혼합형 자가면역성 용혈성 빈혈을 동반한 전신성 홍반성 루푸스 1예

이승철,김선임,이승훈,이현경,조남국,한성훈,유영진,조종래 인제대학교 2000 仁濟醫學 Vol.21 No.2

A 17-year-women developed mixed warm and cold antibody type autoimmune hemolytic anemia associated with systemic lupus erythematosus. The patients was admitted to our hospital for syncope. Jaundice was observed. Urinalysis revealed protein and hemoglobin. Her hemoglobin was 4.6g/dl and reticulocytes were 10%. Total bilirubin was elevated, while haptoglobin and complement were abnormally reduced. ANA and mitochondrial Ab were detected. The direct and indirect Coombs test were positive. The direct antiglobulin test was positive ; IgG and C3d were detected on the red cell surface. The cold agglutinin(CA) titer was 128. The patients was initially treated with high dose steroid therapy. However the patients did not responded to high dose steroid therapy. We treated the patients with plasmapheresis and synchronized cyclophosphamide therapy. Clinical remission of hematologic complications was achieved in this patients. We report a case of mixed type autoimmune hemolytic anemia with SLE that responded plasma pheresis and synchronized cyclophosphamide therapy.

만성두통 환자의 성격유형 A 행태, 스트레스, 우울 및 두통영향정도의 관계 연구

차남현,임사비나,정인태,김수영,안경애,김건식,이재동,이상훈,최도영,이윤호,이두익 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

To examine an estimate factor and grasp the relation of difference for Ype A Behavior Pattern(TABP), Perceived Stress Questionnaire. Depression and HIT-6 in the Chronic headache client. Method: Data collected by self-reported questionnaires from 38 client in S city who were selected by criteria of IHS, from the 19^(th) of October to 10^(th) of December, 2004. Result: 1) Differences between biographical data by TABP was significant by SaSang constitutions, by Stress was significantly influenced by age, and by Depression were significantly influenced health status and SaSang constitutions. 2) Correlations Coefficients among Study Variables were Stress and Depression(r=.494, p=.002) and Depression and HIT-6(r=.432, p=.010). 3) In regression analysis, HIT-6 were significantly influenced by Depression and Type A Behavior Pattern(TABP). These variables explained 38% and 34% respectively. Conclusion: The result suggest that chronic headache management with psychological aspect, as well as physical aspect should be a focus to enhance the quality of life.

만성두통환자에 대한 동서협진의 임상적 연구

정인태,이상훈,김수영,차남현,김건식,이두익,이재동,임사비나,이윤호,최도영 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objective : Because the cause and etiology of chronic headache are not yet fully explained, the treatment of this symptom is not simple. In order to study the effectiveness East-West pain treatment on chronic headache, we evaluated its effect of pain alleviation and quality of life improvement on chronic headache patients who were treated with nerve block and acupuncture, and only acupuncture for eight weeks. Methods : 92 clinical experiment participants were gathered and through a questionnaire patients who experienced headache for more than 4 hours a day and more than 15 days per month were qualified as chronic headache patients. The qualified patients were classified into two groups, nerve block and acupuncture group(EW group, n=49) and acupuncture group(E group, n=43). Treatment was applied 2 times a weeks for 8 weeks. The acupoints, GV20, HN23, ST8, HN46, TE17, GB20, LI20, LI11, LI14, ST36, and LR3 were stimulated for 20 minutes. The effects of two groups were analyzed using VAS scores and BPI(Brief Pain Inventory). Results : The VAS and BPI after four weeks of treatment showed significant improvement among two but differences between the three groups was statistically insignificant. The VAS and BPI of the EW group after eight weeks of treatment showed statistically significant improvement compared to the other two groups. Conclusion : The pain treatment for chronic headache might be contributed to improvement of quality of life as well as alleviation of pain of chronic headache patients. It was suggested that the West pain treatment in combination with East pain treatment might be an useful modality to improve the pain and quality of life in chronic headache patients.

만성두통환자에 대한 침치료가 심박변이도에 미치는 영향

정인태,이상훈,김수영,차남현,김건식,이두익,이재동,임사비나,이윤호,최도영 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objective : The purpose of this study was to assess the effect of acupuncture treatment for chronic headache patients using power spectrum analysis of the heart rate variability(HRV). Methods : 15 clinical experiment participants were gathered and through a questionnaire patients who experienced headache for more than 4 hours a day and more than 15 days per month were qualified as Chronic Headache patients. Treatment was applied 2 times a weeks for 8 weeks. The acupoints, GV20, HN23, ST8, HN46, TE17, GB20, LI20, LI11, LI14, ST36, and LR3 were stimulated for 20 minutes. The effects of acupuncture treatment were analyzed using power spectrum analysis of the HRV, HRV was recorded before and after acupuncture treatment. Results : HRV before and after treatment was compared after 8 weeks of acupuncture treatment. Increase in mean values of SDNN and RMSSD were observed but the increases were not statistically significants. Increase in mean values of TP, LF and HF were observed but, the increase was significant(p<0.05) only in TP. Conclusions : The results suggest that acupuncture treatment on chronic headache patients can increase the activity of autonomic nervous system. Further use of HRV for quantitative analysis of acupuncture treatment on autonomic nervous system related symptoms is suggested.

