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- 저자 : 이봉재 (검색결과 527 건)
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이봉재,김재호,이인철 대한비과학회 1995 Journal of rhinology Vol.2 No.2
Background : The increases of inflammatory cells in the nasal lavages and the mucosal tissues hours after antigen challenge in the allergic rhinitics propose the possibility of the corresponding increase of vascular endothelial adhesion molecules. The purpose the this study is to investigate the effect of allergen challenge on the expression of adhesion molecules and their temporal pattern of expression in the nasal mucosa of allergic rhinitis. Materials and Methods : The inferior turbinate mucosae were taken from 6 patients with perennial allergic rhinitis and cultured in the RPMI 1640 media with relevant antigen(D.farinae) for 0, 1, 2, 4, 6, 12, 24, and 48 hours. The proportion (%) of mucosal vessels expressing endothelial adhesion molecules such as ICAM-1, E-seletin, and VCAM-1 was obtained from the specimens immunostained with ABC-AP method. Results : The expression of E-selectin, with minimal at baseline, was significantly upregulated 1hour after culture with antigen, reached peak at 4 hour (38.3%), and then returned to baseline at 24 hour. The baseline expression of ICAM-1 was most prominent (48%). The incubation of allergic mucosa with antigen increased the ICAM-1 expression slowly until reaching to the peak level (77%) at 12 hour , and the level was maintained as long as 48 hours. Unlike E-selectin or VCAM-1, ICAM-1 was also expressed on the epithelial cells, especially in the basal cell layer. Conclusion : The expression of E-selectin showed a characterisctic of rapid induction and decline in the allergic nasal mucsoa. The prominent expression of ICAM-1 on the epithelial cells as well as on the vascular endothelial cells suggests the active role of ICAM-1 in the extravasation of inflammatory cells and also in the transepithelial migration into the nasal secretion.
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Expression of Adhesion Molecules in the Nasal Mucosal Inflammation
이봉재 대한비과학회 1996 Journal of rhinology Vol.3 No.1
The late phase reaction in allergic rhinitis is now considered to be responsible for the chronic nasal obstruction in the patients with allergic rhinitis. The main pathophysiology of the late phase reaction comprises an accumulation of inflammatory cells including eosinophils and T-lymphocytes. How these cells are preferentially recruited remains incompletely defined. Along with mast cells and other cells, they release a wide variety of mediators, cytokines, and granule constituents that can directly cause inflammation or activate local vascular endothelium to further enhance the recruitment of leukocytes through the expression and the function of adhesion molecules. Cell adhesion molecules are now known to be critical for virtually every step in cell recruitment, including margination, transendothelial migration, chemotaxis, and transepithelial migration. Cytokines can promote cell recruitment by altering the function and/or the expression of leukocyte, endothelial cell adhesion molecules. While the understanding of the importance of leukocytes and endothelial adhesion molecules is still at a very early stage, recent evidence has already begun to implicate these cell surface molecules in the pathogenesis of allergic diseases such as allergic rhinitis and asthma.
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시험관내 항원 투여가 알레르기성 비염 환자의 비점막내 호산구 침윤과 접착분자의 발현에 미치는 영향
이봉재,신현수 (Bong Jae Lee,Hyun Soo Shin) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.2
We aimed to investigate the effect of in vitro allergen challenge on activation of eosinophils and expression of intercellular adhesion molecule-1(ICAM-1) in the epithelial and endothelial cells of the nasal mucosa of allergic rhinitics. Materials and methods . Inferior turbinate mucosal specimens which were obtained from 16 perennial allergic rhinitics and sensitized to D. farinae during conchotomy operations were used. Each mucosal specimen was divided into six pieces. The first two pieces were used as basic control group without culture, the second two pieces as culture-control group which was cultured with diluent only, and the last two pieces as antigen-challenge group cultured with D. farinae solution for 24 hours. Specimens were immunohistochemically stained using monoclonal anti- body against eosinophil cationic protein(EG1 for all eosinophils and EG2 for activated forms) and ICAM-1. Results .' Average counts of EG1 cells and EG2+ cells within 1 mm of lamina propria of nasal mucosa were 14 and 11 respectively in the basic control group, 17 and 19 in culture control group, and 16 and 16 in the antigen-challenge group. ICAM-1 expression on vessels was observed more than half of t,he vessels in the nasal mucosa and there was no significant difference between groups, however, its expression on the epithelial cells was most prominent in the antigen-challenge group (2.1 in basic control group, 3.3 in culture control group, and 6.2 in antigen-challenge group). Conclusion: Most of the eosinophils infiltrat,ing into the nasal mucosae out of vessels in allergic rhinitics are activated forms. Significant up-regulation of epithelial ICAM-1 expression by antigen-challenge suggests that ICAM-1 contributes to the transmigration of eosinophils from the subepithelial tissue into the epithelial cell layer and then finally into the nasal secretion.
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이봉재,김형석 대한비과학회 1997 Journal of rhinology Vol.4 No.2
Authors aimed to know the efficacy of sinus surgery for the chronic sinusitis in the objective and subjective aspects and tocompare the surgical outcomes of endoscopic sinus surgery with those of conventional sinus surgery. Two hundred patientswho had undergone sinus surgery, either conventional (100 patients) or endoscopic (100 patients), for chronic medically recalcitrantsinusitis were retrospectively studied by reviewing medical records and radiological films. Questionnaires asking postoperativechanges of preoperative symptoms were analyzed to assess the subjective improvement. Normalization of the nose,which was defined as free of pathologic secretions and polyp or polypoid growths on endoscopic examination, could be achievedin 41% of 111 patients who had been followed-up for more than 6 months postoperatively, and there was no significant differencein the rate of normalization between the conventional surgery group (40%) and endoscopic surgery group (43%). Postoperativepolyps or polypoid growths were developed in 23% and persistence of mucopurulent secretion was identified in 36%. Overallassessment of patients for the subjective symptoms revealed 77% improvement (64% in conventional group vs. 88% in endoscopicgroup;p>0.05), and endoscopic sinus surgery appeared to be superior to conventional sinus surgery in relieving nasalobstruction and headache with statistically significant difference (p<0.05). Among possible prognostic factors for the recurrence ofpolyps, young age and preexisting nasal polyps were significant. These results suggest that frequent development of polyp orpolypoid mucosal changes after operation and persistence of pathologic secretions mandate the surgeons to be considerate inselecting surgical candidates and to explain the patients preoperatively about the possible poor results necessitating additionalsurgical procedures.
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A Case of Hemangiopericytoma Removed with Facial Translocation Approach
이봉재,이재진,조성래 대한비과학회 1996 Journal of rhinology Vol.3 No.1
Hemangiopericytoma, arised from the Zimmerman’s pericyte around capillaries, can develop anywhere there are capillaries in the body. Histopathological diagnosis separating benignancy from malignancy is very difficult and local recurrences after surgery are frequent. Recently we experienced a case of hemangiopeicytoma extending from right skull base to the oral cavity, which developed in 60 year-old man complaining right cheek swelling and intraoral mass persisting for four months. Preoperative histopathologic diagnosis was made with punch biopsy of the gingivobuccal mass. The extent and the vascularity of the tumor were evaluated with computed tomography, magnetic resonance imaging, and angiogram. We could remove the tumor completely via mini lateral facial translocation approach after embolization, so we report the case with brief review of literature.
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