니페디핀이 암피실린의 흡수에 미치는 영향

정현정,용철순,최윤수,오두만 영남대학교 약품개발연구소 1997 영남대학교 약품개발연구소 연구업적집 Vol.7 No.-

Amino-β-lactam antibiotics are absorbed by the dipeptide transporter in the small intestine. These uptakes are coupled to a proton influx. The inward proton gradient is partly induced by the Na^(+)/H^(+) exchanger and cakium ion is involved in control of this antiport. Interaction between ampicillin which is one of the amino-β-lactam antibiotics and nifedipine which is one of calcium channel blocking agents was studied in rats in vivo and with rabbit jejunum mounted on the Sweetana/Grass diffusion cells in vitro. Bioavailability of ampicillin was increased significantly when nifedipine was co-administered orally in rats. There were no differences in the distribution phase and the elimination phase when ampicillin was given either alone or with nifedipine intravenously. Conditions for in vitro experiments were determined. The lift rate of O₂/CO₂ gas was controlled to 3 bubbles/sec and ampicillin was stable in the Kreb's buffer at pH6.0 Absorption of ampicillin was the greatest when the completely-stripped serosal membrane was used. Transport of ampicillin from mucosal to serosal side in the rabbit jejunum was enhanced by 32% in the presence of nifedipine (p=0.059). Above results suggest that nifedipine might increase the plasma level of ampicillin via the improved absorption in the intestine rather than the reduction in the elimination or/and alteration in the distribution.

감마나이프수술 환자의 만족도 및 재원일수에 대한 고찰

정상순,정현태,백선하,김동규 한국의료QA학회 2001 한국의료질향상학회지 Vol.8 No.1

Background : Since a Gamma Knife had been installed on December 1997, 405 patients have been treated until December 1999 at department of neurosurgery of Seoul National University hospital. The authors analyzed results of a work to improve satisfaction of Gamma Knife surgery patients and to reduce hospital length of stay. Methods : To understand main discontent of patients, a pre-survey was performed from October 1998 to December 1999 using a questionnaire. By Analyzing 93 questionnaire received from 234 patients, pain on frame application, explanation before surgery, waiting time before surgery, waiting time before medical procedure were main discontent factor and overall satisfaction ratio was 71.0%. To improve satisfaction ratio, several quality improvement activity works were designed and applied to 123 patients during the period between January 2000 and September 2000. The same questionnaire were analyzed. Works to reduce the patient hospital LOS were devised and applied during the same period. Results : The overall satisfaction ratio of Gamma Knife radiosurgery patients was increased to 83,7%(P=0.10). The main factor to improve satisfaction ratio was to reduce waiting time(P=0.05) and improvement of discomfort during the surgery(P=0.06). The average LOS was reduced from 3.1 to 2.7 days(P=0.003). Conclusion : As a result of quality assurance activities, the overall satisfaction ratio of patients was improved and LOS was reduced. The pain during frame application was remained as a main discontent factor and a further study is required to reduce this pain.

산업정책의 이론분석

정상현,이순호 又石大學校 1990 論文集 Vol.12 No.-

The idea of industrial policy calls into question many of the economic beliefs that Americans have popularly used since the end of World WarⅡ to explain their own economic preesminence such things as their commitment to market mechanism as the supreme arbiter of economic desions, their reliance on adversarial rather than cooperative public-private relations, and their greater devotion than other peoples to free trade. The purpose of this study puts its first place on the analysis of the idea of industrial policy, and secondly identifies the four approaches on the industial policy.

방사선작업종사자에게 발생한 암의 업무관련성 평가를 위한 선별선량의 활용

정미선,진영우,임현술,김종순 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.3

뇌동맥류 수술환자의 정신신경학적 분석

정현태,박순필,김상진,도종웅 대한신경외과학회 1987 Journal of Korean neurosurgical society Vol.16 No.4

The mortality rate of aneurysmal surgery had recently been reduced remarkably due to mordern microsurgical technique and refinement of the timing of operation. Despite recovery without neurological deficits, many patients remain with emotional and psychological sequelae postoperatively. We evaluated 33 patients, operated on intracranial aneurysm for recent 2 years, about quality of life and degree of cognitive function. For proper evaluation of outcome of aneurysmal surgery, in addition to the neurological outcome, psychological aspects must be considered.

