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        • KCI등재

          한인진(韓茵蔯), 울금(鬱金), 산사(山査), 단삼(丹蔘) 발효복합추출물이 RAW264.7 및 HUVEC 세포에서 나타나는 이상지질혈증 관련 염증인자 발현 및 항산화에 미치는 영향

          이강욱,조현경,유호룡,설인찬,김윤식,Lee,,Kang-wook,Cho,,Hyun-kyoung,Yoo,,Ho-ryong,Seol,,In-chan,Kim,,Yoon-sik 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.4

          Objectives: To investigate the effect of fermented extract of Artemisiae Iwayomogii Herba, Curcumae Longae, Crataegi Fructus and Salviae Miltiorrhizae Radix (FMH) on anti-inflammation associated with dyslipidemia and anti-oxidation in RAW264.7 and HUVEC cells. Methods: The total polyphenols, total flavonoids, DPPH radical scavenging activity, ABTS radical scavenging activity, and cytotoxicity of FMH were measured. RAW264.7 cells treated with FMH were tested for production of NO, and for cytokine and LTB4 levels and HUVEC cells treated with FMH were examined for production of cDNA of genes related to inflammation. Results: 1. FMH contained polyphenols and flavonoids. The DPPH and ABTS radical scavenging activity of FMH increased in a concentration-dependent manner. 2. FMH treatment inhibited the production of nitric oxide (NO), cytokines, and LTB4 in RAW264.7 cell when compared to the untreated control group. 3. FMH decreased the transcription of pro-inflammatory genes, whereas it increased transcription of anti-inflammatory genes, in HUVEC cells. Conclusion: FMH is effective as an antioxidant and for treatment and prevention of dyslipidemia, atherosclerosis, ischemic heart disease, stroke, and other cardiocerebrovascular diseases.

        • KCI등재SCOPUS

          Effects of different types of salts on the growth of lactic acid bacteria and yeasts during kimchi fermentation

          이강욱,심재민,김동욱,Zhuang,Yao,김정아,김현진,김정환 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.2

          Kimchi was prepared with different types of salts: purified salt (PS), solar salt aged for 1 year (SS1), aged for 3 years (SS3), and bamboo salt (BS). Kimchi inoculated with Leuconostoc mesenteroides P30 (starter kimchi), and control kimchi (non-starter kimchi) were prepared, and stored at – 1 °C for 20 weeks. Titratable acidity values increased slowly and reached 0.96– 1.01% (pH 3.73–3.83) at 20 weeks. Proportions of coccustype lactic acid bacteria (LAB) among total LAB were higher in SS kimchi than PS kimchi. Among non-starter kimchi, the proportions were 44.7, 41.6, 29.7, and 32.1% for SS3, SS1, BS, and PS kimchi, respectively, at 2 weeks, and 11.5, 12.8, 6.7, and 5.8%, respectively, at 20 weeks. SS kimchi had much less yeast counts than PS kimchi. Among starter kimchi, yeasts were detected from PS kimchi at 10 weeks but not detected until 18 weeks from SS1 and BS kimchi and 20 weeks from SS3 kimchi.

        • KCI등재

          완전삽입형 인공망막 구현을 위한 인공망막모듈 개발

          이강욱,카이호,요시유키,후쿠시마,타카후미,타나까,테츠,고야나기,미쯔마사,Lee,,Kang-Wook,Kaiho,,Yoshiyuki,Fukushima,,Takafumi,Tanaka,,Tetsu,Koyanagi,,Mitsumasa 대한의용생체공학회 2010 의공학회지 Vol.31 No.4

          To restore visual sensation of blind patients, we have proposed a fully implantable retinal prosthesis comprising an three dimensionally (3D) stacked retinal chip for transforming optical signal to electrical signal, a flexible cable with stimulus electrode array for stimulating retina cells, and coupling coils for power transmission. The 3D stacked retinal chip is consisted of several LSI chips such as photodetector, signal processing circuit, and stimulus current generator. They are vertically stacked and electrically connected using 3D integration technology. Our retinal prosthesis has a small size and lightweight with high resolution, therefore it could increase the patients` quality of life (QOL). For realizing the fully implantable retinal prosthesis, we developed a retinal prosthesis module comprising a retinal prosthesis chip and a flexible cable with stimulus electrode array for generating optimal stimulus current. In this study, we used a 2D retinal chip as a prototype retinal prosthesis chip. We fabricated the polymide-based flexible cable of $20{\mu}m$ thickness where 16 channels Pt stimulus electrode array was formed in the cable. Pt electrode has an impedance of $9.9k{\Omega}$ at 400Hz frequency. The retinal prosthesis chip was mounted on the flexible cable by an epoxy and electrically connected by Au wire. The retinal prosthesis chip was cappted by a silicone to pretect from corrosive environments in an eyeball. Then, the fabricated retinal prosthesis module was implanted into an eyeball of a rabbit. We successfully recorded electrically evoked potential (EEP) elicited from the rabbit brain by the current stimulation supplied from the implanted retinal prosthesis module. EEP amplitude was increased linearly with illumination intensity and irradiation time of incident light. The retinal prosthesis chip was well functioned after implanting into the eyeball of the rabbit.

