Scanning Electron Microscopic Study of the Rat Lung induced by the Paraquat Poisoning

Kim, Moo-Kang,Hirohata, Yasuhisa,Kaoru, Aihara,Ghazizadeh, M.,Lee, Young-Ho,Shin, Tae-Kyun 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.2

제초제로 널리 사용되고 있는 paraquat를 25g정도 체중의 rat 복강내로 20㎎/㎏되게 생리 식염수로 희석하여 주입한 후 시간이 경과함에 따라 폐에서 일어나는 형태학적 변화를 주사전자현미경을 이용하여 관찰한 결과 주입 후 30분부터 전반적으로 폐조직이 불규칙하게 되는 형태학적 변화가 있었으며 1시간후에는 폐포내에 적혈구가 출현하였고 시간이 경과함에 따라 폐조직의 변화가 더 심하였으며 그 주된 변화는 제1형 세포의 감소, 출혈, 섬유성 물질의 증가, 대식세포수의 증가등에 기인하는 섬유성 변화와 폐포간 중격의 증가 그리고 폐포의 폐쇄등이었다.

자발성 뇌실질내 출혈과 간기능 장애의 상관관계에 대한 임상 연구

고현송 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

A study of hemostatic systems was made in 61 patients with ICH. To compare ICH with other neulological disease, data from 76 patients with subarachnoid hemorrhage(SAH) and 49 other with brain tumor were reviewed. The purpose of this study was to investigate the relationship between liver dysfunction and spontaneous intracerebral hemorrhage(ICH) from the hemostatic standpoint, At admission, the medical histories of the patients, including information about previous alcohol consumption and smoking, was taken, and retrospective study of the hemostatic parameters : RBC, WBC, platelet count, prothrombin time, activated partial thromboplastin time, bleeding time, and lever function test were performed. The incidence of liver dysfunction and alcohol consumption in patients with ICH was significantly higher than in patients with SAH and those with brain tumor. Hematoma volume, mortality rate, and past alcohol consumption in patients with ICH significantly worsening severity of liver dysfunction. Although almost all hemostatic parameters became worse with increasing severity of liver dysfunction. In conclusion, liver dysfunction associated with alcohol consumption appears to be an important factor in the deterioration of the clinical status of patients with ICH and may be one of may be partially responsible for these abverse effects of liver dysfunction on ICH , it seems probable that nonhemostatic mechanisms are attributed to the effects.

침전극의 종류에 따른 운동단위활동전위의 정량적 비교

윤승호,손민균 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

Motor unit action potentials(MUAPs) were recorded from the biceps brachii and first dorsal interosseous muscles to identify the electrode effect on the properties of MUAPs between concentric and monopolar electrode in 25 healthy adults. The parameters of MUAPs such as amplitude, area, spike amplitude and number of phases recorded with monopolar electrode were larger than those recorded with concentric needle, but in contrast there were no significant difference on mean MUAP duration between two electrode types in both muscles. The most common shape of MUAPs were triphasic in both electrode recordings and the incidence of polyphasic and polyturn MUAPs were higher in monolar recordings than concentric. The rise time was inverse relationship with the amplitude, and number of phases and turns. And in general there were significant correlation between the duration, the amplitude, the area, the spike amplitude and area, the number of phases and turns. Therefor different reference values must be used in analyzing the MUAP recorded by concentric and monopolar electrodes.

혈우병 환자에 동반된 자발성 후복막강 출혈

김광일,김동호,우상민,이석주,김홍성,조인성,윤환중,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

Spontaneous retroperitoneal hemorrhage due to hemophilia A with impaired coagulopathy is very rare. Spontaneous retroperitoneal hemorrhage has been recorded as having originated from many retroperitoneal organs and blood vessels, and it may be due to local and/or systemic factors. In the majority of the patients, kidney and adrenal gland were the major site of hemorrhage. The systemic causes of spontaneous retroperitoneal hemorrhage are anticoagulation therapy and chronic hemodialysis. During the course of these treatments, hemorrhagic complications may occur at many site, including the retroperitoneal space. Blood dyscrasias including leukemia, polycythemia, sickle cell trait and hemophilia have been reported associated with spontaneous retroperitoneal hemorrhage. We report a case of spontaneous retroperitoneal hemorrhage occurred in a gemophilia A patient with brief review of literature

