정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

산소유리라디칼이 뇌조직 미크로좀분획의 Na⁺-K⁺-ATPase 활성도에 미치는 영향

오세문(Sae Moon Oh)손영숙(Young Sook Son),최길수(Kil Soo Choi),임정규(Jung Kyoo Lim),정명희(Myung Hee Chung) 대한약리학회 1982 대한약리학잡지 Vol.18 No.2

중추신경계의 혈관폐쇄 또는 충격손상에 의한 허혈병소에서 진행되는 병리적 변화에 산소유리라디칼이 중요한 역할을 할 것으로 시사되고 있다. 저자는 산소유리라디칼이 뇌조직에 미치는 영향 중 특히 신경세포 정지막전위 유지에 중요한 Na⁺-K⁺-ATPase의 활성도에 미치는 영향을 관찰하기 위하여 산틴산화효소 반응계와 뇌조직미크로좀을 이용하여 본 연구를 시행하였다. 미크로좀분획(microsomal fraction)을 산틴과 산틴산화효소와 함께 반응시켰을 때, 분획의 Na⁺-K⁺-ATPase의 활성도는 현저한 불활성화를 보인 반면, Mg⁺⁺-ATPase의 활성도는 별로 영향을 받지 않았다. 이 불활성화는 산틴과 신틴산화효소 중 어느 한 물질이라도 반응계에 존재하지 않는 경우에는 나타나지 않았고, 두 물질이 같이 반응계에 존재할 때 나타났다. 산틴과 산틴산화효소의 반응에서 생성되는 산소유리라디칼들 중, 어떤 것이 Na⁺-K⁺-ATPase불활성화에 관계하고 있는가를 알아보기 위하여, 산수유리라디칼 각각에 대하여 제독작용을 가진 효소나 화학물질을 사용하여 불활성화의 저해유무를 관찰하였다. O^-₂⋅의 제독효소인 superoxide dismutase, H₂O₂의 제독효소인 catalase와 ¹O₂의 제독물질인 1,4-diazabixyclo(2,2,2)octane을 각각 사용하였을 때, 이들 물질들이 농도에 비례하여 Na⁺-K⁺-ATPase의 불활성화가 저해되었다. 그러나 OH⋅의 제독물질인 mannitol은 뚜렷한 효과를 보이지 못했다. 이상의 결과는 산소유리라디칼들 중 O^-₂⋅, H₂O₂ 및 ¹O₂가 Na⁺-K⁺-ATPase의 불활성화에 관계하고 있고, OH⋅는 거의 관계하지 않는다는 것을 시사하여 주었다. 이로 미루어, 산소유리라디칼에 의한 뇌조직 Na⁺-K⁺-ATPase의 불활성화는 뇌 허혈병소에서 관찰되는 신경세로의 기능적 장해를 유발시키는 한 요인으로 사료되었다. The effects of xanthine-xanthine oxidase reaction on brain microsomal Na⁺-K⁺-ATPase activity were studied to see possible involvement of oxygen free radicals in pathologic change occurring in ischemic state of CNS accompanied by cerebral vascular occlusion or impact injury. When microsomal fraction was incubated with xanthine ana xanthine oxidase, Na⁺-K⁺-ATPase activity of the fraction was markedly inactivated (80% inactivation) whereas btssl Mg⁺⁺-ATPase was much less sensitive (less than 10% inactivation) compared to that of Na⁺-K⁺-ATPase. The inactivation was observed only in the presence of both xanthine and xanthine oxidase, not either of them alone, and the extent of inactivation was dependent on the concentration of xanthine. In an attempt to determine which of the oxygen species was responsible for the inactivation, the ability of various scavengers to overcome the inactivation was tested. Superoxide dismutase, catalase and 1,4-diazabicyclo(2,2,2)octane were shown to reverse the inactivation of the ATPase in dose-dependent manner. In contrast, mannitol as well as other OH⋅quenchers were ineffective in limiting oxygen radical-induced inactivation. Thus OO^-₂⋅, H₂O₂ and ¹O₂ were implicated to be mediators involved in the inactivation. Since oxygen radicals are suspected as being a cause of the peroxidative damaging process in train ischemia, the ATPase inactivation by oxygen radicals may be a possible contributing factor which gives rise to functional derangement of nerve cells observed in the pathologic process.

