야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

Ki-67이 Luminal B형 유방암 환자의 예후에 미치는 영향

류동원,최우식,이충한 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.1

배경: Ki-67는 세포의 분열지수로서 특히 세포분열초기 나타나는 것으로 알려져 있다. 그래서 Ki-67의 분열지수가 높은 경우 조기 재발 및 예후와 관련되어 있다는 보고가 있다. 본 연구에서는 본원의 자료를 토대로 Ki-67의 분열지수가 예후에 영향을 미치는지를 알아보고자 한다 방법: 2001년 1월부터 2005년 12월까지 본원에서 유방암으로 수술을 받은 679명의 환자를 대상으로 후향적으로 조사를 하였다. 술후 조직병리학적 보고서를 토대로 조사하였다. Ki-67의 수치를 기준으로 10%이하군, 10%에서 20%군, 20%이상군으로 나누었다. 세군사이의 임상병리학적 요소의 분포를 비교하였으며 Kaplan-Meier를 이용하여서 생존율을 분석하였다. 결과: 환자들의 평균나이는 46세였으며, 평균종양의 크기는 3.2cm였다. 20%이상군에서 진행성 유방암환자의 비율이 높았다.(p=0.007) 특히 림프절의 전이정도와도 관련이 있었다.( p=0.003) 그러나 Ki-67과 생존율과는 의미있는 관련성을 없었다.( p=0.6112). 결론: 본원의 조사에 따르면 Ki-67은 진행성 유방암과 호르몬 수용체 음성과는 밀접한 관계를 가지고 있었으나 생존율에는 영향을 미치지 않았다. 그러나 본조사는 추적기간이 짧고 조사 규모가 크지 않아서 향후 계속적으로 추적 관찰한다면 더 의미있는 결과과 나올것이다. Background: Ki-67 expression has been considered to be a reliable marker for assessing tumor cell proliferation. The aims of the ourstudy were to assess the correlationbetween Ki-67 expression and clinocopathologic factors and to analyze the effect of Ki-67 expression on survival rate. Methods:The study subjects, 679 women with breast cancer, were a subset of patients operated at OOO hospital from Jun 2001 to Dec 2005.Patients are grouped into 3 categories according to Ki-67 determined in surgical specimens. Clincopathologic factors were compared with 3 categories of Ki-67. Chi-squared tests were used for statistical analysis. Kaplan–Meier estimates are presented for thesurvival function, and differences in survival were analyzed usingthe log rank test. Results: The median age was 46yrs, and median tumor size was 3.2cm. The strong correlation was observed between tumor staging and Ki-67 staining(p=0.007) and Group III(more than 20% staing) showed more advanced N-staging(p=0.003). The number of patients with estrogen receptor negative was higher in Group III(p=0.001) and that with HER-2 receptor positive was also higher in Group III(p =0.001) comparing with other groups. The univariate analysis for prognostic factors associated with DFS revealed that both the tumor groupas T1, T2, T3 or T4 and lymph node as N0, N1, N2 or N3 were statistically significant(p=0.0003 and p=0.0015 respectively) but the Ki-67 staining as <10%, 10~20%, >20% was statistically not significant(p=0.6112). The univariate analysis for prognostic factors associated with OS revealed that Tumor staging and N-staging was statically significant(p=0.003 and p=0.0015 respectively). Conclusions: According to our study, Ki-67 positive groups was associated with more advanced staging, ER-negative, PR-negative and HER-positive respectively. But there is no significant association between Ki-67 staining and 5-year disease free survival rate including overall survival rate.

지문과 정신분열증

우숙희,정국동,최송표,조근자,양은진,김수일,박경란,이영호,김원식 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Fingerprint patterns of 333 schizophreniacs who met with the diagnostic criterias of International Pilot Study of Schizophrenia except items associated with chronicity in exclusion criteria were studied, and the following results were obtained. 1. The frequency distribution of the fingerprint patterns in the 333 schizophreniacs was ulnar loop, whorl, twinned loop, arch, radial loop in order in both control and schizophrenia groups. 2. Finger ridge counts of both sexes were decreased significantly in schizophrenia group. 3. Dissociation of fingerprint pattern in the schizophrenia group was 51.1%, which was far greater than 6.25% of control group. Number of dissociation was greatest in the thumb, followed by index, middle, ring, and little finger in order. According to the above results, it is considered that both the number of finger ridges and degree of dissociation of fingerprint patterns were closely related with schizophrenia. Analysis of fingerprints and palmprints with the aid of chromosomal analysis would contribute the early diagnosis and prevention of schizophrenia.