유해화학물질의 계통분석

박성우,박유신,이진훈,유재훈,김유나,오세진,이진숙,김남이,박종신,남금문,노동석 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

자가 면역성 간염에서 자가항체의 발현 양상과 스테로이드 치료의 효과

박기오,채경훈,허원석,강윤세,정재훈,김연수,문희석,이엄석,김선문,이병석,김남재,이헌영 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

목적 : 최근 8년간 본원에서 경험한 자기면역성 간염의 혈액학적 특징과 스테로이드의 치료효과를 알아보고자 본 연구를 시행하였다. 방법 : 1996년 이후부터 2002년까지 충남대학교 병원에서 1999년 International Autoimmune Hepatitis Group(LAHG)에서 제시한 수정 진단 기준안에 의거하여 총 진단점수가 probable 이상에 해당하는 환자들을 대상으로 임상적 특징, 검사실 및 조직 소견과 스테로이드와 azathioprine의 치료 효과를 후향적으로 조사하였다. 결과 : 9예의 환자들은 여성이 78%, 40대가 많았고, 급성 발병이 33.3%, 피로감, 식욕부진 및 황달 등이 나타났으며, 항핵항체가 55.6%에서 그리고 항평활근 항체가 77.8%에서 양성이었고, 동반 질환은 류마치스 관절염이 2예, 특발성 혈소판 감소증 1예, Henoch-Sch nlein 자반증 및 그레브스병이 각각 1예 씩이었다. 7예에 대해서 스테로이드와 azathioprine으로 치료하여 생화학적 임상적 완해가 이루어져서 유효한 치료 결과를 얻었다. 결론 : 자가면역성 간염은 우리 나라에서 원인을 찾을 수 없는 만성 간질환의 경우, 특히 중년여성에서 다른 자가면역성 질환이 동반되었을 때 자가면역성 간염을 의심하여 자가항체 선별검사를 시행해 보아야 할 것으로 생각된다. 향후 다기관 연구를 통하여 좀 더 많은 증례를 모으고 전향적인 연구를 시행하여야 할 필요가 있다. Although autoimmune hepatitis(AIH) is common in western contries, some studties have been reported in Korea. The aim of the study was to analyze the clinical and histological features and expression pattern of the autoantibody and to examine clinical course of AIH in Korea. For 9 patients diagnosed as having AIH in our hospital since 1996, we reviewed medical records and analyzed clinical and laboratory findings retrospectively. They had a probable or definite AIH according to the revised criteria of International AIH group. The mean age was 42.7(21∼68)years and 7(77.8%) were female. Three of them(33.3%) showed acute hepatitis and five of them showed cirrhosis. Fatigue and anorexia were the most frequently complained symptoms(55.6%). Four patients(44.4%) were accompanied with other autoimmune diseases. Antinuclear antibody was detected in 5(55.6%) and anti-smooth muscle antibody was detected in 7(77.8%). Three patients showed focal picemeal necrosis and four showed periportal fibrosis. Among 7 patients who received immunosuppressive therapy, six patients(85.7%) showed initial response. and biochemical and serologic remission were achived in 5(71.4%) and 3(42.8%) patients, AIH seems to be partly responsible for chronic liver disease of unknown etiology in Korea. AIH should be suspected in female patients with unknown chronic liver disease of unknown etiolgy, especially accompanied with other autoimmune disease. The clinical characteristics of AIH may not be quite different from those of Western countries.

Contact 경계조건을 이용한 CIB 패키지의 휨 수치모사

이상혁,김선경,박세훈,강남기 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

In this work, we have analyzed the warpage of em packages after processing. Geometric complexity is the main bottleneck in package simulation. Moreover, each layer has been modeled separately and then assembled together by the use of the contact boundary conditions between layers. Thus, modeling with full consideration of temperature-dependent properties and thermal cure is possible by nonlinear simulation with cure model but infeasible in terms of cost-effectiveness. Therefore, we have proposed to use the pseudo processing temperature (PPT) where the stress is free throughout the entire domain. As a result, warpage of CIB packages can be accurately simulated with a linear solver thanks to the use of PPT.