Properties of inverse nonpremixed pure O₂/CH₄ coflow flames in a model combustor

Choi, Sun,Kim, Tae Young,Kim, Hee Kyung,Koo, Jaye,Kim, Jeong Soo,Kwon, Oh Chae Elsevier 2015 ENERGY Vol.93 No.1

<P><B>Abstract</B></P> <P>In order to evaluate the potential of oxy-combustion of inverse nonpremixed coflow flames using a clean fuel to improve the combustion and emission characteristics compared with the normal coflow flames using air, the fundamental properties of inverse nonpremixed pure oxygen (O<SUB>2</SUB>)/methane (CH<SUB>4</SUB>) coflow flames in a model combustor are experimentally investigated. The combustion stability (extinction) limits, structure and nitrogen oxide (NO<SUB>x</SUB>) emissions of the inverse coflow flames in the quartz-windowed combustion chamber with a single shear coaxial injector and a fully opened exhaust nozzle are measured using OH<SUP>∗</SUP> chemiluminescence, a schlieren imaging system and a gas analyzer. Results show four distinct stability regimes and limits: the attached flame regime, the near-blowout flame regime, blowout limits and blowoff limits. The direct flame and OH<SUP>∗</SUP> chemiluminescence images confirm the cooling effects of chamber walls that cause no steady liftoff flame and only the near-blowout flame. The extinction limits of the inverse CH<SUB>4</SUB>/O<SUB>2</SUB> coflow flames are extended compared with the normal CH<SUB>4</SUB>/air coflow flames and reasonable levels of NO<SUB>x</SUB> emissions are observed, which supports that oxy-combustion of the inverse nonpremixed coflow flames using the clean fuel is acceptable for practical application, providing a useful database for modeling the flames in the confined chamber.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Extended stability limits of inverse nonpremixed O<SUB>2</SUB>/CH<SUB>4</SUB> coflow flames are found. </LI> <LI> Stable, attached flames and oscillating, near-blowout flames are observed. </LI> <LI> Direct flame and OH<SUP>∗</SUP> chemiluminescence images indicate no steady liftoff flame. </LI> <LI> Reasonable levels of NO<SUB>x</SUB> emissions are observed. </LI> <LI> Inverse nonpremixed O<SUB>2</SUB>/CH<SUB>4</SUB> coflow flames are acceptable for practical applications. </LI> </UL> </P>

대구지역 거주자의 식생활 습관과 위장질환과의 관계

오미정,김수월,양희면,현재식,허천식,이명화 한국건강관리협회 2000 건협 Report Vol.3 No.-

골수강내 금속정을 이용한 경골 근위간부 골절의 치료 : AO 골절형과 Poller 나사 사용 유무에 따른 분석 Analysis According to AO Classification and the Poller Screw

