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放射線照射가 白鼠顎骨 및 拔齒創 治癒에 미치는 影響에 關한 實驗的 硏究
李義雄 연세대학교 대학원 1980 延世論叢 Vol.16 No.2
This study was undertaken to observe in jaws and extraction-wound healing of rats when exposed to a single dose and fractionated dose of Cobalt-60 irradiation. One hundred-sixty albino rats of a sprague dawley strain, weighing approximately 180 grams each at the begining of the experiment were divided into control group and 3 experimental groups. In experimental groups, group I recieved 1200 rads every week until the 4800 rads reached, group II recieved 2000 rads with a single dose and group III recieved 2500 rads with a single dose. Irradiation was carried out using a RAC-120 Cobalt-60 Teletherapy Unit with a dose rate 62.1 r/min measured at 100cm from source. All animals of III group were died from 8th to 12th day after radiation. Group I and II were divided into 4 subgroups after radiation respectively. Extraction on lower third molar was performed in each group at 1st, 2nd, 3rd and 4th week after exposure. Serial sacrifice of two or three experimental and two control animals was begun one week after extraction and was performed on a weekly basis thereatfter until all experimental arimal were used. When all animals were sacrificed, the following specimens available for hislologic study; Control group; 3,7,10,14,21,28,35 and 42 days postextraction, Group I & II were shown as Figure. After examination and comparision of all specimens, the results of this study were obtained as follow. 표삽입 원문참조 1. The mortality during this experimental period were shown, group I : 50%, group II : 43.75% and group III : 100%. 2. The time when all experimental animals began to recover as normal, appearance group I : from 3 weeks after radiation. group II : from 5 weeks after radiation. 3. Osteoradionecrosis of jaw bone appeared to result primarily from the direct effect of irradiation on the osteocyte, revealed pyknosis and loss of ostescyte, and appeared congestion of blood vessels and thickening the Vessel walls. 4. Subgroup A, and C of group I and A of group II showed pyknosis and loss of osteocyte in bone lacunae, especially 1 week after extraction. 5. Extraction-wound healing in subgroup B. and C of group II took as normal healing process, but subtroup A of group I only continued necrotic process upto 4 weeks post extraction. 6. Extraction-wound healing was in direct relationship to total dosage of radiation and the time interval for extraction after radiation. 7. Epithelization of extraction-wound was influenced by size of wound, mucosal laceration and remained foreign body. 8. General condition after radiation leas improved by tube feeding with milk. -supportive therapy. 9. when teeth are extract following radiation, the time interval for extraction after radiation must be taken two weeks at least.