Rheumatoid 關節炎에 對한 物理治療

徐泰壽 대구보건대학 1991 대구보건대학 論文集 Vol.12 No.-

Physical therapy of Rheumatoid arthritis The author analysis 25 applied Rheumatoid arthritis was diagnosed, on the ARA criteria in the out patient clinics of Young-Nam Medical college during the period May, 1987, through Dec, 1988. The results were : 1. There were 21 female patients as compare to 4 male patients, are ratio of almost 5 to 1 2. In age distribution was between 10 and 69 years old. The average age was 40.28 tears old. 3. The joints involved in order of frequency were as follows : knee*22.58%), wrist(14.51%), Ankle(11.29%) 4. The degrees of symptom : mild 36%, moderate 44%, severe 20%, and 24%, progressive form 76%. 5. The result after physical therapy were Normal 28.0%, Good 44.0%, Fair 20.0%, poor 8.0%

甲狀腺 濾胞性 腺腫의 微細形態學的 硏究

서인수,김태룡,손태중 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.1

갑상선의 선종의 미세형태학적 변화를 알아보기 위하여 인체에서 수술로 적출한 갑상선 선종 총87예 중 scintigram살 cold결절로 나타난 선종 12예를 전자현미경으로 관찰하였던 바 그 성적을 요약하면 다음과 같다. 먼저 Bo¨cker 등이 분류한 세포형에 따라 분류하였던 바 주세포형이 5예,mitochondria풍성형이 2예, ergatoplasm풍성형이 3예, 청명세포형이 1예 이었으며 1예는 혼합형이었다. Mitochondria풍성형 세포는 Hu¨rthle세포와 명칭상 혼돈할 수 있으므로 small-lysosome-rich cell로 개칭할 것을 제안한다. 간질에 있는 모세혈관은 fenestration형과 연속형이 혼재해 있으며, fenestration형에서도 fenestration이 감소되는 경향을 보여 주었다. 모든 종양세포는 비록 colloid형이라 할지라도 세포질내의 소기관들이 매우 풍성하여 이는 결절성 비대증과 감별할 수 있는 구별점이 될 수 있다고 생각된다. This study is carried out to investigate the fine structures of follicular adenoma of thyroid. From the 64 cases of surgically excised thyroid adenoma, 12 cases were selected, which presented as cold nodules in scintigram and examined by electron microscope. The result obtained were summarized as follow: The tumors could be classified as 5 cases of main cell type, 2 cases of mitochondria-rich cell type, 2 cases of ergatoplasm-rich cell type, and 1 case of clear cell type on the basis of the criteria suggested by Bo¨cker. Remaining one case was composed of mixed cellular type. It was suggested to change the term for the mitochondria-rich cell to small0lysosome-rich cells, to avoid confustion with Hu¨rthle cell. Capillaries on the interestitium showed mixture of fenestration type and continuous type. And fenestrations were decreased even in fenestretion type capillaries. All the tumor cells had rich cytoplasmic organelles even in colloid adenoma, what could be the clue for differentiation from nodular goiter.

비만 여성을 대상으로 한 해조류 추출물의 국부처치와 운동 병행을 통한 지방분해 효과의 임상적 검정

서태수,이인숙,변재철,김규호,박승한,김유영,김상국,김현정,김상기,신동철,성미영,박종석,김종기,박언휘 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.3

This study was carried out to test the body fat breakdown during topical seaweed extract treatment and in combination with the aerobic exercise. Of 20 female obesity subjects, ten treated a cream types of seaweed extract(control group) and ten treated a placebo cream(placebo group). Topical treatment of each sample was designed for 4 weeks, and treated with 2 times a day about 10ml on the abdomen and the thigh, respectively. All subjects were participated aerobic dance half hour a day and four times a week. After 4 weeks of topical treatment and exercise, they were measured body fat, skinfold thickness, body circumference. Then venous blood samples were taken and analyzed blood cells, serum enzymes, and serum lipids. There were reduction of body weight, % of body fat, antebrachium, brachium, chest, waist, thigh circumference and abdomen thickness between pre and post treatment in both group. Especially, body weight and % of body fat significantly reduced in the subjects treating the seaweed extract than those treating the placebo. There were significant decrement in total cholesterol and LDL whereas increment in HDL and TBIL in the control group, but no significant difference in the placebo group. In conclusion, there were 7.6% of body fat reduction during 4 weeks of aerobic exercise and 21% of body fat reducement in combination of topical seaweed treatment and exercise, respectively. These results suggest that the topical treatment of seaweed extract should be very effective for fat breakdown. Especially, the body fat breakdown maximized in the combination with the topical seaweed extracts treatment and the aerobic exercise.

