Dipyridamole 부하 심근 SPECT에서 Dipyridamole의 작용과 부작용

고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이동수(Dong Soo Lee),최창운(Chang Woon Choi),배상균(Sang Kyun Bae),양형인(Hyung In Yang),여정석(Jeong Suk Yeo) 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.2

N/A Dipyridamole is an agent that may be used to noninvasively evaluate coronary artery disease. The effect of dipyridamole infusion its generally related to its induced peripheral vasodilatory effect. In normal person, heart rate is generally increased slightly while blood pressure decrease, but the achieved double product and related myocardial oxygen consumption have no significant change. The purpose of this study is to examine the effect and side effect of dipyridamole, and to compare different response to dipyridamole among the patients. We evaluated 847 patients who underwent dipyridamole stress myocardial SPECT. 93.6% of them had induced hypotension 0.9% showed no change of blood pressure, 5.5% had increased blood pressure 8.3% had no change of pulse rate more than 10% of basal pulse rate. Among diabetes, 16.9% was not change of pulse rate, 6.7% in non-diabetes. There was no significant correlation between age and rate pressure product rest(RPPr), in patients without perfusion defects on SPECT(y=7.1x+48.4r=0.13 p>0.01). As increasing age, RPPs/RPPr was declined(y=-11.6x+68.9 r=0.17 p〈0.01), similar results were obtained in patients with perfusion defect. The size of perfusion defect on myocardial SPECT have no correlation between RPPr and RPPs/RPPr. The side effects of dipyridamole included chest pain and chest tightness, headache, abdominal pain, dizzness, nausea, and dyspnea. As increasing age, dipyridamole-induced cardiac work at rest was increased, cardiac response to dipyridamole was decreased.

Al³^(+) 존재가 ^(99m)Tc-MDP의 표지효율과 생체내 분포에 미치는 영향

장영수,정재민,김영주,곽철은,이동수,정준기,이명철,고창순 大韓核醫學會 1996 핵의학 분자영상 Vol.30 No.3

악성종양에서 골수면역신티그라피를 이용한 골수전이의 평가 : 99mTc-MDP 뼈스캔과의 비교

고창순(Chang Soon Koh),김노경(Noe Kyeong Kim),김병국(Byoung Kook Kim),최창운(Chang Woon Choi),정준기(Jun Key Chung),방영주(Yung Jue Bang),이경한(Kyung Han Lee),정홍근(Hong Keun Chung),이명철(Myoung Chul Lee) 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.1

N/A Although bone scan is a highly sensitive test for detecting bone metastasis, its findings are often limited in specificity and cannot be used for assessing the bone marrow. Bone marrow scintigraphy may provide useful information but previous experience with radiolabelled colloid has been disappointing. Recently, 99mTc labeled anti-granulocyte rnonoclonal antibody (anti-NCA-95 MAb) has been introdueed as a new bone marrow imaging agent. To evaluate the usefulness of 99mTc anti-NCA MAb bone marrow scans for detecting skeietal metastasis, bone marrow scans of 44 malignant tumor patients were evaluated and compared with bone scan fmdings. Bone scan showed abnormal lesions in 26(59%) cases, and 18 of these patients also had an abnormal bone marrow scan. Seven of the 8 patients who had normal bone marrow scan despite bone scan lesions were confirmed to be free from metastasis. There was one case with a marrow defect despite normal bone scan but the presence of metastasis was not determined due to loss of follow up. Bone scan demonstrated a total of 64 lesions while bone marrow scan showed 38 lesions. Fifty percent (32/64) of the bone scan lesions had matching marrow defects while the rernaining 50% did not. Most of these non matched lesions were suggested to be nonspecific 1esions such as rib fractures or degenerative change. Meanwhile bone marrow scan was able to detect 6 new lesions not detected by bone scan, but metastasis in each lesion was not confirmed. Bone marrow scan was also helpful in assessing equivocal bone scan lesions to be of metastatic nature in 10 patients by demonstrating a matched marrow defect. Thus 99mTc anti-NCA MAb bone marrow scan can help exclude metastasis in patients with nonspecific bone scan lesions and may be able to detect metastatic lesions not seen with bone scan. It appears useful as a complementary study to bone scan in evaluating malignant tumor patients.

