모 축전지 회사 근로자들의 연폭로 지표에 대한 경시적 관찰

강명식,김용배,이용진,리갑수,김화성,황규윤,장봉기,이성수,안규동,이병국 순천향대학교 산업의학연구소 1998 순천향산업의학 Vol.4 No.1

Lead poisoning is still prevalent and one of important occupational disease in Korea. To prevent undue high lead burden and maintain good health condition of lead workers in lead using industries, periodic health examination and regular biological monitoring of lead workers are often required in addition to the fundamental improvement of their working condition. To evaluate the effect of comprehensive occupational health program with regular biological monitoring on the level of lead exposure of lead workers in lead using industries, 11 year database from 1983 to 1994 of one storage battery factory was reviewed. From 1983 to end of 1986 only periodic health examination was provided to the lead workers, but from 1987 comprehensive occupational health program with regular biological monitoring was provided to maintain better health condition of lead workers. Selected study variables for lead exposure were blood lead(PbB), zinc protoporphyrin in blood(ZPP), δ-aminolevulinic acid in urine(ALAU), hemoglobin(Hb), hematocrit(HCT). Information on sex, age and work duration was also reviewed. 5 years data from 1983 to 1987 and 3 years data from 1990, 1993 and 1994 were available for all lead exposure indices except ALAU which has only 5 years data from 1983 to 1997. The results of 11 years longitudinal observation of lead indices are all follows: 1. The mean value of ZPP of lead workers in 1983 was 148.7±73.1 ㎍/㎗(Male: 145.5±72.3, Female: 168.1±79.1), whereas that of ZPP of lead workers in 1994 was decreased to 64.3±32.7 ㎍/㎗(Male: 60.2±28.8, Female: 95.2±43.4). 2. The mean value of PbB of lead workers in 1983 was 56.4±18.8 ㎍/㎗(Male: 55.59±19.1, Female: 59.6±19.1), whereas that of PbB of lead workers in 1994 was dcreased to 35.4±11.9 ㎍/㎗(Male: 35.7±12.0, Female: 32.8±10.8). 3. The mean value of Hb of lead workers in 1983 was 14.1±1.4 g/㎗(Male: 14.4±1.1, Female: 11.7±0.8), whereas that of Hb of lead workers in 1994 was increased to 15.6±1.5 g/㎗(Male: 15.9±1.2, Female: 12.9±1.1). 4. Blood lead is most highly correlated with ZPP(r=0.522, male:0.54 and female:0.50) and also correlated with ALAU and work duration also. 5. The simple regression analysis of PbB and ZPP showed different coefficient of regression by the measurement year, but there was no difference of coefficient of regression between sex. The slope of equation of pooled data for 1983-1986 without comprehensive occupational health program was 2.16 and differed from that of pooled data for 1987-1994(1.25). This difference suggests that the unit effect of blood lead on ZPP was relatively smaller in later period of comprehensive occupational health program than carly period without comprehensive program. The slope change in the analysis of linear regression of PbB on ZPP in lead workers can be used to evaluate the possible effect of health intervention to prevent undue high lead absorption in lead using industries. 6. 11 years occupational health service in this storage battery factory brought out considerable improvement of health status of lead workers in terms of decrease of PbB and ZPP and increase of Hb and the improvement was more remarkable after the introduction of comprehensive occupational health program.

경골과 골절에 대한 수술적 치료

조용만,박명식,강흥식,이건영,이천동,조규철 대한골절학회 1997 대한골절학회지 Vol.10 No.1

The tibial condylar fracture which involves articular surface of the proximal tibia is common in pedestrian injury of the traffic accident and often produces some disability of the knee joint because of the frequent association with ligamentous and meniscal injuries. Methods of treatment in fracture of the tibial condylas has long been a controversial problems. Recently most authors agree that the method of treatment has to be selected in each individual case and anatomical reduction of fracture and early knee motion are recommended but unsatisfactory results has been reported as between 20% and 40%. The authors analyzed 38 cases of the tibial condylar fractures, which were treated at the orthopedic department of the Lee-Rha general Hospital from 1990 to l994, regarding its type. treatment and results. The results of this study were as follows. l. According to Schatzker classification: the most common fracture was type II. 2. According to Blokker's criteria, 28 cases showed satisfactory results( 74% ). 3. Postoperatively, early knee joint exercise like alternatively applling 90( knee flexion and extension splint were very important factors for good results.

