크론병에 대한 CoPPLX의 방어효과에 대한 연구

이호학,김유림,문창기,이재일,양병윤,김종수,이정민,정재혁,안석진,박상준,김윤권,김소연,김영중,조민구,최영자,장성조 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.1

Protective Effects of Hyperoside against Carbon Tetrachloride-Induced Liver Damage in Mice

Choi, Jun-Ho,Kim, Dong-Wook,Yun, Nari,Choi, Jae-Sue,Islam, Md. Nurul,Kim, Yeong-Shik,Lee, Sun-Mee American Chemical Society and American Society of 2011 Journal of natural products Vol.74 No.5

<P>In this study, the hepatoprotective effects of hyperoside (<B>1</B>), a flavonoid glycoside isolated from <I>Artemisia capillaris</I>, have been examined against carbon tetrachloride (CCl<SUB>4</SUB>)-induced liver injury. Mice were treated intraperitoneally with vehicle or <B>1</B> (50, 100, and 200 mg·kg<SUP>−1</SUP>) 30 min before and 2 h after CCl<SUB>4</SUB> (20 μL·kg<SUP>−1</SUP>) injection. Levels of serum aminotransferases were increased 24 h after CCl<SUB>4</SUB> injection, and these increases were attenuated by <B>1</B>. Histological analysis showed that <B>1</B> prevented portal inflammation, centrizonal necrosis, and Kupffer cell hyperplasia. Lipid peroxidation was increased and hepatic glutathione content was decreased significantly after CCl<SUB>4</SUB> treatment, and these changes were reduced by administration of <B>1</B>. Protein and mRNA expression of tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and heme oxygenase-1 (HO-1) and nuclear protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2) significantly increased after CCl<SUB>4</SUB> injection. Compound <B>1</B> suppressed TNF-α, iNOS, and COX-2 protein and mRNA expression and augmented HO-1 protein and mRNA expression and Nrf2 nuclear protein expression. These results suggest that <B>1</B> has protective effects against CCl<SUB>4</SUB>-induced acute liver injury, and this protection is likely due to enhancement of the antioxidative defense system and suppression of the inflammatory response.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2011/jnprdf.2011.74.issue-5/np200001x/production/images/medium/np-2011-00001x_0006.gif'></P>

지연유합과 불유합에서 저신호 강도 초음파의 유용성

윤여헌,김종오,고영도,유재두,정준모,오종건,방한천,최창호,신명철 대한골절학회 2003 대한골절학회지 Vol.16 No.1

목 적 : 저 신호 강도 초음파를 이용한 지연유합과 불유합의 치료에 대한 유용성을 알아보고자 하였다. 대상 및 방법 : 2001년 7월부터 2002년 5월까지 본원에 내원한 지연유합 7례와 불유합 8례를 대상으로 5개월간 저 신호 강도 초음파로 치료하여 5개월후 골유합 여부를 알아 보았다. 결 과 : 총 15례 중 대퇴골 간부 2례, 경골 간부 1례, 상완골 간부 1례, 요골 1례의 지연유합에서 골유합을 얻었고 대퇴골 간부 불유합 3례에서 유합을 얻었다. 지연주합은 71%의 유합율을, 불유합은 37.5%의 유합율을 보였다. 결 론 : 저 신호 강도 초음파는 골유합을 촉진 시킬 수 있으며 지연유합에서 시도해 볼 만 하나 불유합 치료를 위해서는 보다 많은 연구가 필요 하다. Purpose : To evaluation of usefulness of low-intensity ultrasound for nonunion and delayed union. Materials and Methods : For 5 months, we treated 7 delayed union and 8 nonunion using low-intensity ultrasound. After 5 months, in checked X-ray AP and Lateral view, when cortical bridge formation was done, we through union. Results : In 7 delayed union, 5 cases-2 femur, tibia, humerus, radius were healed. In 8 nonunion, 3 femur nonunion were healed. Union rate was 71% in delayed union 37.5% in nonunion. Conclusion : we thought that the low-intensity ultrasound has capacity of induction of union and was considered as the method of treatment for delayed union.

화훼작물의 여름철 플러그묘 생산에 있어 급격한 엽온저하 쇼크를 이용한 도장억제 가능성 검토

윤재길,박소현,강호종 진주산업대학교 2000 論文集 Vol.39 No.-

One of the most important problem during summer plug plant production is the succulent growth. The possibility of controlling height of plug seedlings by temperature drop shock(TDS) was investigated in Pharbitis, Impatiens and Callistephus. The most sensitive plant to TDS was Pharbitis. By 2℃ water irrigation, height of Pharbitis decreased by 33%. Impatiens showed 16% reduction in height by 2℃ water irrigation. Callistephus showed no reduction in height by any treamtnet. In all plants, stem diameter increased about 10% by the cold water irrigation. Leaf injury such as leaf spot of Saintpaulia was not observed. These results suggested that TDS could be used for controlling height of summer plug seedlings such Pharbitis which is sensitive to TDS.