        • KCI등재

          해마경화증 환자의 어지럼증 치험 1례

          이강욱,유주영,이혜윤,조현경,유호룡,설인찬,김윤식 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.6

          Objectives: The aim of this study was to evaluate the effect of Korean medicine on a patient with dizziness due to hippocampal sclerosis. Methods: A 51-year-old woman with dizziness, diagnosed with hippocampal sclerosis, was treated with herbal medication, acupuncture, and moxibustion. Her improvement was evaluated by a balance test, NRS, and the percentage of dizziness severity compared to that on her admission day. Results: Improvement in the balance test result and NRS, and a decrease of percentage of dizziness severity, were observed after treatment with Korean medicine. Conclusions: This study suggests that treatment with Korean medicine may be an effective therapy for dizziness due to hippocampal sclerosis.

        • KCI등재

          전신성 홍반성 루푸스 환자에서 Ga-67-Citrate 스캔의 임상적 의의

          이강욱,노흥규,김성숙,신영태,정민수,이순구 대한내과학회 1994 대한내과학회지 Vol.46 No.3

          Objectives: We studied to evaluate the relationship between disease activity of lupus nephritis and renal uptake of Ga-67 citrate Methods: Nineteen cases of SLE were evaluated to test a relationship between the renal accumulation of Ga-67 citrate and pathological or clinical parameters. Results: 1) On the 19 patients, 12 (63%) patients had lupus nephritis, among them 7 (58%) patients had renal uptake above Grade 3. And 7 (37%) patients without lupus nephritis had renal uptake below Grade 2. 2) The BUN value of the patients with renal uptake above Grade 3 (group B, 44.0±43.6 mg/dl) were higher than that of the patients with renal uptake below Grade 2 (group A, 12.1±5.9 mg/dl) significantly (p$lt;0.01), 3) The systolic blood pressure was 144±35 mmHg in group B and 115±22mmHg in group A, which was significantly different (p$lt;0.01). And the diastolic blood pressure was 88±23mmHg in group E and 74±12 mmHg in group A, which was significantly different (p$lt;0.01). 4) The degree of renal Ga-67 citrate uptake showed inverse correlation with the degree of serum albumin level (r=-0.64, p$lt;0.01) and correlation to the degree of 24-hours urine protein amount (r=0.54, p$lt;0.05). 5) The serum C3 level was 29.0±18.0 mg/dl in group B and 41.2±26.7 mg/dl in group A, which was significantly different (p$lt;0.01). The serum C4 level was 8.7±3.2 mg/dl in group B and 23.9±16.3mg/dl in group A, which was significantly different (p$lt;0.05). 6) Renal disease activity was 7.3±1.5 in group B and 2.3±1.5 in group A, which was significantly different (p$lt;0.01). 7) In group B, renal biopsy findings were membranous lupus GN in 3 cases, diffuse proliferative lupus GN in 2 cases, and focal and segmental lupus GN in 2 cases. 8) Among the patients with renal uptake above Grade 3, six patients were evaluated after immunosuppressive therapy. Ga-67 citrate were accumulated with the Grade below 2. Serum C3 and albumin values increased and BUN and serum creatinine values were normalized. And renal and extrarenal disease activities were improved, significantly. Conclusion: We could have suggested that Ga-67 citrate scan is useful to diagnose and to estimate the activity of lupus nephritis.

