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빅데이터 텍스트 마이닝을 활용한 소비자 리뷰에서의 의류 소재 키워드 분석
강가은,박지원,유신정 한국의류학회 2024 한국의류학회지 Vol.48 No.4
This research explores consumer preferences for materials in different clothing product categories, using web-crawling and text mining techniques. Specifically, the study focuses on the material-related terms found in consumer reviews across three distinct product categories: functional clothing , formal shirts, and knit sweaters. Top-selling products within each category were identified on the Naver Shopping website based on the volume of reviews, and the four most-reviewed products were selected. Six hundred reviews per product were analyzed using the Textom big-data analysis software to determine the frequency of material-related mentions and word associations. The analysis utilized two comparative metrics: product category and usage duration. Our findings reveal notable variations in the material preferences mentioned by consumers across different product categories. The study suggests a need to re-evaluate existing standardized review criteria to better reflect consumer interests specific to each product category. Additionally, an increase in material-related terms in reviews over one month indicates the potential importance of extending the duration of product reviews to enhance the accuracy of information that reflects longer-term consumer experiences with material quality.
건강한 한국인 자원자에서 리스페리돈 구강붕해 제제인 리스페달 오디^®정 1mg과 리스페달 퀵릿^®정 1mg의 생물학적동등성 연구
강가은,김진,배경열,신희영,정성욱,윤진상,김종근 대한임상약리학회 2011 Translational and Clinical Pharmacology Vol.19 No.1
Background: Risperidone is one of the atypical antipsychotic drugs that have effectiveness in the management of a range of psychiatric illnesses. Orally disintegrating (OD) formulations of risperidone that rapidly dissolve in the mouth, prior to swallowing without water have been developed to overcome any problems related to swallowing and improve acceptability. The goal of this study was to evaluate the bioequivalence of Risperdal OD^® tablet 1mg and Quicklet^® tablet 1mg Methods: This randomized, open-label, 2-way crossover trial was conducted in 36 healthy male volunteers that received OD risperidone tablet, either the reference formulation (Risperdal Quicklet^® tablet 1mg), or the test formulation (Risperdal OD^® tablet 1mg), each in a single administration. Blood samples were obtained during a 24-hour period after dosing. Plasma was analyzed for risperidone by a validated LC-MS/MS. Adverse events were monitored by safety assessments including clinical interview by clinician. Pharmacokinetics were calculated by noncompartmental analysis and compared between two formulations Results: A total of 36 male volunteers (mean age, 24.2 years; height 174.5 cm; weight 67.6 kg) completed the study. The ANOVA showed no significant effect of sequence, formulation and period of Ln (AUC_last) and Ln (C_max). The 90 % confidence intervals for the mean treatment ratios of the Ln (AUC_last) and Ln (C_max) were Ln 0.96 ∼ Ln 1.12, Ln 0.97 ∼ Ln 1.16, respectively. No serious adverse events were caused by both formulations. Conclusion: In this study, a single administration of Risperdal OD^® tablet 1mg was bioequivalent to a single administration of Risperdal Quicklet^® tablet 1mg.
김희경,최수미,강가은,박경화,이동건,박완범,이수진,이승환,정숙인,장희창 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.4
Purpose: Few studies have been investigated the in vivo efficacy of generic vancomycin products available outside of the United States. In this study, we aimed to compare the in vivo pharmacokinetics (PK) and pharmacodynamics (PD) of five generic vancomycin products available in Korea with those of the innovator. Materials and Methods: The in vitro vancomycin purity of each product was examined using high-pressure liquid chromatography. Single-dose PK analyses were performed using neutropenic mice. The in vivo efficacy of vancomycin products was compared with that of the innovator in dose-effect experiments (25 to 400 mg/kg per day) using a thigh-infection model with neutropenic mice. Results: Generic products had a lower proportion of vancomycin B (range: 90.3–93.8%) and a higher proportion of impurities (range: 6.2–9.7%) than the innovator (94.5% and 5.5%, respectively). In an in vivo single-dose PK study, the maximum concentration (Cmax) values of each generic were lower than that of the innovator, and the geographic mean area under the curve ratios of four generics were significantly lower than that of the innovator (all p<0.1). In the thigh-infection model, the maximum efficacies of generic products reflected in maximal effect (Emax) values were not significantly different from the innovator. However, the PD profile curves of some generic products differed significantly from that of the innovator in mice injected with a high level of Mu3 (all p≤0.05). Conclusion: Some generic vancomycin products available in Korea showed inferior PK and PD profiles, especially in mice infected with hetero-vancomycin-resistant Staphylococcus aureus.
