ilmichal’ during ripening with different sowing date. Starch content of Ilmichal was increased as matured (p<0.05). Analysis of pasting properties with waxy corn starch using a rapid visco analyser (RVA) showed linear changes in peak viscosity, trough viscosity, final viscosity, breakdown and consistency according to ripening. There were significantly positive correlation between starch content of Ilmichal and peak viscosity (0.39*), trough viscosity (0.58***), final viscosity (0.58***), and consistency (0.57**). Differential scanning calorimerty (DSC). The enthalpy of gelatinization was increased as ripening. But onset and peak temperature were decreased. There were significantly positive correlation between starch content of Ilmichal and onset temperature (0.44*), peak temperature (0.38*), and completion temperature (0.59***), on the other hand, crude protein content presented significantly negative correlation between completion temperature (-0.41*).