靑皮가 마우스의 免疫細胞에 미치는 影響

殷載淳,吳贊鎬,鄭鉉雨 대한동의병리학회 1998 동의생리병리학회지 Vol.12 No.2

靑皮는 疏肝破氣 및 消積化滯하는 작용이 있는 약물로 대부분 氣滯로 인한 증상들에 사용되고 있지만 임상상 活血之劑와 配合하여 氣滯血瘀나 血瘀脇痛등에 應用되고 있다. 氣滯는 각종의 스트레스등으로 인하여 발생되어 血行을 不暢하게 하고, 심지어는 正氣까지도 손상시킨다. 正氣의 손상은 바로 免疫機能의 低下라고도 말할 수 있는데, 免疫이란 非自己로 인식된 異常細胞를 처리함으로써 個體의 恒常性을 維持하려는 현상을 말한다. 면역에 先天的 免疫과 T림프구 및 B림프구가 관여하는 特異性 免疫이 있고, 免疫作用에 관여하는 細胞로는 特異性 免疫에 관여하는 免疫細胞外에도 Macrophage, NK cell, 수지상 세포 및 랑게르한스 세포등을 들 수 있다. 뇌의 기능은 심장에서 방출되는 혈액의 공급에 의해 이루어지는데, 만약 혈액의 공급이 제대로 이루어지지 않으면 많은 질환들이 발생한다. 그 중 虛血性 腦疾患은 충분한 양의 혈액이 뇌를 공급되지 않거나 공급되고 있는 혈액내의 산소농도가 떨어져 발생하는 것으로써 임상적으로는 運動麻痺·知覺痲痺등 神經機能 消失등의 증상을 보이기 때문에 東醫學的으로는 이를 風病이라 하고, 風病은 대체적으로 陰虛나 血虛등으로도 발생할 수 있어 陰虛動風證 또는 血虛生風證등의 病證들이 있다. 그리하여 각종 氣滯로 인한 氣滯則血滯가 발생되거나 또는 正氣가 손상되어 氣虛則血虛하기 때문에 陰虛나 血虛등으로 인한 運動麻痺나 知覺麻痺가 발생한다. 이러한 이유등으로 本 硏究者들은 혈류장애 질환치료에 사용되는 韓藥材中 靑皮의 작용을 규명하는 硏究의 일환으로 靑皮가 면역기능에 어떠한 영향을 미치는가에 대하여 알아보기 위하여 동결건조된 靑皮를 마우스에 1일 1회씩 7일간 투여한 후 T-lymphcyte의 Apoptosis와 sub-population, 그리고 proliferation 및 Peritoneal macrophage의 nitric oxide 생성과 phagocytic activity를 관찰한 결과 DNA fragmentation과 sub-population에는 별다른 영향을 주지 않았지만 proliferation에 있어서는 증식이 촉진되었고, 복강 macrophage의 nitric oxide 생성과 phagocytic activity에 있어서는 NO는 감소하였으나 phagocytic activity는 현저히 증가하였다. 이는 靑皮가 NO 생성을 억제하여 phagocytic activity를 증가시킨 결과라 思料된다. 이상과 같은 實驗結果들을 통해서 볼 때 靑皮는 臨床的으로 각종 氣滯로 인한 正氣損傷과 血液循環障碍가 동시에 나타날 때에만 正氣를 보충해주는 役割을 할 수 있을 것으로 사료된다. The purpose of this research was to investigate effects of Citri Reticulatae Viride Pericarpium water extract(CRVP) on immunocytes in mice. The administration of CRVP did not affect apoptosis and sub-population of mouse T-lymphocytes, but increased the proliferation of T-lymphocytes. CRVP decreased nitric oxide production from mouse peritoneal macrophage, but increased a phagocytic activity of macrophages. These results suggest that CRVP does not affect T cell mediated immunity, but increases the phagocytic activity of peritoneal macrophages.

