서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

심재성 홍반성 루푸스 1예

이원석,송준영,김용대,박의수 啓明大學校 醫科大學 1988 계명의대학술지 Vol.7 No.2

We report a case of lupus erythematosus profundus in a 16-year old male. He had multiple pea-nut to bean sized subcutaneous nodules with dark brownish colored overlying skin was present on the upper arm, trunk & other systemic disease. Histologically, deep dermis & subcutaneous layer had dense patch lymphocytic infiltration and homogenized hyaline fat necrosis. Direct immunofluorescene studies showed IgM and C?? deposit on the vessel wall. We treated him with chloroquine and corticosteroid.

소상공업의 생산성향상을 위한 소상공인지원센터 개선방안

이의영,김항석 한국생산성학회 2004 生産性論集 Vol.18 No.3

World economy makes rapid progress due to knowledge based economy, globalization, regionalization, and netwPork oriented system. Rapid progress in IT industry and networking. The importance of small business is highlighted as one of the confrontations for these variations. Therefore, the purpose of this survey is groping for the development plan which make the revitalization of the small business support and the higher productivity possible. This survey consists of four chapters. Chapter one is the introduction and deals with the background, the purpose, the method of this study. Chapter two examines the transition of its position, the enlargement of the role, and the present state of the small business. Chapter three is the study about the actual conditions of the support center for small business and the revitalization plan. And Chapter four is the conclusion and presents the results, the limits, and the hereafter assignment of this study.

인터넷 공간데이타 전자유통 시스템에 관한 연구 : A Study on the Internet Spatial Data Electronic Distribution System

이기영,서의석,이용수 韓國컴퓨터情報學會 2000 韓國컴퓨터情報學會論文誌 Vol.5 No.3

최근에 WWW의 등장과 함께 인터넷 사용자가 폭발적으로 증가하고 웹 지리정보시스템의 필요성과 중요성이 크게 대두되어 인터넷을 통한 공간데이타 유통 환경을 구축하기 위하여 여러 기관 등에서 많은 기술개발 연구가 이루어지고 있다. 공간데이타를 인터넷상에서 접근하기 위해서는 WWW상에 공간데이타를 등록하고 필요로 하는 사람에게 판매할 수 있는 공간데이타 전자유통 시스템이 필요하다. 본 논문에서는 WWW과 연동하는 공간데이타 전자유통 시스템을 구축하기 위한 효율적인 공간데이타 전주유통시스템의 모델을 설계하고 제시한다. 또한 시스템의 각 모듈에 대한 기능과 구현 방법을 제안한다. Recently, the advent of WWW increased the population of internet users and many institutions are carrying out technical development research to implement spatial data distribution environment via internet because importance of Web Geographic Information System(WGIS) is being increased highly. To be accessed WGIS data. we need Spatial Data Electronic Distribution System(SDEDS) which registers and sell spatial data in WWW. In this paper. we propose and design effective SDEDS to expel spatial data electronic distribution system which is connected WWW. Therefore. we show how to implement and functions of each module.

