C형 간염바이러스 항체 면역블롯검사에서 불확정판정을 받은 헌혈자의 HCV 양성 확인

조연정,서동희,황병갑,김동집,정남현 大韓輸血學會 2001 大韓輸血學會誌 Vol.12 No.2

도시지역 보건사업에서 컴퓨터의 활용방안에 관한 연구

염용태,이명숙,조병희,송동빈 고려대학교 의과대학 1990 고려대 의대 잡지 Vol.27 No.2

Nacessity of new communication media in information society is repidly increasing in many fields of Korea. It includes the field of primary helath care in the courses of collecting informations on demographic feature, social characteristics and health behavior of peoples. In light of above reasons, the authors attempted to utilize personal computers for the primary health services to promote health of unban people as a pilot study in Guro-6- Dong, Seoul. Five nurses working in Guro-6-Dong Health Subcenter completed family health records of 3,930 households among the total of 4,270. A total of 3,904 family health records among 3,930 were computerized and sorted out in categories of population characteristics, population dymanics, characteristics of householders, housing, family planning, maternal and child health(M.C.H), health status of residents and of others. Names of risky category in M.C.H, and family planning were listed and the lists were handed to the nurses concerned in order to practice proper cares in time. Sorted data were compared with ones of City of Seoul, average of other cities, and ones of nationwide. With the results of above practice, in terms of utilization of computer in uban primary health sevices, the following strategy was proposed. In order to provide proper health services the unban people demanded, efficient devices of information collection, processing and interpretation systems on health were urgently needed in every dong unit(health subcenter) of health centers. Recommended was personal computer network as a new communication media. Additional advantages of the devices were continuity and efficiency in services, and utilization in evaluation of health services and analysis of cost -effectiveness.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

한국 주요정신장애의 유병률 및 관련요인 : 2006 전국정신질환역학조사

조맹제,장성만,함봉진,정인원,배안,이영문,안준호,원승희,손정우,홍진표,배재남,이동우,조성진,박종익,이준영,김진영,전홍진,이해우 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.3

Objectives The aims of this study are to estimate the prevalence of the DSM-IV psychiatric disorders in the Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI), and to compare those with previous studies. Methods The Korean Epidemiologic Catchment Area study Replication (KECA-R) was Conducted between August 2006 and April 2007. The sampling of the subjects was carried out across 12 catchment areas. A multistage, cluster sampling design was adopted. The target Population included all eligible residents aged 181o 64 years. Face-to-face interviews were conducted with the Korean version of Composite International Diagnostic Interview (K-CIDI) based on the DSM-IV (N=6,510, response rate=81.7%). Results A total of 6,510 participants completed the interview. The lifetime and 12-month prevalence rates for all types of DSM-IV disorders were 30.0% and 17.3%, respectively. Those of Specific disorders were as follows : 1) alcohol use disorder, 16.2% and 5.6% ; 2) nicotine use disorder, 9.0% and 6.0% ; 3) specific phobia, 3.8% and 3.4% ; 4) major depressive disorder, 5.6% and 2.5% ; and 5) generalized anxiety disorder, 1.6% and 0.8%. Data relating to nicotine and alcohol use disorder revealed a very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among females than males. Conclusion The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in the distribution of psychiatric disorders across the country and times were observed.

재생골재 혼합율에 따른 콘크리트 압축강도 변화에 관한 연구

조동영,유희중 호남대학교 2003 호남대학교 학술논문집 Vol.24 No.2

레니텍^(�) 정(말레인산 에날라프릴, 10mg)에 대한 에나레이스 정의 생물학적 동등성

조성희,하용화,홍성제,서성훈,류재환,김동현,이경태 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.3

The purpose of present study was to evaluate the bioequivalence of two enalapril maleate tablets, Renitec^(™) (MSD Korea Ltd.) and Enalace ^(™) (Welfide Korea Ltd.), according to the guidelines of Korea Food Drug Administration (KFDA). Twenty-four normal male volunteers, 22.33±2.55 year in age and 66.54±8.30 ㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After two tablets containint 10 ㎎ of enal-april maleate per tablet wre orally administered, blood was taken at predetermined time intervals and concentrations of enalapril in plasma were determined using LC-MS-MS. Pharmacokinetic parameters such as AUC_(t), C_(max) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t) and C_(max) untransformed T_(max). There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transfored data were acceptance range of log0.8 to log1.25(e.g., log1.02∼log1.14 and log1.03∼log1.19 for AUC_(t) and C_(max), respectively). The major parameters, AUC_(t) and C_(max), met the criteria of KDFA for bioequivalence indicating that Enalace^(™) tablet is bioequivalent to Renitec^(™) tablet.

자가 골수 중간엽줄기세포와 생분해성 고분자 스캐폴드를이용한 조직공학적 인공혈관 제조

조승우,김동익,박희정,임상현,전오주,김수현,김영하,최차용,이민재,김종성,장인성,김병수 대한혈관외과학회 2003 Vascular Specialist International Vol.19 No.2

水紅花子의 抗癌活性 및 抗轉移 效果에 關한 硏究

曺永周,金聖勳,金東熙 대전대학교 한의학연구소 2002 혜화의학회지 Vol.10 No.2

To evaluate the antitumor activity and antimetastatic effects of Polygoni Orientalis Fructus(POF), studies were done experimentally. The results were obtained as follows: 1. In cytotoxicity against A549, and XF498 cell concentration inhibiting cell growth up to below 30% of control was recognized at 200㎍/㎖ of POF. Also POF inhibited cell growth up to below 30% of control against SK-OV-3, SK-MEL-2, HCT15 and MCF-7 cell at 100㎍/㎖. 2. The concentration inhibiting adhesion of A549 and SK-OV-3 to complex extracellular matrix up to below 70% of control was recognized at 100㎍/㎖ of POF. 3. In pumonary colonizatin assay, a number of colonies in the lungs were decreased signiicantly in POF treated group as compared with control group. These results suggested that POF extracts might be usefully applied for prevention and treatment of cancer.