동서양의 식용꽃에 대한 고찰 : 조리방법을 중심으로

김영순,이정희,오순덕,정은미,최지영,유은순,장정미,정진선,하상민 高麗大學校 倂設 保健大學 保健科學硏究所 2001 保健科學論集 Vol.27 No.2

Edible flower means a flower that is good to eat is subject to either cooking or appetizing. In general, people eat edible flower as raw so that the loss of vitamin and inorganic are minimal. Edible flower is usually utilized as salad material or aromatic, decoration for jelly or cake and solid stuff in soup. Thus, decorating food by edible flower improves flavor, fragrance and appetite. Edible flower serves various purposes both east and west. In Korea, Edible flower is mainly subject to soup, cooked potherbs, frying, tea stuff, brewing and etc, whereas in Japan, its various usage covers cooked potherbs, pickle, sliced raw fish, frying, salad, jelly and decoration. On the other hand, Edible flower is used as numerous salad and tea stuff, condiment, roasting, meat, sweets and desserts in Western Hemisphere.

충주시 고등학생의 최근 4년간(1988-2001) B형간염 표면항원 및 항체 양성률 조사

김형수,이건세,장성훈,박수경,김청식,이창희,권혁중,정순섭 한국역학회 2002 Epidemiology and Health Vol.24 No.2

Objective : Since Korea has been known to be of the endemic area for hepatitis B virus(HBV) infection, vaccination for HBV has been recommended for all neonates in Korea. After starting vaccination in 1983, the change of sero-positivity of HBsAg and HBsAb is expected. This study was carried out to investigate the seropositive rate of hepatitis B virus surface antigen and antibody in high school freshmen students in Chungju-city. Methods and Materials : From 1998 to 2001, a total of 11,735 who were born in 1982 to 1986, were enrolled in this study. HBsAg and anti-HBs were tested by reversed passive hemagglutination and passive hemagglutination, respectively. Results : The study population was 11,735 students who were composed of 5,813 males (49.6%) and 5,914 females (50.4%). The HBsAg sero-positivity of male and female students was 3.25% (n=381) and 2.59% (n=153) respectively. The anti-HBs sero-positivity of male and female students was 62.2% (n=3,154) and 64.1% (n=2,969) respectively. There are significant difference observed in comparison of HBsAg and anti-HBs seropositivity according to sex (p<0.05). From 1982 to 1986 on birth year, anti-HBs sero-positivity has been increased significantly from 63.3% to 73.3%. But the change of HBsAg sero-positivity has not been changed significantly. Conclusions : As compared with previous studies of HBsAg and anti-HBs, the sero-positive rate of HBsAg has not been changed but that of HBsAb has been increased significantly. This result revealed that the effect of HBV vaccination program was successful.

흰쥐 수정란 착상시기에 있어서의 호르몬 농도의 변화와 자궁내막의 구조에 관한 연구

윤미정,손성향,김창미,최임순,Yoon, Mi-Chung,Sohn, Seong-Hyang,Kim, Chang-Mee,Choe, Rim-Soon 한국현미경학회 1993 Applied microscopy Vol.23 No.1

The mechanism by which blastocysts implant to uterine endometrium has not been clearly understood. In the present study, the following question was investigated: how are hormonal levels changed and how is uterine endometrium morphologically changed? Results obtained are as follows: Concentrations of serum estradiol and progesterone were significantly increased on day 4 and 5 of pregnancy. Uterine concentrations of PGE and $PGE_{2a}$ were sharply increased on day 1 and maintained similar concentrations thereafter, reaching the maximum on day 5. Both prostaglandins (PGs) concentrations were gradually decreased thereafter. Furthermore, concentrations of PGs in implant sites were greater than those in non-implant sites. PBR (pontamine blue reaction) in uterine endometrium was positive on day 6 of pregnancy, indicating that vascular permeability was increased. Edema and changes in structure of cell components were pronounced in stroma where PBR was developed. Moreover, these were more prominent in implant sites than non-implant sites. These results suggest that uterine PGs as well as steroid hormones increase during implantation in rats and these hormones might be involved in the process of implantation by modulating vascular permeability and the fine structures of uterine endometrial cells.