대변에서 동시에 분리된 vibrio parahaemolyticus와 Vibrio alginolyticus 1예

김지수,박수연,길영철,이희주,서진태 대한임상미샐물학회 2000 Annals of clinical microbiology Vol.3 No.2

Alloxan 유발 당뇨 생쥐에 미치는 Evening Primrose 종자유의 영향

김수조,신인철,서대규 漢陽大學校 環境科學硏究所 1988 環境科學論文集 Vol.9 No.-

근대 사람의 평균 수명이 연장됨에 따라 당뇨병이 증가하는 경향을 보이고 있으며, 또한 당뇨병 소인의 주요인자인 비만증이 점차 증가하는 경향을 보여 당뇨병은 현대의학에 있어서 해결되어야 할 중요한 질병이 되고 있다. 당뇨병은 인슐린 결핍에 의한 혈당상승을 주 증상으로 하며, 지방 및 단백질 대사이상을 수반하여 심한 당원성 ketoacidosis와 혈관 증후군을 초래하는 만성질환으로서 Mering과 Minkowski가 췌장을 절제함으로써 개에서 당뇨병을 발생시켰으며 실험적으로는 인슐린에 대한 항체, alloxan 또는 streptozotocin등에 의하여 당뇨병을 유발시킬 수 있다. Alloxan 투여에 의하여 발생한 실험적 당뇨병의 조직학적 소견으로는 췌장의 Langerhans씨 섬내 β세포의 핵막비후, 과립소실 및 수포성 병변등을 볼 수 있으며 당뇨병의 치료에 대해서는 식이요법, 경구혈당강하요법 및 인슐린 요법이 널리 사용되어 오고 있다. Evening Primrose 종자유는 죽상 경화증, 고지질혈증 및 비만증 등에 효과가 있다고 보고되고 있으나 고혈당증에 대한 효과는 보고된 바 없어서 고혈당증에 대한 효과와 당뇨병성 병변에 대하여 Evening Primrose 종자유가 어떻게 작용하는지를 조직학적으로 규명하기 위하여 실험동물을 정상 대조군, alloxan 처치군, alloxan 처치후 Evening Primrose 종자유 투여군 및 Evening Primrose 종자유 단독 투여군으로 구분, 실험30분, 1,2,4,8,16,32,64,128 및 256시간후에 혈당량을 측정하고 도살하여 적출한 췌장조직의 경검소견을 비교 검토한 결과 Evening Primrose 종자유는 고혈당증을 경감시킬 뿐 아니라 췌장 Langerhans씨 섬 β세포의 제병변을 경감시켰다. Recently, corresponding to the lengthening of our life span, obesity which predisposes a person to diabetes mellitus have gradually been increased as well as the number of diabetics. There fore, diabetes mellitus has become one of the most important problems in modern medical science. The effects of evening primrose seed oil on atherosclerosis, hyperlipidemia and obesity have been reported, but the effect of evening primrose seed oil on hyperglycemia is rarely reported. This study is conducted to evaluate the effect of evening primrose seed oil on hyperglycemia and diabetes mellitus. Mice weighing about 25gm were used for this experiment and observed on the 4 groups, control group, alloxan administered group, alloxan and evening primrose seed oil administered group, and evening primrose seed oil administered group. Alloxan was injected intraperitoneally with normal saline added 100㎎ per ㎏ alloxan to each mouse, and evening primrose seed oil was administered enterally by intubation with 1.5㎖ per ㎏ to each mouse. The pancreas was examined histologically, and blood glucose level in each mouse was measured. The results obtained from this study were as follows: 1. Blood glucose levels were markedly elevated, and the histological changes usually seen in diabetes were noted in the mice treated with alloxan. 2. The elevation of blood glucose levels in mice treated with both alloxan and evening primrose seed oil was statistically lower than that of the alloxan administered group and pathological changes in the former were also milder than those in the latter. 3. No significant changes were noted in both control and evening primrose seed oil administered group. The data obtained from this experiment indicated that evening primrose seed oil reduces diabetic changes as well as lowers abnormally elevated blood glucose levels.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