오창욱,김성중,전인호,경희수,박병철,인주철,김경훈,우연기 대한골절학회 2004 대한골절학회지 Vol.17 No.2

급성 백혈병 환자에서 수두양 피부병변을 보인 파종성 Fusarium 감염 1예와 국내 파종성 Fusarium 감염증에 대한 고찰

오수진,정희선,김준성,김태석,조병식,최수미,김명신,이연수,이석,신완식 대한감염학회 2007 감염과 화학요법 Vol.39 No.5

최근 면역저하환자의 증가와 함에 국내에서도 점차 침습성, 파종성 Fusarium 감염증 보고가 증가하고 있다. Fusarium 감염은 아스페르길루스 감염과 유사한 임상양상을 보이지만 특징적인 피부병변을 동반하고 혈액배양에서 균이 분리되는 경우가 더 많다. 저자들은 급성 림프구성 백혈병으로 진단받고 치료중인 30세 남자 환자에서 중증의 호중구 감소 상태에서 비특이적인 피부병변을 동반한 파종성 Fusarium 혈류감염을 경험하였기에 국내 증례 고찰과 함께 보고하는 바이다. 환자의 초기 피부병변은 구진에서 시작하여 주로 소포성 병변과 일부 통증을 동반한 결절 등 여러 형태로 나타났고, Tzank 도말검사 양성으로 비정형 수두로 오인되었다. 이후 피부병변은 농포로 변하였고, 혈액배양 및 피부 조직검사에서 파종성 Fusarium 감염으로 진단받았다. 환자는 liposomal amphotericin B, voriconazole 병합요법과 G-CSF 투여, 과립구 수혈을 받았으나, 호중구 감소증에서 회복하지 못하고 급성 호흡곤란증후군과 다장기 기능부전으로 사망하였다. 본 증례는 파종성 Fusarium 감염의 경우에도 수두양 병변으로 비특이적인 양상으로 나타날 수 있으므로, 감별진단을 위해 적극적으로 혈액배양과 피부조직검사를 시행해야 함을 보여준다. Recently, we experienced a case of disseminated fusarial blood stream infection with varicelloid skin eruptions, who had suffered from persistent neutropenic fever after salvage chemotherapy for relapsed acute lymphocytic leukemia (ALL). Neutropenia continued in spite of G-CSF and granulocyte transfusion, and he failed to respond to conventional amphotericin B initially, and then liposomal amphotericin B and voriconazole combination therapy. Disseminated fusariosis can be diagnosed by blood cultures in 50% of patients and present skin lesions in more than 80% of patients. So, typical skin lesions are important clue to diagnose of the disseminated fusariosis. However, many skin lesions in immunocompromised hosts are due to various infectious and non-infectious causes. So, this case shows that it is important to obtain biopsy specimens of skin lesions for histopathologic examination, culture and staining. Here, we present our case with the review of the literatures reported in our country, so far.

멸치를 이용한 식품가공용 중간소재의 가공

오광수,노락현,이응호,박희열 國立統營水産專門大學 附設 水産科學硏究所 1989 수산과학연구소보고 Vol.1 No.-

멸치를 보다 효율적으로 이용하기 위한 일련의 연구로서 각종 조리재료나 식품가공용 중간소재로 이용할 수 있는 냉동멸치조미육의 가공조건을 구명하고 본 시제품의 화학성분을 분석하였다. 냉동멸치조미육제품을 가공하기 위하여 채육, 세절한 멸치육에 대해 분리대두단백:물:대두유(1:5:2)로 만든 유화커어드 12.8%, 식염 0.5%, 설탕 2.0%, sodium bicarbonate 0.4%, 중합인산염 0.2%, MSG 0.2%, 분리대두단백 3.05, 양파가루 0.3%, 생강가루 0.1%, 후추가루 0.1% 및 항산화제로서 sodium erythrobate를 0.2% 첨가하여 멸치육 알맹이가 붕괴되지 않도록 혼합한후 -35℃에서 급속동결시켜 carton box로 포장하여 -25±2℃에 동결 저장하는 것이 가장 좋았다. 냉동멸치조미육제품의 수분함량은 73.0%, 조단백질 19.1%, 조지방은 5.0%였으며 생균수는 1.5~1.6x 10^5/g, histamine 함량은 70.6mg/100g이었다. 유화커어드를 첨가함으로써 제품의 지방함량 조정 및 조직감을 개선시킬 수 있었다. 제품의 주요구성 지방산은 linoleic, oleic, palmitic, docosahexaenoic, linolenic, palmitoleic, eicosapentaenoic acid 등으로 고도불포화지방산이 많이 함유되어 있었고, Glu, Asp, Leu, Lys, Als 등이 주요 구성아미노산이었다. 멸치조미육제품의 정미성분은 IMP(160.9mg/100g)와 같은 핵산관련물질 및 Glu(179.4mg/100g), His(85.7mg/100g), Ala(54.4mg/100g), Leu(37.9mg/100g) 등 유리아미노산이 정미성 및 약적으로 보아 주체를 이루고 있었고, 이 외에 total creatinine (158.3mg/100g), 미량의 TMAO, betaine 등으로 이루어져 있었다. Processing conditions and food components of frozen seasoned anchovy meat products were investigated. The separated anchovy meat was chopped, mixed with 12.8% emulsion curd, 0.5% table salt, 2.0% sugar, 0.4% sodium bicarbonate, 0.2% polyphosphate, 0.2% monosodium glutamate, 0.3% onion powder, 0.1% garlic powder, 0.1% ginger powder, 3.0% soybean protein, and 0.2% sodium erythorbate by remodeled stone mortar. This seasoned anchovy meat was frozen with contact freezer, packed in a carton box and then stored at -25±2℃. The major fatty acids of product were linoleic, oleic, palmitic, docosahexaenoic, linolenic, palmitoleic, eicosapentaenoic acid. Amino acid composition of product were mainly consisted of Glu, Asp, Leu, Lys and Ala. The taste compounds of product were IMP 160.0 mg/100g; free amino acids such as Glu, His, Ala, Leu 503.7 mg/100g; total creatinine 158.3 mg/100g and small amounts of betaine, TMAO.

