血量減少後性 "��에 對한 高壓靜注療法.

徐大圭 경북대학교 의학연구소 1966 慶北醫大誌 Vol.7 No.1

食品公害의 醫學的 硏究 : 淸凉飮料 및 드링크劑에 對하여 Ⅰ. Acute Toxicity of Coca-cola, Fanta, Bacchus-D, Bactan-D and Aspara-S in Mice or Rabbits

徐大圭,金重暎 慶北大學校 醫科大學 1975 慶北醫大誌 Vol.16 No.2

食品公害의 醫學的硏究의 一部로서 코카콜라, 환타와 이들과 類似하게 消費되고 있는 박카스-디, 박탄-디, 아스파라-에스의 마우스에 對한 腹腔內注射와 家兎에 對한 腹腔내 注入으로서 惹起되는 急性中毒의 症狀에서 다음과 같이 要約할 수 있을 것이다. 1. 박카스-디, 박탄-디, 아스파라-에스, 코카콜라, 환타를 마우스의 腹腔內注射하면 體重 100gm 當 10㎖, 乃至 15㎖以上 用量에 있어서는 痙攣을 일으키고 死亡하는 수가 있었다. 2. 上記한 淸凉飮料와 드링크劑를 家兎의 腹腔내에 持續的으로 注入했을 境遇에는 모두 用量에 比例하는 血壓下降을 볼 수 있었고 呼吸에도 變動이 많았으며 注入量에 따라서는 死亡할 수도 있었다. 3. 이와 같은 急性中毒의 症狀과 文獻上의 考察에 依한 判斷으로서는 庶民層에 廣範圍하게 利用되고 있는 淸凉飮料와 드링크劑에 對한 急性中毒에 關한 體系的인 檢討가 時急한 것으로 思料되며 詳細한 科學的인 分析에 依한 正確한 資料를 土臺로 이들의 醫學的 營養學的 眞價를 一般 消費者에게 明示하여야 할 社會的인 義務가 있는 것으로 思料된다. As a part of studies on food hazards the acute toxicity induced by intraperitoneal or intravenous injection to mice or rabbits such soft drinks as Coca-cola, Fanta orange and Fanta grape, and drinks as Bacchus-D, Bactan-D and Aspars-S were investigated. 1. Intraperitoneal injection of 1.0 and 1.5㎖.of the drinks per 100gm. of body weight to mice caused convulsions leading to the death. 2. All of the above mentioned drinks were found to lower the blood pressure in proportion to doses when administered intravenously in rabbits. Such application also brought about a marked changes in breathing and killing the rabbits with larger doses. 3. Judging from the resultant acute toxicity and references available it is urgently required to set up a systematic studies on the chronic toxicity caused by such drinks as so popular among the general public. It is also requisite for the community to inform the consumers the true nature of such drinks from medical and nutritional points of view. To support it, accurate information by minute scientific analysis is most desirable.

패랑이꽃(Dianthus Superbus. 瞿麥)의 藥理學的 硏究

徐大圭 慶北大學校 醫科大學 1958 慶北醫大誌 Vol.1 No.1

1. The water-extract of the DIANTHUS SUPERBUS increases the movement of isolated intestine and uterus of the rabbit. The pregnant uterus of rabbit is more susceptible to this extract than the non-pregnant uterus. 2, In living rabbit a marked increase in the uterine movement is observed even when a small amount, which is not sufficient to produce a significant change in the movement of intestine, blood pressure or the rate of respiration, has been administered. This effect is also more marked in the pregnant uterus than the non-pregnant one. 3. The potency of 20mgm of this water-extract of dianthus superbus is equivalent to 0.2mgm of Ergometrine maleate or to 4 units of Posterior Pituitary Injection, U.S.P. 4. This extract possesses the peripheral vaso-constrictor effect. 5. This material inhibits the motility of the cultured unicellular organisms.

不整脈 治療劑의 藥理作用

徐大圭 現代醫學社 1966 現代醫學 Vol.5 No.-

Cholesterol의 合成·吸收沮止劑의 藥理作用

徐大圭 藥業新聞社 1983 (月刊) 醫藥情報 Vol.1983 No.11

狹心症 治療劑의 藥理作用

徐大圭 現代醫學社 1969 現代醫學 Vol.11 No.-

자연관해를 보인 성인 급성 골수성 백혈병 2 예

서대규,신왕식,한길성,황기석,정재근 대한내과학회 1995 대한내과학회지 Vol.49 No.6

The authors report the two cases about spontaneous remission of acute myelogenous leukemia developed after severe infection with brief review of leterature. The one case was that of a 31-year-old female admitted with acute myelogenous leukemia and orbital cellulitis, and the other case was that of a 25-year-old female admitted with acute myelogenous leukemia and pneumonia. In those two cases, we delayed chemotherapy because of severe infection. After that, we nuexpectedly could observe the spontaneous remission of acute leukemia. The two patients respectively had a short duration of remission for 6 weeks and 5 months.