正常 Rat에서의 蔗糖經口投與에 依한 高血糖症에 미치는 대추나무 葉 抽出物의 影響

고현철,서대규,김병수,강주섭 漢陽大學校 環境科學硏究所 1994 環境科學論文集 Vol.15 No.-

대추나무의 열매는 漢方에서 여러方面에 廣範이 利用되고 있으나 그 잎은 利用되지 않고 있으나 이 잎에는 甘味受容抑制用과 糖의 腸에서의 吸收抑制作用을 가지는 成分이 含有되어 있음이 밝혀져 糖吸收抑制物質로서의 開發의 對象이 될 수 있을 것이다. Insulin??乏等으로 因하여 耐糖能에 異常이 있는 疾患에서는 糖吸收을 抑制함으로 腸管에서의 急擊한 大量의 糖의 吸收를 事前에 防上시켜 Insulin分泌細胞에 대한 負荷를 輕減시켜 줄 수 있는 것임으로 대추나무 葉 抽出物이 糖吸收抑制作用이 있는지를 確認코져 蔗糖負荷動物에서의 血糖値 上昇反應에 미치는 대추나무 葉 抽出物이 作用을 檢討하여 다음과 같은 成績을 얻을 수 있었다. 1. 대추나무 葉 抽出物이 負荷된 蔗糖量의 1/10에 該當되는 比較的 少量에서는 蔗糖負荷에 依한 血糖値上昇作用을 抑制할 수 없었다. 2. 比較的 大量 卽 蔗糖負荷量의 3/10에 該當되는 用量에서는 대추나무 葉 抽出物이 蔗糖負荷에 依한 血糖値上昇을 有意하게 抑制하였다. 以上의 結果로 미루어 보아 대추나무 葉 抽出物은 糖攝取에 의한 血糖値上昇反應을 억제하여 비만과 당뇨병치료에 이용될 수 있을 것으로 사료된다. The fruits of the Ziziphus jujuba have been to use an application in the various ways of chinese medicine and the leaves of this plant have been not to use for this purpose. But, It was pointed out that leaves of the Ziziphus jujuba contain the ingredients of inhibitory action in sweet taste reception of the tongue and intestinal absorption of glucose. Therefore, it is done to developing substance as inhibitory substance of intestinal glucose absorption. The patients with glucose intolerance because of insulin deficiency have a condition of a sudden intestinal glucose absorption. For this reason, the suppression of the sudden glucose absorption alleviate loads of insulin secretion of pancreatic islet cell. In this study, the author have the purpose which confirms the effect of EZJ to intestinal glucose absorption by sugar intake with this substance, that is, levels of blood glucose after sucrose in dose of 6g/kg of body with EZJ in dose of 0.6g/kg of weight were determined to investigate the effect of EZJ on the elevation of blood glucose levels with sugar intake in normal rats. After an overnight fasting, sucrose solution was given orally to the control group. Experimental groups were divided into single EZJ, Triple EZJ, EZJ administered at 2 hours and 1 hours before sucrose and another one with sucrose. Blood glucose levels were determined with Glucoscott at just before and 15, 30, 60, 90 and 120 minutes after sucrose adminstration. The results were as follow : 1. The relative small amounts of EZJ in does of a tenth of sucrose loading dose was not suppressed the elevation of blood glucose levels with oral sugar intake. 2. The relative large amounts of EZJ in does of three tenth of sucrose loading dose was significantly suppressed the elevation of blood glucose levels with oral sugar intake. Presnt results suggest thae EZJ has a suppressive effect on raising blood glucose levels after oral sucrose administration. This fact would be the advantage of EZJ in an application to the therapy or prevention of dabetes mellitus and obesity.

