정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

가새배치에 따른 고층건물의 변위에 관한 연구

최영화,임헌욱 대구대학교 산업기술연구소 2014 産業技術硏究 Vol.25 No.1

Mordern structures tend to be high-rise buildings because of the population growth, restraint of lands and the high value of lands. In aspect to the control of lateral displacement, the importance of wind load and seismic load is also increasing to get the resistance against lateral load. The purpose of this study is to analyze the base building and 12-case models according to the bracing arrangement, the relative stiffness ratio of column and girder, the number of floor and the bracing section area by using MIDAS/GENw computer program. The results are as followings ; 1. Case 2 is effective in the vertical bracing arrangement. 2. Case 6 is effectual in the group bracing arrangement. 3. Case 8 and 10 are efficient in the diagonal and the horizontal bracing arrangements, respectively. 4. Case 8 among the diagonal bracing arrangements shows the smallest displacement value in all 12 cases, compared with the base building by decreasing as much as 48%.

혈액 투석 환자에서 중심정맥 협착에 대한 스텐트 삽입술 : Wallstent Placement

임대승,노상필,이유선,정승현,김보영,이정우,강정아,김정희,이민수,정준용,최시완,정진옥,성인환,이강욱,신영태 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

Stenosis of central vein is a common complication arising after percutaneous subclavian vein catheter insertion performed for temporary vascular access in chronic renal failure patients undergoing hemodialysis. There are several treatment methods for the condition like percutaneous angioplasty(PTA), stent insertion, and surgery, but recent trend is toward PTA and stents. Among the patients diagnosed with chronic renal failure from March 1993 to May 2002 and undergoing hemodialysis through AV fistula, the 14 Patients in whom central vein stenosis arose were selected for the study. A total of 28 percutaneous interventions(5 PTA and 23 stent placement) were performed, and restenosis rate and the time taken till the restenosis in de novo lesions and instant lesions were compared. All 28 cases were operated successfully. The 14 cases that received both anigioplasty and stent placement initially. (de novo lesion : 14 cases), Among the 10 cases with de novo lesion that followed up more than 1 year, 3 cases are currently undergoing hemodialysis without restenosis, and the remaining 7 cases have recurred stenosis with the mean time to restenosis of 10.9 months. In the 7 cases in whom stenosis recurred, 11 interventions were done(instent lesion: 11 cases). 4 of these were using only ballon angioplasty with 100% restenosis rate and the mean time of 3 months until restenosis. The remaining 7 cases were using both balloon angioplasty and stent placement, also with 100% restenosis rate but with the mean time of 12 months until restenosis, which was later than the group receiving only balloon angioplasty. In treating the patients with central vein stenosis, stent placement seems to be more advantageous over PTA in terms of restenosis rate and the mean duration of patency. In the case of instent lesion, inserting the stent for the second time after stenosis recurred lengthened the duration of patency compared to performing balloon angioplasty alone.

승모판협착증환자에서의 운동능력 및 운동 후 회복능력 : 경피적풍선판막성형술과 운동치료가 이에 미치는 영향

임희영,이철환,박성욱,김재중,송재관,홍명기,진영수,박승정 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.4

흡연자와 비흡연자의 타액에서 코티닌 정량 및 ETS 노출량 평가

임흥빈,강영국,손형옥,이영구,문자영,이동욱 충북대학교 엽연초연구소 2001 煙草硏究 Vol.18 No.-

This study was conducted to measure and compare the salivary cotinine concentration between smokers and nonsmokers, and to investigate the effect on the exposure to environmental tobacco smoke(ETS) with housewives, living on an apartment of Korea. Saliva samples were taken from all volunteers and salivary cotinine was analyzed by a developed radioimmunoassay(RIA) method. The median salivary cotinine levels were 52.8±12.6 ng/ml and 44.6± 9.7 ng/ml in male smokers and in female ones, respectively, and they were 4.3±2.1 ng/ml and 2.9±3.1 ng/ml in male nonsmokers and in female ones, respectively. In addition, average salivary cotinine levels were 3.8±2.7 ng/ml in housewives from smoking homes and 2.4±2.4ng/ml in ones from nonsmoking homes. Results obtained from the analysis of salivary cotinine demonstrate that smokers had a significantly higher concentration of salivary cotinine than nonsmoker. But, there was no significant difference in the salivary cotinine concentration for housewives living in apartment between with smoking husband and with nonsmoking husband.

