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김준성,오유환,심재민,김영훈,황성호 대한자기공명의과학회 2017 Investigative Magnetic Resonance Imaging Vol.21 No.3
Purpose: To optimize the timing of scans using cardiac magnetic resonance contrastenhanced timing robust angiography (CMR-CENTRA) for electroanatomic mapping (EAM) of the right atrium (RA) and left atrium (LA) in patients with atrial fibrillation (AF). Materials and Methods: Fifty patients with AF (38 men; mean age, 59.6 ± 9.3 years) underwent CMR-CENTRA in preparation for EAM. The CMR-CENTRA data were acquired at five different scan times: 0 seconds, 5 seconds, 10 seconds, 15 seconds, and 20 seconds after an intravenous injection of contrast media. To evaluate the degree of contrast enhancement, right atrial relative contrast (RA-RC) and left atrial relative contrast (LA-RC) on the CMR-CENTRA scans were assessed at each time point. The three-dimensional (3D) reconstruction of the RA and LA for the EAM system was performed using the CMR-CENTRA data. Results: A CMR-CENTRA at a scan time of 10 seconds showed significantly greater LA-RC (P < 0.05) compared with all other scan times. A CMR-CENTRA at a scan time of 15 seconds showed significantly greater RA-RC (P < 0.05) compared with all other scan times. In the 3D reconstruction of the RA, the success rates of CMR-CENTRA at scan times of 10 seconds and 15 seconds were 18% and 100%, respectively. In the 3D reconstruction of the LA, the success rates of CMR-CENTRA at 10- and 15-second scan times were 100%. Conclusion: The CMR-CENTRA data acquired at 15 seconds after the injection of contrast media is appropriate for the preparation of an EAM system that is focused on the RA and LA in patients with AF.
김준성,Kyeong Nam Yu,Mi Suk Noh,Min-Ah Woo,Sung-Jin Park,Jin Hong Park,Jin Hua,Hyun Sun Cho,Soon Kyung Hwang,Eun-Sun Lee,Youn-Sun Chung,In-Young Choi,Se-Chang Kwon,조명행 대한수의학회 2008 Journal of Veterinary Science Vol.9 No.1
Interferon (IFN) has therapeutic potential for a wide range of infectious and proliferative disorders. However, the half-life of IFN is too short to have a stable therapeutic effect. To overcome this problem, serum immunoglobulin has been fused to IFN. In this study, the efficacy of serum immunoglobulin fused INFs (si-IFN1 and si-IFN2) was evaluated on athymic mice bearing colon 26 adenocarcinoma cells. Seven days after the implantation of tumor cells, each group of mice was injected once a week with si-IFN1 and si-IFN2 at two different concentrations (10 × : 30 μg/kg and 50 × : 150 μg/kg). A slight anti-tumoral effect was observed in all 10 × groups compared to the control. In the 50 × groups, however, si-IFN1 and si-IFN2 showed significant anti- tumoral effects compared to the control. To gain more information on the mechanisms associated with the decrease of tumor size, a Western blot assay of apoptosis-related molecules was performed. The protein expression of cytochrome c, caspase 9, 6, and 3 were increased by si-IFN1 and si-IFN2. These 2 IFNs also increased the expressions of p53, p21, Bax and Bad. Interestingly, si-IFN1 and si-IFN2 decreased the expression of VEGF-β. Taken together, serum immunoglobulin fused IFNs increased therapeutic efficacy under current experimental condition.
김준성,김병욱,Su Jin Hong,김진일,Ki-Nam Shim,김지현,백광호,Sang Wook Kim,Hyun Joo Song,Ji Hyun Kim 거트앤리버 소화기연관학회협의회 2016 Gut and Liver Vol.10 No.4
Background/Aims: Eradication of Helicobacter pylori infection with standard triple therapy (TT) has declined primarily because of increased antibiotic resistance. Sequential therapy (ST) has been suggested as an alternative to TT for the first-line treatment of H. pylori. The purpose of this study was to compare the efficacy of ST with TT. Methods: This was a multicenter, randomized open-label trial performed at nine centers in Korea. Patients with H. pylori infection were randomly assigned to receive either 7 day TT or 10 day ST. Eradication rates, drug compliance, and adverse events were compared among the two regimens. Results: A total of 601 patients were enrolled between March 2011 and September 2014. The intention-to-treat eradication rates were 70.8% for TT and 82.4% for ST (p=0.001). The corresponding per protocol eradication rates were 76.9% and 88.8% for TT and ST, respectively (p=0.000). There were no statistically significant differences between the two regimens with respect to drug compliance and adverse events. Conclusions: ST achieved better eradication rates than TT as a first-line therapy for H. pylori eradication in Korea.
인과에 대한 확률 이론과 반 사실적 확률 궤적으로 해명된 법적 상당성으로서 인과 책임에 대한 평가 모형
김준성 명지대학교(서울캠퍼스) 인문과학연구소 2016 인문과학연구논총 Vol.37 No.4
In this paper, I formally articulate the concept of causal responsibility as the legal probability, and propose a model founded on the probabilistic theory of individual - level causality that enables us to evaluate causal responsibility in terms of the legal probability. First, I critically examine the theory of legal probability that is the received theory of causal responsibility. Second, I explicate causal responsibility as the legal probability in terms of probability trajectory of the probabilistic theory of individual - level causality. Third, I show how we are able to evaluate causal responsibility, while contrasting factual probability trajectory with counterfactual probability trajectory. Finally, I briefly show that counterfactual probability trajectories are qualified conceptually and practically.