구순열과 구개열환자의 특성에 관한 분석

나후자,양은진,김선,김수일,김원식 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

The cleft lip and cleft palate has relatively high incidence among congenital anomalies. The etiological factors of these anomalies have been studied widely, but they are not yet understood perfectly. So, the authors reviewed and analyzed retrospectively 505 cases of cleft lip and cleft palate patients who were treated at the Chungnam Uiversity Hospital during the past 12 years from January 1985 to December 1996 for evaluation of etiological factors of cleft lip and palate, and the results were as follows : 1. The male was affected 1.6 times more frequently in cleft lip with palate, but the female was affected 1.8 time more frequently in cleft palate alone. 2. The incomplete cleft lip was 1.7 times higher than complete type and the ratio of left, right and bilateral was 2.1 : 1 : 0.3, and complete cleft lip with palate was 4 times higher than incomplete type and the ratio of left, right and bilateral was 1.2 : 1 : 0.9. 3. The incomplete cleft palate was 6.6 times higher than complete cleft palate. 4. There was positive family history in 11.8% of all the patients. 5. There was combined congenital anomalies with cleft lip and palate in 18.8% of all patients, and the most frequently involved anomaly was the ear anomaly. 6. U.R.I was the most frequently involved disease and herb medicine was the most frequently administered drug during the frist trimester. 7. In educational level of parents, senior high school was 66.5% of all.

정신 분열증 환자의 말초혈액림프구에서 BrdU에 의해 유도되는 Fragile Sites

박경란 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

The expression frequency of BrdU-induced fragile sites was examined in schizophrenia patients to determine whether this parameter could be used as a marker of genetic susceptibility in at-risk individuals. No difference was found in expression frequency between the schizophrenia patients and a group of normal individuals. This indicates that the expression frequency of bromodeoxyuridine induced fragile sites is not a suitable marker for assessing genetic susceptibility in schizophrenia.

Seltzer Model에서 인삼과 morphine의 공동투여가 통각행동에 미치는 영향

홍선미,강영님,김광진 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

The aim of this study was to compare the effects of the ginseng total saponin(100㎎/㎏, i.p., GTS), morphine(3㎎/㎏, i.v.) and the co-administration of the GTS and morphine at same time after the unilateral tight ligation of about half of the sciatic nerve in rats. This tight ligation evoked a markedly different responses of the neuropathic pain in both injured left sides and non-injured right side, which is representing the mirror effect in spite of the time courses of the various stimili; mechanical, chemical and cold, but exception of spontaneous. The maximal responses of each stimulus showed neuropathic pain evoked at the seventh day, and the values of the response were used as a indicater of the nerve injury group for drugs; GTS alone, morphine alone, and the co-administration of GTS and morphine at same time. The effect of the GTS was continued for approximate 48 hours and morphine for 2 hours, respectively. The co-administration of the GTS and morphine at same time, however, showed the no considerable antinociceptive effect at first injection, but the consideralble difference after injection of 24 hours of 48 hours. And also these responses showed the mirror-like response after the drug treatments. These results suggest that partially tight ligation evoked the neuropathic pain in the various stimuli showing the mirror-like effect, and the actions between GTS and morphine has the antagonistic relationship with each other, and the action mechanism is partly involved the non-opioid and opioid mechanisms.