정상교합자의 사춘기 성장과 수완부골 성숙단계, 치아석회화도 및 악골 성장에 관한 연구

오희수,양규호 전남대학교 치과대학 1991 전남치대논문집 Vol.3 No.1

To investigate the relationship between pubertal growth spurt in body height, skeletal maturity stages of the Hand-wrist, tooth calcification stages and maxilla and mandibular growth in normal occlusion, the author took the Hand-Wrist radiograph, lateral cephalogram and panoramic view from 464 subjects(boy 220, girl 244), aged 7 through 17 years, having normal occlusion. Skeletal maturity was assessed on the hand-wrist view by Fishman's SMI method and jaw growth was determined by 3 mandibular linear measurements ; Ar-A, Ar-Pog. Go-Me in the cephalograph. Tooth calcification stage was rated on the panoramic view using the method described by Demirjian in which 8 stages of calcification. Menarche age was investigated and pubertal growth spurt was assessed with longitudinal datas of body height from 7 to 17 years. The results were as follows ; 1. The peak height velocity(PHV) during pubertal growth occurred at the age of 12Y 11M boys, 11Y 4M in girls and 17months earlier in girls than in boys. The period of ONSET to END of the pubertal growth was 5Y 1M in boys, 4Y 5M in girls and longer in boys than in girls. The growth velocity at PHV was 9.7cm/year in boys, 8.7cm/year in girls and greater in boys than in girls. 2. In the skeletal maturity stages of hand-wrist, the pubertal growth spurt appeared between SMI level 4 and 5 in boys and SMI level 6 in girls. The ossification of the ulnar sesamoid bone(SMI level 4) occured 7 months earlier than PHV in boys and about 14 months earlier than PHV in girls. 3. PHV was coincident with G-stage of maxillary and mandibular canine, mandibular first and second premolar, mandibular second molar in boys, and G-stage of maxillary and mandibular canine and F-stage of mandibular second premolar and mandibular second molar in girls. 4. The mean age of menarche was 12Y 11Month and the menarche occurred at 19months after maximum pubertal growth. 5. The correlations coefficients(r) were 0.73 between PHV and skeletal age, 0.72-0.75 between PHV and calcification of the teeth, and 0.82-0.84 between skeletal age and calcification of the teeth. The correlation coefficients were 0.48 between menarche and PHV, and 0.61 between menarche and skeletal age. 6. Peak velocity in maxilla and mandibular growth was coincident with PHV during pubertal growth spurt both boys and girls. Particularly, Ar-Pog growth curve indicating mandibular growth coincident with pubertal growth spurt in body height. The strong correlation between PHV, skeletal age, calcification of the selected teeth and menarch suggest that these indicators might used efficiently in the estimating the level of skeletal development and the planning of orthodontic treatment.

