간내 담석과 동반된 간내 담도암에서의 p53과 Ki-ras의 발현

김명환,이성구,서동완,이승규,남승우,박능화,민영일,김연석,심기남,공경엽 대한소화기학회 1997 대한소화기학회지 Vol.30 No.5

Background/Aims: Hepatolithiasis or primary intrahepatic stones may be accompanied later by intrahepatic cholangiocarcinoma. This cancerous lesion is frequently associated with atypical hyperplastic epithelium that was suspected of being precancerous. To investigate the Ki-ras or p53 mutation may play a role in carcinogenesis, and to determine whether atypical hyperplastic epithelium may be precancerous, this study was performed in intrahepatic cholangiocarcinomas associated with hepatolithiasis. Methods: We examined 12 patients with intrahepatic cholangiocarcinomas associated with hepatolithiasis. Ki-ras point mutations were assessed by direct DNA sequencing. Expressions of p53 protein were immunohistochemically assessed. The overexpression of p53 and point mutation of Ki-ras were examined in normal, hyperplastic, atypical hyperplastic, and can- cerous tissues separately. Results: The expressions of p53 protein were detected in 4 (33%) of 12 cholangiocarcinomas and Ki-ras point mutations at codon 12 were found in 2 (17%) of 12 cholangiocarcinomas. In those two carcinoma cases which contained the mutant sequence of Ki-ras, the same point mutation from wild type GGT (glycine) to GAT (aspartic acid) was. found in the associated atypical hyperplastic epithelium. However, none of the normal and hyperplastic epithelium harbored Ki-ras or p53 mutations. Conclusions: The overexpression of p53 may play a part in the carcinogenesis of some intrahepatic cholangiocarcinomas associated with hepatolithiasis, whereas the role of Ki-ras mutations in those cases is dubious. However, Ki-ras point mutation at codon 12 may be responsible for either cancer or atypical hyperplastic epithelium associated with hepatolithiasis in certain cases, suggesting atypical hyperplastic epithelium may give rise to carcinoma.

수족냉증(手足冷症) 환자(患者)에 대(對)한 컴퓨터 적외선(赤外線) 체열촬영(體熱撮影)의 의의(意義)

조유경,오수완,조남희,김동묵,김진성,류봉하,박동원,류기원,Cho, Yu-Kyung,Oh, Su-Wan,Cho, Nam-Hee,Kim, Dong-Mook,Kim, Jin-Seong,Ryu, Bong-Ha,Park, Dong-Won,Ryu, Ki-Won 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.2

To make a objective diagnosis of the syndrome of cold-limbs, We investigated the 20 patients with cold limbs and GI trouble and 20 normal people as a control group. And we compared the thermal difference between Chon-jung(CV17) and Chung-wan(CV12 中脘), Chon-jung(CV17) and Ki-hae(氣海 CV6) and we compared the thermal differences of No-gung(PE8 勞宮) and Yong-chon(湧泉 KI1), too. The results were as follows. 1. All 20 patients had GI trouble and cold limbs. They had the symptom-Indigestion(16 cases-80%) with heart burn, tympanites, abdominal distention, hiccup, belching. Beside that symptom they also had constipation(6 cases-30%), diarrhea(3 cases-15%), headache & dizziness(6 cases-30%). And some had the menstrual syndrome, chronic fatigue, palpitation, insomnia, edema, arthralgia. 2. The thermal difference of the palms between the patients group and the control group were $25.70^{\circ}C,\;25.82^{\circ}C$, but they were not significant. 3. The thermal difference of the soles between the patients group and the control group were $23.58^{\circ}C,\;24.42^{\circ}C$ and the significancy was P=0.020 so it was significant(P<0.05). 4. The thermal difference of the palms and Chon-jung(CV17) between the patients group and the control group were $1.08^{\circ}C,\;0.76^{\circ}C$, but they were not significant. 5. The thermal difference of the sales and Chon-jung(CV17) between the patients group and the control group were $3.01^{\circ}C,\;1.90^{\circ}C$ and the significancy was P=0.003 so it was significant(P<0.05). 6. The thermal difference of Chon-jung(CV17) and Chung-wan(CV12 中脘) between the patients group and the control group was $0.30^{\circ}C,\;0.62^{\circ}C$ and the significancy was P=0.793 so it was significant(P<0.05). 7. The thermal difference of Chon-jung(CV17) and Ki-hae(CV6 氣海) between the patients group and the control group was $0.53^{\circ}C,\;0.68^{\circ}C$, but they were not significant. From the above, I could find the significance of D.I.T.I to diagnose the cold-feet not the cold-hands and the thermal difference between the trunk and limbs was more significant on cold-feet than on cold-hand, either.

