실리카흄을 흔입한 고강도 콘크리트 개발

홍창우,김태경,김경진,김성환,김남윤,심도식,이정호,윤청호,백민경,원치문,박제선,이주형,정경일 강원대학교 석재복합신소재제품연구센터 1996 석재연 논문집 Vol.1 No.-

콘크리트 구조물이 대형화됨에 따라 설계단면이 증대되어 상대적으로 많은 경제적 손실을 부담하게 된다. 따라서 단면을 감소시키면서도 소요의 하중에 안전한 구조물을 건설하기 위해서는 우선적으로 구조물 건설에 기초가 되는 고품질, 고내구성의 고강도 콘크리트 개발이 절실히 요구된다 본 연구에서는 일정 시멘트비 및 혼화재 비율하에서 소요의 워커빌리티가 확보되는 고강도 콘크리트를 시간과 온도의 변화에 따라 증기 양생하여, 압축, 인장, 휨강도 뿐만 아니라 파괴특성을 실험적으로 연구하였다. 시료 제작시 시멘트 입자 사이의 공극 및 불연속 영역을 충전하여 고밀도화하기 위한 콘크리트용 혼화재로 시멘트 비표면적이 상당히 작은 초미립 분말인 실리카흄을 이용하였다. 또한 AE감수제 및 고성능 유동화제를 사용하여 혼화재의 첨가에 의하여 발생될 수 있는 워커빌리티의 감소를 방지하였다. 실험결과에 의하면 일정 양생 지속 시간하에서 온도의 증가에 따라 콘크리트의 압축, 인장 및 휨강도가 전반적으로 증가하였다. 동일하게 일정 온도하에서 양생 지속시간이 커짐에 따라 강도들이 증가됨을 알 수 있었다. 따라서 상대적으로 높은 온도와 긴 지속 양생 조건하에서 파괴에 대한 저항력이 크게 나타났다. The compressible, tensible, and flexibleresistance of the high strength concrete is analyzed by the experimentation in the present study. For the test, we cure several samples with the silica fume as a mixture being become dense the spaces between the particle of cement under the variation of both the temperature and the curing-interval. Then, the superplasticizer and the ezcon are also used to satisfy the required workability for construction. The compressible, tensible, and flexible resistances to a stress are increased as increasing the temperature and the time interval for the curing. Therefore it is concluded that the overal fractural and mechanical properties is improved by mixing the silica fume into the cement.

Helicobacter pyloir 양성 소화성 궤양에서 lansoprazole 포함 삼제요법의 제균율 및 제균판정에 있어서 요소호기검사의 유용성