실리카가 첨가된 PEHA/PS 코어-쉘 압력가소성 고분자의 합성

양의석,김유진,이상석,류상욱 충북대학교 산업과학기술연구소 2011 산업과학기술연구 논문집 Vol.25 No.2

본문참고

축구 오버헤드 킥 동작의 운동학적 분석

김의환,이요열,김성섭,권문석,김성호 한국운동역학회 2003 한국운동역학회지 Vol.13 No.1

Kim, E-H · Lee , Y-Y · Kim, S-S· Kwon, M-S · Kim, S-H. The kinematical Analysis of the Overhead Kick on Soccer. Korean Journal of Sport Biomechanics. Vol. 13, No. 1,pp. 155-171. The purpose of this study was to analyze the kinematic variables of over head Kick(OHK) in soccer with three dimensional analysis technique and show the kinematic characteristics of it. The 7 subjects were university football player who have been playing football more than 7 years. The OHK was filmed on 16mm video camera(30frame/sec.) kinematic variables were temporal, postures, and COG(center of gravity). The mean values and the standard deviation for each variables were obtained and used as basic factors for examining characteristics of OHK. the results of this analysis were as follows : Temporal variables : The total time elapsed(TE) of OHK was0.94~1.14sec., the 1st phase was 0.35sec., 2nd phase was 0.46sec., and 3rd phase was 0.22sec.. Posture variables : When subjects performed OHK at the impact event, the ankle and knee angle of kicking foot were more extend than supporting foot. but the hip angle of supporting foot were more extend than kicking foot. Moving distance of the center of mass of the both foot : When subject performed OHK at the impact event, the range of distance on mediolateral direction aspect into right · left shoulder line, anteroposterior direction aspect was 20.9±10.5cm, vertical direction aspect was 92.3±19.9cm. Angular velocity : the faster angular velocity of knee · ankle on the kicking foot grew form jump position to landing position, the faster velocity of ball became. C. O. G. variables : When subject performed OHK at the impact event, upper part of the body was getting lower, lower part of the body was getting higher.

내륙화물기지의 위치결정을 위한 요인분석법

변의석,이장룡 선문대학교 2000 공학계열 논총 Vol.3 No.-

Most of logistics activities increase the efficiency of production and distribution. As a hub function of logistics, Korea government plans to launch Inland Container Depot(ICD). There are lots of criteria and schemes to decide hub-and-spoke locations. In this paper a facility location problem is introduced, and the solution methodology of Analytic Hierarchy Process(AHP) is used. We investigated some important attributes for deciding logistics facilities.