오옥신의 종류 및 농도가 가이즈까 향나무의 삽목 발근에 미치는 영향

윤재길,송시호,박상현 진주산업대학교 농업기술연구소 2001 農業技術硏究所報 Vol.14 No.-

Effects of auxin and Rootone on the rooting of Juniperus chinensis var. Kaizuka cutting were investigated to improve propagation efficiency. When Rootone treated, rooting was 100% compared with the control, 33%. IBA 200ppm 1h and NAA 100ppm 12h improved evidently rooting, 93% and 90%, respectively. Root fresh weight increased up to 131mg by Rootone. NAA 200ppm 12h, NAA 500ppm 1h, and IBA 200ppm 1h were also very effective to root fresh weight more than 110mg. Shoot growth(height, fresh weight and dry weight) did not increase largely, but increased a little. Dipping into high concentration auxin solution for 1min increased rooting rate and root fresh weight, but was less effective than low concentration treatment. Shoot growth did not increase largely, but increased a little. These results indicate that Rootone and IBA 200ppm 1h are most effective for improvement of rooting in Juniperus chinensis var. Kaizuka cutting.

전격성 경과를 취한 만성 호산구성 폐렴 환자 1예

윤호상,진춘조,유광하,이상엽,이수인,정상만,김선두,이순제,이길도,전혜정 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Chronic eosinophilic pneumonia(CEP) is a rare disease of unknown etiology characterized by chronic infiltration of the lung with eosinophils. It presents with profound systemic symptoms comprising fever, night sweats, weight loss, dyspnea and blood eosinophilia with nonsegmental air-space consolidation confined to the outer third of the lung, the "photographic negative of pulmonary edema". Histopathologic features of chronic eosinophilic pneumonia are intraalveolar and interstitial infiltrations with eosinophils, histiocytes, giant cells, scattered lymphocytes and plasma cells. Glucocorticoid therapy cause prompt resolution of symptoms as well as disappearans of blood eosinophils, elevated serum Ig E levels and the roentgenographic lesions. Infrequent radiographic findings include nodular infiltrates, consolidations, cavitations, atelectasis and pleural effusions. Deaths from CEP although rare, have been reported, but the majorities of CEP have benign courses and do not need a therapy with ventilator. We report a case of chronic eosinophilic pneumonia, which had a sudden course associated with diffuse pneumonic consolidations on the both lung and bilateral pleural effusion.

소아 대퇴골 간부 골절에 대한 유연 골수정 삽입술

윤여헌,최창호,정재학 대한골절학회 2003 대한골절학회지 Vol.16 No.3

목적: 4세부터 11세 사이의 소아 대퇴골 간부 골절을 유연 골수정 삽입술로 치료한 결과를 후향적으로 분석하여 이 치료 방법의 장점과 단점 등을 논하고자 하였다. 대상 및 방법: 최근 3년간 치험한 27명 28례를 1년 이상 추시하였으며, 임상 기록과 방사선 사진을 분석하여, 슬관절 운동 회복, 체중 부하 가능 시점, 골절 유합 시점, 입원 및 재활 치료 기간, 각 변형과 하지 부동 등 후유증과 기타 합병증 여부를 평가하였다. 결과: 슬관절 운동은 전례가 술후 2~4주 사이에 회복되었다. 부분 체중 부하는 보조기 착용상태에서 술후 2~4주에 대부분 가능하였으며, 보조기 없이 전체중 부하가 가능하고 방사선 사진상 견고한 골 유합이 확인된 시점은 수술 후 6~12주 (평균 8.4주)였다. 최종 추시 사진상 5도 이상의 각 변형은 5례 (18%)에서 있었으며, 다리 길이가 1㎝ 이상 차이를 보여 수술 또는 신발로 후속 교정이 필요하였던 경우는 2례 (5%)였다. 지연 유합, 불유합, 재골절 등의 합병증이 없었으나, 고정 실패로 인한 재수술 (1례)과 금속정 도입부의 심부 연부 조직 감염 (1례)이 있었다. 결론: 4세부터 11세 사이의 소아 대퇴골 간부 골절의 치료에서 유연 골수성 삽입술은 석고 고정 등 비수술적 치료에 비하여 조기 슬관절 운동과 체중 부하가 가능하고, 재활 치료 기간이 짧으며 각 변형과 다리 길이 차이 등 부정유합의 빈도가 적은 장점이 있으며, 외고정 등 다른 수술적 치료에 비하여 지연 유합, 불유합, 핀 감염, 재골절 등의 합병증이 거의 없는 등 장점이 뚜렷하였다. Purpose: We report a treatment result and the pros-cons of the flexible intramedullary nailing for femoral shaft fractures in children between the age of 4 and 11 years. Materials and Methods: During the recent three years, 28 femoral shaft fractures in 27 consecutive pediatric patients were treated with flexible intramedullary nailing. We restrospectively reviewed their clinical and radiological records, follow-up for at least one year, in respects to the recovery of knee joint motion; time of fracture union; period of admission and rehabilitation; angular deformity and leg length discrepancy; and other complications. Result: In all children, the knee joint motion was rapidly recovered to near normal range within 2~4 weeks. Partial weight bearing with wearing functional brace was possible within 2~4 weeks, while full weight bearing without brace was started until 6~12 (average 8.4) weeks after the nailing. In the last follow-up radiograghs, five cases (18%) showed 무 angular deformity in any direction of more than 5 degrees. Two children represented leg length discrepancy of more than 1㎝. Other complications were one fixation failure, and one deep soft tissue infection at the entry point of the nail. Conclusion: We strongly recommend the flexible intramedullary nailing in this injury because the fixation is strong enough to permit early knee motion and weight bearing in orthosis, the fracture healing was so rapid without any case of delayed or nonunion, and the incidences of residual angular deformity and leg length discrepancy were significantly less than the nonoperative treatment.