배경열,양수진,김재민,강가은,김영옥,윤진상 대한신경정신의학회 2009 신경정신의학 Vol.48 No.6
Antipsychotic poisoning may cause significant adverse effects, su-ch as a change in consciousness and extrapyramidal symptoms (EPS), in infants and toddlers. We report the sibling cases of a 33- month-old sister and 11-month-old brother who both presented with altered states of consciousness and cervical rigidity after acute haloperidol poisoning. Initially, the pediatrician suspected a central nervous system infection, as the patients exhibited confused mental states, cervical rigidity, and ataxia in the emergency room. Various laboratory and imaging tests, including cerebrospinal fluid examinations, electroencephalograms, and brain computerized tomography did not show any particular abnormalities. After 1 day, the patients’ mother reported that she had a current haloperidol prescription, for the treatment of schizophrenia. After 3 days of symptomatic treatment, the two siblings recovered completely, without significant sequelae. Haloperidol was detected in their plasma, at concentrations of 2.1 ng/mL in the sister and 2.5 ng/mL in the brother. We emphasize that, when administering antipsychotics to patients living with young children, family education to prevent unintentional antipsychotic poisoning is essential. Clinicians must take account of the possibility of antipsychotics poisoning when a child suddenly presents an altered state of consciousness and/or suspicious EPS with no clear reason.
PP2A negatively regulates the hypertrophic response by dephosphorylating HDAC2 S394 in the heart
윤소미,국태원,민현기,권덕화,조영국,김미라,신세라,정호석,정승훈,이수민,강가은,박윤철,김용숙,안영근,Julie R. McMullen,Ulrich Gergs,Joachim Neumann,김경근,김정철,남광일,김영국,국현,엄광현 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Cardiac hypertrophy occurs in response to increased hemodynamic demand and can progress to heart failure. Identifying the key regulators of this process is clinically important. Though it is thought that the phosphorylation of histone deacetylase (HDAC) 2 plays a crucial role in the development of pathological cardiac hypertrophy, the detailed mechanism by which this occurs remains unclear. Here, we performed immunoprecipitation and peptide pull-down assays to characterize the functional complex of HDAC2. Protein phosphatase (PP) 2 A was confirmed as a binding partner of HDAC2. PPP2CA, the catalytic subunit of PP2A, bound to HDAC2 and prevented its phosphorylation. Transient overexpression of PPP2CA specifically regulated both the phosphorylation of HDAC2 S394 and hypertrophyassociated HDAC2 activation. HDAC2 S394 phosphorylation was increased in a dose-dependent manner by PP2A inhibitors. Hypertrophic stresses, such as phenylephrine in vitro or pressure overload in vivo, caused PPP2CA to dissociate from HDAC2. Forced expression of PPP2CA negatively regulated the hypertrophic response, but PP2A inhibitors provoked hypertrophy. Adenoviral delivery of a phosphomimic HDAC2 mutant, adenovirus HDAC2 S394E, successfully blocked the anti-hypertrophic effect of adenovirus-PPP2CA, implicating HDAC2 S394 phosphorylation as a critical event for the anti-hypertrophic response. PPP2CA transgenic mice were protected against isoproterenolinduced cardiac hypertrophy and subsequent cardiac fibrosis, whereas simultaneous expression of HDAC2 S394E in the heart did induce hypertrophy. Taken together, our results suggest that PP2A is a critical regulator of HDAC2 activity and pathological cardiac hypertrophy and is a promising target for future therapeutic interventions.