매립폐기물의 혐기성분해에 소각재가 미치는 영향에 관한 연구

이남훈,송선호 안양대학교 산업기술연구소 2004 自然科學硏究 Vol.11 No.1

본 연구는 소각재가 매립폐기물의 혐기성 분해과정에 미치는 영향을 생분해성도 평가방법인 BMP(Biochemical Methane Potential) test를 이용하여 정량적으로 평가하였다. 폐기물의 생분해도 실험은 음식물류, 종이류, 섬유류, 목초류에 대해 실용량 303mL의 serum bottle을 사용하여 각각 실시하였으며, 실험은 총 60일간 실시하였다. 이때 소각재 혼합매립으로 인한 강알카리성 환경에서 매립폐기물의 미생물분해에 미치는 영향을 평가하기 위한 pH 조정방법은 각각의 폐기물 시료와 식종슬러지, 영양배지를 주입한 serum bottle에 직접 소각재를 주입하면서 pH를 4단계(7.0, 7.5, 8.0, 8.5)로 조절하여 소각재 혼합매립된 매립지의 침출수의 pH 범위를 모사하였다. 실험결과 생분해도는 소각재 함유량이 많을수록 pH가 높아져 혐기성미생물 활동에 저해요소로 작용하여 분해에 소요되는 시간이 길어지는 것으로 나타났다. 아울러 pH가 높아짐에 따라 폐기물로부터 메탄발생량은 감소하였는데, 이는 소각재 함유량이 많을수록 미생물활동을 저해하여 메탄발생량은 감소하는 것으로 평가되었다. 따라서 매립폐기물이 생분해과정에서 최종메탄수율과 발생속도상수 모두 pH와 높은 상관관계를 보이고 있음이 입증되었다. This study was conducted to evaluate the biological effect of bottom ash on the anaerobic biodegradation in the MSW landfill site using the BMP(Biochemical Methane Potential) assays. typically used to assess anaerobic biodegradability of liquid wastes with added nutrients and bacteria. BMP assays using a serum bottle of 303mL were performed for food, paper, textile and wood wastes respectively. In order to simulate the same pH value of leachate from the MSW landfill site, 4 kinds of pH value (7.0, 7.5, 8.0 and 8.5) were adjusted putting bottom ash from a MSW incineration facility into serum bottles. The results of this study suggest that, as pH is getting higher with increasing in the content of bottom ash in the MSW, the lag-phase period of biodegradation for every waste were growing longer, and the methane yield decreased. It is considered that the effect of bottom ash varying alkalinity of leachate on the microbial activity appeared sensitively. Finally, it was found that, in the biodegradation process of landfilled wastes, both ultimate methane yield and kinetic were dependent upon pH of leachate.

40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

폐기물매립지로 인한 지가하락 피해액 산정방법에 관한 연구

이남훈 안양대학교 산업기술연구소 2001 自然科學硏究 Vol.8 No.-

폐기물매립지는 악취와 소음, 분진 등과 같은 공해에 의한 직접적인 피해보다는 이를 매개로 한 재산과 정신적인 피해가 더욱 크다는 특징이 있다. 또한 피해를 주장하는 권역이 실제보다 광범위하고 명확한 경계가 없으며 행정구역과도 일치하지 않는다. 따라서 폐기물매립지가 환경적으로 안전하더라도 기존의 부정적인 인식으로 인해 폐기물매립지가 입지하는 것만으로도 충분히 주변지역의 토지나 주택, 생산 농산물 등의 상품가치를 하락시키게 된다. 또한 폐기물매립지로부터 발생된 침출수나 악취, 분진 등으로 인해 주변 지하수와 토양을 오염시키거나 생활환경을 악화시켜 인체와 재산상에 직접적인 피해를 주게 된다. 그리고 나아가 주변 지가하락 등의 피해를 주게되어 환경분쟁의 소지가 되는 경우가 많이 있다. 따라서 본 연구에서는 폐기물매립지로 인한 지가하락에 대한 환경분쟁 발생 가능성에 대해 단순히 매립지의 입지로 인해 발생하는 경우와 매립지로 인해 지하수나 토양이 오염되었을 경우를 가정하여 각각의 지가하락 판단기준을 설정하고 피해액 산정기준을 검토하였다. Solid waste landfill site has the characteristics of having not only for the individual property but also the larger damage in mental aspect due to the fact that the landfill site is in existence more so than the direct damages by the pollution such as odor, noise, dust and others. In fact, even if the solid waste landfill site is environmentally safe, the values of land, residential property, agricultural product and others are declined only by the fact that the solid waste landfill site is there. This is attributable to the existing negative images on such a site. Also, the direct damages on human body and property are incurred by contaminating the groundwater and soil or worsening the surrounding living environment caused by the leachate, odor, dust and others from the solid waste landfill site. Furthermore, the damage is still incurred due to the decline in the land price in the area to become the source of environmental disputes. The study is focused on the possibility of having a dispute on environmental issues on the land price decline due to the solid waste landfill site. It assumes the case of having damages by the location of landfill site and the case of contamination done unto the groundwater or soil in a way to set the standard for land price decline and suggest the determination method of the sum of damages.