췌십이지장절제술 후 발생한 지속적인 구토증과 Wernicke 뇌병증

박우영,김성완,이삼연,신일선,김재민,박기형,양수진,윤진상 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.3

Wernicke encephalopathy is an acute neurologic disorder attributable to thiamine (vitamin B1) deficiency. We report the case of a 61-year-old female patient who presented Wernicke encephalopathy after surgery for pancreatic head cancer. From the ninth postoperative day, she had suffered from nausea and vomiting and had difficulties ingesting food, she was given total parenteral nutrition (TPN), but lacked adequate vitamin (thiamine) supplementation. After 28 days, she developed ataxia, ophthalmoplegia, and mental confusion. The magnetic resonance image showed pathologic changes in the medial thalamus,periaqueductal gray matter, medulla and mamillary bodies. The blood level of thiamine was very low. After intravenous and oral supplementation of thiamine (200 mg/day), consciousness was soon normalized and neurologic symptoms have gradually been improving. Nausea and vomiting disappeared after administration of a low dose of mirtazapine (7.5 mg/day). We emphasize the importance of thiamine supplementation to the patients who suffer from vomiting which hinders them from taking food and who require prolonged TPN.

사립체 DNA 뉴클레오타이드 3243 A→G 돌연변이 [MTTL1^*MELAS3243G]에 의한 MELAS 증후군

박기형,김승현,이영주,김희태,김주한,김명호,박성섭 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

韓國 在來 山羊의 反芻胃內 微生物의 分離 및 同定에 관한 硏究 : Ⅱ. 反芻胃內 Gram 陽性菌의 分離 및 同定 Ⅱ. Isolation and Identification of Gram Positive Bacteria

朴基文,辛炯泰,姜國熙 成均館大學校 科學技術硏究所 1993 論文集 Vol.44 No.1

This study was undertaken to isolate and identify the gram positive bacterial flora in the rumen of Korean native goat. The results which were obtained in this experiment are as follows : 1. The gram negative cocci which were isolated are Veillonella alcalescens, Megaspharea elsdenii and Quin's Oval. The M-VS medium and PMS medium could be used successfully as a selective medium for the isolation of Veillonella and Megasphaera in the rumen, respectively. 2. The gram negative rods which were isolated are Bacteroides ruminicola subsp. ruminicola, Bacteroides ruminicola subsp. breuis, Bacteroides succinogenes, Fusobacterium necrophorum, Butyriuibrio fibrisoluens, Succinimonas amylolytica, Selenomonas ruminantium and Clostridium clostridiiforme. The CC-NBGT medium and FS medium could be used successfully as a selective medium for the isolation of Bacteroides and Fusobacterium in the rumen, respectively.

일반 측방 두부규격 방사선사진과 측방 두부규격 전산화 방사선사진에서의 계측점의 신뢰도에 대한 비교 연구

김형돈,박창서,김기덕 大韓口腔顎顔面 放射線學會 1997 Imaging Science in Dentistry Vol.27 No.1

The purpose of this study was to compare & to find out the variability of head film measurements(landmarks identification) between Fuji computed radiographic cephalometry and conventional cephalometry. 28 Korean adults were selected. Lateral cephalometric FCR film and conventional cephalometric film of each subject was taken. Four investigators identified 24 cephalometric landmarks on lateral cephalometric FCR film and conventional cephalometric film. The comparable measurements between lateral cephalometric FCR film and conventional cephalometric film were statistically analysed. The results were as follows: 1. In FCR film & conventional film, coefficient of variation (C.V.) of 24 landmarks was taken horizontally & vertically. There is no significant difference of rank order of landmarks in C.V. between two films. 2. In comparison of significant differences of landmarks variability between FCR film & conventional film, horizontal value of coefficient of variation showed significant differences in four landmarks among twenty-four landmarks, but vertical value of coefficient of variation showed significant differences in sixteen landmarks among twenty-four landmarks. FCR film showed significantly less variability than conventional film in 17 subjects among 20(4+16) subjects that showed significant difference.

