생약제제인 이공산(異功散)의 Cisplatin 유도 신장독성 보호 및 항산화 효과

Lee, Kyung-Tae,Ahn, Kyoo-Seok,Chang, Sung-Goo,Oh, Soo-Myung,Jung, Jee-Chang 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung-Tae Lee, Kyoo-Seok Ahn¹, Sung-Goo Chang², Soo-Myung Oh²and Jee-Chang Jung²¹College of Pharmacy, ²Oriental Medicine and ³College of Medicine, and East-West Medical Reserch Institute, Kyung Hee University, Seoul, Korea. Preventive and Antioxidative Effects of Crude Drug Preparation(E-kong-san) on Cisplatin Induced Nephrotoxicity. Proceedings of International Symposium on East-West Medicine, Seoul. 201-211, 1999. -Nephroprotective effects of a crude drug-prearation (E-kong-san) were determined from cisplatin on rabbit kidney proximal tubule and human renal cortical cells by MTT assays and sustained glucose consumption on ciplatin-induced human renal cortical tissue. Levels of creatinine and blood ure nitrogen(BUN) in serum after administration of cisplatin(0.75mg/kg,i.p.) to E-kong-san(0.75g/kg/day,p.o.)-pretreated rats were markedly lower compared to those of cisplatin-treated rats. Moreover, the administration of E-kong-san significantly inhibited the loss of body weight of cisplatin injected rts. These findings suggest that E-kong-san on the cisplatin induced nephrotoxicity led us to investigate whether the effect of this water extract was a result of anti-oxidation. E-kong-san showed strong free radical scavenger activities on 1,1-dipheny1-2picrylhydrazil(DPPH) radical and xanthine/xanthine oxidase(XOD) generated superoxide anion radical(O2-). We further studied the effects of E-kong-san on lipid peroxidation in rat liver microsomes induced by enzymatic and nonenzymatic methods. E-kong-san exhibited significant inhibition on both ascorbic acid/Fe2+and ADP/NADPH/Fe3+ induced lipid peroxidation in rat liver microsomes. Based on these results, we suggest that-E-kong-san attenuate the cisplatin induced cytotoxicity and its mechanism can be eplained by antioxidant.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

구루텐을 사용해 제조한 새알심의 물성

이태규,김종화 우석대학교 생명과학연구소 1998 생명과학연구소 논문집 Vol.2 No.-

Adzuki-bean porridges containing Sealsim made of gluten and wet grinded glutinious rice were produced and sterilized under condition of 120℃ for 20 min. This study examined rheological properties of Sealsim in adzuki-bean porridge under room temperature for 35 days. The results summarized as follows. Sealsim made by mixture 1 without arrowroot starch showed better quality than that made by mixture 2 containing arrowroot starch. Sealsim dried under 100℃ for 20 min. showed better quality for early 5 days. But the quality was decreasing continuously and became similiar after 30 days.

소아의 상완골 원위부 과간 골절

이우석,정환용,김우식,김용찬,전택수,김남현,김규태 대한골절학회 2004 대한골절학회지 Vol.17 No.4

상완골 원위부 과간 골절은 소아에서는 매우 드물게 발생되는 골절로 대부분 주관절의 굴곡상태로 주관절 후방부에 직접적인 충격에 의해 발생하는 것으로 보고되고 있다. 전위가 없거나 경미한 경우 도수적 정복술 혹은 도수적 정복술 후 경피적 핀고정술을 시행하며, 전위가 심한 골절이거나 도수적 정복술이 불가능한 경우 관혈적 정복술 후 핀고정술을 시행하는 것으로 알려져 있다. 저자들은 전위된 상완골 원위부 과간 골절 환아 2예에서 각각 도수적 정복술과 관혈적 정복술 후 K 강선 고정술을 시행하여 만족한 결과를 얻었기에 보고하는 바이다. Intercondylar fractures of the distal humerus are very rare in children. The pattern of the fracture would suggest that the mechanism of injury involves a fall directly on the flexed elbow. Most agree that the undisplaced fracture can be managed conservatively. With increasing displacement and comminution, the opinions tend to differ. We suggest that closed reduction with percutaneous K wire pinning and open reduction with percutaneous K wire pinning offer a satisfactory methods by which to treat displaced intercondylar fracture in children.

High Pressure Liquid Chromatography에 의한 김치중의 Nitrosodimethylamine의 檢出

李泰圭,權泰英,梁熙天 又石大學校 1983 論文集 Vol.5 No.-

Winter Kimchi added with salted Anchovy was fermented for 25 days at 5℃. Then, this Kimchi was gone under the process of steam distillation with alkaline condictions, and High Pressure Liquid Chromatography was employed to detect nitrosodimethylamine(NDMA). It was concluded that NDMA contents and recovery ratio were 0.15ppm and 61.0%, repectively. Sucrose and radish juice effected on the formation of NDMA in Kimchi.

