Hitachi 7600-110 자동 화학 분석기의 성능 평가

조성은,남준우,홍기숙 대한임상병리학회 2001 대한임상병리학회지 Vol.21 No.5

경옥고와 경옥고 가미방의 면역활성에 관한 연구

이은숙,서부일,이준우,배진숭 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2

Objectives : This study was conducted to investigate the immunological activities of Kyungohkgo and prescription of modified Kyungohkgo. Methods : Raw 264.7 macrophage treated with Kyungohkgo or other simuli enhanced production of the nitric oxide and TNF-α. Results : Among the sample 1. sample 2 and 3 of Kyungohkgo, sample 2 exerted more favorable influence on nitric oxide(NO) production than the sample 3. And production of NO and TNF-α were dependent on the concentration of Kyungohkgo. Conclusion : These results suggested that Kyungohkgo-activated macrophage induce the NO and TNF-α, and its containing in immunoregulatory components.

연쇄알구균 감염에 의한 급성 인후염 후 반응성 관절염 1예

박은하,도연실,양정채,강미라,서현주,정숙인,손준성,기현균,오원섭,백경란,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

연쇄알구균에 의한 급성 인후염 후 발생한 반응성 관절염은 급성 류마티스열의 개정된 진단기준을 충족하지 못하면서, 지속적 혹은 재발성의 비이동성 관절염과 발열, 홍반성 결절, 일시적 간기능 이상 등을 보이면서 심장염과 무도증을 드물게 동반하는 질환이다. 따라서, 발열을 동반한 급성 관절염 환자에서 감별해야 할 질환 중의 하나이며, 심근염 예방을 위한 페니실린 요법의 적응증 및 기간에 대해서는 아직 이론이 많은 상황으로, 보다 광범위한 연구가 필요하다. 저자들은 연쇄알구균에 의한 급성 인후염 1주 후에 발생한 하지의 다발성 비이동성 관절염과 함께 결절홍반 및 일시적 간기능 이상을 보인 환자에서 PSRA로 진단하고 비스테로이드성 항염증제 및 스테로이드로 성공적인 치료를 하였기에 이를 문헌 고찰과 함께 보고하는 바이다. Poststreptococcal reactive arthritis (PSRA) is associated with recent streptococcal infections. However, PSRA is distinct from acute rheumatic fever by its clinical manifestations: non-migrating arthritis, erythema nodosum or erythema multiforme, and transient elevation of serum transaminases. We experienced a 33-year-old man who presented with fever, arthritis of both knees and ankles, and erythema nodosums on extensor surfaces of lower legs which developed 6 days after the onset of pharyngitis symptoms. Blood and urine cultures were negative. Throat culture was negative for group A β-hemolytic streptococcus. The ASO titers increased up to 2080 IU/mL in sequential monitoring. The result of bone scan was compatible to arthritis of both knees and ankles. There were no signs or symptom of carditis. He showed clinical improvement with anti-inflammatory drugs (naproxen 1,000 mg/day and prednisolone 7.5 mg/d). PSRA should be included in the differential diagnosis of patients presenting with arthritis combined with fever.