비소세포 폐암 환자의 이차 치료로서 Gemcitabine과 Vinorelbine 혼합 요법의 효과

장필순,강현모,이정은,권선중,안진영,이연선,정성수,김주옥,김선영 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-

Background : Both gemcitabine and vinorelbine are effective anticancer drugs with mild toxicity on non-small cell lung cancer, and monotherapy of these drugs are effective as a second-line chemotherapy. The aim of this trial was to assess the response and toxicity of a combination of gemcitabine and vinorelbine in patients of previously treated for non-small cell lung cancer. Materials and Methods : 24 patients, initial stage III A/B,IV and previously treated with platinium and taxane based regimens, were enrolled from June 2000 to March 2004. The regimens consisted of vinorelbine 25mg/㎡ followed by an infusion of gemcitabine 1000mg/㎡ on day 1 and day 8 every three weeks. This course was repeated more than twice. Results : Twenty-four patients were analyzed for the response, survival rate, and toxicities. The overall response was 17% with a complete remission rate of 4%. The median time-to progression (TTP) was 3.1 months (95%, CI l-10months), and the survival time was 8.2 months (95%, CI 1-23 months). The grade 3/4 toxicities encountered were neutropenia (12.5%), anemia (0%), thrombocytopenia (0%). Non-hematological 3/4 toxicities were not observed. Conclusion : A combination of gemcitabine and vinorelbine in patients previously treated for non-small cell lung cancer provides a relatively good response rate, and a low toxicity profile. However, further study will be needed to confirm its effectiveness. (Tuberc Respir Dis 2005; 58: 344-351)

항생제 혼합 시멘트 정을 이용한 장관골 감염성 불유합의 이단계 치료

조세현,정순택,박형빈,황선철,하용찬,황인환 대한골절학회 2004 대한골절학회지 Vol.17 No.4

목적: 장관골 감염성 불유합의 치료 시 항생제 혼합 시멘트 정을 이용한 이단계 재건술의 결과를 분석하고자 한다. 대상 및 방법: 1998년 1월부터 2002년 9월까지 장관골 감염성 불유합으로 이단계 재건 수술을 받은 41예 (대퇴골 26예, 경골 15예)를 대상으로 하였다. 일단계 수술에서는 광범위한 변연 절제술, 부골 제거 및 세척술과 기존 고정 장치의 제거 또는 외고정 장치로의 교환을 시행한 후 시공 (dead space)과 불유합 주변 연부조직 내 항생제 혼합 시멘트 정을 삽입하였다. 임상적 감염 증상이 호전된 평균 8.7주 (3주~32주) 후 이단계 재건술로서 Ⅰ군은 내고정 장치 (금속판 5예, 골수강내 금속정 8예), Ⅱ군은 외고정 장치 (Ilizarov 25예, Monofixator 3예)로 각각 고정하고 17예에서는 골내 이동술이나 골 연장술을 시행하였다. 양군 모두 필요한 경우 골 이식과 시멘트 정의 교환을 추가하였다. 추시 기간은 16개월에서 최장 71개월로 평균 45개월 이었다. 치료 결과는 골유합 기간 및 Paley 방법에 의한 방사선상 골유합 상태와 하지 기능으로 평가하였다. 결과: Ⅰ군 13예 전부와 Ⅱ군 28예 중 26예에서 감염의 치료와 골유합을 얻었다. 이단계 재건술 후 골 이식술, 골 소파술, 외고정 핀 교환과 각변형 교정술, 피부 이식 또는 근육 피판 회전술 등의 보조적 시술이 Ⅰ군은 평균 2회, Ⅱ군은 평균 6.2회 추가되었다. 평균 골유합 기간은 Ⅰ군이 19.3주이고 Ⅱ군이 23.1주로 내고정군이 더 빨랐다. 방사선상 Paley 골유합 상태는 Ⅰ군이 우수 8예, 양호 5예이었고, Ⅱ군이 우수 18예, 양호 7예, 보통 1예, 불량 2예 이었다 (p=0.492). 기능적 결과는 Ⅰ군에서 우수 6예, 양호 6예, 보통 1예 이었고, Ⅱ군에서는 우수 10예, 양호 13예, 보통 3예, 불량 2예 이었다 (p=0.267). 결론: 항생제 혼합 시멘트 정의 골수염 치료 효과가 관찰되었으며, 감염이 호전된 후 내고정 장치로 교환해 준 군이 외고정을 유지한 군에 비하여 추가 수술 횟수가 적고, 골유합 기간도 빨랐다. Purpose: To evaluate treatment results between internal na external fixation groups in two-stage reconstruction of infected nonunion of long bones using antibiotics-impregnated cement beads. Materials and Methods: In the first stage, preexisting hardwares were removed and radical debridement was done. The dead space was filled with antibiotics -impregnated cement beads and the nonunion sits was immobilized by external fixation, cast or skeletal traction. In the second stage, all cases were divided into two groups; the nonunion was fixed by internal fixation in group Ⅰ versus external fixation in group Ⅱ. The intervening period between the first and second stage was average 8.7 weeks (range, 3~23 weeks). Results: The follow-up period was average 45 months (range, 16~71 months). Infection control and bone union were achieved in all 13 cases of group Ⅰ. Infection recurred in two of 28 cases in group Ⅱ, one underwent above-knee amputation and the other case was lost in follow-up. The mean number of supportive operations including repeated curettage, augmentation and change of infected pins, angular correction, and soft tissue flap was average 2 and 6.2 times respectively in group Ⅰ and group Ⅱ. Bony union period was average 19.3 and 23.1 weeks in each group. According to Paley's classification, group Ⅰ was similar to group Ⅱ in bony and functional result (p>0.05). Conclusion: Antibiotics-impregnated cement beads provided positive effect on infection control. Internal fixation group showed less number of additional operations and earlier bony union than external fixation group.

