再生펄프를 利用한 카르복시메틸셀룰로오스의 製造(Ⅱ) : CMC의 物性 測定 Physical Charateristic of CMC

崔正憲,趙炳默,吳正壽 동국대학교 생명자원과학대학 연습림 1993 연습림논문집 Vol.- No.3

Carboxymethylation of recycled pulp was investigated. For both recycled pulp and dissolving pulp was carboxymethylated by the organic solvent method and tested some industrial analyses, water solubles content, low concentration of NaCl solution solubles and acid hydrolysis. The water solubles content depend on degree of substitution, and low concentration of NaCl did not affected solubilities of the CMC. Prehydrolysis of CM groups prior to reaction with L­cystein, we can obtain the residual unsubstitued anhydroglucose(USAG). The lower amount of USAG in recycled pulp, compared to theorecal data, was suggested that the recycled pulp should obtain the more CM group in the same conditions.

급성 진행형 국소 신경학적 증상을 보인 쯔쯔가무시병 1예에서 고용량 스테로이드의 사용

최현철,위성헌,이소연,김상일,박성경,정연주,정소령,전정수,강문원 대한감염학회 2002 감염 Vol.34 No.6

자살 시도의 심각도와 혈청 지질농도의 관련성

이헌정,최낙경,김린,이민수,김용구 대한신경정신의학회 2000 신경정신의학 Vol.39 No.6

연구목적 : 낮은 혈청 콜레스트롤 농도와 자살과 같은 폭력적 행동에 관한 관련성에 관한 논란이 있어왔다. 본 연구는 자살 시도 후 응급실로 내원한 환자에서 혈청 총 콜레스테롤 농도만이 아닌 전반적인 혈청 지질 농도의 저하 여부를 조사하였으며, 자살 시도 상황을 평가하는 객관적 척도를 통하여 자살 시도 상황에서 자살 시도의 심각도와 혈청 지질 농도의 관계에 대하여 연구하였다. 방 법 : 1998년 7월부터 1999년 6월 사이에 자살 시도후 고려대학교 의료원 응급실로 내원한 50명의 자살 시도자를 연구대상으로 하였다. 이들은 정신과 의사의 면담을 통하여 정신과적 진단을 받았으며 동시에 위험-구조척도(RRR). HDRS, BPRS 등이 평가되었다. 또한 동 기간에 본원 정신과에서 입원 치료를 받은 자살 시도가 없었던 환자중, 대상군과 나이, 성별, 진단을 맞추어서 50명의 환자를 선정하여 정신과 환자 대조군으로 하였다. 자살 시도군과 대조군의 혈청 지질농도가 t-test를 통하여 비교되었으며, RRR점수와 혈청 지질 농도, HDRS,BPRS와의 사이의 연관성 Spearman순위 상관계수로 분석되었다. 결 과 : 자살 시도자중 주요우울증이 29명, 정신분열병이 2명, 인격장애가 19명이었으며, 자살 시도군의 혈청 총 콜레스트롤 농도(t=---3.29, p=.001). 총 지질 농도(t=-2.62, p=.01), LDL농도(t=-2.64, p=.011)가 대조군보다 유의하게 낮았다. 진단별로는 주요우울증에서는 총 콜레스트롤 농도, 총 지질 농도, LDL 농도가 대조군에 비하여 낮았으나, 인격장애에서는 혈청 콜레스트롤 농돤이 대조군보다 낮았다. 자살 시도군에서 RRR 점수는 혈청 콜레스테롤 농도와 부적 상관관계를 보였으나 (γ=.-293,p=.039), BPRS(γ=.544, p<.001)와 HDRS(γ=.488, p=.001)와는 정적 상관관계를 보였다. 결 론 : 자살 시도군에서 혈청 지질 농도 중 총 콜레스테롤, 총 지질, LDL농도가 유의하게 저하되어있음을 확인하였다. 또한 자살의 심각도를 평가한 RRR 정수가 혈청 총 콜레스테롤 농도와 유의하게 상관성이 있음이 확인되었다. 이는 낮은 혈청 총 콜레스테롤 농도가 심각한 자살 시도와 연관이 있음을 보여주는 것이다. Objectives : Many studies have demonstrated that suicide is related to low serum cholesterol level, whereas conflicting results have also reported. The aims of the present study are to determine whether suicidal attempters have low lipid concentration and to identify the relationship between suicidal attempt severity and serum lipid levels. Methods: Subjects were 50 suicidal attempters who visited the emergency room in Korea University Medical Center between July 1998 and June 1999. All subjects had been interviewed by psychiatrist and evaluated with Risk-rescue rating, HDRS and BPRS. They were diagnosed as major depressive disorder(n=29), personality disorder(n=19), and schizophrenia(n-=2). Serum lipid levels in 50 suicidal attempters were compared with those in 50 nonsuicidal psychiatric inpatients corresponding to the age, sex and diagnosis of the suicidal attempters. We also examined the Spearman's rank correlations between serum lipid levels and risk-rescue score. Results : The serum total cholesterol level(t=-3.29, p=.001), total lipid level(t=-2.62, p=.01), and LDL level(t=-2.64, p=.011) in suicidal attempters were significantly lower compared with nonsuicidal controls. In major depressive patients, total cholesterol level, total lipid level, and LDL level in suicidal attempters were significantly lower than those of nonsuicidal controls. In personality disorder patients, however, only serum total cholesterol level was significantly lower. Risk-rescue rating score was negatively correlated with serum total cholesterol level(p=.-293, p=.039), and positively correlated with BPRS(p=.544, p<.001), and HDRS(p=.488, p=.001). Conclusion : The lipid levels in suicidal attempter were significantly lower. Suicidal attempt severity was also significantly correlated with serum total cholesterol level. These findings suggest that low serum cholesterol should be related with severs violent suicidal attempt.

