추계학술대회 : 일반연제 ; 담마진 및 약진 : 피부묘기증(3) - 급,만성 담마진에서의 출현빈도 -

김수조,유희준,손숙자 대한피부과학회 1987 대한피부과학회 학술발표대회집 Vol.39 No.2

개 난자의 체외성숙중 핵변화

김수조,박성은,이상호 한국동물생명공학회(구 한국동물번식학회) 1993 Reproductive & developmental biology Vol.17 No.3

증식성 모낭종양을 동반한 유전성 모낭종

김수조,천병남,유희준,손숙자,손진희 ( Soo Jo Kim,Byung Nam Chun,Hee Joon Yu,Sook Ja Son,Jin Hee Son ) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.2

We report a case of hereditary trichilemmal cyst with proliferating trichilemmal tumor in a 64-year-oid man, who has generalized 157, variable sized firm cutaneous nodules for 40 years. The cystic nodules are chiefly located on the scalp and trunk which showed characteristic histopathologieal findings of trichilemmal cyst and proliferating trichilemmal tumors. His son also has multiple trichilemmal cysts and his mother seems to have had clinically similar lesions. The patient and his son were treated with surgical excision and therapeutic trial of oral isotretinoin for 2 months. Isotretionoin was ineffective in the patient, but the lesions of his son were decreased in size.

추계학술대회 : 홍반 및 수포성질환 ; 피부묘기증(2) -임산부에서의 출현빈도-

김수조,유희준,손숙자 대한피부과학회 1986 대한피부과학회 학술발표대회집 Vol.38 No.2

Gymnema산이 췌장도의 Beta-세포에 미치는 영향

강주섭,서대규,김수조 한양대학교 의과대학 1991 한양의대 학술지 Vol.11 No.2

The present study was undertaken to investigate the effect of gymnemic acid(GA) on the ultrastructure as well as cellularity of β-cell in the pancreas of rats(N=12). Also studied was the effect of GA on the serum insulin and blood glucose levels during intravenous glucose tolerance test(IVGTT) in man(N=10). Healty adult male rats(Wistar strain) weighing around 200 gm were divided into the three groups; the control, 500mg-GA, and 800mg-GA groups. GA was administered orally 3 times daily for 14 days. All experimental animals were given food and water ad labitum and were sacrificed at 15th day after the administeration of GA and starved for 24 hours before sacrificing them. The specimens obtained from the pancreatic tissues were fixed in 10% neutral formalin for 18 hours at 4℃. After embedding in paraffin, the specimens were sectioned with microtome to a theckness of 6mm. For observing the cellularity of β-cell in the pancreatic islets, Gomori's stain was performed. For studying the ultradtructural changes in pancreatic β-cell, pancreas specimens of 1m㎥ size were prefixed in 2.0% glutaraldehyde-2.5% parpformaldehyde phosphate buffer solution(pH7.2) and post-fixed in the 1% osmic acid. After specimens were dehydrated and embedded in the Epon 802, sectioned by ultramicrotome(HT-2, Sorvall Porter-Blum, USA) to a thickness of 600Å, and stained with uranyl acetate and lead citrate by double contrast method. And these preparations were observed with electron microscope (Hitachi H-600). In IVGTT with or without oral GA(15mg), the subjects were fasted for 12 hours before glucose loading(20ml of 25% glucose solution). The blood glucose and serum insulin level were determined respectively by Glucoscot GT-4301 and EIA(enzyme immunoassay)-insulin kit "Insulotek Mochida" before and at 30, 60, 90 and 120 minutes after glucose loading. The results obtained were as follows: 1. In GA(500 mg/kg & 800 mg/kg) treated rats, the cellularity of β-cell throught the pancreatic islets were markedly increased. 2. The insulin secretoty granuled with or without dense core increased in the 500mg-GA group, and the similar changes were obtained in the 800mg-GA group. 3. Following glucose loading, blood sugar level of normal subject elevated from 80.7±2.7 mg/dl to 163.2±15.9mg/dl in 60min. On the other hand, blood glucose level increased from 78.0±2.9mg/dl to 152.1±10.7mg/dl in 30 min after simultaneous administration of glucose and GA. 4. In the IVGTT the serum insulin concentration rose from the basal level of 7.1±1.4 mU/ml to 74.8 15.5 mU/ml while it elevated from 7.4±1.4mU/ml to maximal level of 113.9±33.1 mU/ml in the IVGATT with oral GA. Consequently, it is suggested that gymnemic acid has the direct simulatory effects on the insulin production and secretion of the pancreatci β-cell, and therfore it may be useful for the therapy or prevention of diabetes mellitus.

피부묘기증 ( II ) - 임산부에서의 출현 빈도 -

김수조(Soo Jo Kim),유희준(Hee Joon Yu),손숙자(Sook Ja Sohn),박인서(In Suh Park) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.2

The prevalence of dermographism in 249 Korean pregnant and puerperal women was studied using a dermographic tester. The result was summarized as follows: 1. The prevslence rate of dermographism was 8.0%(20/249). 2. The prevalence rate of dermographism was not significantly correlated with the stages of pregnancy(p>0.1). 3 There was no significant difference in the prevalence rate of dermographism between the pregnant and puerperal women(8.0%) and the control group of Korean women in the same ages(9.5%) (p>0.1).