능이(능이)가 生産하는 Proteolytic Enzyme의 軟肉效果

李泰圭,張在哲 群山大學校自然科學硏究所 1986 自然科學硏究 Vol.1 No.-

능이로부터 단백질 분해효소를 분리·정제하고, 쇠고기에 대한 연화효과를 조사하였다. 작용 최적pH는 10.5로 alkaline protease였으며, 작용최적온도는 55℃부근이었다. 탈지우육분에서의 효소활성은 alkaline protease가 papain, bromelin, trypsin보다 우수한 것으로 나타났다. This study carried out to find out the nature and meat tenderizing ability of proteolytic enzyme from Neungee [Sarcodon aspratus (Berk.) S. Ito]. The optimum pH was 10.5, indicating the enzyme to be alkaline protease and the optimum temperature was 55℃. The proteolytic activity found in reaction nonfat beef powder more excellent alkaline protease than papain, bromeline and trypsin.

장기간의 트레이닝이 체격 및 체력에 미치는 영향

윤규태,이승준,이승준 순천향대학교 기초과학연구소 2000 순천향자연과학연구 논문집 Vol.6 No.1

The purpose of this study is to investigate how a long-term training affect a physique and a physical strength on two groups of being trained and untrained. There are 11 items divided under as a factor of the physique and 12 items as a factor of the physical strength to be measured and compared the relationship between two factors. The results of this study are as follows: 1.The most significant differences statistically among factors of the physique in this study appears in chest, lower limb length and upper arm girth. 2.In case of the physical strength, there are significant differences in vertical jump, side step, sit-up, chinning bar, toe touching and mobility tests Like above the results showing, it causes that trainees have been more grown up than untrainees in the development of Staying power, muscular power and promptitude. In addition, there are a lot of benefit to keep the continuant exercises for the development of the body and the physical strength

비가열 축합에 의한 포도당 정량법

윤규태,이미영 순천향대학교 기초과학연구소 2002 순천향자연과학연구 논문집 Vol.8 No.1

Glucose concentration was determined by using the modified method of o-toluidine /boric acid condensation method. Instead of heating in the presence of acetic acid in o-toluidine /boric acid condensation method, NaOCl, H₂O₂or ClC_(6)H₄CO₃H was used to stimulate the formation offufural derivative. The r values of calibration curve for glucose determinatiion by using H₂O₂, NaOCl, and ClC_(6)H₄CO₃H without heating were 0.97, 0.99 and 0.76, respectively. These results suggest that NaOCl might be the most effective condensation stimulator in glucose determination in terms of high r value when non-heating condensation method was used.

정기적 운동이 노인의 건강체력에 미치는 영향

윤규태,이범규 순천향대학교 기초과학연구소 2000 순천향자연과학연구 논문집 Vol.6 No.2

The purpose of this study was to investigate the health-related fitness and its characteristic in the elder woman. A number of physique and measurement were collected from a group of 40 female volunteers mean age 68 years. The health-related fitness of cardiovascular-respiratory function, muscular strength, and muscular endurance, flexibility and body composition were measured. The subjects of this study were elder womans who were divided into two group : 20 periodical exercise in the elder woman(Group A) and periodical non-exercise in the elder woman(Group B). The results obtained from the experiment were as follows. (1)Cardiovascular - respiratory function The study showed that exercise group performed better than non-exercise group in sit-and-stand test(p<.05). (2)Grip strength We could not found significance difference between exercise group and non-exercise group in Grip strength (3)Muscular endurance The study showed that exercise group performed better than non-exercise group in sit-and-stand test(p<.001). (4)Sit-and-Reach Test The study showed that exercise group was more flexible than non-exercise group in sit-and-reach test(p<.05). (5)%Fat The study showed that the %fat of the exercise group was significantly less than non-exercise group(p<.001).

클러스터링 기법을 이용한 퍼지 모델링에 관한 연구

원태현,김문수,이용길,강석규 동의공업대학 2000 論文集 Vol.26 No.1

In this paper, a new approach to modeling of static and dynamic systems using clustering techniques. To express the various and complex behavior of systems, we combine multiple model method. The Gustafson-Kessel algorithm is used in partitioning of system, and Takaei Sugeno rule structure is adopted to form the fuzzy rules. According to simulation, the performance of fuzzy modeling technique is evaulated.