Gymnema산이 췌장도의 Beta-세포에 미치는 영향

강주섭,서대규,김수조 한양대학교 의과대학 1991 한양의대 학술지 Vol.11 No.2

The present study was undertaken to investigate the effect of gymnemic acid(GA) on the ultrastructure as well as cellularity of β-cell in the pancreas of rats(N=12). Also studied was the effect of GA on the serum insulin and blood glucose levels during intravenous glucose tolerance test(IVGTT) in man(N=10). Healty adult male rats(Wistar strain) weighing around 200 gm were divided into the three groups; the control, 500mg-GA, and 800mg-GA groups. GA was administered orally 3 times daily for 14 days. All experimental animals were given food and water ad labitum and were sacrificed at 15th day after the administeration of GA and starved for 24 hours before sacrificing them. The specimens obtained from the pancreatic tissues were fixed in 10% neutral formalin for 18 hours at 4℃. After embedding in paraffin, the specimens were sectioned with microtome to a theckness of 6mm. For observing the cellularity of β-cell in the pancreatic islets, Gomori's stain was performed. For studying the ultradtructural changes in pancreatic β-cell, pancreas specimens of 1m㎥ size were prefixed in 2.0% glutaraldehyde-2.5% parpformaldehyde phosphate buffer solution(pH7.2) and post-fixed in the 1% osmic acid. After specimens were dehydrated and embedded in the Epon 802, sectioned by ultramicrotome(HT-2, Sorvall Porter-Blum, USA) to a thickness of 600Å, and stained with uranyl acetate and lead citrate by double contrast method. And these preparations were observed with electron microscope (Hitachi H-600). In IVGTT with or without oral GA(15mg), the subjects were fasted for 12 hours before glucose loading(20ml of 25% glucose solution). The blood glucose and serum insulin level were determined respectively by Glucoscot GT-4301 and EIA(enzyme immunoassay)-insulin kit "Insulotek Mochida" before and at 30, 60, 90 and 120 minutes after glucose loading. The results obtained were as follows: 1. In GA(500 mg/kg & 800 mg/kg) treated rats, the cellularity of β-cell throught the pancreatic islets were markedly increased. 2. The insulin secretoty granuled with or without dense core increased in the 500mg-GA group, and the similar changes were obtained in the 800mg-GA group. 3. Following glucose loading, blood sugar level of normal subject elevated from 80.7±2.7 mg/dl to 163.2±15.9mg/dl in 60min. On the other hand, blood glucose level increased from 78.0±2.9mg/dl to 152.1±10.7mg/dl in 30 min after simultaneous administration of glucose and GA. 4. In the IVGTT the serum insulin concentration rose from the basal level of 7.1±1.4 mU/ml to 74.8 15.5 mU/ml while it elevated from 7.4±1.4mU/ml to maximal level of 113.9±33.1 mU/ml in the IVGATT with oral GA. Consequently, it is suggested that gymnemic acid has the direct simulatory effects on the insulin production and secretion of the pancreatci β-cell, and therfore it may be useful for the therapy or prevention of diabetes mellitus.

TiO₂ 졸-겔 코팅 막에 의한 Humic Acid의 광분해 : 화학적 산화법에 의한 부식산의 분해처리 기술에 관한 연구(Ⅱ);Characterization of Humic Acid in the Chemical Oxidation Treatment (Ⅱ)