PLT 절연층을 이용한 ZnS:Mn TFEL소자의 제조 및 특성

박욱동,박경빈,박재현,김영진,최병진,김기완 경북대학교 센서기술연구소 1995 센서技術學術大會論文集 Vol.6 No.1

Thin film electroluminescent(TFEL) device has been fabricated using ZnS:Mn phosphor and PLT insulator. The ZnS:Mn and PLT thin film for TFEL device was deposited by vacuum evaporation method and RF magnetron sputtering method, respectively. The TFEL device using ZnS:Mn(6000 Å) and PLT(1000 Å) thin films showed the threshold voltage of 50 Vrms at the driving frequency of 3 kHz. The brightness of TFEL device was 250 μW/cm^(2) at the applied voltage of 74 Vrms. Also the output current of TFEL device was linearly increased with applied voltage.

비정질 Se 광도전 타겟을 이용한 고감도 HARP 촬상관의 제작 및 특성

박욱동,김기완,Kubota, M.,Suzuki, S.,Katoh, T.,Tanioka, K. 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1

A high sensitivity HARP(High-gain Avalanche Rushing amorphous Photoconductor) image pickup tube using 4 μm thick amorphous Se photoconductive target was fabricated and its characteristics were investigated. When the target voltage was increased more than 360 V, the signal current increases rapidly and the dark current of the target was suppressed at 3.2 nA up to the voltage of 490 V. And the peak spectral response of the target was obtained at the wavelength of 460 nm. Also the amplitude response of the HARP tube was 7.5% at 800 TV lines, and the decay lag was 3.4%.

ZnS:SmF₃박막전계발광소자의 제작 및 특성

박욱동,배승춘,김기완 동양대학교 산업기술연구소 2000 東洋大學校 産業技術硏究所 論文集 Vol.2 No.1

A red colored thin film electroluminescent(TFEL) device was fabricated with a ZnS:SmF3 phosphor layer and BST insulating layers. The BST thin film was deposited on ITO coated glass substrate by RF magnetron sputtering method using a target of Ba0.5Sr0.5TiO3. The thickness of ZnS:SmF3 thin film, upper and lower BST insulating layer for a TFEL device were 500nm, 400nm, and 200nm, respectively. The ZnS:SmF3 TFEL device showed that the threshold voltage and maximum brightness of a TFEL device were 160Vrms and 125cd/㎡, respectively.

이차원 LMS 알고리즘의 Systolic Array 구현

박완수,최훈,홍기섭,박봉수,배현덕 충북대학교 컴퓨터 정보통신 연구소 2000 컴퓨터정보통신연구 Vol.8 No.1

적응알고리듬의 VLSI 구현에 있어서 파이프라이닝이나 시스토릭과 같은 구조적 설계기법을 이용하여 알고리듬을 변환하는 것은 효과적이다. 알고리듬 변환은 z-변환 영역에서 연산의 규칙성과 반복성을 찾아 이루어 진다. 본 논문에서는 이차원 필터와 계수갱신 시스템을 시스토릭 구조로 설계하여 LMS의 확장 형태인 TDLMS을 STDLMS로 변환한다. 변화된 STDLMS를 이용 이차원 ALE를 Altera사의 Max-PlusII 상에서 구현하여 시뮬레이션을 통해 성능을 평가한다. 시뮬레이션 결과 salt-pepper 잡음과 가우시안 잡음에 오염된 화상을 ALE가 개선할 수 있음을 보였다. In VLSI realization of adaptive algorithm. it is necessary and efficient that the algorithm is transformed to structural one suitably using architectural design techniques such as pipelining or systolic array. These transform method use regular and recursive of operation of the algorithm on z-transform domain. In this paper, the TDLMS which is a extended version of LMS is transformed to STDLMS which has systolic array architecture in two dimensional filter and coefficients update system. The transformed STDLMS is applied for realization of two dimensional ALE. And the ALE performances are evaluated by Max-PlusII of Altera Co.. The simulation results show that the ALE enhances image data which were corrupted by salt-pepper noise and Gaussian noise.