악성 신경교종에서 기관형적 배양후 형성된 미세종양 구상체의 초미세구조적연구

신형진,정천기,박인성,정영섭,정희원,한대희 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.3

The present study investigated not only the feasibility of organotypic spheroid culture system taken from human malignant gliomas but also the similarities and differences between surgical specimens and cultured spheroids using light microscopy electron microscopy, and flow cytometric examination. Surgically resected tumor specimens from eighteen human malignant gliomas were minced and explanted into agarose-coated culture wells. After three to five days these microtumor fragments emerged as spheroids and could be maintained as organotypic spheroids for more than eight weeks. Measurements of the spheroids showed that they decreased during the initial two to three weeks and afterwards remained unaltered over a specific period of time. This growth pattern of the spheroids was consistent with the condition of tumors in vivo suggesting the linkage of cell proliferation and loss. Light microscopic and electron microscopic studies of the spheroids demonstrated that morphological structures were similar to those of the original tumor tissue in vivo and histopathologic characteristics of the original tumor were maintained over a long culture period. The spheroids contained connective tissues, blood vessels, macrophages and neutrophils maintaining a three-dimensional architectural resemblance to the original tumors. Of three pairs of the surgical and spheroid specimen examined by the flow cytometry, one showed a change of ploidy pattern and two contained increased fictions of proliferating cells. It is concluded that this microtumor spheroid system can maintain the characteristics of the original tumors and may serve as an alternative to the in vivo xenograft model for the research of brain tumor biology, invasion and immunology while providing a valuable technique for the evaluation of new therapies such as biological response modifiers.

중심 정맥 삽관법에 의한 동정맥루: 증례 및 문헌 고찰

이 근,원형섭,양기창,박철완,김상일,정호성,이종호 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

A 36-year old woman with end stage renal failure and hypertension was transferred from a university hospital to our emergency department due to a enlarging right cervical mass associated with a palpable thrill and a bruit. Over a 2 month period, she required hemodialysis for severe azotemia at a university hospital in Seoul. 3 days after a difficult attempt at a internal jugular cannulation, she developed a progressive swelling in the right lower cervical area. An arch and primary branch arteriogram revealed a arteriovenous fistula between right innominate artery and internal jugular vein with a large intervening pseudoaneurysm. She underwent vascular surgery within 1 week of injury and subsequent postoperative angiogram showed complete resolution of the fistula. This rare condition is reported with a review of the literature.

질량의 최적 배치에 의한 구조물 진동 감소 연구

申龜秀,李祺形,朴泰圓,鄭寅聖 全北大學校 1996 論文集 Vol.42 No.-

In this paper, a theoretical optimization approach is presented in order to consider natural frequencies for vibration transmitted to the fuselage. Also, this paper describes methods for reduction of structural vibration by the optimal placement of masses for formal mathematical optomization techniques. An optimization procedure is developed which employs the tuning masses and corresponding locations as design valiables which are systematically changed to achieve low values of shear without a large mass penalty. Three optimazation strategies are developed and tested. The first is based on minimizing the modal shaping parameter which indirectly reduce the modal shear amplitudes corresponding to each harmonic of airload. The second strategy reduces these amplitudes directly and the third strategy reduces the shear as a function of time during a revolution of the blade.

광중합기의 광원에 따른 브라켓 전단결합강도 비교

차정열,이기준,박선형,김태원,유형석 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.3

제논 플라즈마 아크 광중합기나 LED 광중합기가 치과영역에 소개된 이후로 기존의 텅스텐 할로겐 광중합기를 사용할 때에 비해 교정장치의 부착시간이 현저하게 줄어들 수 있게 되었다. 제논 플라즈마 아크 광중합기에 대한 중합시간과 전단강도에 대해서는 여러 연구가 있어왔던 반면, LED 광중합기를 이용하여 교정용장치의 부착을 위한 중합시간에 대한 연구는 미진하다. 본 연구의 목적은 LED 광중합기의 중합시간에 따른 결합강도를 플라즈마 아크 광중합기와 비교하여 적절한 브라켓의 부착강도를 얻기 위해 요구되는 중합시간을 알아보는데 있다. 120개의 발치된 사람의 소구치에 컴포짓 레진으로 브라켓을 부착시킨 후 4초, 6초, 8초 동안 플라즈마 아크 광원과 LED 광원으로 각각 중합시켰다. 그 후 결합강도를 만능시험기(Universal Testing Machine)로 계측한 결과, 플라즈마 아크 광중합기에서는 4초 이상에서, LED 광중합기에서는 8초 이상의 중합시간에서 기존의 할로겐 광원을 40초간 노출시켰을 때와 비슷한 전단결합강도를 나타내었다. 플라즈마 아크 광중합기와 LED 광중합기의 중합시간이 접착제 잔류지수(adhesive remnant index) 수치에 대해 영향을 미치지 않았다. With the introduction of the xenon plasma arc curing light and the LED curing light as orthodontic curing lights, the polymerizing time of orthodontic composites has clearly decreased. In contrast to various research cases regarding the polymerization time and bond strength of the xenon plasma arc curing light, not enough research exists on the LED curing light, including the appropriate polymerization time. The objective of this research was to compare the bond strength of the plasma curing light and the LED curing light in regards to the polymerization time. The polymerization time needed to achieve an appropriate adhesion strength of the bracket has also been studied. After applying orthodontic brackets using composite resin onto 120 human premolars, the plasma arc curing light and the LED curing light were used for polymerization for 4, 6, and 8 seconds accordingly. This research proved that the LED curing light provided appropriate bond strength for mounting orthodontic brackets even with short seconds of polymerization. The expensive cost and large size of the device limits the use of the plasma arc curing light, whereas the low cost and easy handling of the LED curing light may lead to greater use in orthodontics.