흉요추 방출성 골절의 방사선학적 소견

오연희,이현경,이원재,이성우,박수성 동국대학교 경주대학 1993 東國論集 Vol.12 No.-

A retrospective review of 22 burst fractures of the thoracolumbar spine was performed to define the radiographic features found on CT and plain radiography. Characteristic components of the injury include : 1. Male to female ratio was 2.7 : 1, and the most prevalent age was 21 to 40 years. 2. Multiple level injuries were 6 cases (27.3%), and the most common cause of injury was fall down(14 cases, 63.6%). 3. The most cammon location was L1(45.5%) 4. The most common pattern of the retropulsed fragment in burst fracture was single midline fragment type(14 cases, 63.6%) and the most common type of burst fracture was classical form(10 cases, 45.5%). 5. Posterior element involvement of vertebra was seen in Ⅱ cases(50%) and the most common finding was laminar fracture in 9 cases. 6. The degree of anterior wedging above the 50% in height of vertebral body was in 4 cases (18.2%). 7. Degree of spinal canal narrowing and degree of neurological impairment is not directly correlated.

정상교합자의 사춘기 성장과 수완부골 성숙단계, 치아석회화도 및 악골 성장에 관한 연구

오희수,양규호 大韓小兒齒科學會 1992 大韓小兒齒科學會誌 Vol.19 No.2

To investigate the relationship between pubertal growth spurt in body height, skeletal maturity stage of the Hand-wrist, tooth calcification stages and maxilla and mandibular growth in normal occlusion, the author tootk the Hand-Wrist radigraph, lateral cephalogram and panoramic view from 464 subjects(boy 220, girl 244), aged 7 through 17 years, having normal occlusion. Skeletal maturity was assessed on the hand-wrist view by Fishman's SMI method and jaw growth was determined by 3 mandibular linear measurements : Ar-A, Ar-Pog, Go-Me in the cephalograph. Tooth calcification stage was rated on the panoramic view using the method described by Demirjian in which 8 stage of calcification. Menarche age was investigated and pubertal growth spurt was assessed with longitudinal data of body height from 7 to 17 years. The results were as follows : 1. The peak height velocity(PHV) during pubertal growth occurred at the age of 12Y 11M boys, 11Y 4M in girls and 17 months eariler in girls than in boys. The period of ONSET to END of the pubertal growth was 5Y 1M in boys, 4Y 5M in girls and longer in boys, 8.7㎝/year in girls and greater in boys than in girls. 2. In the skeletal maturity stages of hand-wrist, the pubertal growth spurt appeared between SMI level 4 and 5 in boys and SMI level 6 in girls. The ossification of the ulnar sesamoid bone(SMI level 4) occured 7 months earlier than PHV in boys and about 14 months earlier than PHV in girls. 3. PHV was coincident with G-stage of maxillary and mandibular canine, mandibular first and second premolar, mandibular second molar in boys, and G-stage of maxillary and mandibular canine and F-stage of mandibular second premolar and mandibular second molar in girls. 4. The mean age of menarche was 12Y 11M and the menarche occurred at 19 months after maximum pubertal growth. 5. The correlation coefficients(r) were 0.73 between PHV and skeletal age, 0.72-0.75 between PHV and calcification of the teeth, and 0.82-0.84 between skeletal age and calcification of the teeth. The correlation coefficients were 0.48 between menarche and PHV, and 0.61 between menarche and skeletal age. 6. Peak velocity in maxilla and mandibular growth was coincident with PHV during pubertal growth spurt in both boys and girls. Particularly, Ar-Pog growth curve in dicating mandibular growth was coincident with pubertal growth sput in boys height. The strong correlation between PHV, skeletal age, calcification of the selected teeth and menarch suggest that these indicators might be used efficiently in estimating the level of skeletal development and planning the orthodontic treatment.