분산 연성 실시간 시스템에서 공평한 부 태스크 데이라인 할당

문원식,안진우 평택대학교 1999 論文集 Vol.13 No.-

분산연성 실시간 시스템은 태스크가 순차적으로 혹은 병렬적으로 수행되는 시스템으로 실패하는 태스크의 수를 기준치 한도 내에서 허용하는 시스템이다. 기존의 시스템들은 도미노현상과 과부하 상태를 고려하지 않은 가상데드라인 방법을 사용했지만 본 논문에서는 도미노 현상과 과부하 상태를 고려한 2단계 가상 데드라인방법을 사용하여 태스크를 할당함으로써 도미노 현상을 줄이고 과부하 상태에서도 태스크간의 공평성을 실현하였다.

Para형 다단맥동 추출탑에서의 액-액 물질전달 효과

김우식,이호원,이성,염경호 연세대학교 산업기술연구소 1988 논문집 Vol.20 No.1

The mass transfer characteristics of para-type plate pulse column were studied in Toluene-Acetone-Water system. The mass transfer effects in this column were investigated by the changes of the amplitude, frequency and each phase velocity, and the overall volumetric mass transfer coefficient was correlated as follow: Koc·a = 0.02595 A¹????f¹??³????³U??????⁴?????? This result coincided with the Higbie's penetration theory. The efficiency of this column was decreased with the increase of pulse velocity, and was 70-95% in the range of 30-90 cm/min of the pulse velocity. The acetone concentration profile at the steady state was coincident with the diffusion model and the back flow model within the relative error range of 0.15.

신부전이 동반된 당뇨병 환자에서 발생된 침습성 모균증 : 수술과 Liposomal amphotericin B 및 GM-CSF 병합 요법에 의한 성공적인 치험 1예

이원영,오기원,임국희,장재혁,이동건,최정현,강무일,신완식,차봉연,이광우,손호영,강성구 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.4

저자들은 신부전이 동반된 당뇨병 환자에서 발생된 부비동형 모균증에 대하여 수술과 함께 liposomal amphotericin B 및 GM-CSF의 복합치료를 하여 성공적으로 치료한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Mucormycosis (zygomycosis) primarily affects diabetic or immunocompromised patients and typically progresses rapidly, necessitating surgical excision and antifungal therapy with amphotericin B. Large doses of amphotericin B are needed for cure, but it has the risk of causing significant renal toxicity. The recent development of liposomal amphotericin B allows antifungal therapy to be administered with potentially improved efficacy and reduced nephrotoxicity. We have experienced a case of paranasal mucormycosis successfully treated with surgery, liposomal amphotericin B and GM-CSF. A 59-year-old male suffering from diabetes mellitus for 6 years was admitted with pain at left maxillary area. He was diagnosed as mucormycosis after cytologic exam on the necrotic nasal mucosa, which showed typical hyphae. He have had diabetic nephropathy with macroproteinuria and had rapidly rising serum creatinine levels with the amphotericin B treatment: creatinine levels reverted to basal level with the use of liposomal amphotericin B. Despite surgical excision and continued antifungal therapy, his infection was not effectively controlled. Therefore, GM-CSF was administered additionally to improve phagocytic activity of leukocytes. He was finally cured after receiving a combination of aggressive surgery, liposomal amphotericin B and GM-CSF. To our knowledge, this is the first detailed clinical description of the treatment of mucormycosis with liposomal amphotericin B in Korea.

실관형 막모듈을 이용한 투과추출의 분리특성에 관한 연구

김우식,이호원,오준택 연세대학교 대학원 1991 延世論叢 Vol.27 No.1

The purpose of this study is to analyze separation characteristics in perstraction using hollow fiber modules. The perstraction experiments of acetic acid have been undertaken under various experimental conditions such as pressure changes, superficial velocity changes in aqueous and organic phases, and potting density changes in two systems with different distribution coefficients. There was no change in overall mass transfer coefficient with a change in the pressure difference between inside and outside hollow fiber. Tortuosity of hollow fibers used was obstained from mass transfer coefficients in membrane phase. The overall mass transfer coefficient increased nonlinearally with increase in organic and aqueous phase velocity where the proportion exponent was obtained to be 0.35 and 0.56 respectively.