지역사회에서 형성된 사회적 지지와 근로자의 사회심리적 스트레스간의 관련성

임화영,김형수,최영환,장성훈,이건세,정최경희,오원기,최재욱,정춘화 대한산업의학회 2006 대한직업환경의학회지 Vol.18 No.4

Objective: This study was performed to examine the relationship between community-based social support and psychosocial distress in workers. Methods: The study subjects were 596 workers recruited from 11 companies in Chungju city. A structured questionnaire was used to assess sociodemographics, health-related behaviors, job characteristics, job stress, work-based social support, community-based social support and level of psychosocial distress. Results: Hierarchical multiple regression analysis showed that workers with no chronic disease, exercise and sufficient sleep had a higher score of psychosocial distress than those with chronic disease, no exercise, and not enough sleep. Coworker's work-based social support and community-based social support were negatively associated with psychosocial distress. The R square value of total independent variables on psychosocial distress was 0.409, and that of community-based social support on psychosocial distress was 0.052. Conclusion: This study showed that community-based social support served as a protective factor against psychosocial distress in some workers. We recommend the establishment of a worksite stress reduction program in occupational level as well as community-based social support.

생쥐 피부손상 후 재생 시 세포사이물질의 세포내 출현에 대한 면역전자현미경적 연구

임형수,송영주,김용욱,이세정,황덕호 대한해부학회 2003 Anatomy & Cell Biology Vol.36 No.6

1999년에 발생한 기상재해 유형별 벼 수량반응조사 연구

주영철,임갑준,한상욱,박중수,조영철,김순재 한국농림기상학회 2000 한국농림기상학회지 Vol.2 No.1

The objectives of this study were to investigate weather conditions which induced discolored grains and viviparous germination, and to evaluate yield responses following viviparous germination during mid- and late- ripening stage, the submergence during reproductive growth stage, and lodging in the yellow ripe stage. Weather conditions which caused glume discoloration at heading stage were 21.3-26.4℃ in average temperature, 75.2-98.4% in relative humidity, 19.3 in transpiration coefficient and 10.8-13.8 m/sec. in wind speed. Yield reduction was 26-27% and 10∼17%, respectively, when the glume discoloration rates were 63.2-65.7% and 38.3-45.2%, obviously due to the decrease in percent of fertile grain and ripening ratio. Weather conditions during continuous rain for 7 days were 96% in relative humidity, 18.9℃ in average temperature, 21.9℃ in maximum temperature, and 16.8℃ in minimum temperature, causing the most viviparous germination in Juanbyeo(45.5%), followed by Jinbubyeo(14.5%), Bongkwangbyeo(14.2%), and Obongbyeo(12.6%). Lateral tillers started to occur when the submergence at the depth of 1.5-2 m lasted one day during the reproductive growth stage. The submergence for 2-3 days at 3-4 m of water depth induced 269-571 lateral tillers/㎡, supporting 32-52% of the total yield. The rice yield in the paddy fields which were left under the lodging conditions until harvesting was not different compared to that of the paddy fields which were kept upright by tieing them together after lodging, but perfect grain ratio decreased about 9.1% in the transplanting culture and 12.5% in the direct seeding culture on dry paddy field because of the increase in immature grains.

배양한 NG-108 세포에서 Haloperidol에 의한 c-fos mRNA의 발현

이제욱,채영규,임은정,양병환,조연규 漢陽大學校 精神健康硏究 2000 精神健康硏究 Vol.19 No.-

포스트-텐션 프리캐스트 외부 넓은 보-기둥 접합부의 비탄성 거동

박상욱,최윤철,김영찬,김대중,임재형,권기혁,문정호,이리형 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

Experimental results from the cycle lateral load tests for post-tensioned precast wide beam-column connections were presented. Six exterior beam-column assemblages of half scale were tested in the laboratory. The specimens consist of U-shaped precast wide beams and concrete columns. The continuity at the beam-column joint is achieved with the topping concrete and post-tensioning. The specimens were designed with parameters of the beam-to-column depth ration and the number of tendons within column core. The test results showed that the post-tensioned precast wide beam-column connection satisfied the provisional standard by ACI of acceptance criteria for concrete special moment frames.