任意의 面內集中荷重과 面外集中荷重을 받는 變斷面 圓弧 ARCH에 關한 硏究

朴文浩,金基完 慶北大學校 1975 論文集 Vol.19 No.-

The behaviors of vertically loaded Archs of uniform cross sections and tapered archs have been extensively investigated in elastic ranges. The analysis of lateral concentrated loads are so complicated that sufficient studies have not been made until now. In this paper Ⅰ, therefore, study the analysis of tapered-circular arch with fixed ends, when vertical concentrated loads of any point and lateral concentrated load are worked at the same time. I attempt to obtain the general solutions of bending monent, torsional moment and deflections of tri-axial direction and torsional angles applying to tapered circular arch the differential equation of elastic curve of curved beam, and the particular solution considering the boundary, continuous, symmetric, and unsymmetric conditions. For an example, I compare the result between tapered circular arch of this paper and arch of uniform cross section by professor Hwang Hak-Joo. The result of this comparison proved that tapered circular arch is much more economical than equated cross section arch. I hope that the result presented here is applied to the deflection of given point from the tri-axial direction of tapered circular arch bending monent, and torsional monent, and that at the same time the result to be used for archwise structures in reinforced concrete, and steel structures.

활동성 화농성 고관절염에 시행한 2단계 인공 고관절 치환술

박윤수,문영완,성기선 대한고관절학회 2003 Hip and Pelvis Vol.15 No.3

교합-압박 골수정으로 치료한 대태골 간부 골절의 불유합

박윤수,문영완,성기선 대한골절학회 2003 대한골절학회지 Vol.16 No.2

목 적: 내고정술 후 발생한 대퇴골 간부 불유합에서 골절 부에 압박을 가할 수 있는 교합-압박 골수정(IC Nail??, Osteo, Switzerland)을 사용한 동적 압박 골 유합술의 임상적 결과를 보고하고자 하였다. 대상 및 방법: 20명, 21례의 대퇴골 간부 불유합율 교합-압박 골수정 고정술로 치료하였다. 평균 나이는 44 (18~69)세였으며, 골절 후 기준 수술까지 8에서 45 (중앙값 19)개월이 경과하였고, 추시 기간은 6에서 49 (평균 29)개월이었다. 천지료로 폐쇄적 골수정 삽입술이 10례, 개방적 골수정 삽입술이 10례, 금속판 삽입술이 1례였고 17례에서 골이식 및 동역화 (dynamization) 등 한 번 이상의 부가적 시술이 시행되었고, 과혈관성 불유합이 17례, 부혈관성이 3례였으며, 감염성은 1례였다. 시술은 골수강 확공 후 골수정 고정을 하였고, 근위부에 동적 교합 나사못을 삽입한 후 압박 나사를 이용하여 골절 부위를 압박하였고, 골이식은 하지 않았다. 결 과: 1례를 제외한 20례에서 임상적, 방사선학적 유합이 이루어졌다. 방사선학적 유합은 기준 수술 후 4에서 15 (평균 7.4)개월에 이루어졌다. 개방적 골수정 삽입술 후 1회의 골수정 치환술과 2회의 골이식을 받은 36세 남자에서 술 후 12개월까지 유합을 얻지 못했다. 결 론: 확공 후 교합-압박 골수정 삽입술은 초기 치료 방법에 상관 없이 대퇴 간부 불유합의 치료에 효과적인 방법이라 생각된다. 그런, 이전의 골수정 치환술이 실패한 무혈관성 불유합에서는 부가적인 시술이 고려되어야 할 것으로 사료된다. Purpose: To evaluate the effectiveness of a specially designed Interlocking-Compression Nail(IC Nail??, Osteo, Switzerland) which allows compression force across the nonunion site for the treatment of femoral shaft nonunions. Materials and Methods: Between Nov. 1998 and June 2002, twenty one nonunions of femoral shaft fractures in twenty patients were treated with reamed IC nails of larger diameters without bone grafting in 9 men and 11 women, 8 to 45 months after initial operations. Seventeen cases were hypervascular nonunions, 3 avascular, and 1 infected. For initial operation, 10 closed nailing, 10 open nailing and 1 plate fixation were performed. One or more additional procedures had been done in 17 cases prior to IC nailing. Results: The nonunion gap was considerably narrowed from 7.4㎜ to 3.1㎜ with IC nailing and bony unions were achieved in all but one case. The time for radiographic union was 4 to 15 months posteoperatively with an average of 7.4. Conclusion: Reamed IC Nail?? with a larger diameter is an effective procedure for femoral shaft fracture nonunion regardless of initial treatment modalities and even in 3 avascular nonunions, 2 have shown radiographic union without bone grafting. Additional procedures are to be considered in failed surgery of avascular nonunions.

