HPLC를 이용한 초산 Midecamycin 및 그 제제의 분석법에 관한 연구 : 항생물질 분석법의 기기화

최윤수,이성혜 한국위생과학회 1998 한국위생과학회지 Vol.4 No.1

Among the sixteen-membered ring macrolide antibiotics containing multicomponents, midecamycin acetate modified from midecamycin as shown broadspectrum of antimicrobacterial activity and its metabolites also showed certain degree of antibacterial activity although they gave higher MIC values than midecamycin acetate. Especially midecamycin acetate has no bitter taste, low toxicity for liver, kidney and gastro-intestinal organs. Our study an this paper was to develop a high performance liquid chromatographic method for assay of midecamycin acetate. So we attempted to determine the potencies of midecamycin acetate and its preparations by HPLC in comparison with microbiological assay. The analysis of midecamycin acetate and its preparations was achieved by HPLC method using a μ -Bondapak C_(18) column and acetonitrile - methanol - IPC B_6 as a mobile phase. The column effluent was monitored at 231nm by UV-spectrophotometer. The retention time of midecamycin acetate was less than 4 minutes. So this method was very simple and rapid. Therefore we obtained better result for assay of midecamycin acetate by HPLC method than that of microbiological method.

敬順王子(全三幕)

崔允秀 朝鮮敎育會 1927 文敎の朝鮮 Vol.- No.1

Board drain 工法에 關한 實驗的 硏究

崔允秀,具滋甲 안성산업대학교 1991 論文集 Vol.23 No.-

The drain capacity of drain board depends on the circumference length rather than the cross section of drain board. This paper based on the fact written above, throuth the vacuum consolidation test about "+" type board increased circumference lengh and existing "-" type board, intends to compare the cnsolidation effect between two types of board. 1. consolidation time of the "+" type board is shorten than "-" type board by 1.6 times. 2. The "+" type board is more effective improving the soil than "-" type board. 3. When 4 sheets board with 5cm breath is disposed in the form of "+" type, it seems to be good to use 0.65 as conversion coefficient.

합성곱 신경망을 이용한 아스팔트 콘크리트 도로포장 표면균열 검출

최윤수,김종호,조현철,이창준 한국구조물진단유지관리공학회 2019 한국구조물진단유지관리공학회 논문집 Vol.23 No.6

A Convolution Neural Network(CNN) model was utilized to detect surface cracks in asphalt concrete pavements. The CNN used for this study consists of five layers with 3x3 convolution filter and 2x2 pooling kernel. Pavement surface crack images collected by automated road surveying equipment was used for the training and testing of the CNN. The performance of the CNN was evaluated using the accuracy, precision, recall, missing rate, and over rate of the surface crack detection. The CNN trained with the largest amount of data shows more than 96.6% of the accuracy, precision, and recall as well as less than 3.4% of the missing rate and the over rate. 본 연구에서는 아스팔트 콘크리트 도로포장의 표면균열 검출을 위해 합성곱 신경망을 이용하였다. 합성곱 신경망의 학습에 사용되는 표면균열 이미지 데이터의 양에 따른 합성곱 신경망의 성능향상 정도를 평가하였다. 사용된 합성곱 신경망의 구조는 5개의 층으로 구성되어있으며, 3x3 크기의 convolution filter와 2x2 크기의 pooling kernel을 사용하였다. 합성곱 신경망의 학습을 위해서 도로노면 조사 장비를 통해 구축된 국내 도로포장 표면균열 이미지를 활용하였다. 표면균열 이미지 데이터를 학습한 합성곱 신경망 모델의 표면균열 검출 정확도, 정밀도, 재현율, 미검출율, 과검출율을 평가하였다. 가장 많은 양의 데이터를 학습한 합성곱 신경망 모델의 표면균열 검출 정확도, 정밀도, 재현율은 96.6% 이상, 미검출율, 과검출율은 3.4% 이하의 성능을 나타내었다.

Renovation of Korean Geodetic Control Points

최윤수,권재현,홍창기,이지선 대한공간정보학회 2008 Spatial Information Research Vol.16 No.4

In this contribution, the renovation of the Korean geodetic control points is introduced. The renovation is described in terms of structure and accuracy. Mainly the establishment of the three-dimensional control points is the renovation on structure which leads many changes in accuracy, contents and hierarchy of the control points. The accuracy of the information is being improved based on the satellite positioning technology and precision geoid being developed. Diverse spatial information such as gravity and environmental elements are considered to be measured at the position of the control points so that the related research is enhanced through the analysis of combined information. In addition, an access to the information of control points and service to the public with spatial information will be faster and more efficient through RFID and CDMA communication. With all these efforts being made currently, the Korean geodetic network will provide the most accurate and diverse spatial information in an efficient way. We hope that these activities lead the trends, roles, and future direction of the geodetic control points.