IH-201 카바페넴 항생제의 주요 임상분리세균에 대한 항균력

김의종,김재석,이재규 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.1

목적 : 카바페넴 항생제 IH-201에 대한 국내 임상 분리 균주의 감수성 여부를 파악하기 위하여 임상 환자에서 흔히 분리되는 통성 혐기성 세균을 대상으로 최소억제농도를 측정하였으며, 대조 항생제로는 meropenem을 사용하여 그 결과와 서로 비교하였다. 방법 : 시험 균종은 2000년 서울대학교병원 임상병리과로 세균배양이 의뢰된 혈액, 객담, 소변 등 임상 검체에서 분리한 균주로서 임상 환자에서 흔히 분리되는 통성 혐기성 세균 총 516주를 대상으로 하였다. 미국 임상검사표준화협회(NCCLS)에서 권장하는 방법에 따라 S. pneumoniae를 제외한 모든 균종은 한천희석법으로 MIC를 측정하였으며, S. pneumoniae는 microdilution broth법으로 MIC를 측정하였다. 결과 : IH-201의 MIC는 일반적으로 E. coli와 K. pneumoniae를 포함한 Enterobacteriaceae과에 대하여 MIC_(90)가 0.06㎍/mL로서 meropenem과 유사하였다. E. cloacae, C. freundii, S. marcescens의 경우 IH-201의 MIC 누적백분율곡선이 meropenem보다 다소 오른쪽으로 치우쳤지만, 이 균종운 모두 감수성 범위안에 들었다. P. aeruginosa와 A. baumanii의 IH-201과 meropenem에 대한 MIC_(90)는각각 2㎍/mL과 1㎍/mL이었다. Imipenem에 대해 내성인 P. aeruginosa 29주 중 7주가 meropenem에 대해 감수성이었으나, IH-201에 대하여는 낮은 MIC가 관찰되지 않았다. S. aureus의 IH-201과 meropenem에 대한 MIC_(90)는 각각 >128㎍/mL과 32㎍/mL이었다. E. faecalis의 IH-201과 meropenem에 대한 MIC_(50)는 각각 8㎍/mL과 16㎍/mL이었다. E. faecium의 경우 IH-201과 meropenem에 대한 MIC_(50)는 둘 다 >128㎍/mL이었다. S. pneumoniae의 IH-201과 meropenem에 대한 MIC_(90)는 각각 1㎍/mL과 0.5㎍/mL이었다. 결론 : IH-201은 E. coli, K. pneumoniae 및 S. pneumoniae에 대해 meropenem과 유사한 항균력을 갖고 있다. P. aeruginosa와 A. baumanii에 대하여는 meropenem이 IH-201보다 더 항균력이 높다. S. maltophilia와 E. faecium은 IH-201과 meropenem에 대하여 내성이다. 앞으로 인체의 혈중농도 및 독성에 관하여 IH-201의 연구가 지속되어야 할 것으로 생각된다. Background : Minimal inhibitory concentrations (MICs) of facultative anaerobic bacteria isolated from several kinds of specimens of patients were determined for the in vitro susceptibility against the new carbapenern IH-201 and compared with MICs of meropenern in Korea. Methods : Total 516 strains isolated from blood, sputum, or urine of patients at Seoul National University Hospital in 2000 were examined by agar dilution or microdilution broth method according to the recommendations of National Committee for Clinical Laboratory Standards. Results : In general, the MICs of IH-201 against family Enterobacteriaceae including Escherichia coli and Klebsiella pneumoniae were similar with those of meropenern, as MIC_(90) of 0.06㎍/mL. For Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens, the MIC cumulative percentage curves of IH-201 were shifted more right-sided than meropenern. but the MICs of all isolates were within the susceptible criteria. The MIC_(50) of Pseudomonas aer㎍inosa and Adnetobacter baumanii against IH-201 and meropenern were 2 and 1㎍/mL, respectively. Among 29 strains of imipenem-resistant P. aer㎍inosa, 7 were susceptible to meropenern, but none had low MICs (<4 ㎍/mL) to IH-201. The MIC_(90) of Staphylococcus aureus against IH-201 and meropenern were >128 and 32 ㎍/mL, respectively. The MIC_(50) of Enterococcus faecalis against IH-201 and meropenern were 8 and 16 ㎍/mL, respectively. For Enterococcus faecium, the MIC_(50) of both IH-201 and meropenern were >128 ㎍/mL The MIC_(90) of Streptococcus pneumoniae against IH-201 and meropenern were 1 and 0.5 ㎍/mL, respectively. Conclusion : IH-201 has the similar antimicrobial activity as meropenern against E. coli, K. pneumoniae, and S. pneumoniae. Meropenern is more active than IH-201 against P. aer㎍inosa, and A. baumanii. Stenotrophomonas maltophilia and E. faecium are highly resistant against both of IH-201 and meropenern. The further data of IH-201, such as blood level and toxicity for human, should be accumulated in the near future.