고수의 유리 아미노산, 무기성분 및 정유성분에 관한 연구

한준희,신미경,서은숙 圓光大學校 1995 論文集 Vol.30 No.2

고수의 일반성분, 유리 아미노산, 무기성분 및 정유성분을 분석한 결과는 다음과 같다. 1. 일반성분은 수분 82.1%, 단백질 4.06%, 지방 1.83%, 섬유소 2.52%, 회분 2.27%이었다. 2. 확인된 아미노산은 glutamic acid, leucine, aspartic acid, phenylalanine, glycine, alanine, lysine, isoleucine, threonine, valine, arginine, serine, proline, histidine, tyrosine, methionine 등 총 16종으로 이들중 glutamic acid의 함량이 가장 높고, methionine이 가장 낮은 수준이었으며 필수아미노산인 tryptophan은 검출되지 않았다. 데쳤을 경우 아미노산의 손실율은 총 아미노산 함량의 약 16.7% 이었다. 3. 무기성분 중 Ca함량이 53.7mg으로 가장 많았으며, Cd이 3.6mg으로 가장 적었다. 데쳤을 경우 Na, K, Mg함량은 생것과 큰 차이가 없었으나 Ca과 Cd 함량은 생것의 각각 13%, 44.5%가 감소되었다. 4. 정유성분으로는 linalool, isopulegol, terpinen-4-ol, α-terpineol이 확인되었으며 이중 α-terpineol의 함량이 13,982㎍으로 가장 많았고, terpinen-4-ol 8,285㎍, linalool 5,142㎍, isopulegol 3,579㎍순이었으며 데쳤을 경우 isopulegol은 거의 존재하지 않았다. This study was carried out in order to investigate the content of amino acids, minarals and essential oil in coriander. The contents of moisture, protein, lipid, crude fiber and ash were 82.12%, 4.06%, 1.83%, 2.52% and 2.27%, repectively. 16 Kinds of amino acid were analyzed by amino acid autoanalyzer and total free amino acid content was 15,733mg/100g, after blanching, that was 13,099mg/100g and decreased to 83.3%. glutamic acid(2,004mg/100g) was the richest among amino acids and total amounts of the essential amino acids was 6,612mg/100g and was 40.03% of total amino acids. contents of Na, K, Ca, Mg and Cd in raw coriander were 26.8mg, 24.6mg, 53.7mg, 17.6mg and 3.6mg, respectively and Ca content was the richest. Na, K and Mg contents in banching coriander were similiar to raw coriander, but Ca and Cd content were lower than raw coriander. the essential oil components of coriander were α-terpineol, terpinen-4-ol, linalool and isopulegl, and α-terpineol content was richest and isopulegl content was lowest.

경옥고 및 경옥고 가미방이 폐암에 미치는 영향

이은숙,서부일,이준우,배진숭 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2

Objectives : This research is to test anti-cancer effect of kyungohkgo (sample 1) and modified kyungohkgoes (sample 2 and sample 3) when they prescribed to mice that translate a 3LL lung cancer cell. A sample 1, 2, and 3 are prescribed for the 1st, 2nd and 3rd group, respectively. Methods : Inoculate mouse lung carcinoma cells to a BDFI mouse and did an experiment about tumor occurrence periods, body weight, tumor volume, survival rate, life prolongation. Results : The development time of tumor lump to the 3rd group is latest as 181.71±18.88 hours. That is, it means that a lung cancer of this group was induced latest. In tumor size, the 3rd group is also fewest by 1,536~9,375㎣. The tumor growth rate of the 3rd group appeared lowest by 610.35 percent. Only the 3rd group was appeared that has a control effect of tumor growth. Also, 3 mice of the 3rd group were survived for 30day after translating the lung cancer cells. The survival extension rate of the 3rd group was highest by 38.39 percent. Conclusion : In these experiments, it appears that the sample 3 prescribed by modified kyungohkgo has the highest anti-cancer effect. It is proved that the modified kyungohkgo affects the 3LL lung cancer cell by acting complexly.

學校事故와 損害賠償責任

韓恩淑,延和駿 청주대학교 교육문제연구소 1998 교육과학연구 Vol.12 No.-

당뇨병과 동반된 화농성 간농양의 임상상 및 예후인자

오은숙,강무일,이원영,오기원,임동준,이소영,이정민,고승현,김성래,안유배,손현식,윤건호,차봉연,이광우,손호영,강성구 대한당뇨병학회 2000 임상당뇨병 Vol.1 No.1