성선자극호르몬유리호르몬 길항제인 Antide가 수컷 생쥐의 유해감각예민도에 미치는 영향

박정현,박제민,김명정,이국희,최상헌,장세헌 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.1

To investigate testosterone effect on nociception, tail flick latency(TFL, sec, 50±1℃) was measured before and after administration of antide(a gonadotropin releasing hormone antagonist) in male mice(Institute of Cancer Research, age of 7-8 weeks, weight 30.5-37.5gm). Testosterone replacement effect on TFL was also examined in antide pre-treated male mice. Experiment 1:30 male mice were randomized into 3 groups(N=10 each). Antide 100㎍/kg, 300㎍/kg or same volume(5.7ml/kg) of 0.2% bovine serum albumin was administered intraperitoneally. TFL was measured before and at 3,6, 9, 12 and 24 hours after injection. Experiment 2 : 40 novice male mice were randomized into 2 groups(N=20 each) and both groups were pre-treated with antide 300㎍/kg i.p.6 hours after antide injection, testosterone 1mg/kg or same volume(5.7ml/kg) of sesame oil was administered i.p. TFL was measured before and 6 hours after antide pre-treatment and 30 min after testosterone/vehicle injection. 1) TFL was significantly shortened by antide in dose dependent manner, In control group, baseline TFL(mean±SD) and those measured at 3,6,9,12 and 24 hours after injection were 4.8±0.7, 5.6±0.7, 5.3±0.6, 5.4±0.6 and 4.7±0.6 sec, respectively. In antide 100㎍/kg group, TFLs were 5.2±0.9, 5.1 ±1.1, 4.2±0.9, 4.4±0.8, 5.1±0.8, and 4.7±0.8 sec, respectively. Compared with baseline, significant hyperalgesia appeared 6 and 9 hours after treatment. TFL measured at 6 hours after treatment was significantly shorter than control. In antide 300㎍/kg group, TFLs were 5.6±0.4, 4.5±0.9, 4.3±0.6, 3.9±1.0, 4.6±0.8 and 4.7±0.9 sec. Significant hyperalgesia appeared 3 hours after treatment and continued thereafter. TFLs measured at 3, 6 and 9 hours after treatment were significantly shorter than control, and TFL at 9 hours was significantly shorter than antide 100㎍/kg group. 2) Hyperalgesia induced by antide pre-treatment was recovered by testosterone replacement. In control group. TFL was shortened by antide pre-treartment(baseline : 6.1±1.0 sec ,6 hr after antide : 4.7±1.0 sec) and there was no significant change after vehicle injection(4.6±0.8 sec). In testosterone group, shortening of TFL induced by antide pre-treatment(baseline: 6.2±0.8 sec; 6 hr after antide: 4.6±0.9 sec) disappeared after testosteronen replacement(0.6±0.8sec). From these results, it is suggested that testosterone has a role of maintaining baseline antinociception and acute decrease in testosterone level results in hyperalgesia.