Alloxan 유발 당뇨 생쥐에 미치는 Evening Primrose 종자유의 영향

김수조,신인철,서대규 漢陽大學校 環境科學硏究所 1988 環境科學論文集 Vol.9 No.-

근대 사람의 평균 수명이 연장됨에 따라 당뇨병이 증가하는 경향을 보이고 있으며, 또한 당뇨병 소인의 주요인자인 비만증이 점차 증가하는 경향을 보여 당뇨병은 현대의학에 있어서 해결되어야 할 중요한 질병이 되고 있다. 당뇨병은 인슐린 결핍에 의한 혈당상승을 주 증상으로 하며, 지방 및 단백질 대사이상을 수반하여 심한 당원성 ketoacidosis와 혈관 증후군을 초래하는 만성질환으로서 Mering과 Minkowski가 췌장을 절제함으로써 개에서 당뇨병을 발생시켰으며 실험적으로는 인슐린에 대한 항체, alloxan 또는 streptozotocin등에 의하여 당뇨병을 유발시킬 수 있다. Alloxan 투여에 의하여 발생한 실험적 당뇨병의 조직학적 소견으로는 췌장의 Langerhans씨 섬내 β세포의 핵막비후, 과립소실 및 수포성 병변등을 볼 수 있으며 당뇨병의 치료에 대해서는 식이요법, 경구혈당강하요법 및 인슐린 요법이 널리 사용되어 오고 있다. Evening Primrose 종자유는 죽상 경화증, 고지질혈증 및 비만증 등에 효과가 있다고 보고되고 있으나 고혈당증에 대한 효과는 보고된 바 없어서 고혈당증에 대한 효과와 당뇨병성 병변에 대하여 Evening Primrose 종자유가 어떻게 작용하는지를 조직학적으로 규명하기 위하여 실험동물을 정상 대조군, alloxan 처치군, alloxan 처치후 Evening Primrose 종자유 투여군 및 Evening Primrose 종자유 단독 투여군으로 구분, 실험30분, 1,2,4,8,16,32,64,128 및 256시간후에 혈당량을 측정하고 도살하여 적출한 췌장조직의 경검소견을 비교 검토한 결과 Evening Primrose 종자유는 고혈당증을 경감시킬 뿐 아니라 췌장 Langerhans씨 섬 β세포의 제병변을 경감시켰다. Recently, corresponding to the lengthening of our life span, obesity which predisposes a person to diabetes mellitus have gradually been increased as well as the number of diabetics. There fore, diabetes mellitus has become one of the most important problems in modern medical science. The effects of evening primrose seed oil on atherosclerosis, hyperlipidemia and obesity have been reported, but the effect of evening primrose seed oil on hyperglycemia is rarely reported. This study is conducted to evaluate the effect of evening primrose seed oil on hyperglycemia and diabetes mellitus. Mice weighing about 25gm were used for this experiment and observed on the 4 groups, control group, alloxan administered group, alloxan and evening primrose seed oil administered group, and evening primrose seed oil administered group. Alloxan was injected intraperitoneally with normal saline added 100㎎ per ㎏ alloxan to each mouse, and evening primrose seed oil was administered enterally by intubation with 1.5㎖ per ㎏ to each mouse. The pancreas was examined histologically, and blood glucose level in each mouse was measured. The results obtained from this study were as follows: 1. Blood glucose levels were markedly elevated, and the histological changes usually seen in diabetes were noted in the mice treated with alloxan. 2. The elevation of blood glucose levels in mice treated with both alloxan and evening primrose seed oil was statistically lower than that of the alloxan administered group and pathological changes in the former were also milder than those in the latter. 3. No significant changes were noted in both control and evening primrose seed oil administered group. The data obtained from this experiment indicated that evening primrose seed oil reduces diabetic changes as well as lowers abnormally elevated blood glucose levels.

피부묘기증 ( III ) - 급성 · 만성 담마진에서의 피부묘기증 -

김수조(Soo Jo Kim),유희준(Hee Joon Yu),손숙자(Sook Ja Son) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.2

The prevalence of dermographism in 96 patients of acute or chronic urticaria was studied using dermographic tester. The results were summarized as follows : 1. The prevalence rate of dermographism in acute or chronic urticaria was 26.0% (25/96). 2. Dermographism was more common in acute or chronic urticaria than in the general population(p<0.005). 3. There was no significant difference in the prevalence rate of dermographiam between acute and chronic urticaria. 4. The prevalence rate of dermographism was not significantly correlated with the level of serum IgE.

춘계학술대회 : 본 연제 ; 약진 및 과민성 질환 : 과호산구증후군으로 사료되는 1예

서동헌,김수조,유희준,손숙자 대한피부과학회 1986 대한피부과학회 학술발표대회집 Vol.38 No.1

선천성 피부칸디다증 예

유희준,천병남,김수조,손숙자 임상약학사 1992 臨床藥學 Vol.12 No.3