폐동맥고혈압이 동반된 만성폐쇄성폐질환 환자에서 혈중 Brain Natriuretic Peptide, 폐동맥압 및 St. George Respiratory Questionnaire의 상관성과 안지 오텐신전환효소억제제 치료 효과

김명아 ( Myung A Kim ),김덕겸 ( Deog Kyeom Kim ),이창훈 ( Chang Hoon Lee ),정희순 ( Hee Soon Chung ) 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.68 No.5

Background: Pulmonary hypertension is considered as a poor prognosis factor in patients with chronic obstructive pulmonary disease (COPD). There has been reported brain natriuretic peptide (pro-BNP) is related with increased right ventricular (RV) workloads. However, there are few studies that evaluate the relationship between BNP and pulmonary arterial pressure (PAP), RV function and St. George Respiratory Questionnaire (SGRQ) score in patients with COPD, and the effects of angiotensin converting enzyme inhibitor (ACEI) on these parameters. Methods: Pulmonary function test, echocardiography, blood BNP, and SGRQ score were evaluated in stabilized moderate degree COPD patients (FEV1/FVC<70%, 50%≤FEV1<80%) aged 45 years and over, without worsening of symptoms within recent 3 months. After treating with ramipril 10 mg for 3 months, the same evaluation was repeated. Results: Twenty-two patients were included in this study. BNP was significantly correlated with PAP (Pearson coefficient ρ=0.51, p=0.02), but not with RV ejection fraction (EF) and predicted FEV1%. The values for predicted FEV1% showed significant correlation with SGRQ total score and activity score, but not with BNP or PAP. After ramipril treatment, PAP showed significant decrease (42.8±8.1vs.34.5±4.5 mm Hg p=0.0003), tricuspid annular plane systolic excursion significant increase (21.5±3.3vs.22.7±3.1 mm p=0.009). BNP showed a tendency to decrease without statistical significance (40.8±59.6vs.18.0±9.1 pg/mL p=0.55). SGRQ scores showed no significant change. Conclusion: BNP showed significant correlation with resting PAP, which means BNP could be used as markers for pulmonary hypertension. Treatment with ACEI didn`t show significant change in the Level of BNP, while pulmonary hypertension and RV function were improved.

악성종양에서 골수면역신티그라피를 이용한 골수전이의 평가 : $^{99m}Tc$-MDP 뼈스캔과의 비교

이경한,최창운,방영주,정준기,정홍근,이명철,김병국,김노경,고창순,Lee, Kyung-Han,Choi, Chang-Woon,Bang, Yung-Jue,Chung, Jun-Key,Chung, Hong-Keun,Lee, Myoung-Chul,Kim, Byoung-Kook,Kim, Noe-Kyeong,Koh, Chang-Soon 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.1

Although bone scan is a highly sensitive test for detecting bone metastasis, its findings are often limited in specificity and cannot be used for assessing the bone marrow. Bone marrow scintigraphy may provide useful information but previous experience with radiolabelled colloid has been disappointing. Recently, $^{99m}Tc$ labeled anti-granulocyte monoclonal antibody (anti-NCA-95 MAb) has been introduced as a new bone marrow imaging agent. To evaluate the usefulness of $^{99m}Tc$ anti-NCA MAb bone marrow scans for detecting skeletal metastasis, bone marrow scans of 44 malignant tumor patients were evaluated and compared with bone scan findings. Bone scan showed abnormal lesions in 26(59%) cases, and 18 of these patients also had an abnormal bone marrow scan. Seven of the 8 patients who had normal bone marrow scan despite bone scan lesions were confirmed to be free from metastasis. There was one case with a marrow defect despite normal bone scan but the presence of metastasis was not determined due to loss of follow up. Bone scan demonstrated a total of 64 lesions while bone marrow scan showed 38 lesions. Fifty percent (32/64) of the bone scan lesions had matching marrow defects while the remaining 50% did not. Most of these non matched lesions were suggested to be nonspecific lesions such as rib fractures or degenerative change. Meanwhile bone marrow scan was able to detect 6 new lesions not detected by bone scan, bit metastasis in each lesion was not confirmed. Bone marrow scan was also helpful in assessing equivocal bone scan lesions to be of metastatic nature in 10 patients by demonstrating a matched marrow defect. Thus $^{99m}Tc$ anti-NCA MAb bone marrow scan can help exclude metastasis in patients with nonspecific bone scan lesions and may be able to detect metastatic lesions not seen with bone scan. It appears useful as a complementary study to bone scan in evaluating malignant tumor patients.