비소세포 폐암종에서 Epidiermal growth factor receptor(EGFR)의 발현 양상

임석호,이지혜,조현득,오미혜,김의한 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.1

배경: 비소세포 폐암종에서 epidermal growth factor receptor (EGFR)의 발현이 예후에 미치는 영향에 대해서는 아직 일치된 결론에 이르지 못하고 있으며, 비소세포 폐암종의 조직 병리학적 소견으로는 종양의 진행 및 예후에 대해 예측이 불가능하다. 이에 저자들은 종양의 EGFR 발현과 임상 및 병리학적 특징과의 관계를 관찰하였다. 재료 및 방법: 1990년부터 2004년까지 순천향 대학교 천안병원에서 수술로 절제된 95명 환자의 포르말린에 고정한 파라핀 포매 조직을 이용하여 EGFR 항체를 이용한 면역조직화착 검사를 시행하였으며 이의 결과를 환자의 임상양상과 병리학적 소견과 비교 분석하였다. 결과: EGFR 발현과 환자의 생존기간을 비롯한 성별, TNM 임상병기, TU댕기, N-병기와는 관련이 없었으나 조직학적 유형중 편평상피암종은 47예중 43예가 양성 반응을 보여 통계학적으로 의미 있는 상관관계를 보였다(p=0.005). 그 외에 성별, 조직학적 유형, TNM 임상병기, T-병기, N-병기중 어떠한 변수도 생존기간과의 연관성을 보이지 않았다. 결론: 비소세포 폐암종에서 EGFR의 발현은 환자의 생존기간 및 임상병리학적 소견과 유의한 상관관계를 보이지 않으므로 예후인자로서의 이용은 현재로선 불가능하여 좀 더 많은 증례를 통한 연구가 필요할 것으로 사료된다. Background: The prognostic role of epidermal growth factor receptor (EGFR) remains controversial in patients with non-small cell lung cancer (NSCLC). Histopathologic findings cannot adequately predict disease progression, so we investigated the reladonship between EGFR and clinicopathologic feature. Methods: Using immunohistochemical techniques, we retrospecdvely analyzed formalin-fixed, paraffin-embedded samples from 95 padents with resected pathological NSCLCs. Then, we correlated these data with padents' clinical outcome and pathologic finding. Results: No reladonship was found between EGFR overexpression and patient survival when the entire cohort was considered. Multivariate factors including gender, histologic type, TNM stage, T stage and N stage were not correlated to poor outcome. Also, no factors revealed correlation with EGFR overexpression except histologic type. Squamous cell carcinoma showed positive reaction in 43 out of 47 patients(p=0.005). Condusion: This result indicated that EGFR overexpression in NSCLC showed no reladonship with patients' survival. Therefore, EGFR overexpression could not be used as a poor prognostic marker.

최근 6년간 연세의료원에서 경험한 한국인 안면골 골절에 대한 임상적 연구

권준호,이충국,이의웅,민우석,윤중호,박형식 大韓顎顔面成形外科學會 1989 Maxillofacial Plastic Reconstructive Surgery Vol.11 No.1

This is a series of continuing research on facial bone fractures of Koreans worked by Dept. of Oral and Maxillofacial surgery, Dental College of Yonsei University, Seoul, Korea, since 1972. The study was based on a series of 630 patients with facial bone fractures treated as in patient at Yonsei Medical Center, Yonsei University, during the period of Jan. 1982 through Dec, 1987. The results obtained are as follows: 1. The ratio of Men to Women was 4.3 : 1, and admissions for facial bone fractures have been increased year after 1984. 2. The age frequency was highest in the third decade(38.3%). and fourth, second, fifth decade in orders. 3. The traffic accident was the most frequent cause of facial bone fractures(51.3%). 4. The most common location of facial bone fractures was the Mandible(35.3%), and Zygoma complex(29.8%), Nasal bone(15.0%), Maxilla(11.0%) were next in order of frequency. 5. In 291 patients of Mandible fractures, 226(77.7%) had fractures only in Mandible and 65(22.3%) had another facial bone fractures. The most frequent fracture site of mandible was the Symphysis(43.0%) and Angle(22.4%), and Simple fracture was the most frequent in type of fracture(66.9%). Intermaxillarty fixatin & Open reduction was major method of treatment(36.9%). 6. In 394 patients of Midface fractures 323(82.0%) had fractures only in Midface and 71(18.0%) had another facial bone fractures. The most frequent site of Midface fractures was zygoma complex & zygomatic arch(42.7%), and Simple fracture was the most common type of fractures. Observation(Maxilla :44.2%, Zygoma :51.0%) and Open Reduction(Maxilla :20.0%. Zygoma :23.5%) were the major method of treatment. 7. The frequency of Nasal bone fracture was about 1/5 of Midface fractures, and Closed Reduction(42.2%) was the major method of treatment. 8. The complication was reported in only 16 patients, and Malunion was the major complication. 9. Head(44.4%), Lower extrimities(14.5%) and Eye(12.3%) were injured commonly with facial bone fractures. 10. The elapsed time from injury to hospital was within 24 hours in 73.8% of patients, however 15.5% of patients arrived the hospital 72 hours after injury.