정혜경,곽재진,유민아,배기선,권정미,이종수,김도영,문일환 대한감염학회 2003 감염과 화학요법 Vol.35 No.3

목적 : 본 연구는 Helicobacter pylori (이하 H. polyri) 양성인 소화성 궤양 환자에서 lansoprazole 포함 삼제요법의 제균율을 알아보고, 제균 치료 후 제균 판정에 있어서 요소 호기 검사(Urea breath test, 이하 UBT) 및 신속요소분해(rapid urease test, 이하 RUT test)와의 일치율에 대하여 알아보고자 하였다. 방법 : 상부위장관내시경 검사에서 H. polyri 양성인 소화성 궤양환자에서 lansoprazole 60㎎+amoxicillin 2g+clarithromycin 1g의 약제를 2회 분복하여 1주간 복용하는 삼제요법을 실시하였다. 최소 4주후 추적 상부위장관내시경을 실시하였고, 전정부와 체부에서 각각 RUT를 실시하였으며 UBT(5분, 20분)를 시행하였다. 결과 : 대상환자는 총 46명으로 남자 34명(48±13세), 여자 12명(53±14세)이었다. LAC 삼제요법의 제균율은 40/46명(87.0%)이었고, 궤양의 치유율도 42/46명(91.3%)이었다. RUT와 20분 UBT 결과가 모두 음성이었던 경우는 41예, 모두 양성이었던 경우는 4예로 RUT와 UBT는 97.8% (45/46)의 일치율을 보였고, 1예는 UBT는 음성이었으나 체부에서 시행한 RUT가 양성이었다. 5분 UBT 검사가 양성이었던 예는 14/34 (41.2%) 이었고, 이 14예 중 12예(85.7%)는 20분 UBT 검사 음성, RUT 음성이었다. 결론 : Lansoprazole과 amoxicillin, clarithromycin 1주일 병합요법은 H. polyri 양성인 소화성 궤양 환자에서 87.0%의 제균율을 나타내어 우수한 효과를 보였고, 요소호기검사는 제균 치료 후 제균 판정에 유용한 비침습적인 방법임을 확인할 수 있었다. Background : There are only a few studies on Helicobacter pylori (H. pylori) for its eradication rates of lansoprazole-based triple therapy in Korea, and the results are controversial. Therefore, we undertook to investigate the eradication rate of lansoprazole-based triple therapy, and compare the concordance rate of urea breath test (UBT) and rapid urease test (RUT) in evaluating H. pylori eradication. Methods : Patients with acute peptic ulcer who were H. pylori-positive were recruited by prospective, consecutive manner. They received lansoprazole 30 ㎎ b.d., amoxicillin 1 g b.d. and clarithromycin 500 ㎎ b.d. for 1 week. Upper endoscopy was performed after 4 weeks to check for ulcer healing, and UBT and RUT were performed to evaluate H. pylori eradication status. Results : A total of 46 patients were recruited, and they were all compliant. H. pylori eradication rate was 87.0% (40/46) and ulcer healing rate was 91.3% (42/46). Forty one patients showed negative in both UBT and RUT, and 4 patients revealed positive in both tests, therefore, the concordance rate of UBT and RUT was 97.8% (45/46). Conclusion : Our study showed that 1-week lansoprazole-based triple therapy was effective in H. pylori eradication and ulcer healing. UBT can be an effective, noninvasive method for evaluating H. pylori status after H. pylori eradication.

初期發熱患者에 대한 防風解毒湯의 經時的 解熱效果

정우상,문상관,조기호,김영석,배형섭,이경섭 경희대학교 1997 慶熙醫學 Vol.13 No.4

무균성 뇌막염에 있어 뇌척수액 추적검사에 대한 재평가

정은경,김경석,김갑승,문경래,박상기 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1

The author evaluated the clinical manifestation of forty cases of aseptic meningitis who were admitted in the pediatric department of the Chosun University Hospital from March 1990 to September 1990, and also observed the clinical course of two groups of aseptic meningitis divided by admitting time and reevaluated the needness of follow-up lumbar puncture for CSF examination. The author performed follow-up lumbar puncture for CSF examination to the first group, on the 7th hospital day by conventional way, otherwise only observed the clinical course without follow-up lumbar puncture for CSF examination to the 2nd group. There was no difference between both groups, and clinical improvement was seen in both groups. In conclusion, the author considers that if clinical and laboratory finding were compatible with aseptic meningitis, there may be no need for follow-up lumbar puncture for CSF exmenation.

자각증상으로 평가한 남성택시운전기사의 건강위험도

정문희,오경숙 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.2

This survey was conducted to evaluate the level of health risks of taxi drivers. Data were collected from April 20 to May 8 of 1997 and analyzed by descriptive statistics of SPSS/PC+ package. 1. Fifteen percent of 139 taxi drivers could be classified as having high level of health risks, suggesting secondary medical examinations. 2. Most frequent symptoms related to their jobs included backache, joint pain, nervousness, etc. Most of the symptoms related to their daily-living patterns are mainly caused by improper eating habit and lack of regular exercise. According to the above outcomes, following services are recommendable for their health management : 1) regular medical examinations as individual unit, 2) health education as group unit, and 3) health promotion campaign as total job unit.