政治學의 科學的 方法論 批判的 檢討

鄭然植,梁淳彰 경북대학교 사회과학연구소 1992 社會科學硏究 Vol.8 No.-

The paper is designed to analyze the so-called scientific approach in Political Science and through its criticism present a general framework for a new methodology mostly focused on the Marxist perspectives. To meet the basic requirements for the fulfilment of the above mentioned purpose, the paper sets the history of modern Western philosophy with respect to methodology on the opposition between the problem of value and that of fact. Historicism was mostly wrapped up in the problem of value, while positivism that of fact. The so-called scientific approach can be understood in the positivist tradition, dealing solely with the problem of fact and thus excluding that of value, as was shown in Max Weber and Talcott Parsons. Scientific approach in contemporary Political Science is integrated under the comprehensive category of behavioralism, which is composed of two main trends, that is, System Analysis and Structral-functional Analysis. Contrary to its original project, scientific approach only made it clear that objective investigation of fact cannot be indifferent to the problem of value. Post-behavioral revolution aims at the dialectical synthesis of value and fact. Till the present time, despite various theoretical attempts such as behavioralist revisionism and the revival of political philosophy, the dialectical synthesis of value and fact is possible only within the Marxist perspectives. However, apart from the validity of its philosophical premises, Marxist perspectives bring forth a complexity of problems when applied to the actual political research. This revolves around the interpretation of Social Formation. To present the Marxist perspectives as a refined methodology both in domestic and international political researches, it is necessary to make sure that the interpretation of Social Formation should be performed within the following three categories : determination of superstructure by economic base, relative autonomy of superstructure, and interactions between economic base and superstructure.

제2형 당뇨병 환자에서 비만 지수와 죽상경화증 위험인자들과의 상관성

정병천,박순홍,이주영,이신원,정성창,김정국,하승우,김보완 대한비만학회 2003 The Korean journal of obesity Vol.12 No.2