입상활성탄에 의한 방향족, 지방족고리 아민류 및 아미노산의 액상흡착

이성식,김형준,유명호,박성은 동아대학교 공과대학부설 생산기술연구소 1998 生産技術硏究所硏究論文集 Vol.3 No.1

Equilibrium studies for the adsorption of aromatic, alipatic cyclic amines and amino acid from aqueous solutions onto granular activated carbon have been carried out at 298K. Two and Three-parameter isotherms were tested. Among the equations tried, the two-parameter equations of Freundlich equation yield a better fit, The Langmuir equation, However gives the poorest overall fit. For three-parameter isotherm equation, the Redlich-Peterson equation gives the most satisfactory fit over the entire range of concentrations. The adsorption amounts of the aromatic amines onto GAC increase with the number of methyl group in pyridine ring.

소아 확장성 심근증의 임상적 고찰

이성환,김준식,박근수,김명성,권태찬,김천수,이상락 啓明大學校 醫科大學 1996 계명의대학술지 Vol.15 No.1

A Clinical assessment of the 25 patients with dilated cardiomyopathy who were admitted to the Department of Pediatrics, Keimyung University Dong San Hospital from January, 1982 to June, 1993 was performed. The result were as follows: 1) Among 25 patients with dilated cardiomyopathy. 8(32%) were younger than 1 year of age at the time of admission. 2) Adriamycin toxicity was the only encountered etiologic factor in 1 patient. 3) On admission, hepatomegaly and tachycardia were noted in almost all patients. 4) The Chest X-rays showed cardiomegalies in all 25 patients, pulmonary vein congestions in 15(60%) and pleural effusion in 2(8%). 5) The electrocardiography showed left ventricular hypertrophy in 72% and supraventricular tachycardia in 32%. 6) The echocardiographic examination showed left ventricular dilatations in all patients and left atrial dilatations in 20(80%). 7) Of 18 patients who had followed mean period of 2.9 years, 10 patients died within 9 months after the diagnosis.

지역사회내 직업재활 참여중인 만성정신질환자의 욕구 조사

이종국,황태연,한은선,김명식,이충순 용인정신의학연구소 1998 용인정신의학보 Vol.5 No.1

施設園藝地에서 有效硼素 含量에 대한 土壤有機物의 相對 寄與度

李在奭,최명자,정재식 대구효성가톨릭대학교 1997 연구논문집 Vol.56 No.2

우리나라 시설원예지에서 유효불소 함량에 대한 토양유기물의 상대 기여도를 구명하고자 경기, 충남, 경북, 제주도에서 채취한 시설원예지 토양을 공시하여 얻은 결과는 다음과 같다. 1. 시설원예지의 유효불소 함량은 최저 0.17ppm, 최고 2.24ppm이었고, 육지토양이 0.93±0.62 ppm이었고 제주도 토양은 0.41±0.20ppm이었다. 2. 토양유기물의 함량은 최저 0.46%, 최고 15.20%이었으며, 평균함량은 육지토양이 1.93±1.21%이었고, 제주도 토양은 13.4±1.95%로 육지토양보다 높았다. 3. 표토의 유기물 함량과 유효불소함량 간에 육지토양은 고도의 유의성(r=0.6440**)있는 정상관이었으나, 제주도 토양은 유의성(r=0.5024)이 없었다. 4. 토양유기물이 1단위 증가함에 따라 붕소의 함량은 육지토양이 1.1596 ppm, 제주도 토양은 0.0392 ppm씩 통계적으로 증가하는 경향이었다. 5. 유효붕소 함량에 대한 토양유기물의 기여도는 유기물의 함량이 적은 육지토양에서 높았고, 유기물의 함량이 많은 제주도 토양은 낮았다 This study was conducted to identify the contribution ratio of soil organic matter for an available boron content in plastic film house soils which were obtained from the soils of Gyeong-gi, Chung Nam, Gyeong Buk and Jeju areas. The results are summarized as follows; 1. Available boron content in plastic film house soils was from 0.07 ppm to 2.24 ppm, average content was 0.93±0.62 ppm(inland soils) and 0.41±0.20ppm(Jeju soil), respectively. 2. The content of organic matter was from 0.46% to 15.20% average content was 1.93±1.21%(inland soil) and 13.4±1.95%(Jeju soil), respectively. 3. The inland soils between organic matter content and available boron content showed a highly positive correlation coefficiency (r=0.6440**), while Jeju soil was positive correlation coefficiency (r=0.5024). 4. The content of available horon, as increasing 1 unit of soil organic matter, was increased as 1.1596 ppm in inland soils, while it was increased as 0.0392 ppm in Jeju soil. 5. The contribution ratio of soil organic matter for avaiable boron content was high in inland soils, which have low content of ofganic matter, while it was low in Jeju soil containing a high content of organic matter.

