Integrative Physiology: Defined Novel Metabolic Roles of Osteocalcin

김유식,박일영,이영준,서상훈 대한의학회 2010 Journal of Korean medical science Vol.25 No.7

The prevailing model of osteology is that bones constantly undergo a remodeling process,and that the differentiation and functions of osteoblasts are partially regulated by leptin through different central hypothalamic pathways. The finding that bone remodeling is regulated by leptin suggested possible endocrinal effects of bones on energy metabolism. Recently, a reciprocal relationship between bones and energy metabolism was determined whereby leptin influences osteoblast functions and, in turn, the osteoblast-derived protein osteocalcin influences energy metabolism. The metabolic effects of bones are caused by the release of osteocalcin into the circulation in an uncarboxylated form due to incomplete γ-carboxylation. In this regard, the Esp gene encoding osteotesticular protein tyrosine phosphatase is particularly interesting because it may regulate γ-carboxylation of osteocalcin. Novel metabolic roles of osteocalcin have been identified, including increased insulin secretion and sensitivity, increased energy expenditure, fat mass reduction, and mitochondrial proliferation and functional enhancement. To date, only a positive correlation between osteocalcin and energy metabolism in humans has been detected,leaving causal effects unresolved. Further research topics include: identification of the osteocalcin receptor; the nature of osteocalcin regulation in other pathways regulating metabolism; crosstalk between nutrition, osteocalcin, and energy metabolism; and potential applications in the treatment of metabolic diseases.

CFBC 보일러 내화재 관리 방안 연구

김유식,윤호근,민설희,조재윤,안현오 한국화재소방학회 2017 한국화재소방학회 학술대회 논문집 Vol.2017 No.춘계

현대중공업(주)-세계 최고의 첨단 기술을 갖춘 종합 중공업 기업

김유식,Kim, Yu-Sik 한국원자력산업회의 2007 원자력산업 Vol.27 No.11

Alginate-Catechol Cross-Linking Interferes with Insulin Secretion Capacity in Isolated Murine Islet Cells

김유식,조승우,고보민,신지수,안철우 대한당뇨병학회 2018 Diabetes and Metabolism Journal Vol.42 No.2

Over the past three decades, human pancreatic islet isolation and transplantation techniques have developed as a routine clinical procedure for selected patients with type 1 diabetes mellitus. However, due to the donor shortage and required chronic systemic immunosuppression, the widespread application of islet transplantation is limited. To overcome these limitations, providing a physical barrier to transplanted islet cells with encapsulating biomaterial has emerged as a promising approach to enhance engraftment and promote islet survival post-transplantation. Alginate has been considered to be a reliable biomaterial, as it enhances islet survival and does not hamper hormone secretion. Alginate-catechol (Al-CA) hydrogel was reported to provide high mechanical strength and chemical stability without deformation over a wide range of pH values. In this study, we, demonstrated, for the first time in the literature, that encapsulation of murine pancreatic islet cells with Al-CA hydrogel does not induce cytotoxicity ex vivo for an extended period; however, it does markedly abate glucose-stimulated insulin secretion. Catechol should not be considered as a constituent for alginate gelation for encapsulating islet cells in the application of islet transplantation.

수돗물 감성분석을 통한 수질하고에 따른 만족도 분석

김유식,최용준,조형락,주재현,이상호 한국공업화학회 2021 한국공업화학회 연구논문 초록집 Vol.2021 No.0

미국에 거주하는 대한민국 이민자의 문화적응 척도 연구

김유식,이솔잎 인문사회 21 2019 인문사회 21 Vol.10 No.5

This study aims to develop an acculturation scale for Korean immigrants in the United States. For this purpose, the instrument was based on consideration on theories and prior research related to acculturation, 11 interviews, and feedback from the expert group. The survey was conducted on 247 Korean immigrants living in California, US. The data was analyzed by frequency analysis, exploratory factor analysis, Cronbach’ s α, correlation analysis and confirmatory factor analysis by using SPSS 20.0 and AMOS 20.0 programs. The result shows that the acculturation scale of Korean immigrants living in the US is composed of 41 items and 9 factors; 6 items of language, 3 items of foreign food, 2 items of Korean food, 5 items of foreign friends relationship, 7 items of Korean friends relationship, 7 items of living environment, 2 items of media, 5 items of openness, and 4 items of children’s school life. Through this research, it is expected to be utilized in the theoretical and practical area for acculturation of Korean immigrants living in the US. 본 연구는 미국에 거주하는 대한민국 이민자를 위한 문화적응 척도를 개발하는데 목적이 있다. 이러한 연구 목적을 달성하기 위해 문화적응과 관련한 이론 및 선행연구를 고찰하고, 11명의 심층면접을 하였으며, 전문가 집단 피드백을 통해 연구 도구를 구성하여 미국 캘리포니아에 거주하는 대한민국 이민자 247명을 대상으로 설문조사를 수행하였다. 자료처리는 SPSS 20.0 및 AMOS 20.0 프로그램을 이용하여, 빈도분석, 탐색적 요인분석, 신뢰도 분석, 확인적 요인분석, 상관관계 분석 등을 수행하였다. 이러한 과정을 통해 미국에 거주하는 대한민국 이민자의 문화적응 척도는 언어 6문항, 외국음식 3문항, 한국음식 2문항, 외국 친구관계 5문항, 한국 친구관계 7문항, 생활환경 7문항, 미디어 2문항, 개방성 5문항, 자녀학교생활 4문항 등 총 9개 영역 41문항으로 구성되었다. 이를 통해 미국에 거주하는 대한민국 이민자의 문화적응을 위한 이론 및 실무적 영역에서 활용이 기대된다.