연구배경: 감염질환은 혈관질환과 함께 당뇨병의 중요한 사망원인의 하나이며, 혈당조절이 불량할수록 감염 빈도가 증가됨은 잘 알려져 있다. 간농양의 발생이 있어서도 당뇨병은 중요한 기저질환 중의 하나이다. 일반적으로 간농양의 가장 흔한 원인균은 Escherichi coli라고 알려져 있으나, 최근 당뇨병을 가진 간농양 환자에서 Klesiella pneumoniae의 검출이 증가되고 있다. 또 최근 연구에 의하면 K.pneumonie가 간농양의 가장 흔한 원인균이며, K. pneumoniae에 의한 간농양은 K.pneumoniae 이외의 균주에 의한 간농양보다 당뇨병과 밀접히 관련되어 있다고 보고된 바 있다. 이에 저자들은 간농양 환자를 대상으로 당뇨병환자의 빈도를 알아보고, 그 원인균 및 특징을 비당뇨병 환자들의 경우와 비교해 보고자 하였다. 방법: 1992년 1월부터 1999년 6월까지 방사선학적 검사 혹은 수술에 의해 간농양이 확인되거나, 경피적 천자나 수술을 통한 배농액 배양, 혹은 혈액 검사에서 원인균이 증명된 182명의 환자를 대상으로 후향적 임상고찰을 실시하였다. 결과: 화농성 농양을 가진 167명의 환자(남:94명, 여:73명)중 당뇨병을 가진 환자는 54명 (남:30명, 여:24명)으로 32.3%를 차지하였다. 환자의 평균나이는 당뇨군에서 62.1 ± 13.4세, 비당뇨군에서는 55.1 ±15.5세로 당뇨군에서 높았으며(p=0.0021), 남녀간의 평균나이 비교 시 두 군 모두 여성의 나이가 의미있게 높았다. 비당뇨군에 비하여 당뇨군의 경우 저알부민혈증의 빈도와 aspartate transaminase가 증가되어있었다. 원인균주는 K. pneumoniae (당뇨군54%, 비당뇨군 39.1%), E. coli(당뇨군 17.5%, 비당뇨군 18.8%), Pseudomonas aeruginosa, Streptococcus viridans, Enterococcus 순이었으며 두 군간의 의미는 차이는 없었으나 K. pneumoniae의 경우 다른 균종에 비해 단독감염의 빈도가 높았다(82.8%). 사망률은 당뇨군에서 16.7%, 비당뇨군에서 7.1%로 당뇨군에서 의미있게 높았으며(p=0.019), 당뇨군에서의 사망환자는 모두 패혈증이 동반되어 있었다. 당뇨환자의 사망군은 생존군에 비해 당뇨병 이환기간이 길고 혼합감염의 빈도가 높았다(p=0.046). 검사실 소견에서는 총 빌리루빈 및 알카리성 포스파타제의 증가가 관찰되어 있었다. 결론: E. coli가 간농양의 주된 원인균이라는 기존 보고와는 달리 당뇨군과 비당뇨군 모두 K. pneumoniae가 간농양의 주된 원인균이었다. 또한 당뇨 유병기간이 길고 당뇨조절이 불량한 환자에서 혼합감염이며 총 빌리루빈 및 알카리성 포스파타제의 증가등과 같은 위험인자가 존재할 경우 사망률이 증가될 수 있으므로 이들 군에서는 적극적인 치료가 필요할 것으로 사료된다. Background: Liver abscesses are commonly associated with underlying disease, particularly diabete mellitus. The number of the liver abscesses caused by Klebslella pneumoniae in diabetic patient has been increased in Korea nowadays. This study was conducted to clarify the clinical presentation and prognostic factors of pyogenic liver abscesses, especially in diabetic patients and to determine the proportion of K. pneunomiae as a pathogen in liver abscess in Korea. Methods: Medical records of 167 patients treated for pyogenic liver abscess from January, 1992 through June, 1999 were reviewed retrospectively in detail. Major Pathogenic organism, clinical manifestations, prognostic factors, the importance of diabetes mellilus as an underlying disease and its effect on clinical features and prognosis were analyzed. Results: Among 167 cases of pyogenic liver abscess, underlying diabetes mellitus was present in 32.3%. The mean age of patients was 62.7 13.4 years in diabetic liver abscess group and 55.1 15.5 years in non-diabetic liver abscess group. Most liver abscesses were cryptogenic in origin or secondary to the billary tree diseases. The clinical presentations among the two groups were not significantly different. When compared to patients without diabetes, patients with diabetes had significantly higher proportions of hypoalbuminemia and elevated aspartate transaminase level. The most common organism of the pyogenic abscess was K. pneumoniae in both groups. Percutaneous drainage of the abscess with appropriate antibiotics was the most commonly used therapeutic modality in liver abscess. The mortality rate of diabetic liver abscess is 16.1 % and 7.1% in nondiabetic liver abscess. Complications, especially septicemla, were found more frequently in patients with diabetes than in patients without diabetes (64.8% vs 28.3%, septicemia : 31.5% vs 9.7%). The factors influencing mortality in the diabetic liver abscess were disease duration, mixed infection, presence of septicemia, elevated bilirubin and alkaline phosphatase. Conclusions: In contrast to prior report that the E. coli was the most common pathogen in liver abscess, we found that K. pneumoniae was the most common organism cultured in liver abscess. Diabetic patients have more complications and higher mortality than patients without diabetes. Early detection and proper treatment are needed to improve the outcome for diabetic patient with liver abscess.