소아 백혈병의 혈청 철, 총 철결합능 Transferrin포화율 및 Ferritin치에 관한 연구

문경래,정은경,박상기 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1

Author reviewed the clinical symtoms, hematological findings and serum Fe, total iron binding capadty(TIBC), transferrin saturation and levels of 40 children diagnosed as leukemia at the pediatric department of Chosun University hospital during a period of 7 years from Jan. 1983 to Dec. 1989. Also, 20 normal children as control group were studied. The results were summarized as follows: 1) The Mean±S.D. levels of the serum Fe, TIBC, transferrin saturation and ferrtin of leukemia 40 cases and control group were 126.8±37.8㎍/㎗, 276.1±37.8㎍/㎗, 47.1±15.6%, 244.5±52.7ng/㎖ and 107.2±34.2㎍/㎗, 309.9±31.8㎍/㎗, 34.7±11.4%, 69.6±30.8ng/㎖, respectively. The difference of the serum Fe levels between leukemia and normal control was statistically not significant (P>0.1) but the serum Fe, TIBC, transferrrin saturation and ferritin levels were significantly different(P<0.05, P<0.01, P<0.001). 2) The differences in the mean levels of the serum Fe, TIBC, transferrin saturation and ferfitin among the types of leukemia were not significant. 3) The differences of the serum TIBC, transferrin saturation and ferritin levels between leukemia and normal control were statistically significant. From the very high serum ferritin levels, it is thought that serum ferritinemia as tumor marker may be useful in diagnosis of leukemia.

웅접흄이 환기기능에 미치는 영향

문태인,구정완,정치경 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.3

In order to study the effects of welding fume on ventilatory function, forced expiratory spirogram was performed on 563 male workers exposed to welding fume in motor vehicles industry and 589 male control workers. Ventilatory indices such as forced vital capacity (FVC), forced expiratory volume in one second (FEV₁), the ratio of one-second forced expiratory volume to forced vital capacity(FEV₁%=FEV₁/FVC) and maximal mid-expiratory flow(MMF) were obtained by analyzing forced expiratory spirogram which were measured by Vitalograph in standing position. The result were as follows: 1. Mean values of FVC, FEV₁, FEV₁%, and MMF expressed as percent of the predicted were significantly lower in exposure group than in control group. 2. No significant differences for mean ventilatory indices were demonstrated between smokers and nonsmokers both in exposure group and control group. However, mean MMF of welders tended to reduce in smokers(77.4%) than in nonsmokers(82.4%). 3. In exposure group mean FEV₁was significantly lower in more than 20 years than those of control group. However, mean MMF, FEV₁% were significantly reduced with increasing exposure duration compared to control group, indicating 90.8% and 62.2% of the predicted in more than 20 years group. 4. In exposure group workers with obstructive ventilatory impairment(7.5%) was markedly higher than that with restrictive ventilatory impairment(2.0%). 5. In exposure group the proportion of workers with low ventilatory indices was the highest in MMF(26.8%), and followed by FEV₁(11.9%), FEV₁(7.6%) and FVC(2.1%) in descending order. Workers with low MMF and FEV₁% were significantly increased with increasing exposure duration compared to control group, indicating 64.3% and 32.1% in above 20 years group. With the above consideration in mind it suggested that the exposure to welding fume be associated with reduced pulmonary function and obstructive ventilatory impairment, increasing exposure duration be associated with reduced pulmonary function, and MMF be the most sensitive index in the evaluation of ventilatory impairments of workers exposed to welding fume.