비선형 특성과 4bit(LSB) 오차를 가진 10비트 감마(r)시스템의 설계

장원우,김현식,김인규,강봉순 東亞大學校附設 淸報技術硏究所 2006 情報技術硏究所論文誌 Vol.13 No.2

이 논문에서, 제시된 감마(r)라인 시스템은 해당 공식에 의해 만들어진 비선형 감마 곡선과 하드웨어로 구현된 결과 사이의 오차를 최소화하기 위해 만들어 졌다. 제시된 알고리즘과 시스템은 특정 감마값이 2.2, 즉 {0,1}^(2.2)에 의해 생성되는 공식과 입, 출력 데이터 크기가 10bit를 기반으로 한다. 오차를 최소화하기 위해, 시스템은 데이터 점들 사이를 지나 적합한 다항식을 만드는 수치해석 방법, 최소 자승 다항식을 사용하였다. 제한된 감마 라인은, 정밀도를 높이기 위해, 서로 각각의 중첩된 범위를 가지는 2차 다항식 9개로 구성되어 있다. MATLAB™7.0으로 검증된 알고리즘을 바탕으로, 제한된 시스템은 Verilog-HDL으로 구현되었다. 시스템은 2 클럭 지연을 가지며 1 클럭마다 결과가 생성된다. 오차 범위 (LSB)는 -4에서 +3이다. 표준편차는 1.287956238을 가진다. 시스템의 전체 게이트 값은 2,083이며, 최대 타이밍은 15.56[ns] 이다.

Para형 다단맥동 추출탑의 유동특성과 물질전달

윤장효,염경호,김우식,김원규 연세대학교 대학원 1986 延世論叢 Vol.22 No.1

The dynamic characteristics and mass transfer effects in Para-type plate pulsed column was investigated. The axial dispersion coefficient of continuous phase was constant in the range above that continuous phase flow rate was 200ml/min, and was more influnced by amplitude than by frequency. The hold-up of continuous phase was more influnced by amplitude and saunter mean diameter was more influnced by frequency. As the experimental results of acetone extraction, the column efficiency was slightly decreased with the pulse velocity increased, but was stabilized in the range of 80~90%. The acetone concentration profiles with the change of column height at steady state more approached to the backflow model than the diffusion model.

방사선학적 치근단병소의 크기와 특징에 대한 치근단낭종 및 육아종의 상관관계연구

최호식,이우철,손원준,금기연,배광식,백승호 大韓齒科保存學會 2010 Restorative Dentistry & Endodontics Vol.35 No.1

The purpose of this study was to find out the relationship of radiographic lesion size, gender, age of patients and radiographic character to the diagnosis of periapical cyst and granuloma. The data was collected from 187 periapical lesions of 167 patients who undergone apical surgery at Department of Conservative Dentistry, Seoul National University Dental Hospital from 2003 to 2005. The lesion were surgically removed and send for biopsy to the Oral Pathology Laboratory. From the initial radiograph, lesion size was calculated using PiViweSTAR (INFINITT, Korea) program. The obtained data were statistically evaluated using SPSS (p<0.05). The result were as followings: 1. From 187 biopsy samples, the incidence of periapical cyst was 28.34% and granuloma was 65.24%. 2. There was a significant correlation between periapical cyst and the size of radiographic lesion (p<0.01). 3. There were no significant correlations between age, gender, location of lesion and the final diagnosis (p>0.05). 4. There was a significant correlation between the non-demarcation of the lesion and the incidence of periapical granuloma (p<0.01). 본 연구는 2003년부터 2005년까지 서울대학교 치과병원 보존과에 내원한 환자 중 치근단수술을 시행한 환자 167명에서 생검을 위해 적출한 187개의 치근단병소를 대상으로 하였다. 수술 후 조직검사 결과 얻은 진단명과 환자의 진단기록에서 환자의 성별, 나이, 발병 부위, 방사선 사진 상의 특징 그리고 병소의 크기와의 상관관계를 조사하였다. 초진시 방사선 사진에서 치근단병소의 크기를 PiViewSTAR (INFINITT, Korea)를 이용하여 화소를 계산함으로써 면적을 구하였다. 이를 바탕으로 통계 분석프로그램 SPSS (version 12.0K, SPSS Inc., Chicago, IL, USA)를 이용해 방사선사진상 크기와 진단명과의 상관관계를 조사하였다. 나이와 진단명과의 상관관계는 일원배치 분산분석을 시행하고 성별, 부위, 방사선사진상의 특징과 진단명과의 상관관계는 교차분석을 통해 카이제곱검정으로 조사하여 다음과 같은 결론을 얻었다. 1. 187의 치근단병소 조직검사결과 치근단병소 중 치근단낭종의 비율은 28.34%, 육아종의 비율은 65.24%, 기타병소의 비율은 6.42%로 나타났다. 2. 방사선사진상 병소의 크기가 커질수록 치근단 낭종일 확률이 높았다(p<0.01). 3. 나이, 성별, 발병부위와 진단명사이에서 유의 한 상관관계가 없었다(p>0.05). 4. 병소의 경계가 명확하지 않은 것과 치근단육아종의 발생빈도는 통계적으로 유의한 상관관계를 보였다(p<0.01).