지역사회 획득 급성 신우신장염 여성환자에서 검출된 원인균의 항균제 감수성 및 항균제의 사용

위성헌,최수미,이동건,김수영,김상일,유진홍,신완식,강문원 대한감염학회 2002 감염 Vol.34 No.6

2001년부터 2006년까지 지역사회 획득 급성 신우신장염 여성환자의 임상상 및 원인균의 내성 양상

위성헌,장우임,김형욱,김영식,김수명,허지안,김상일,김양리,강문원 대한감염학회 2007 Infection and Chemotherapy Vol.49 No.1

최근 10년간 화농성 간농양 141예의 임상적 특성 및 원인균의 항균제 감수성 양상

위성헌,장우임,김진동,이정록,백창렬,정우철,이강문,양진모 대한감염학회 2008 Infection and Chemotherapy Vol.40 No.4

Background : Pyogenic liver abscess is an acute infectious disease caused by bacteria and can become severe and potentially life-threatening, with a mortality rate of 6-18%. The purpose of this study is to provide the basic informations for the management of liver abscess and the choice of the most effective and economic antibiotics. Materials and Methods : We investigated clinical, laboratory, radiologic findings and the results of bacteriological studies retrospectively by reviewing the medical records of 141 cases of pyogenic liver abscess patients, admitted to Catholic University St Vincent's Hospital from January 1998 to December 2007. Results : Patients demographics revealed a mean age of 57.1, (age: 18 to 87), and 71 of the 141 patients were male (50.4%). Cure was achieved in 51 (98.1%) of the 52 patients who were treated with the combination of percutaneous drainage and antibiotics, and in 80 (90.0%) of 89 patients who were treated only with antibiotics. However, there were no significant differences in mortality (P=0.092) and the time to defervescence between both groups. The mean duration of percutaneous drainage was 15.8±9.7 days. Sixty-four of 141 patients showed positive culture results, and K. pneumoniae (70.3%) was the most common organism. Among 45 K. pneumoniae, the rates of resistance were 73.3% to ampicillin, 66.7% to piperacillin, 8.9% to cefazolin, 2.2% to cefuroxime, 0% to ceftriaxone, and 0% to ciprofloxacin. Conclusions : Combination treatment of intravenous antibiotics and percutaneous drainage was effective for the treatment of pyogenic liver abscess. Initial broad spectrum antibiotic coverage and then switch to first or second cephalosporin according to the susceptibility results, could be recommended especially in patients with monomicrobial K. pneumoniae liver abscess. Background : Pyogenic liver abscess is an acute infectious disease caused by bacteria and can become severe and potentially life-threatening, with a mortality rate of 6-18%. The purpose of this study is to provide the basic informations for the management of liver abscess and the choice of the most effective and economic antibiotics. Materials and Methods : We investigated clinical, laboratory, radiologic findings and the results of bacteriological studies retrospectively by reviewing the medical records of 141 cases of pyogenic liver abscess patients, admitted to Catholic University St Vincent's Hospital from January 1998 to December 2007. Results : Patients demographics revealed a mean age of 57.1, (age: 18 to 87), and 71 of the 141 patients were male (50.4%). Cure was achieved in 51 (98.1%) of the 52 patients who were treated with the combination of percutaneous drainage and antibiotics, and in 80 (90.0%) of 89 patients who were treated only with antibiotics. However, there were no significant differences in mortality (P=0.092) and the time to defervescence between both groups. The mean duration of percutaneous drainage was 15.8±9.7 days. Sixty-four of 141 patients showed positive culture results, and K. pneumoniae (70.3%) was the most common organism. Among 45 K. pneumoniae, the rates of resistance were 73.3% to ampicillin, 66.7% to piperacillin, 8.9% to cefazolin, 2.2% to cefuroxime, 0% to ceftriaxone, and 0% to ciprofloxacin. Conclusions : Combination treatment of intravenous antibiotics and percutaneous drainage was effective for the treatment of pyogenic liver abscess. Initial broad spectrum antibiotic coverage and then switch to first or second cephalosporin according to the susceptibility results, could be recommended especially in patients with monomicrobial K. pneumoniae liver abscess.

개원의 연수강좌 : 요로감염의 진단과 치료

위성헌 대한내과학회 2014 대한내과학회 춘계학술대회 Vol.2014 No.-

성인 요로감염 항생제 사용지침

위성헌 대한내과학회 2018 대한내과학회 춘계학술대회 Vol.2018 No.-

성인 요로감염 항생제 사용지침

위성헌 대한내과학회 2018 대한내과학회 추계학술대회 Vol.2018 No.2

The 2013 Clinical Guidelines for the Diagnosis and Treatment of HIV/AIDS in HIV-Infected Koreans

위성헌,김남중,방지환,최준용,신범식,한상훈,신소연 대한감염학회 2013 Infection and Chemotherapy Vol.45 No.4

While a variety of clinical guidelines for the diagnosis and treatment of HIV/AIDS are used extensively around the world, theimplementation of such guidelines is not assured in Korea due to constraints with respect to the diagnostic tests and antiretroviraldrugs currently available in the country. Consequently, the Committee for Clinical Guidelines for the Diagnosis andTreatment of HIV/AIDS of the Korean Society for AIDS was founded in 2010, and the first edition of the Korean guidelines waspublished a year later. However, due to the rapid discovery of new data in the field of HIV and the evolution of the clinical environmentin Korea in the last few years, it has become necessary to revise the first set of guidelines. This guideline aims to providecomprehensive information regarding the diagnosis and management of HIV/AIDS in Korea. The recommendations containimportant information for physicians working with HIV/AIDS in the clinical field. A brief summary of the revised guidelines andkey changes to the original version of the guidelines are summarized below.