Carbamoylethyl Starch의 製造와 종이 製造時 添加效果에 관한 硏究

尹世永,崔正箕,鄭文箕,趙炳默,吳正壽 동국대학교 생명자원과학대학 연습림 1995 연습림논문집 Vol.- No.4

Recently, paper strength properties come up to be lowered by increasing ratio of utilization of recycling paper. In order to overcome these problems, strengthening agents which may cause enviromental problems have been used. Therefore, acrylamide was added to starch which is a cheap natural polymer, carbamoylethyl starch(CES) with high activity was prepared, and so the applicability as a paper additive was examined. The results are following; FT-IR spectra of CES of which degree of substitution was 0.25 showed strong C=O band at 1680㎝^-1 which corresponds the carbonyl group n amides(amide Ⅰ). Analysis of bravender viscosity showed that cooking start point of CES is 60℃ and instant viscosity is 830 B.U.(bravender unit). Effect of carbamoylethl DS on strength properties was resulted that CES of DS 0.20 appeared to be the best choice for making handsheets from KOCC with good overall strength properties, and it was selected as standard sample. Effect of pH on strength properties was obvious for their increasing values as decreasing pH. Also, a 5-fold increase in size rate as well as significant increase in wet-tensile strength were obtained in handsheets from KOCC by 3% wet-end addition of CES.

원발성 간암종의 조직 발생에 대한 면역조직학적 연구

강대영,최정목,송규상,이헌영 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To assess the utility of cytokeratin(CK) profile in the differential diagnosis of primary liver carcinomas(PLCs),we evaluated a series of needle biopsied specimens and surgically resected PLCs, comprising 30 pure hepatocellular carcinomas(HCCs) and 20 cholangiocarcinomas(CCs). The results are summarized as follows: 1) The pure hepatocellular carcinomas showed intense cytoplasmic expression of anti-cytokeratin (AE1/AE3);28/30 (93.3%). 2) The cholangiocarcinomas showed cytoplasmic expression of 2 types of CK(Anti-CK19,AE1/AE 3);14 of 20 (70.0%) of the CCs evidenced mature bile duct phenotype (CK 19), whereas 10 of 20 (50.0%) displayed the hepatocytic profile(AEl/AE3). 3) Nine of 30 HCCs also displayed the bile duct cell profile; high grade HCCs(8/20), and low grade HCCs(1/10). The above results show that a mixed biological phenotype can be found both among morphologically pure HCCs and peripheral CCs, suggesting that these two forms could share a common histogenesis.