갑상선 유두상 암종과 유두상 증식에 대한 S-100 단백 및 EMA 발현에 대한 연구

강대영,김경희,최정목,송규상,강동욱 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

The diagnosis of papillary carcinoma of the thyroid is readily achieved based on a defined aggregate of histopathologic features. A papillary architecture is an imporant but not pivotal component of the diagnosis. The classic nuclear features are the essential diagnostic element. However, both papillary architecture and nuclear features may be encountered in other conditions and produce problems in histopahologic interpretation. A papillary architecture may be found within a follicular or an oncocytic neoplasm of within the nodules of hyperplastic nodular goiter. Moreover, there may be scattered cells within several thyroid lesions that display some of the nuclear characteristics of papillary carcinoma. The distinction of these lesions from papillary carcinoma is important for differential diagnosis. Thus, the availability of supportive diagnosic evidence would be helpful. Immunoreactivity for S-100 and epithelial membrace antigen was investigated in 16 papillary thyroid carcinomas(PTC), including three examples of the follicular variant, 16 cases of papillary hyperplasis, 8 follicular adenomas, and 6 follicular carcinomas. The degree of reaction was rated on a four point scale: +++, most cells(>51%) have positive staining; ++, 11-50% of cells have positive staining; +, less than 10% of cells have positive staining; -, no positive staining is present. The results are summarized as follows: 1) All the papillary carcinomas showed intense nuclear and cytoplasmic expression of S-100 (+++; 7 cases, ++; 9 cases), and EMA was expressed(++; 7 cases, ++; 6 cases, +; 3 cases). 2) In the cases of papillary hperplasia, papillary foci were generally negative for S-100 and EMA(12/16 ; -). In some areas, they were focal, of weak intensity, and showed preferential apical cytoplasmic location of oncocytic change. 3) Four of eight follicular adenomas expressed S-100(++;2 cases, +; 2 cases), whereas four were completely negative. EMA was also expressed(++; 2 cases, +; 3 cases). 4) Follicular carcinoma showed variable expression of S100 and EMA Five of six follicular carcinomas expressed S-100(++; 2 cases, +; 3 cases), whereas one was negative. EMA was also expressed(++; 2 cases, +; 1 case). In conclusion, in the distinction of papilary carcinoma from papillary hyperplasia, we would recommend an initial histological appraisal, with immunohistochemical staining of S100 and EMA in difficult cases.

내과병동에 입원한 환자를 돌보는 가족의 부담감, 정신건강 및 사회적 지지의 관계

박영희,오경옥 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

The purpose of the study was to investigate the relationship between the burden, mental health and social support of family caregivers having of internally ill inpatients. The sample for the study consisted of 169 family caregivers of internally ill inpatients at 'C' University Hospital in Taejon. The data were collected for about 4 months from August 20, 1995 to December 30, 1995. The instruments used for the study were: (a) the Burden Scale developed by Zarit et al. and modified by Seo and Oh; (b) the SCL-90 to measure mental health; and (c) the Social Support Questionnaire translated from Brandt and Weinert's PRQⅡ. In this study, Cronbach's a coefficients were 0.90 for the Burden Scale, 0.89 for the SCL-90, The findings were as follows: 1. Family caregiver's relationship with patients(p< .001), financial responsibility (p< .001), duration of caregiving (p< .001), religion (p< .01), having other disease of not(p< .01), age(p< .05), marital status(p< .05), patient's disease duration(p< .001)m prognoses of disease(p< .01), and number of admission(p< .01) were indicated as significant factors on burden. 2. Family caregiver's financial responsibility(p< .001), shift(p< .01), relationship with patients(p< .05), monthly income(p< .05), having other disease of not(p< .05), duration of caregiving(p<. 05), patients' disease duration(p< .001), number of admission(p< .001), marital status(p< .05), and experience of admission(p< .05) had significant impact on mental health. Family caregiver's marital status(p< .05), patient's marital status(p< .050 and disease duration (p< .05) had significant impact on social support. 4. Caregiver's mental health had a significant influence on burden(r=0.62, p< .001). In other was associated with more social support(r=-0.20, p< .05). Suggestion : 1. It is necessary to assess problems that family caregivers experience in order to provide effective interventions. 2. This kind of research should be studied in other populations such as family caregivers of chronic and acute ill patients. 3. Researchers should study how to provide more effective and specific social-support to specific family caregivers.

한국인 성인에서 Fm θ의 출현 양상에 관한 연구

도정수,신석철,왕성근 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

The distinctive theta rhythm that appears at the frontal midline during the performance of mental tasks has been designated as frontal midline theta(Fmθ). Author tried to confirm the appearance pattern of Fmθ in Koean young adults, and investigated the relations among the appearance rates of Fmθ, sex, kinds of mental tasks, characteristics of personality trait, impulsiveness, temperament, and anxiety level. The subjects were 42 healthy male and female students(28 male, 14 female) aged 23 to 25(average age 23.9±0.6). The results were summarized as follows. 1. The individual variation of the appearance and appearance rates of Fmθ were large, and the appearance rates of Fmθ under Uchida-Kraepelin test were ranged 28.6~31.0%, and under reaction time were ranged 4.8%~21.4%. 2. The appearance rates of Fmθ tend to increase under continuous mental task than simlpe concentration. 3. There were no sexual difference in the apearance rate of Fmθ. 4. In the aspect of the anxiety level, the appearance rate of Fmθ seems to bo increased when the person's level of anxiety is low, the excitement strength is high, and less impulsive. 5. In the aspect of the personality, the appearance rate of Fmθ seems to be increased when the person's personality is introvert, the excitement strength is high, and the motility of temperament is high.