일회통과 관류실험시 물의 수송 : 관류액의 종류와 삼투압의 영향 Effects of Some Perfusates and Their Osmolality

이정화,이현주,용철순,오두만 영남대학교 약품개발연구소 1995 영남대학교 약품개발연구소 연구업적집 Vol.5 No.-

The single pass perfusion experiments were performed in anesthetized rata to investigate the effects of perfusates and their osmolality on the water transport and to determine the correlation between the extent of water transport and the volume change of perfusate. Phenol red was used as a nonabsorbable marker. In normal rats, when perfused at a flow rate of 0.5 ml/min 2-(N-morpholino) ethanesulfonic acid (MES) aid Sorensen's phosphate hullers showed minimal net water transport as 0.125 and 0.173 %/cm of intestinal length, respecetively. Hypotonic perfusate of 200 mOsm㎏ of water and hypertonic perfusate of 400 mOsm/㎏ of water generated significant water transport compared with isotonic perfusate of 300 mOsn/㎏ of water. There was a linear correlation between the attent of water transport and the volume change of perfusate, suggesting that the volume change can be used as a measure of water transport.

방사선사진에서의 골질과 임상적으로 평가한 골질 분류의 상관관계

김현우,허경회,박관수,김정화,이원진,허민석,이삼선,최순철 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.37 No.1

Purpose : To investigate the validity of digital image processing on panoramic radiographs in estimating bone quality before endosseous dental implant installation by correlating bone quality in radiographic images with clinical bone quality classification. Materials and Methods : An experienced surgeon assessed and classified bone quality for implant sites with tactile sensation at the time of implant placement. Including fractal dimension eighteen morphologic features of trabecular pattern were examined in each anatomical sites on panoramic radiographs. Finally bone quality of 67 implant sites were evaluated in 42 patients. Results : Pearson correlation analysis showed that three morphologic parameters had weak linear negative correlation with clinical bone quality classification showing correlation coefficients of -0.276, -0.280, and -0.289, respectively (p<0.05). And other three morphologic parameters had obvious linear negative correlation with clinical bone quality classification showing correlation coefficients of -0.346, -0.488, and -0.343 respectively (p<0.05). Fractal dimension also had a linear correlation with clinical bone quality classification with correlation coefficients -0.506 significantly (p<0.05). Conclusion : This study suggests that fractal and morphometric analysis using digital panoramic radiographs can be used to evaluate bone quality for implant recipient sites. (Korean J Oral Maxillofac Radiol 2006; 36 : 25-32)