기능성 생식, 다이어트식 및 장개선제가 비만개선에 미치는 영향

전태일,전은자,김창성,이주용,안홍석,임병우,최영숙,박웅채,박동기 建國大學校附設農業資源開發硏究所 2001 農資源開發論集 Vol.23 No.-

Obesity is defined as an excess of body fat and is closely related to diabetes, hypertension and heart disease. Dietary cure has been paid attention as a method for preventing from or curing obesity. The effect of some food products developed in this laboratory, such as, functional saengsik (Health & Joy saengsik), diet food (Health & Joy diet meal) and intestine function activator (Cell-pa, commercial name) on curing and protecting from obesity were investigated. Diet program was applied to 31 adults (Males 22, Females 9) with above 120% body mass index (BMI). After diet program was applied, body weight, body fat and fat weight decreased by 1, 4.8 and 4.5% (p<0.01), HDL-cholesterol increased by 3.6% and LDL-cholesterol and atherogenic index decreased by 6.6 and 7.7% (p<0.05). Consequently, the food products developed in this laboratory effectively reduced the obesity.

교정용 밴드 제거 후 미생물 분포 및 치주 조직의 임상적 변화

양유미,김성식,전은숙,박수병 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.4

본 연구는 밴드 제거 직후 및 4주 경과 후 치주조직의 임상적인 환경변화와 미생물 분포 변화를 알기 위해 시행하였다. 최후방 구치에 밴드를 포함하는 고정식 교정 장치를 장착하고 교정 치료를 1년 이상 시행한 17명의 환자를 대상으로 하였다 (평균 나이 22세, 남자 6명, 여자 11명). 최후방 구치의 밴드를 제거한 직후와 제거 후 4주가 경과한 다음에 치주조직의 탐침 깊이와 출혈 빈도를 측정하였으며, 치은 연하의 치태를 채취하여 미생물의 분포를 조사하였다. 치주질환에 관련성이 깊은 미생물 중 Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola를 직접 Polymerase Chain Reaction 방법으로 존재 여부를 확인하였다. 밴드 제거 직후와 제거 후 4주가 경과한 시점의 치주조직의 탐침 깊이와 출혈 빈도, 병원성 미생물의 존재 여부를 통계적으로 비교하였다. 탐침 깊이와 출혈 빈도는 모두 하악 좌측 구치 협면에서 감소율이 가장 크게 나타났고, 상악 우측 구치 설면에서 감소율이 가장 작게 나타났다. 병원성 미생물 중 T. denticola가 밴드 제거 4주 후에 가장 높은 감소율을 보였으며, 하악보다 상악에서 감소율이 더 크게 나타났다. 이는 비록 밴드를 장착하여 치주 환경이 불량해졌다 하더라도 올바른 구강 위생 관리가 시행된다면 밴드를 제거한 후 정상적인 치주 상태로 회복될 수 있음을 예시한 것으로 생각되었다. Objective: The purpose of this study was to evaluate clinical and microbiological changes in periodontal tissue around the banded molars after debanding. Methods: This study included 17 young adult patients treated with fixed orthodontic appliances including bands on the last molars more than 1 years. Probing depth and bleeding frequency were measured and plaque samples were collected from the last banded molars in all quadrants of each patient. All the data were collected immediately after debanding and 4 weeks after debanding. Results: Using polymerase chain reaction based on 16S rDNA, the presence of Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola was detected. After debanding, probing depth, bleeding frequency, and prevalance of periodontopathogens were reduced. Probing depth and bleeding frequency were most decreased in the buccal site of the mandibular left molar and were least decreased in the lingual site of the maxillary right molar. Conclusion: The results of this study indicated that proper management of oral hygiene after debanding can recuperate unfavorable periodontal condition caused by orthodontic treatment.

