감조하천의 계획고수위 산정에 미치는 제요소

강경욱,박상길,최선호 대한토목학회 1993 대한토목학회 학술발표회 논문집 Vol.1993 No.2

Trends in Prescribing of Antiseizure Medications in South Korea: Real-World Evidence for Treated Patients With Epilepsy

강경욱,이혜승,신주영,문혜진,이서영 대한신경과학회 2022 Journal of Clinical Neurology Vol.18 No.2

Background and Purpose We investigated the trends in the prescribing of antiseizure medication (ASM) over a 9-year period, and provide real-world data regarding ASM prescriptions of patients with epilepsy in South Korea. Methods This study used data in the Korean National Health Information Database for the period from 2009 to 2017. We included 18 oral ASMs, which were classified into older and newer ASMs based on them first becoming available on the market before or after 1991, respectively. The annual trends in ASM prescriptions were plotted over the 9-year study period, and changes in these trends were evaluated as average annual percentage changes (AAPCs) using Poisson regression. Age- and sex-stratified analyses were also conducted. Results Overall, the proportion of prescriptions involving polytherapy with three or more ASMs increased from 10.08% in 2009 to 10.99% in 2017 (AAPC=0.9%, p<0.001) over the 9-year study period. Among monotherapies, although valproate (VPA) was the most frequently prescribed ASM, the prescription rate of levetiracetam (LEV) steadily increased regardless of age and sex over the study period. The monotherapy prescription trends differed depending on age and sex. In the five most frequently used ASM combination regimens, the prescription rates of VPA/LEV, LEV/oxcarbazepine, and LEV/lamotrigine regimens showed increasing tendencies. In contrast, prescription rates for all combined regimens of older ASMs declined over time in all age groups. Conclusions This is the first epidemiological study of the changes in prescription trends for ASM in South Korea based on nationwide data from 2009 to 2017. We found progressive increases in the use of newer ASMs for both monotherapy and duotherapy, and for polytherapy with three or more ASMs over the 9-year study period.

인권교육 프로그램이 초등학생의 반 편견 및 장애 인식에 미치는 영향

강경욱 한국특수교육교과교육학회 2012 특수교육교과교육연구 Vol.5 No.1

The purpose of this study is the effects of human rights education programs on anti-bias and disability awareness of elementary school students. In order to achieve these objectives, we chose the following research questions. First, how have human rights education programs influence the anti-bias of elementary school students ? Second, how have human rights education programs influence on disability awareness of elementary school students ? The human rights education programs of this study selected the programs of human rights group and human rights education teachers' meeting . Then, we have done a comparative analysis in building on contents of the The National Human Rights Commission. In this study, the data was treated to obtain the mean and standard deviation as descriptive statistics, and performed ANCOVA to verify the difference of the effects. The results of this study are as follows. First, the experimental group that participated in the session of human rights education was proved to be more effective on enhancing the anti-bias of elementary school students rather than the control group. Second, the experimental group that participated in the session of humane rights education was proved to be more effective on enhancing the disability awareness of elementary school students rather than the control group. As mentioned above, having a human rights programs are the effective way toimprove anti-bias and disability awareness. Therefore, human rights education programs have to be used by many to educate on virtues and disability awareness. 본 연구는 인권교육 프로그램이 초등학생의 반 편견 및 장애인식에 미치는 영향을 알아보는데 그 목적이 있다. 이러한 목적을 달성하기 위해 선정한 연구문제는 다음과 같다. 첫째, 인권교육 프로그 램이 초등학생의 반 편견에 어떠한 영향을 미치는가? 둘째, 인권교육 프로그램이 초등학생의 장애인 식에 어떠한 영향을 미치는가? 본 연구의 인권교육 프로그램은 인권단체와 인권교육교사 모임의 프 로그램을 선택하여 국가인권위원회의 인권교육 내용 영역을 기반으로 구안한 다음 특수교육 전문가 의 자문을 얻어 수정․보완하였다. 본 연구는 실험집단과 비교집단을 대상으로 사전 및 사후 검사를 실시하여 각 검사별 평균점수와 표준편차를 산출하고, 공변량분석(ANCOVA)을 통해 효과 차이를 검 증하였다. 본 연구의 결과는 다음과 같다. 첫째, 인권교육 프로그램을 적용한 실험집단이 적용하지 않은 비교집단에 비해 사후검사 점수가 사전검사 점수보다 높은 점수를 보임으로써 실험집단의 반 편견이 비교집단보다 향상된 것으로 나타났다. 둘째, 인권교육 프로그램을 적용한 실험집단이 적용하 지 않은 비교집단에 비해 사후검사 점수가 사전검사 점수보다 높은 점수를 보임으로써 실험집단의 장애인식 개선이 비교집단보다 향상된 것으로 나타났다. 이상에서와 같이 인권교육 프로그램은 초등 학생의 반 편견 및 장애인식 개선에 효과적인 방법으로 나타났다. 따라서 초등학교에서 이루어지는 다양한 인성교육과 장애이해교육활동으로 인권교육 프로그램을 적극적으로 활용할 필요가 있다고 할 수 있다.