동물과 사람유래 Vancomycin 내성 장구균의 항균제 감수성 비교

조윤상,이희수,김종만,류판동,박용호,유한상,이문한 한국수의공중보건학회 2003 예방수의학회지 Vol.27 No.1

It has been recently reported the possibility in the bansfer of antimicrobial resistance to other animals and humans. In particular, vancomycin resistant enterococci (VRE), which have been known as a principal antimicrobial resistant bacteria in humans, have been increased as a pathogen of nosocomial infections. And then animal VRE were suspected as an origin of human VRE. In this study, we isolated Enterococcus spp. from animals, identified by bio- chemical tests, examined for antimicrobial susceptibility, and then compared the antimicrobial susceptibility of VRE among each other as well as human VRE. Enterococcus iecium (29%) was predominant in Enterococcus species (n=122) isolated from animal feces in this study. E. hirae, E. iecalis, E. casseliflam and E. gallinarum were also isolated as rates of 24%, 21%, 16% and 7%, respectively. The resistance of enterococci to penicillin and tetracycline were 66% and 78%, respectively, and the susceptibility of them to chloramphenicol was 66%. Antimicrobial susceptibility test has shown that 91% of VRE from humans (n=11) was susceptible to chloramphenicol and all resistant to penicillin, rifampin and streptomycin. Seventy-five percentage of VRE from chickens (n = 12) was susceptible to rifampin and resistances of them to penicillin, tetracycline and sbeptomycin were 75%, 83%, and l00%, respectively. Therefore, we confirmed the difference of antimicrobial susceptibility from animals and humans, and the antimicrobial susceptibility test could be one of the simple and useful methods for the epidemiological survey of VRE.

의료복지용 센서 및 시스템의 개발(Ⅱ)

조진호,강희동 경북대학교 센서기술연구소 1997 연차보고서 Vol.1997 No.-

본 연구에서는 향후 중요한 의료 복지시스템으로 국내외에서 널리 쓰이게 될 MSGC형 온라인 X선 촬영 사진 촬영 장치를 개발하고자 하였다. MSGC형 은라인 X선 촬영장치는 기존의 X선 필름에 비해 조사선량을 크게 낮출 수 있으며 계조도(gray level)및 범위가 디지털 x-ray 시스템에 비해 훨씬 넓다. 그리고 MSGC형 센서는 비슷한 메카니즘으로 작동되는 MWPC형 위치검출센서 보다 높은 해상도를 얻을 수 있으며 센서제작에 대량화와 간편성을 동시에 제공할 수 있는 잇점이 있다. 본 연구는 MSGC센서를 제작하여 이로부터 X선 조사선량에 관계되는 기체 증폭펄스를 얻기 위한 연구 분야와, 이 센서를 이용하여 영상이 얻어질 수 있도록 시스템을 제어하고 영상을 재구성 및 처리하는 두 가지 연구 분야로 나누어 진행된다. MSGC형 센서개발에서는 해상도가 높고 기체증폭이 안정적으로 일어날수 있는 센서를 설계 제작하였고 다양한 실험자료를 수집하였다. MSGC형 센서 개발에서 핵심부분은 기판의 재질과 마이크로스트립형 전극 그리고 챔버 및 기체 증폭이 일어났을 때의 펄스를 샤프하게 분리시켜 계수할 수 있는 기술이다. 디지털 X선 장치 제어 및 영상처리 연구에서는 1차 년도에 제작된 제어 컴퓨터와 X-ray 인터페이스 회로가 가진 수동 조작의 불편함, 타이밍 제어시 오차 발생 및 X-선 Expose속도의 한계 등의 문제점을 개선시킨 인터페이스 보드를 개발하였다. We have developed the MSGC type on-line digital radiography system that will used widely in medical welfare system in future. The MSGC type can reduce the X-ray exposure to the object significantly as compared with X-ray film and its the dynamic range of gray level is more wide than the conventional digital X-ray system. And the MSGC type sensor can obtain much higher resolution than the position detecting sensor of MWPC type which has a similar mechanism to MSGC type and also it can provide an advantage of mass-production and a simplicity to produce the sensors. We divided into two research fields. One is the field of implementing the MSGC sensor and measuring pulses produced by gas multiplication related with the X-ray. The other field is developing the method of controlling digital image acquisition part, image reconstructing, and processing. In the development of MSGC type sensor, we designed and implemented the sensor with a high resolution and a stable gas multiplication. And we collected various experimental data. In the development of MSGC type sensor, the core parts are the materials of substrate, microstrip type electrode and chamber, and technique to split the pulses of gas multiplication sharply and count them. In the field of system controlling and image processing, we developed the new-interface board which has been improved some problems in the first research step, i.e. inconvenient operations of control computer and X-ray interface circuit, error occurrence in timing control, and the limitation of X-ray expose velocity.