부산지역 강하먼지 중 불용성 중금속 함유량

이용범,황용식,이창희,박명희,이채관,강동묵,김정원,전병일,문덕환 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.1

■ Objectives The purpose of this study was to estimate qualitatively various bulk deposition flux of insoluble heavy metal components by applying regional and seasonal distribution. our institution from January 1980 to December 31th, 2001. ■ Materials and Methods Dustfall particles were collected by the modified American dust jar (wide inlet bottle type) at 6 sampling sites in Pusan area from March, 1999 to February, 2000. Five chemical species (Cd, Cr, Mn, Ni and Pb) were analyzed by AAS(Perkin-Elmer 4100ZL). ■ Results The mean values of each heavy metal concentrations were Cd for 3.947 g/㎢/month, Cr for 0.191 ㎏/㎢/month, Mn for 0.375 ㎏/㎢/month, Ni for 0.176 ㎏/㎢/month, and Pb for 0.823 ㎏/㎢/month. ■ Conclusions Insoluble heavy metal amount of regional variations were found in order of industrial zone, coastal zone, commercial zone, agricultural zone and residential zone.

QUAL2E 모형을 이용한 서해안개발사업에 따른 금강의 수질오염도 예측

이정식,이명훈,이재준 金烏工科大學校 1992 論文集 Vol.13 No.-

This study is to simulate the future water quality(BOD) of the Geum river by the development works in the west coastal area. The development works in the Geum river basin consist of 14 works including 4 industrial complexes, 1 agricultural development district and 9 agricultural-industrial areas. A simulation for predicting the future water quality of the Geum river from year 1996 to 2001 is performed by using the QUAL2E model. In this case the flow condition is assumed that the river maintenance water of main river is discharged 20㎡/sec from the Daechong dam and tributaries are maintained the 330-th daily flow in descending order. From the results of water quality simulation, the construction of wastewater treatment plants in the upper reaches of the Geum river was not effective enough to improve the water quality of downstream part below Buyo 1. It is necessary to construct more wastewater treatment plants in the lower reaches of the stream for improving the water quality of the Geum river.

동물원에서 사육중인 Japanese Macaque (Macaca fuscata)에서 Zoletil 마취에 관한 연구

이재일,이수진,홍성혁,신남식,김덕환,박창식,전무형,조종민,김영석,김명철 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8

To evaluate the effects of Zoletil (tiletamine-zolazepam) that have been widely used for the chemical restraint and anesthesia of primates, on physiologic alteration, blood gas analysis and anesthetic duration in the Japanese macaque(Macaca fuscata), this study was carried out. Zoleril was administered by intramuscular injection, Evaluation of temperature, heart rate, respiration rate and blood gas analysis were performed before administration ancl at 1,10, 20, 30, 40, 50 and 60 min after administration, and induction and maintenance time was recorded. There was no significant difference in heart rate, PCO₂PO₂after Zolcril administration and temperature, respration rate, pH were significant difference compared with those of before administration, The induction time was 2.5±l.Omin and maintenance time was 86±23.2min. It was considered that Zoletil could he usefully used for the sedation and immobilization of Japanese macaque reared in zoological garden.

Trichoplusia ni 세포의 apoptosis 메커니즘 규명을 위한 기초연구

이종민,정인식,양재명,이윤형 한국농화학회 2001 Applied Biological Chemistry (Appl Biol Chem) Vol.44 No.1

To elucidate the apoptosis mechanism of Trichoplusia ni cell, fundamental studies for apoptosis induction and suppression were performed. Hygromycin B, a known inducer of apoptosis, started the inhibition of T. ni cell growth at 200 ㎍/㎖ concentration. Furthermore, at 400 ㎍/㎖ concentration, DNA fragmentation was detected on day 2 of incubation. Although both dexamethasone and sodium butyrate inhibited T. ni cell growth, DNA fragmentation was not detected by both treatments. Also, when apoptosis induced T. ni cells with 200 ㎍/㎖ hygromycin B were treated with caspase inhibitor (Ac-DEVD-CHO), the apoptotsis was suppressed by 36%. In addition, N-acetylcysteine, another apoptosis repressor, also inhibited the apoptosis of T. ni cells. In order to express the anti-apoptosis gene (bcl-2), T. ni cells were transiently transformed with bcl-2 and its expression was confirmed by western blot analysis. These results showed the potential of developing new insect cell lines with suppressed apoptosis.