FLUENT를 활용한 콘크리트 저장용기의 공기유로내 유속에 따른 대류열전달 해석

강경욱,김형진,조천형 한국방사성폐기물학회 2015 한국방사성폐기물학회 학술논문요약집 Vol.2015 No.10

정상조건에서의 콘크리트 건식 저장용기 자연대류 유동 해석

강경욱,김형진,조천형 한국방사성폐기물학회 2016 한국방사성폐기물학회 학술논문요약집 Vol.2016 No.05

Multidimensional Early Prediction Score for Drug-Resistant Epilepsy

강경욱,조용원,이상건,정기영,김지현,김동욱,이상암,홍승봉,나인섭,이소현,백원기,최석용,김명규 대한신경과학회 2022 Journal of Clinical Neurology Vol.18 No.5

Background and Purpose Achieving favorable postoperative outcomes in patients with drug-resistant epilepsy (DRE) requires early referrals for preoperative examinations. The purpose of this study was to investigate the possibility of a user-friendly early DRE prediction model that is easy for nonexperts to utilize. Methods A two-step genotype analysis was performed, by applying 1) whole-exome sequencing (WES) to the initial test set (n=243) and 2) target sequencing to the validation set (n=311). Based on a multicenter case–control study design using the WES data set, 11 genetic and 2 clinical predictors were selected to develop the DRE risk prediction model. The early prediction scores for DRE (EPS-DRE) was calculated for each group of the selected genetic predictors (EPS-DREgen), clinical predictors (EPS-DREcln), and two types of predictor mix (EPS-DREmix) in both the initial test set and the validation set. Results The multidimensional EPS-DREmix of the predictor mix group provided a better match to the outcome data than did the unidimensional EPS-DREgen or EPS-DREcln. Unlike previous studies, the EPS-DREmix model was developed using only 11 genetic and 2 clinical predictors, but it exhibited good discrimination ability in distinguishing DRE from drug-responsive epilepsy. These results were verified using an unrelated validation set. Conclusions Our results suggest that EPS-DREmix has good performance in early DRE prediction and is a user-friendly tool that is easy to apply in real clinical trials, especially by nonexperts who do not have detailed knowledge or equipment for assessing DRE. Further studies are needed to improve the performance of the EPS-DREmix model.