유아특수교육 기관의 개별화교육프로그램 운영실태 및 개선 방안

조광순,전병운,박혜준,홍은숙 국립특수교육원 2005 특수교육연구 Vol.12 No.1

본 연구에서는 유아특수교육교사 8명과의 심층면담과 30개의 IEP 문서 분석을 통해, 특수교육진흥법 상의 규정과 유아특수교육 추천 실제에 따른 IEP의 질적 수준을 알아보았다. 연구결과 특수학급 교사의 경우 유치원 교육과정과의 연계가 부족한 IEP를 작성하여 운영하고 있으며, 개별화교육운영위원회는 실질적으로 소집되지 못하고 있고, IEP의과정에 보호자의 참여 정도는 미미한 것으로 나타났다. 대부분의 IEP 내용은 유아의 현 수행수준에 근거한 장 · 단기 목표의 기술을 제외하고는 상당히 형식적이고 제한적이어서 IEP 운영에 도움을 주지 못하고 있는 것으로 나타났다. 그러나 특수교육진흥법 상에 규정되어 있지는 않지만 실제 현장에서는 가족지원이 다양한 방식으로 이루어지고 있으며, 다학문적 팀의 구성과 구성원들 간의 협력은 교사에 따라, 또는 기관에 따라 큰 차이가 있는 것으로 나타났다. 일반 유치원 프로그램의 일일 계획안과 IEP와의 연계, 발달적 교육과정과 유치원 교육과정과의 연계, 목표의 수정, 개별화교육운영위원회의 협력적 참여, 객관성 있는 수행 평가 면에서 유아특수교육교사들은 어려움을 나타내 보였으며, IEP 작성과 운영에 따른 문제를 해결하기 위해서는 무엇보다도 표준화된 IEP 양식 또는 구조화된 IEP와 평가준거의 예가 제시된 IEP 모델이 필요한 것으로 교사들은 제안하고 있다. Various research has identified a number of problems with individualized education program (IEP) development and implementation among schools, including a lack of adequate teacher training, poorly developed team processes, minimal coordination with general education, and failure to develop measurable goals and objectives to evaluate child achievements. The purpose of this study was to evaluate the quality levels of IEPs implemented in early childhood special education (ECSE) settings based on recommended ECSE practices and requirements of the Korean Special Education Enhancement Act. Through an in-depth focus group interview with eight ECSE teachers from eight different programs and an analysis of 30 IEPs, the study investigated: 1) how regulations on IEP development and implementation of the Special Education Enhancement Act, specifically regulations on IEP team organization and implementation, parent participation, and IEP contents, are interpreted in ECSE programs; 2) how ECSE program professionals collaborate with families and how family supports are provided; 3) how a multidisciplinary approach is put into practice and effective levels of collaboration among IEP team members; 4) ECSE teacher suggestions for solving problems with IEP development and implementation, and for improving practices. The results indicate that special education classroom teachers of regular kindergarten programs develop and implement IEPs that are irrelevant to their curricular. IEP procedural deficits were found in the area of team process. It was found that the ECSE programs lack a multidisciplinary team approach when developing and implementing IEPs. Overall, parental participation was not ensured even though regulations require IEP teams to include parental requests in IEPs and implement their signed IEPs. Key personnel such as regular early childhood education teachers and therapists were found to be absent from IEP meetings. However, differences were found among the programs in the team process. Programs specialized only for young children with disabilities demonstrated higher levels of team approaches than those of ECSE programs in special schools and regular kindergartens. In this study, limited content of IEPs were found to be developed for young children with disabilities. IEP goals and objectives analyzed in this study were shown to be generally adequate, showing that children's levels of performance information and annual goals were congruent and that measurable goals and objectives were developed. During the in-depth interview, it was learned that ECSE teachers provide support to children and families, coordinating services in the community for children with disabilities. The results of this study also show that ECSE teachers in regular kindergarten programs have difficulties in linking IEP goals with their daily instructional plans as well as linking their general curriculum with developmental goals for young children with disabilities. Overall, teachers in this study demonstrated difficulties with modification of IEP goals, facilitating collaborative IEP team participation, and objective monitoring of IEP goals. They suggest that standards for IEP and structured IEP forms be developed. They also suggest that model IEPs be introduced by school districts. The findings of this study suggest that: 1) specific IEP procedures need to be mandated through special education laws and regulations in order to facilitate and monitor team approaches when developing and implementing IEPs in ECSE settings; 2) a coordinated service system is needed to provide comprehensive services to young children with special needs and their families; 3) there is an urgent need for comprehensive curriculum-based assessment tools that reflect various developmental aspects as well as diverse special needs and suggest assessment guidelines; 4) it is important to provide strong pre-service teacher education programs as well as in-service work shops for teachers in order to develope skills in developing meaningful IEP goals and objectives linked to curriculum and daily classroom routines; and 5) IEP model development research should be facilitated.