柴胡가 free radical에 의한 脂質過酸化物 生成에 미치는 效果

문진영,최미정,남경수,임종국 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

Antioxidant effects of aqueous Siho extract on lipid peroxidation were determined by TBA value and also by lipid peroxidation value during the autoxidation of Iinoleic acid. Siho extracts exhibited markedly antioxidant aCtivity, which inhibited 99% of linoleic acid peroxidation. And Siho extracts showed 42% scavenging effect on α,α-dlphenyl-β-pjcrylhydrazyl radical, also exhibited a 60-94% inhibitory effect on superoxide generation. Siho extracts dose-dependently protected the cell death induced by tert-butyl hydroperoxide (t-BHP) and significantly increased cell viability In the normal rat liver cell(Ac2F) . These results suggested that Siho might play a protective role in lipid peroxidation by free radicals. Key Words: lipid peroxidation ; Siho extracts; scavenging effect

비만을 동반한 위암 환자에서 두 병을 같이 수술 치료한 경험(증례)

최경현,윤기영,문형환,신연명,서경원,안수미,송윤미,석정희,정경연,이은하 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Obesity is growing problem in Korea. We had a case of bariatric surgery during gastric cancer operation. Patient was 29 year old Korean lady with early gastric cancer located in the lesser curvature side of the middle 1/3 of the stomach. Her body weight was 89 kg, height 163 cm, and thus body mass index was 33.5 kg/m2. Preoperative blood pressure was 130/90 mmHg, hemoglobin 12.9 g/dL, total lymphocyte count 3,280/mL, serum albumin 4.3 g/dL, CEA 1.1 ng/mL, CA 19-9 9.1 ng/mL, and alpha fetoprotein 2 ng/mL. Another associated disease was right thyroid follicular neoplasm. The chest X-ray was normal. After IM injection of 2,500 units of heparin 30 minutes before the induction of general anesthesia, she received curative subtotal gastrectomy and Roux en Y gastrojejunostomy when a malabsorption loop of 120 cm jejunum was incorporated between the Treitz ligament and the end to side jejuno-jejunostmy site at May 29th 2006. Her postoperative course was uneventful except a minor wound seroma and the elevations of serum amylase(up to 4 folds) and lipase(up to 2 folds). She lost her body weight 9 kg in 5th, 21 kg in 7th, and 27 kg in 10th postoperative months to became 61.5 kg. On follow up exams in July 2008, she gained 4 kg to overcome her weakness and fatigue. From the above result, the incorporation of a malabsorption loop during reconstruction phase of gastric cancer operation was a good option for obese gastric cancer patients especially in cases of early gastric cancer.

한국 정상인에서 연령에 따른 뇌혈류분포와 혈류예비능의 변화 : Tc-99m HMPAO SPECT 에 의한 연구

문대혁,이희경,송호천,이재태,범희승,손혜경,정환정,민정준,김지열 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.3

Purpose: The aim of this study was to evaluate the normal values of regional cerebral blood flow (rCBF) and cerebrovascular reserve (CVR) in normal children to aged volunteers using Tc-99m HMPAO. Materials and Methods: Thirty four right-handed normal volunteers (20 males, 14 females, mean age 40.3±24.9 years, range 4 to 82 years) were underwent rest/acetazolamide (ACZ) brain SPECT using Tc-99m HMPAO and the sequential injection and subtraction method. rCBF was estimated on the basis of a semiquantitative approach by means of right/left ratio, region/cerebellum and region to whole brain ratios in frontal, parietal, temporal, and occipital lobes, basal ganglia, thalami, and cerebellum. CVR was measured by means of % perfusion increase calculated as % mean count change compared to rest rCBF in each regions. Results: Mean values of right to left ratios range from 1.004 to 1.018. rCBF was highest in cerebellum and lowest in basal ganglia and thalami. Frontal and temporal rCBF decreased while occipital and thalami rCBF increased according to age. No sexual difference of rCBF was noted. Mean CVR was 29.9±12.9%. Mean CVR significantly increased to late teens, and declined thereafter. After 6th decade, CVR in both frontal lobes, left parietal lobe and right basal ganglia decreased significantly with advancing age. There was no sexual difference of CVR. Conclusion: Quantitative assessment of CVR was possible by ACZ Tc-99m HMPAO brain SPECT. It revealed that rCBF and CVR changed according to age in normal Korean volunteers. There was no sexual difference.