Association Between Sleep and the Metabolic Syndrome Differs Depending on Age

강경욱,김명규,남태승,강경호,Park Won-Ju,문희수,오형근,이은정,주은연 대한수면연구학회 2023 Journal of sleep medicine Vol.20 No.1

Objectives: Sleep quality and duration are significantly associated with metabolic syndrome (MetS), especially among individuals in the middle-aged and elderly age groups; however, it is inconsistent among the age groups in previous studies. This study investigated the effect of age on the association between sleep and MetS in a large sample size.Methods: Health-related data on MetS in males and females (n=22,995; age: 23–79 years) were collected from annual health examinations, including the Pittsburgh Sleep Quality Index (PSQI). MetS was diagnosed based on the 2009 Joint Interim Statement.Results: In total, 4,660 (20.3%) participants were diagnosed with MetS. The data showed a significant association between poor sleep quality (PSQI >5), shorter sleep durations (<6 hours), and MetS in the older group (≥40 years) after adjusting for age, smoking status, alcohol consumption, sex, and exercise. However, this association was not observed in the younger group (<40 years). Regardless of age, global PSQI scores and sleep durations were significantly related to abdominal obesity (male ≥90 cm, female ≥85 cm in waist circumference) and general obesity (body mass index ≥30 kg/m²).Conclusions: This study demonstrates that sleep quality and duration are related to obesity across all age groups and that sleep quality and duration are only related to MetS in older individuals. These findings suggest that satisfactory sleep in adults aged ≥40 years may play a crucial role in preventing MetS.

사용후핵연료 금속겸용 운반용기의 열전달 최적을 위한 열전달 핀 성능 평가

강경욱,김형진,윤정현,이동규 한국방사성폐기물학회 2013 한국방사성폐기물학회 학술논문요약집 Vol.11 No.2

The impact of head repositioning accuracy and proprioception on cervical stabilization exercise in healthy adults

강경욱,강대원,권구예,김한별,노경민,백지현,차진관,김현희 물리치료재활과학회 2015 Physical therapy rehabilitation science Vol.4 No.1

Objective: Cervical stabilization exercises are frequently to improve strength and endurance of cervical muscles. The purpose of this study was to identify changes in head repositioning accuracy (HRA) and neck proprioception through cervical stabilization exercises in healthy adults. Design: One group pretest-posttest design. Methods: Thirteen participants with no previous history of neck pain or injury to the cervical spine were recruited. HRA was measured by equipment including laser pointer, helmet, eye patch and marking pens. The distance between the spot where the beam had stopped and the center of the graph paper was measured three times with the averaged value used as the head repositioning accuracy. Neck proprioception was measured by a cervical range of motion device (CROM). Subjects wore the CROM tester and were to look straight ahead while bending his/her neck. Subjects were instructed to perform extension, lateral flexion and rotation, and the values were then measured and recorded. The measurements were performed pre-intervention, and after cervical stabilization exercise. Results: There was no significant difference on HRA after intervention. In addition, there was no significant difference on neck proprioception compared with pre-intervention. Conclusions: The present study did not identify any effect on HRA and neck proprioception of cervical stabilization exercise. Further investigations are required to elucidate this in old aged participants and patients with neck pain.

Lead Poisoning at an Indoor Firing Range

강경욱,박원주 대한의학회 2017 Journal of Korean medical science Vol.32 No.10

In March 2014, a 39-year-old Korean male presented with a 6-month history of various nonspecific symptoms including dizziness, fatigue, asthenia, irritability, elevated blood pressure, palpitation, eyestrain, and tinnitus. His occupational history revealed that he had been working as an indoor firing range manager for 13 months; therefore, he was subjected to a blood lead level (BLL) test. The test results showed a BLL of 64 µg/dL; hence, he was diagnosed with lead poisoning and immediately withdrawn from work. As evident from the workplace environmental monitoring, the level of lead exposure in the air exceeded its limit (0.015–0.387 mg/m3). He received chelation treatment with calcium-disodium ethylenediaminetetraacetic acid (1 g/day) for 5 days without any adverse effects. In the follow-up results after 2 months, the BLL had decreased to 9.7 µg/dL and the symptoms resolved. This report represents the first occupational case of lead poisoning in firing ranges in Korea, and this necessitates institutional management to prevent the recurrence of poisoning through this route. Workplace environmental monitoring should be implemented for indoor firing ranges, and the workers should undergo regularly scheduled special health examinations. In clinical practice, it is essential to question the patient about his occupational history.