우리나라 해상경계 획정기준에 관한 기초 연구

최윤수,김재명,김현수,박병문,Choi, Yun-Soo,Kim, Jae-Myeong,Kim, Hyun-Soo,Park, Byung-Moon 한국공간정보학회 2012 한국공간정보학회지 Vol.20 No.2

최근 국내 여러 지방자치단체들은 해양개발이 활성화됨에 따라 관할해역 확보에 총력을 기울이고 있으며, 인접 지방자치단체간 분쟁의 증가로 인하여 관할해역 구분의 기준이 되는 해상경계의 중요성이 급격히 부각되고 있다. 특히, 해상경계 획정기준의 부재는 인접 지방자치단체들 간 분쟁을 발생시킬 수 있는 요소를 많이 내포함에 따라서 해상경계 획정기준 마련을 위한 노력이 절실히 필요하다고 할 수 있다. 본 논문에서는 과학적이고 합리적인 해상경계 획정기준을 마련하기 위하여 기 고시된 "해상경계 확인을 위한 수로측량업무규정"을 조사 분석하여 개선사항을 도출하였다. 그 결과 첫째, 해상경계 획정의 개념을 수립하였고 둘째, 해상경계 획정기준의 범위와 내용 및 절차를 구체적으로 설정하였으며, 마지막으로 지방자치단체들 간 해상경계 분쟁의 사전예방 및 사후 합법적 해결을 목적으로 해상경계조정위원회의 설치, 구성, 직무, 조정결과의 효력 등과 같은 해상경계 분쟁조정방법을 제시하였다. Recently, local governments in Korea are promoting the rapid development of marine for delineating jurisdictional sea area. The importance of a maritime boundary has being emphasized, as jurisdictional sea area disputes among local governments have been increasing. The absence of the delineating standard of maritime boundary has become a source of contention between neighborhood local governments. So the delineating standard of maritime boundary in Korea will be required. The purpose of this study is to derive an improvement plan for the scientific delimitation standard of maritime boundary by analyzing "A hydrographic survey guideline for confirmation of maritime boundary". The results of this study are as follows. Firstly, we defined the concept of the delimitation standard of maritime boundary. Secondly, we set the boundary, factors and processes of the delineating standard of maritime boundary through classifying them in detail. Lastly, we suggested the makeup of a conflict adjustment committee for preventing jurisdictional sea area disputes among local governments.

과학 기술 문헌 분석을 위한 기계학습 기반 범용 전문용어 인식 시스템

최윤수,송사광,전홍우,정창후,최성필,Choi, Yun-Soo,Song, Sa-Kwang,Chun, Hong-Woo,Jeong, Chang-Hoo,Choi, Sung-Pil 한국정보처리학회 2011 정보처리학회논문지D Vol.18 No.5

문헌에서의 전문용어 인식 연구는 정보검색, 정보추출, 시맨틱 웹, 질의응답 분야 등의 연구를 위한 선행 연구로서, 지금까지 대부분 특정 분야, 특히 생의학 분야에서 집중되어 연구되어 왔다. 그러나 기존 연구들이 특정 도메인 또는 문헌 내부 통계 정보를 활용함으로써 범용적인 전문용어 인식에 한계점을 보여 왔기 때문에, 본 연구에서는 웹 검색 결과와 사전, 후보용어의 문형 특징 등을 활용하는 기계 학습 기반 범용 전문용어 인식 방법을 제안하였다. 제안한 방법을 문헌의 지역 통계 정보를 사용하는 방법(C-value)과 비교 실험하여 80.8%의 F-값으로 6.5%의 성능향상을 보였다. 다양한 응집도 자질들을 접목한 두 번째 실험에서는 Normalized Google Distance 방법과 접목한 방식이 F-값 81.8%의 성능으로 최고의 성능을 나타냈다. 기계 학습 방법으로는 로지스틱 회귀분석, C4.5, SVMs 등을 적용하였는데, 일반적으로 이진 분류에 좋은 성능을 보이는 SVMs과 로지스틱 회귀분석 방법보다 결정 트리 방식의 C4.5가 전반적으로 좋은 성능을 보였다. Terminology recognition system which is a preceding research for text mining, information extraction, information retrieval, semantic web, and question-answering has been intensively studied in limited range of domains, especially in bio-medical domain. We propose a domain independent terminology recognition system based on machine learning method using dictionary, syntactic features, and Web search results, since the previous works revealed limitation on applying their approaches to general domain because their resources were domain specific. We achieved F-score 80.8 and 6.5% improvement after comparing the proposed approach with the related approach, C-value, which has been widely used and is based on local domain frequencies. In the second experiment with various combinations of unithood features, the method combined with NGD(Normalized Google Distance) showed the best performance of 81.8 on F-score. We applied three machine learning methods such as Logistic regression, C4.5, and SVMs, and got the best score from the decision tree method, C4.5.