신이식환자의 말초혈액에서 면역세포화학적방법에 의한 Cytomegalovirus 감염의 진단 및 임상적 응용

위성헌,송호철,윤선애,이승헌,양철우,김용수,김석영,방병기 대한신장학회 1995 춘계학술대회 초록집 Vol.1995 No.-

최근 10년간 화농성 간농양 141예의 임상적 특성 및 원인균의 항균제 감수성 양상

위성헌,장우임,김진동,이정록,백창렬,정우철,이강문,양진모 대한감염학회 2008 감염과 화학요법 Vol.40 No.4

Background : Pyogenic liver abscess is an acute infectious disease caused by bacteria and can become severe and potentially life-threatening, with a mortality rate of 6-18%. The purpose of this study is to provide the basic informations for the management of liver abscess and the choice of the most effective and economic antibiotics. Materials and Methods : We investigated clinical, laboratory, radiologic findings and the results of bacteriological studies retrospectively by reviewing the medical records of 141 cases of pyogenic liver abscess patients, admitted to Catholic University St Vincent's Hospital from January 1998 to December 2007. Results : Patients demographics revealed a mean age of 57.1, (age: 18 to 87), and 71 of the 141 patients were male (50.4%). Cure was achieved in 51 (98.1%) of the 52 patients who were treated with the combination of percutaneous drainage and antibiotics, and in 80 (90.0%) of 89 patients who were treated only with antibiotics. However, there were no significant differences in mortality (P=0.092) and the time to defervescence between both groups. The mean duration of percutaneous drainage was 15.8U9.7 days. Sixty-four of 141 patients showed positive culture results, and K. pneumoniae (70.3%) was the most common organism. Among 45 K. pneumoniae, the rates of resistance were 73.3% to ampicillin, 66.7% to piperacillin, 8.9% to cefazolin, 2.2% to cefuroxime, 0% to ceftriaxone, and 0% to ciprofloxacin. Conclusions : Combination treatment of intravenous antibiotics and percutaneous drainage was effective for the treatment of pyogenic liver abscess, Initial broad spectrum antibiotic coverage and then switch to first or second cephalosporin according to the susceptibility results, could be recommended especially in patients with monomicrobial K. pneumoniae liver abscess.

신종 인플루엔자 A (H1N1)의 진단과 치료

위성헌,김우주 대한가정의학회 2009 Korean Journal of Family Medicine Vol.30 No.11

Since the World Health Organization has offi cially declared a global infl uenza pandemic, the number of human cases of pandemic infl uenza A (H1N1) in 2009 has been increasing in many countries. Especially from mid-October, the number of domestic cases of infl uenza A (H1N1) has been exponentially increasing, with the number of confi rmed cases reaching over 100,000. The clinical symptoms of novel infl uenza A (H1N1) include fever, cough, sore throat, runny nose, myalgia, headache, chills and fatigue. Nucleic acid amplification tests, including real time RT-PCR assay specific for 2009 novel influenza A (H1N1) can be used in the patients with suspected influenza. Antiviral treatment by using neuraminidase inhibitors (oseltamivir, zanamivir) is recommended by Centers for Disease Control and Prevention for treatment of novel influenza A (H1N1) disease. Personal and public efforts to control the outbreak of novel influenza A (H1N1) disease are required. Vaccination against pandemic H1N1 is important for personal health, but also to build community-level immunity to novel infl uenza A. 멕시코와 미국 등 북미 지역에서 시작된 신종 인플루엔자가 전 세계로 전파되면서 WHO는 6월 11일에 금세기 최초의 인 플루엔자 대유행을 선언하였고, 국내에서도 10월 중순 이후 는 신종 인플루엔자 확진 환자가 학생들을 중심으로 급격하 게 증가하여 약 100,000명 이상의 확진 환자가 보고되어 있다. 신종인플루엔자의 임상 증상은 계절인플루엔자와 별 차이가 없는 것으로 알려지고 있는데, 발열, 기침, 인후통, 콧물, 두통 및 근육통 등이 나타나며, 설사와 구토 등 위장관 증상이 나타 나기도 한다. 잠복기는 계절 인플루엔자와 비슷한 1-7일로 알 려져 있고, 대부분 감염자와 접촉 후 1-4일 이내에 발병한다. 급성 열성호흡기질환 환자에서 real-time RT-PCR, conventional RT-PCR, 바이러스 배양 등을 통해 신종 인플루엔자 A (H1N1) 바이러스 병원체 감염이 확인되면 신종 인플루엔자 A (H1N1) 으로 확진할 수 있다. 신속한 진단을 위해 주로 real-time RTPCR이 확진검사법으로 이용되고 있다. 신종 인플루엔자 바이 러스에 효과적인 항바이러스제로는 oseltamivir와 zanamivir가 권장되고 있다. 신종 인플루엔자로 진단된 성인 환자의 치료 를 위해서는 oseltamivir 75 ㎎ 캡슐을 1일 2회, 5일간 투여할 수 있다. 노출 후 화학적 예방을 위해서는 oseltamivir 75 ㎎ 캡슐 을 1일 1회로, 10일간 투여한다. 신종 인플루엔자의 예방을 위 한 가장 좋은 해결책은 백신의 개발 및 투여이다.