간경변증 환자에서 Escherichia coli 균혈증 합병 시 간기능 장애에 따른 C-reactive protein 생성 능력에의 영향

박완범,강철인,김동민,이기덕,장희창,김홍빈,오명돈,이효석,최강원 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

목적 : C-reactive protein(CRP)은 간에서 생성되는 급성 반응물질이다. 하지만 간부전증 환자에서 CRP의 반응이 간기능에 따라 어느 정도 영향을 받는지는 별로 알려진 바가 없다. 본 연구에서는 간기능에 따른 CRP 생성 능력을 평가하고자 하였다. 방법 : E. coli 균혈증이 있는 간경변증 환자 30명을 대상으로 하였고 간기능은 균혈증이 발생하기 전 2개월 이내에 측정된 혈청 빌리루빈, 혈청 알부민, 프로트롬빈시간, Child-Pugh 점수로 평가하였다. 대조군 A는 간질환이 없으면서 E. coli 균혈증이 발생한 환자 30명으로 하였고 대조군 B는 간경변증이 있으면서 급성 감염의 증거가 없는 환자 30명으로 하였다. 환자군과 대조군 간에 CRP의 최대값을 비교하였다. 결과 : CRP의 최대값은 환자군에서 7.3±5.0㎎/dL, 대조군 A에서 17.9±8.3㎎/dL로 환자군에서 유의하게 낮았다.(P<0.001). 간경변증 환자에서 CRP의 생성은 Child-Pugh 점수에 비례하여 감소하였으나(P=0.004) Child=Pugh class C의 간기능을 가진 환자군에서도 대조군 B와 비교하여 의미있는 CRP의 생성을 보였다(5.3±3.2 vs. 0.5±0.4㎎/dL, P<0.001). 결론 : 간기능부전 환자에서 CRP 반응은 간기능 저하 정도에 따라 둔화되지만 심한 간기능 장애를 가진 환자에서도 CRP의 생성은 유지된다. Background : C-reactive protein (CRP) is an acute phase reactant produced in the liver. To assess the influence of liver dysfunction on the production of CRP, we evaluated CRP response to E. coli bacteremia in patients with or without liver cirrhosis (LC). Methods : 30 LC patients who developed spontaneous peritonitis with E. coli bacteremia were enrolled in the study. Baseline values of total bilirubin, serum albumin, and prothrombin time were obtained within 2 months prior to infection. Liver dysfunction was categorized according to the Child-Pugh score. 30 patients with E. coli bacteremia who had no underlying liver dysfunction were included as a control group. Matched-control of 30 LC patients without evidence of acute infection was also included. The peak CRP values were compared among the groups. Results : In the patients with E. coli bacteremia, the mean value of peak CRP was 7.3 (+/- 5.0) ㎎/dL in LC patients, 17.9 (+/- 8.3) mg/dL in patients without liver dysfunction (p<0.001). In the advanced LC patients with Child-Pugh class C, the level of CRP was 5.2 (+/- 3.3) ㎎/dL in patients with E. coli bacteremia, 0.5 (+/- 0.4) ㎎/dL in patients without acute infection (P<0.001). Child-Pugh score had correlation with decrease of CRP (linear regression test, P=0.004). Conclusion : CRP response during E. coli bacteremia was attenuated but maintained even in patients with advanced liver dysfunction.