연구배경: 비만은 제2형 당뇨병의 중요한 병인이면서 죽상경화성 동맥질환의 위험인자인 인슐린 저항성, 지질대사 이상 및 고혈압의 원인으로도 인정되고 있다. 한편 비만에 의한 대사성 및 혈관 합병증은전신적 지방량의 증가보다 복강내 지방축적이 병인적 중요성을 가지고 있다고 한다 그러나 국내의 제2형 당뇨병 환자를 차상으로 비만과 이들 죽상경화증 위험인자와의 상관관계를 연구 조사한 성적은 많지않다. 이에 제2형 당뇨병 환자에서 전신적 비만과 복강내 지방 축적을 반영하는 각각의 신체계측지수들과 죽상경화증 위험인자와의 상관성을 검토함으로써 국내 제2형 당뇨병 환자의 비만도가 대사성 및 혈관성 합병증에 미치는 영향과 신체계측지수들의 임상적 가치를 평가하고자 하였다. 방법 : 제2형 당뇨병 환자 425명 (남자 196명, 여자 229명)을 차상으로 하였다 임상적 단백뇨가 있거나 인슐린 치료, 혈압강하제 또는 지질대사개선제를 복용하는 환자는 제외시켰다. 전신 비만은 체용적지수 그리고 피부두겹 두께로 산출한 체지방률을, 복강내 지방축적도는 허리둘레 및 요둔위비를 이용하였다. 죽상경화증의 위험인자로는 혈당 조절 정도를 나타내는 공복 혈당과 당화혈색소 농도, 인슐린 저항성을 나타내는 공복 인슐린 및 C-peptide 농도, 지질 대사 상태를 나타내는 총 콜레스테롤, 중성지방, 고밀도지단백 콜레스테롤 및 저밀도지단백 콜레스테롤 농도 그리고 수축기 및 이완기 혈압을 선택하였다. 전신 비만지수 및 복부 비만지수와 이들 위험인자와의 상관관계는 연령과 당뇨병 이환기간을 보정하고 편상관분석법을 사용하였다. 결과: 1 여성군에서 남성군에 비해 체용적지수(24.2 대 23.0kg/㎡, p<0.01) 및 체지방률(23.8 대13.5%, p<0.01)은 다소 높았으나 허리둘레 (87.0 대 85.8 cm)와 요둔위비 (0.96 대 0.96)는 차이가 없었다. 2. 인슐린 저항성을 반영하는 공복 인슐린 및 C-peptide 농도는 체용적지수. 체지방률, 허리둘레 및 요둔위비가 커질수록 증가하는 양의 상관관계를 보였다(상관차수 0.21∼0.42, 모두 p<0.05). 3. 혈청 지질중에는 고밀도지단백 콜레스테롤만이 남성 환자군에서 비만지수들과 약한 음의 상관성을 보이는 경향이었고, 총 콜레스테롤 및 중성지방농도는 상관성이 없었다. 4. 수축기 및 이완기 혈압은 남성군에서만 체용적지수. 체지방률, 허리둘레 및 요둔위비가 커질수록 상승하는 양의 상관관계를 보였다(상관차수 0.21∼0.33, 모두 p.0.05). 결론. 국내 제2형 당뇨병 환자들의 전신 비만도 및 복부 비만도가 서구인에 비해 심하지는 않으나 포도당 대사, 인슐린 저항성, 지질 대사 및 고혈압에 위해한 영향을 미칠 수 있는 수준에 이르고 있으며 이는 결국 죽상경화증의 위험인자로도 작용하게 될 것임을 시사한다고 하겠다. 그리고 신체계측을 통한전신 비만 및 복부 비만 지수 모두가 당뇨병 및 죽상경화증의 위험을 간접적으로 예견하는 유용한 척도가 될 수 있을 것이다. Background: Obesity is the powerful risk factor for type 2 diabetes and also associated with a significantly increased risk of insulin resistance, dyslipidemia, hypertension and atherosclerosis. Although obese individuals have these diseases, the relationship between obesity and these diseases was not certain until regional fat distribution was taken into account. Reports about the relationship between obesity and the risk factors of atherosclerosis in type 2 diabetics in Korea are very rare. To evaluate the relative importance of anthropometric indices on the development of atherosclerosis and obesity-related metabolic and vascular complications, the correlations of these indices with the risk factors for atherosclerosis were studied. Methods: Patients with type 2 diabetes mellitus (n=425, male 196, female 229) who not used antihy- pertensives or anti-lipidemic agents were investigated. Body mass index (BMI) and percentage of body fat (%BF) estimated by skinfold-thickness in assessing generalized adiposity, and waist circumference (Wc) and waist-to-hip ratio (WHR) in assessing visceral adiposity were taken as anthropometric indices. We included the indicators of glycemic control (fasting blood sugar and HbAlc), insulin resistance (fasting serum insulin and C-peptide concentrations), lipid abnormalities (serum total cholesterol, triglyceride, HDL-cholesterol, and LDL-cholesterol concentrations), and systolic and diastolic blood pressure as risk factors for the development of atherosclerosis. Partial correlations of the anthropometric indices with those risk factors were investigated with adjustment of age and duration of illness. Results: 1. BMI and %BF in female patients group were higher than those in male (24.2 vs 23.0 kg/㎡, 23.8 vs 13.5%, respectively, p<0.01 in all) although Wc and WHR were similar between both groups. In general, both body adiposity and abdominal obesity in them were much lower than in the Western. 2. Serum insulin and C-peptide levels were positively correlated with BMI, %BF, Wc and WHR (r=0.21~42, p<0.05 in all). 3. Serum total cholesterol, triglyceride and LDL- cholesterol were not correlated with any anthropometric indices. A weak negative correlation of serum HDL-cholesterol with these indices was found in male patients group. 4. Both systolic and diastolic blood pressures were positively correlated with all these indices only in male group (r=0.21~33, p<0.05 in all). Conclusion: These results suggested that the severity of both generalized and visceral adiposity in these patients with type 2 diabetes mellitus were only mild but adiposity with abdominal distribution of body fat in diabetes mellitus could be a significant risk factor of developing atherosclerosis. In clinical practice, these anthropometric indices indicating general adiposity and abdominal obesity may provide useful information for predicting disease risks, especially of diabetes and cardio- vascular disease indirectly.