뇌하수체 종양 제거술 시행 후 뒤늦게 발생한 횡문근 융해증과 동반된 중추성 열

장제혁,최규남,김일환,노은지,김윤정,유충헌,고정해,박봉수,김태균,권민정,이순희,박정현 인제대학교 2008 仁濟醫學 Vol.29 No.-

Body temperature is controlled by thermoregulatory center of the hypothalamus. We report a case of 24 years old man with central fever. He was subjected to a partial excision of pituitary tumor compressing optic chiasm four years ago. He has received hormonal therapy for panhypothyroidism after removal of pituitary tumor. And He received gamma knife operation for partially contrast-enhancing masses in suprasellar and both hypothalamic areas that is probably postoperatively remnant or recurrent tumor of pituitary adenoma. One year after gamma knife operation, he presented with a febrile syndrome of unknown origin including rhabdomyolysis. All usual investigations proved negative. We diagnosed him as central fever with rhabdomyolysis. He received medical ICU care with cooling bed, ice pack. And his symptom improved. Postoperative hyperthermia may result following resection of the pituitary tumor. When central fever is suspected taking note of past history, a quick recognition of course of fever can help reduce the using of unnecessary antibiotics and hospital stay.

전방 십자인대의 파열시의 자기공명영상:직접소견의 중요성

신현준,이창희,최영칠,전혜정,박정희,김동헌 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

It is Important to know the normal size, shape, and signal intensity of anterior cruciate ligament in the evaluation of knee injury Many studies have reported findings of tear or rupture as well as normal anatomy of these structure, especially with MR images. To our knowledge, there are few studies about normal structures of anterior cruciate ligament in MR images. The purpose of this study is to compare normal finding with tear of anterior cruciate ligament on MRI. Twenty-three cases with rupture of anterior cruciate ligament were evaluated on MRI, measuring the length, thickness, width of anterior cruciate ligament, and angles of anterior and posterior cruciate ligaments. Mean length, thickness, and width of anterior cruciate ligament in patients with rupture were 37.7±4.8mm, 9.0±1.2mm, 8.0±0.8mm, and mean angles of anterior cruciate ligament, and posterior cruciate ligament were 48.1±9.6˚, 118.8±13.1˚. Curvature ratio of posterior cruciate ligament was 0.25±0.09. The results showed significant differences between normal persons and patients with complete or partial rupture, and the mean angle and curvature ratio of posterior cruciate ligament which are known to related with indirect sign in tear of anterior cruciate ligament showed significant differences between ours and that of western countries. These results will be useful in the evaluation of patient wish rupture of anterior cruciate ligament, especially on MRI.

TEOS와 Condensed Ethyl Silicate(CES)로부터 제조된 고순도 SiO₂분말의 특성

노재성,조헌영,최정봉 忠南大學校 産業技術硏究所 1994 산업기술연구논문집 Vol.9 No.2

SiO₂powders were manufactured from TEOS, CES(condensed ethyl silicates) and PHT(partially hydrated TEOS) by sol-gel method. Then the chemical and the physical properties of the SiO₂powders are measured by IR, GC, TGA-DTA, XRD, SEM and particle size analyser. The chemical properties in IR spectra and GC analysis of CES are similar to those of PHT. Also the physical properties of SiO₂powders made from PHT are very analogous with the one manufactured from CES. The results suggest that the PHT in manufacturing of mullite and cordierite ceramics can be replaced with the CES.

배·급수 시스템에서 부식방지제의 적용 평가 연구

우달식,문정기,구성은,최종헌,김주환,문광순 대한상하수도학회 2003 상하수도학회지 Vol.17 No.5

This study evaluated the effect of the corrosion inhibitors on the corrosion control performance in drinking water distribution system. A phosphate-zinc based inhibitor formulated was for the efficient corrosion control in drinking water distribution system. In a continuous-circulation test, 99% reduction in corrosion rate was achieved. The optimum concentration of the corrosion inhibitor was found to be 2.2㎎ PO₄/L. The effect of the corrosion inhibitor was significant for the pipes of carbon steel, galvanized steel and copper, but less for that of stainless steel. The corrosion inhibitor can be an effective cure for corrosion and red water problems by prevention the old pipes from further corrosion. Tap water in Mokpo and Kwangyang were more corrosive than the water in the rest of 4 other regions(Seoul, Pohang, Pusan, Puyeo). Tap water in Pusan was high in various ionic concentrations in general. The corrosion inhibitor reduced the corrosion rate by 76-94%, depending on the origin of the tap water.