혼합용매법에 의한 Mullite 전미분체 생성기구에 관한 연구

황운연,이정운,박형상,김용렬,구기갑 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.4

Si-와 Al-알콕시드의 반응속도 차이를 조절하기 위한 부분 가수분해법과 입자 형태를 제조하기 위한 혼합용매법을 이용하여 구형의 미세한 mullite 전미분체를 제조하였다. Mie 이론을 적용시켜 반응시간에 따른 반응용액의 탁도 및 입자 수밀도의 변화를 측정하여 혼합용매법에 의한 입자 생성기구에 대하여 고찰하였다. 알콕시드와 옥탄올 용액에 아세토니트릴을 첨가하면 알콕시드의 용해도가 낮아지고 따라서 알콕시드의 일부가 액적을 형성하며, 액적은 안정화제 (HPC)에 의하여 구형을 유지하게 된다. 그리고 가수분해 및 축합중합 반응에 의하여 액적의 입자 크기는 감소하며, 동시에 혼합용액에 용해되어 있던 알콕시의 가수 분해 및 축합중합 반응에 의하여 미세 입자가 생성된다. 액적형태로 생성된 큰 입자와 미세 입자의 응집에 의하여 최종 입자가 생성되었다. In this study, spherical fine pre-mullite particles were prepared by partial hydrolysis method to control the reaction rate difference of two alkoxides, and by mixed solvent method to control the particle shape. Based on the adaptation of Mie theory, the formation mechanism of pre-mullite particle in alkoxide-octanol-acetonitile system has been investigated by measuring of the turbidity of solution, the number density and the size of the particles during the reaction. As the acetonitrile was added in the alkoxide-octanol solution, the solubility of the alkoxide decreased. A part of alkoxide was segregated from solution in the form of droplets. whereas the rest of the alkoxide existed as dissolved state in octanol. The droplets are stabilized with stabilizer (HPC). In the next step. hydrolysis and condensation reactions of the alkoxide droplets decrease the size of droplets and, at the same time, fine particles are formed from the alkoxide dissolved in octanol. Subsequently, the final particles are produced by aggregation between the large particles through the droplet form and the fine particles.

Hypophosphatasia 환아의 치료 증례

최병제,최형준,이제호,김기덕,박수정 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.3

1. Hypophosphatasia 는 골조직 및 치아조직의 비정상적인 석회화를 나타내는 대사장애로, 특징적구강내 소견 인 우치의 조기탈락 양상으로 치과에서 조기진단이 가능하다. 2. 본 증례에서 상악궁 확장을 동반한 의치 제작으로 심미적, 기능적으로 양호한 결과를 얻었으며, 영구치열기 까지 장기적 관찰 및 치료가 필요할 것으로 사료된다. hypophosphatasia is a rare metabolic disorder which manifests characteristics such as abnormal mineralization of bone and dental tissues, diminished serum and tissue alkline phosphatase, and increased urinary secretion of PEA. It ingerited as an autosomal recessive or dominant trait and occurs in all races. In general, hypophosphatasia can be classified in 4 subtypes which are the perinatal, infantile, childhood, adult type depending upon the age at presentation and severity. In young children with Hypophosphatasia the long bones show irregular defects, and the skull showes poor calcification. In older children with premature closure of the skull sutures there may ve multiple lucent area called gyral or convolutional markings, described as resimbling beaten copper, presumably resulting from increased intracranial pressure,Examination of the jaws reveals a generalized lucency of the maxilla and mandible, the cortical bone and lamina dura are thin, and the alveolar bone may be deficient. Clinical features of Hypophosphatasia imclude premature loss of deciduous teeth, especially incisors, hypoplasia of aplasia of root cementum, enamel hypoplasia, irregular calcification of dentin, large pulp chamber, and resorption of marginal alveolar bone and roots. Our report involves a patient with a chief complaint of early loss of both Mx. and Mn. deciduous ncisors. after conducting a through clinical and radiographic examination this patient was referred to pediatrics under the suspicion of hypophosphatasia, the diagnosis proved to be correct and successful results were accomplished through a denture made to improve esthetics and function.