영해기준점의 효율적 유지관리 방안에 관한 연구

최윤수,김재명,윤창범,Choi, Yun-Soo,Kim, Jae-Myeong,Yun, Chang-Beom 한국공간정보학회 2010 한국공간정보학회지 Vol.18 No.1

Recently, many countries are promoting the rapid development of marine for securing territorial sea. The importance of territorial sea has being emphasized as territorial disputes among countries has been increasing. The South Korea should be encouraged to expand the territory due to territorial disputes with neighborhood countries. The purpose of this study is to derive a improvement plan for the efficient control of the territorial base point through analyzing the existing territorial base point and checking the territorial base point. Therefore, we proposed a variety of new plans for accurate positioning by sea level observation and MBES, reduced the surveying procedure through analyzing the existing territorial base points and provided a basis for the territorial base points which can be the 2nd grade national control points by improving a grade. We also suggested that the territorial base points and sub-territorial base points' database should be given standardized number for increasing the efficient management of other national control points and territorial base points. Finally, we suggested a improved work regulation about analysis and maintenance for territorial base points, the information activity of territorial base points and the new plan of community relations. This study will be a basis for the foundation of maritime territory which could be superior to other countries and the expansion of maritime territory. 최근 세계 여러 나라들은 해양개발이 활성화됨에 따라 자국의 해양영토 확보에 총력을 기울이고 있으며, 인접국가간 분쟁이 잦아지면서 해양영토의 중요성은 급격히 부각되고 있다 특히 삼면이 바다로 이루어진 우리나라의 경우 주변국들과 분쟁의 소지를 많이 내포함에 따라 우리나라의 해양영토 확보를 위한 노력이 매우 필요하다. 따라서 본 연구에서는 국가의 해양영토의 국가관할권을 결정하는 영해기준점의 실태 조사 및 분석을 통하여 영해기준점의 재질, 매설 지역 선정 및 측량절차 간소화, 조위관측 및 멀티빔 음향측심기를 이용한 정확한 위치 선정 등의 정비방안을 제시했으며, 국가 기준점으로서 영해기준점의 등급향상 방안을 제시함으로써 2등 국가기준점으로 자리매김할 수 있는 근거를 마련하였다. 또한 타 국가기준점과의 상호 연계 및 영해기준점 관리의 효율성 및 효용성을 극대화하기 위하여 영해기준점과 영해보조기준점 DB 표준방안을 제시하였다. 마지막으로 현 영해기준점관련 작업규정의 검토를 통하여 조사 및 유지관리에 관한 개선된 작업규정과 영해기준점의 홍보 및 대외협력 방안을 제시함으로써 향후 주변국가와의 영토분쟁 시 우위를 선점할 수 있는 해양영토의 기준 및 해양영토 확장을 위한 기반을 마련하고자 하였다.

Nitrofurazone의 광흡수에 대한 용매 효과

최윤수,석경순,최요인 대구효성가톨릭대학교 자연과학연구소 1990 基礎科學硏究論集 Vol.4 No.-

The maximum UV absorption spectra(λmax) of nitrofurazone was measured in several polar solvent systems. As the dipole moments of solvents are increased, the UV λmax of alkaline nitrofurazone(π→π*)were shifted to red than neutral of species(π→π*)and the equilibrium constants of them were increased. The structure of alkaline nitrofurazone was studied by UV, IR and NMR spectra. It was found that the keto group of nitrofurazone was changed to enolic form caused by proton migration. The new determination method of nitrofurazone was established in alkaline solution and it was more sensitive than other spectrophotmetries.

Nitrofurazone 의 光分解에 關한 硏究(第二報)

최윤수,석경순 대구효성가톨릭대학교 자연과학연구소 1989 基礎科學硏究論集 Vol.3 No.-

Nitrofurazone is decomposed by light of UV-A region to form a stable product which has an absorption maxima at 210nm (UVλmax.210) The process is an acid catalysed reaction, and during the early decomposing stage, compounds having an absorption maxima at 420nm(UVλmax.420) and 530nm (UVλmax 530) are formed as intermediates. Each intermediate cha-nges to the final compound of UVλmax210 via respective pathways. UVλmax420 and UVλmax530 are seperated by TLC, HPLC and column chromatography, and the multiplicities of the excited state of the intermediates are examined. UVλmax 530is very unstable on heat, stable in acid. Both compounds are triplet sensitized by benzophe-none to be decompose very rapidly. In the NMR spectrum, the dissociation and the exchange of protons on the imino group are observed and it is identified that a radical formation on the hetero ring may occur