대학 부설 평생교육원 학습자의 온라인 수업 장애요인이 평생교육원만족에 미치는 영향

김유식,정병철 인문사회 21 2020 인문사회 21 Vol.11 No.3

Phenomenon such as COVID-19 bring many changes to the educational environment. In addition, lifelong education is an important for an individual`s valuable life. Therefore, research related to this educational environment and lifelong education is a demand of the times. To this end, this study has investigated the effects of obstacles to online course of the lifelong education center learner’s affiliated with university on lifelong education center satisfaction. The subject of the study was 171 learners of the institutes of lifelong education affiliated with H, I and K universities. For data processing, frequency analysis, correlation analysis, reliability analysis, and multiple regression analysis were performed using SPSS 20.0 program. As a result of the study, it was found that the learning environment, social presence, self directed learning and communication among instructor and students of the lifelong education center learner’s affiliated with university influenced lifelong education center satisfaction. Through this, it is expected to activate lifelong education and use basic data for a new educational environment. 코로나바이러스감염증-19 같은 현상은 교육환경에 많은 변화를 가져온다. 또한 평생교육은 개인의 가치 있는 삶을 위한 중요한 요소이다. 따라서 이러한 교육환경 및 평생교육과 관련된 연구는 시대적 요구이다. 이를 위해 본 연구는 대학 부설 평생교육원 학습자의 온라인 수업장애요인이 평생교육원만족에 미치는 영향을 규명하였다. 연구대상은 H, I, K대학 부설 평생교육원 학습자 171명을 대상으로 설문조사를 수행하였다. 자료처리는 SPSS 20.0 프로그램을 이용하여 빈도분석, 상관관계분석, 신뢰도분석, 중다회귀분석을 실시하였다. 연구 결과, 대학 부설 평생교육원 학습자의 학습환경, 사회적실재감, 자기주도적학습, 상호작용이 평생교육원 만족에 영향을 미치는 것으로 나타났다. 이를 통해 평생교육 활성화 및 새로운 교육환경을 위한 기초자료 활용이 기대된다.

스토리 뷰잉(Story-viewing)을 적용한 화력발전분야 안전교육 콘텐츠 연구

김유식,민설희,성윤학,박영제 한국화재소방학회 2016 한국화재소방학회논문지 Vol.30 No.3

There have been happening small and big fires due to the various causes in the thermal power plants which are the highrisk buildings with the high possibility of big sizes of accidents, so the people in the power plants distribute the workers“the site action manuals in thermal power plants” and try to minimize the rate of disasters like fires through the regulareducation and training. However, in the Five Thermal Power Plants in Korea, there are no the standard of “the site actionmanuals” and Furthermore, the present educational manuals are mostly the hard copies with poor readability. So the standardizationof the manuals are definitely needed. Therefore, in this research, we proceed the standardization of the manualsfor the five areas of the site action manual s in the thermal power plants which are oil fires, electric fires, buildingfires, facility fires and gas leaking reaction SOP to improve the reaction power on the disasters in the power plants whichare the national significant infrastructures, thus by using the manual, we propose the safety education contents for thethermal power plants based on the visualization technology using story-viewing method to complement the hard copytype disaster manuals. 화력발전소는 중대형사고의 발생위험이 높은 고위험군 건물로 다양한 원인에 의하여 크고 작은 화재 등이 발생하고 있어 화력발전소 현장에서는 ‘화력발전분야 현장조치 행동 매뉴얼’을 배포하고 정기적인 교육 및 훈련을 통하여 화재 등재난발생률을 최소화하기 위하여 힘쓰고 있다. 그러나 현재 국내 5개 화력발전회사에서 사용되는 교육자료는 대부분 가독성 낮은 인쇄물(Hard Capy) 형태이며, 발전화사별, 사업소별로 상이하게 구성된 점이 있어 표준화 작업이 요구된다. 그러므로 본 연구에서는 국가 중대 기반시설인 발전소의 재난대응력을 향상하기 위한 방법으로 ‘화력발전분야 현장조치행동 매뉴얼’의 ‘유류화재 · 전기화재 · 건물화재 · 설비화재 · 가스누출 대응 SOP’ 5개 부분에 대하여 매뉴얼 표준화작업을 진행하고, 이를 바탕으로 인쇄물(Hard Capy)형 재난매뉴얼을 보완할 수 있는, 스토리뷰잉(Story-viewing) 기법을적용한 시각화 기반 화력발전분야 안전교육 콘텐츠를 제안하고자 한다.

YABEC 2017 행사 보고

김유식 한국화학공학회 2017 NICE Vol.35 No.6

수돗물 적수사태 감성분석을 통한 수돗물 만족도 평가기술 개발 방법론 도출

김유식,최용준,조형락,주재현,이상호,이송 한국공업화학회 2021 한국공업화학회 연구논문 초록집 Vol.2021 No.0