프리캐스트 포스트텐션 콘크리트 넓은 보-기둥 내부 접합부의 비탄성 거동

황재환,최윤철,김영찬,김대중,임재형,권기혁,문정호,이리형 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

The purpose of this paper is to evaluate the response of Precast Prestressed Concrete Interior Wide Beam-Column Joint subjected to cyclic lateral loading. To this end, the experimental investigation was performed with six half-scale specimens of interior connection. The design parameters are the beam to column depth ratio, and the number of tendons within column core. One of the specimens, IJH-6, is modeled for the connection at the top floor of a structure. The test results showed that the specimens sufficiently resist up to limiting drift ratio of 0.035 in accordance with the provisional standard by ACI of acceptance criteria for concrete special moment frames.

심장 이식 환자에서 발생한 Cryptococcus neoformans에 의한 뇌막염 2예 : The report of two cases

박재형,이윤정,강수진,정영훈,장진석,정준원,최상호,김순종,김양수,김재중 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.3

최근 장기 이식과 관련된 면역억제제의 사용 빈도의 증가 및 후천성면역결핍증 환자의 증가 등으로 인해 기회감염이 증가되고 있으며, C. neoformans에 의한 감염도 증가되고 있다. 저자들은 심장이식 후 6개월이상 지난 환자에서 발생한 크립토코쿠스 뇌막염 2예를 경험하였는데, 한 예의 경우는 거대세포 바이러스 감염과 함께 C. neoformans의 전신적 파급성 감염의 형태로 나타났었고, 폐에 A. fermigatus에 의한 감염이 같이 병발된 경우였다. 이들은 모두 경미한 증상만을 호소하였고, 뇌척수액 검사를 통해 진단받았으며 liposomal amphotericin B와 경구용 fluconazole을 사용하여 완치되었기에 문헌고찰과 함께 보고하는 바이다. Cryptococcal meningitis is a subacute or chronic mycotic infection caused by Cryptococcus neoformans and it is a second most common central nervous system (CNS) infection in organ transplant patients. The recent rise in incidence of the disease can be attributable to the wide use of immunosuppressive agents in organ transplant patients, the advent of acquired immunodeficiency syndrome (AIDS) patients and increased use of chemotherapeutic agents. We report two cases of cryptococcal meningitis after cardiac transplantation. Their symptoms were not typical and neurologic examination was nonfocal. One patient had disseminated cryptococcal infection and invasive pulmonary aspergillosis, it might be assodated with cytomegalovirus infection. They were diagnosed by cryptococcus latex agglutinin test and culture study with cerebrospinal fluid and treated with liposomal amphotericin B and oral fluconazole without any neurologic defects.

화상 대화 시스템의 객체지향 설계

장재명,김윤호,이정환 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-

This paper presents an object-oriented design for a video conversation system. This paper adapts the traditional client/server architecture and uses JMF for process media transmission. It starts from the analysis of functional/non-functional requirements and it documents the model of the system based on'4+1 View Model.' The manifest in this paper will be used usefully to design a system for cyber university or visual conference based audio/video media transmission.