석상일,안복엽,서태수,이동석 江原大學校 附設 環境硏究所 2000 環境硏究 Vol.17 No.-

The degradation of humic acid using TiO₂ coatings studied. TiO₂ coatings were prepared by dip-coating method. Sol solutions for coating were prepared by mixing the gel, which can be produced by the reaction of TiOCl₂ and NH₁OH solution, and hydrogen peroxide solution, and hydrolysis of titanium tetraisopropoxide (TTIP). It was shown from SRD that coatings from sol aged at 100℃ for 18h with titanium peroxo solution were crystallized to anatase in the range of temperatures of 25℃ to 500℃. In contrast, those coated from TTIP were crystallized to anatase at temperature above 400℃. So the sols originated from TiCl₄ can be applied for not only on the heat-resistance substrates but on the plastic substrates. Thickness and the quality of the films were dependent on the withdrawing speed, the concentration of sol, and the number of coating. The films showed various interference colors depending on the thickness of them. In the case that the films coated 2 times at withdrawing speed of 2.5cm per minute by 0.2M sol, the films had a transparent light blue color with thickness of around 50nm. It was known from the result of photo-degradation by TiO₂ coatings using humic acid that the removal efficiency of COD_(cr) was over 85% after illumination of UV/H₂O₂ for 40min, and that of UV/VIS absorbable materials was over 95%. TiO₂코팅매체를 이용한 humid acid의 광분해 특성을 조사하였다. TiO₂코팅은 TiOCl₂ 수용액을 암모니아수로 침전시킨 겔을 과산화수소로 용해한 용액 혹은 졸이나 titanium tetraisopropoxide (TTIP)의 가수분해로부터 제조한 졸을 이용하여 dip-coating법으로 제조하였다. Titanium peroxo 용액을 열처리하여 제조한 졸을 이용한 코팅층은 X-선 회절 분석으로부터 25℃~500℃ 온도 범위에서 모두 anatase형 결정구조를 가지고 있었다. 반면에 TTIP의 가수분해로 생성된 졸로부터 만든 코팅막은 400℃ 이상에서 anatase의 결정형이 나타났다. 이로부터 titanium peroxo 용액을 열처리하여 제조한 졸은 내열성 및 비내열성 기판에도 결정성 TiO₂ 코팅층을 만들 수 있는 장점이 있다. 코팅막의 두께 및 균일성은 인출속도, 코팅졸의 농도 및 코팅 횟수에 영향을 받았으며, 코팅막의 두께에 따라 다양한 간접색상을 나타냈다. 0.2M 졸을 이용하여 인출속도 2.2cm/min로 2회 코팅했을 경우, 약 50nm 두께의 투명하면서도 균일한 흐린 남색을 띠는 TiO₂코팅막을 얻을 수 있었다. 이상의 방법으로 직경 0.3cm의 유리구슬에 TiO₂ 코팅막을 제조한 후 580cm³의 반응조를 사용하여 UV/H₂O₂ 공정으로 humic acid를 40분 동안 광반응시킨 결과, 초기 시료의 COD_(cr)(40ppm)을 약 85% 이상, 흡광물질을 약 95% 이상 제거하였다.

주형을 이용한 실리카 나노구조체 합성

김효중,곽중협,서태수,서동수 한국화학공학회 2002 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.40 No.3

나노미터 직경을 갖는 침상형의 주형(hydroxyapatite)을 이용한 새로운 접근 방법으로 실리카 나노구조체를 졸-겔법을 근간으로 합성하였다. 본 합성법은 나노전구체(실리카 피복 주형) 제조, 나노전구체 소성 및 주형제거 과정으로 구성되어 있다. 나노전구체에 대한 주사 전자현미경(SEM), 투과 전자현미경(TEM), X-선 회절 분석(XRD) 및 광전자 분광 분석(XPS) 결과를 통해 주형 표면에 실리카가 피복되어 있음을 확인할 수 있었다. 또한, 고분해능 XPS 분석에 의해 관찰되는 넓고 비대칭적인 O 1s 스펙트럼의 curve-fitting을 검토한 결과 나노전구체 표면에 여러 종류의 산소가 존재함을 보였다. 또한, 에너지 분산 X-선 분석(EDS)을 통해 나노구조체는 실리콘과 산소로 조성되어 있음을 확인할 수 있었다. 실리카 나노구조체 직경은 대부분 50-200㎚ 정도로 주형의 직경과 동일한 양상을 보였다. 이상의 결과를 통해 본 연구에서 제안한 방법이 나노구조체의 새로운 합성방법으로써 적용 가능함을 확인할 수 있었다. A novel technique for the synthesis of silica nanostructures with needle-like template, hydroxyapatite, having nanometer diameter was investigated in this study. The synthetic method consisted of the following main steps: the preparation of nanoprecursor(silica-coated templates), the calcination of nanoprecursor and the removal of templates. The analysis results of scanning electron microscopy(SEM), transmission electron microscopy(TEM), X-ray diffraction(XRD) and X-ray photo-electron spectroscopy(XPS) for nanoprecursor revealed that silica particles were deposited onto the surface of templates. Further examinations(curve-fitting processing) of the asymmetrical broadening of O 1s peaks in the XPS spectra indicate the presence of multiple oxygen species on the surface. Energy dispersive X-ray spectroscopy(EDS) result confirmed that nanostructures were composed of silicon and oxygen. The diameters of the synthesized nanostructures, mainly in the range of 50-200㎚, correspond to the diameters of the templates. The results confirm that the proposed technique in this study can be utilized as a new method to fabricate the nanostructures.