        • 韓牛 卵巢의 生物 統計學値 및 卵巢 疾患에 관한 硏究

          李康郁,李元暢,尹快炳 건국대학교 1972 學術誌 Vol.13 No.1

          Korean native cow 2567 slaughtared in abattoir were investigated fur studying the incidence of ovarian disease and biostatistical value of ovaries. The result obtained in the experiment are summarized as follows : 1) The average length of the ovary; 3.63±0.57cm ... right. 3.41±0.71 cm... left, The average width of the ovary; 2.36±0.49cm ... right. 2.02±0.54cm... left, According to the result the right ovary is bigger then the left. 2) The average waight of the ovary: 6.80±2.05g ... right. 5.40±2.69g ... left. According to the result is that the right ovary is heavier than the left by 1.40g Observation on the correlation between the ovary length and the weight was carried out as follows; r=0.568 ... right ovary. r=0.721 ... left ovary. The result shows that the correlation between two is close. 3) The average diameter of the corpus luteum; 1.15±0.43 cm ... right. 1.17±0.39 cm ... left, The average deep of the corpus luteum 1.34±0.06 ... right. 1.87±0.07 ... left. The result shows that the left is more diameter and deep then the right. 4) The average surface area of the ovary; 11.79±0.24 cm ... right. 11.68±0.25cm ... left. The result shows that the right is more wide then the left. 5) The incedence attributed to the ovarian disease was about 5.36% which includes; 3.11% of follicular cyst, 0.39% of lutein cyst, 1.22% of atrophic ovary and 0.36% agenesis of ovary. 6) Among the incidence, ovarian disease on both side occupied 32.35% whereas 41.9% right side, 25.17% left side, 67.64% was observed on any one side. 7) The average size of cystic ovary was 1.5-2.0 cm in diameter and then followed the size of 3.1-4.0 cm. 8) In 136 case 9, or 2.86%, occurred in cattle from 1 to 3 years outage; 21 or,5.46% in four; 54 or, 10.76% in five; 23 or,7.08% in six; 21 Or, 314 of in 7 to 9; and 2 or, 1.9% occurred over 10 years of age.

        • KCI등재

          Nano-Scale Cu Direct Bonding Technology Using Ultra-High Density, Fine Size Cu Nano-Pillar (CNP) for Exascale 2.5D/3D Integrated System

          이강욱 한국마이크로전자및패키징학회 2016 마이크로전자 및 패키징학회지 Vol.23 No.4

          We propose nano-scale Cu direct bonding technology using ultra-high density Cu nano-pillar (CNP) with for high stacking yield exascale 2.5D/3D integration. We clarified the joining mechanism of nano-scale Cu direct bonding using CNP. Nano-scale Cu pillar easily bond with Cu electrode by re-crystallization of CNP due to the solid phase diffusion and by morphology change of CNP to minimize interfacial energy at relatively lower temperature and pressure compared to conventional micro-scale Cu direct bonding. We confirmed for the first time that 4.3 million electrodes per die are successfully connected in series with the joining yield of 100%. The joining resistance of CNP bundle with 80μm height is around 30 m for each pair of 10μm dia. electrode. Capacitance value of CNP bundle with 3μm length and 80μm height is around 0.6fF. Eye-diagram pattern shows no degradation even at 10Gbps data rate after the lamination of anisotropic conductive film.

        • KCI등재SCOPUS

          The Effect of Choline Acetyltransferase Genotype on Donepezil Treatment Response in Patients with Alzheimer's Disease

          이강욱,이정희,이동영,윤종철,김정란,문석우,김봉조,유승호,김문두,이창욱,장성만,김영훈,김도훈,이혜국,우종인,김기웅,주진형,Nam-Jin,Lee 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.2

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          Objective: We examined the difference in responses to donepezil between carriers and non-carriers of the A allele at the +4 position of the choline acetyltransferase (ChAT) gene in Koreans. Methods: Patients who met the criteria for probable Alzheimer's disease (AD) (n=199) were recruited. Among these, 145 completed the 12-week follow-up evaluation and 135 completed the 26-week scheduled course. Differences and changes in the Korean version of the mini-mental state examination (MMSE-KC) score, Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery (CERAD-K[N]) wordlist subtest score (WSS), CERAD-K(N) total score (TS), and the Korean version of geriatric depression scale (GDS-K) score between baseline and 12 weeks or 26 weeks were assessed by the Student's t-test. Results: At 12 weeks, the changes in the MMSE-KC score, CERAD-K(N) WSS, and CERAD-K(N) TS from baseline were not significant between ChAT A allele carriers and non-carriers; however, at 26 weeks, these changes were significantly larger in ChAT A allele carriers than in non-carriers (p=0.02 for MMSE-KC and p=0.03 for CERAD-K(N) WSS respectively). Conclusion: Our findings in this study suggested that presence of the A allele at the +4 position of ChAT might positively influence the treatment effect of donepezil in the early stages of AD in Koreans.

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