良品公害의 醫學的 硏究 : 淸凉飮料 및 드링크劑에 對하여 Ⅰ. Acute Toxicity of Coca-cola, Fanta,Bacchus-D, Bactan-D and Aspara-S in Mice or Rabbits.

徐大圭,金重暎 慶北大學校 醫科大學 1975 慶北醫大雜誌 Vol.16 No.2

接着劑 및 數種揮發性 物質의 吸入으로 因한 有害作用

徐大圭 漢陽大學校 環境科學硏究所 1985 環境科學論文集 Vol.6 No.-

向精神作用의 效果를 爲해 靑少年層에서 蔓延되고 있는 接着劑 및 揮發性 物質의 吸入으로 招來될 수 있는 組織臟器의 器質的 變化를 觀察하여 이들 物質의 吸入을 規制할 수 있는 對策樹立의 參考資料를 얻고자 mouse에 본드, 세메다인, 揮發油 및 paint thinner를 動物이 死亡할 때까지 持續的으로 또는 1日 2回 5日 및 10日間 間歇的으로 吸入시켜 藥物의 體內에서의 處理에 關與하는 肝臟과 腎臟에 對한 組織學的 變化를 檢索하고 肝機能에 미치는 影響을 檢討하였든 바 다음과 같은 結論을 얻었다. Recently youngsters who deliberately sniff glue and other volatile solvents to alter mental state are increasing in number creating one of the serious socio-medical problems. The present study was undertaken to investigate the adverse effects induced by sniffing of glue, model cement, gasoline, and paint thinner in ICR mice. Sniffing of glue and others were conducted for 5,10 days twice a day to loss of righting reflex, and to expired. All mice were excited initially and followed by a later depressive state in general activity. Time required to loss of righting reflex by sniffing of glue and gasoline were shorter than those of model cement and paint thinner. Blood cell count, either in leukocyte, erythrocyte and the differential count, were decreased in all mice, and the changes of those were more significant in mice for 10 days-sniffing of gasoline. More severe histological changes in liver and kidney were evoked by sniffing of glue and gasoline for 10 days than that of model cement and paint thinner, that for 5 days. In liver, these include cellular swelling, sinusoidal congestion, infiltration of monocyte with karyorrhexis and Karyopyknosis. In kidney, tubular epithelial necrosis and destruction of glomerulus were identified. It can be concluded that the damages by sniffing of glue and gasoline were more serious than those by model cement and paint thinner with increasing frequency of sniffing.

고추(蕃椒)及 마늘(大蒜)이 正常血液中의 Chylomicrons의 出現에 미치는 影響

徐大圭 慶北大學校 醫科大學 1958 慶北醫大誌 Vol.1 No.1

It is well known that many factors are responsible for the absorption of various nutrients in the gastro-intestinal tract. Different spicies are used by different nationalities and races in their daily cooking to suit their taste for foods, although they may not have much of nutritional value. In the current study we tried to investigate certain relationship between some of the spicies used in Korean cooking and the absorption of nutrients from the gut. The red pepper and garlic are probably the most frequently used spicies by Korean. Many reports appeared in the literature regarding the chemical, pharmacological and clinical aspect of these two spicies but as far as we know the exact relationship between these substances and fat absorption has not been reported. Frazer and Steward confirmed the presence of chylomicron in normal serum using dark-ground illumination technique which was called earlier ac "blood dust" by Edmunds, Muller, Gage and Fish. They demonstrated that the number of chylomicron increases and varies at different time intervals after ingestion of fatty meals by using this rather simple method. We used this finding in our study as an objective method to determine the relationship between the rate of fat absorption from the gastro-intestinal tract and ingestion of red pepper and garlic. The Wistar albino rats are used as an experimental animal and olive oil and butter oil are used as fatty meals. These substances as well as red pepper and garlic are introduced directly into the stomach of the animals through French No. 8 catheter. Blood samples are obtained from the tail veins of the rats and examined by the method described by Frazer and Steward. There is a marked rise in the number of chylomicron after a fatty meal and this increase is always amplified and reached the peak in shorter period by the administration of red pepper or garlic. When the red pepper and garlic are administered before the fatty meals the rise is more marked than they are administered after the fatty meals. When these spicies and fatty meals are administered at the same time the rise is intermediate. It is known that the chief pharmacological action of these two spicies is local irritant action. Thus it may be reasonable to assume that the mechanism of changes in the number of chylomicron produced by the ingestion of red pepper and garlic is due to the increased peristaltic movements of the intestine and mucosal vasodilatation which may facilitate the absorption of fats from the gastro-intestinal tract.