정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

한국 주요정신장애의 유병률 및 관련요인 : 2006 전국정신질환역학조사

조맹제,장성만,함봉진,정인원,배안,이영문,안준호,원승희,손정우,홍진표,배재남,이동우,조성진,박종익,이준영,김진영,전홍진,이해우 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.3

Objectives The aims of this study are to estimate the prevalence of the DSM-IV psychiatric disorders in the Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI), and to compare those with previous studies. Methods The Korean Epidemiologic Catchment Area study Replication (KECA-R) was Conducted between August 2006 and April 2007. The sampling of the subjects was carried out across 12 catchment areas. A multistage, cluster sampling design was adopted. The target Population included all eligible residents aged 181o 64 years. Face-to-face interviews were conducted with the Korean version of Composite International Diagnostic Interview (K-CIDI) based on the DSM-IV (N=6,510, response rate=81.7%). Results A total of 6,510 participants completed the interview. The lifetime and 12-month prevalence rates for all types of DSM-IV disorders were 30.0% and 17.3%, respectively. Those of Specific disorders were as follows : 1) alcohol use disorder, 16.2% and 5.6% ; 2) nicotine use disorder, 9.0% and 6.0% ; 3) specific phobia, 3.8% and 3.4% ; 4) major depressive disorder, 5.6% and 2.5% ; and 5) generalized anxiety disorder, 1.6% and 0.8%. Data relating to nicotine and alcohol use disorder revealed a very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among females than males. Conclusion The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in the distribution of psychiatric disorders across the country and times were observed.

한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

무도 전공 학과별 취업인식 조사 : 용인대학교 무도대학 소속 학과를 중심으로

이병익,강성철,김도준,박준석,김주연 용인대학교 2011 용인대학교 논문집 Vol.29 No.-

The aim of this survey is employment perception of martial arts major students in yongin university. The university education has various objects, one of the most important purpose is opportunities for employment. As time have changed, martial arts major students pointed out that their needs for employment. If universities accept their needs, it can be raise competitiveness of martial arts major departments in the academic world. This research is released its earnings report, the data will have significant meanings for the martial arts major departments sector grappling with traditional understanding. Therefore a realistic employment measure is urgently needed for martial arts major students, because it will need to be tailored to fit into the realities and by the limitations of martial arts major's departments curriculum. The research found the martial arts major students's cognitions on employment planning of individualized department education, employment education management of martial arts major departments and martial arts education system from university to society through questionnaires. From this point of view, this research was based on students who belonging to the college of martial arts(judo, taekwondo, combative martial arts, oriental martial arts, security service) in yongin university.

전류모드방식 적분기의 구조개선을 통한 성능비교

이근호,조성익,방준호,김동용 全北大學校 論文集 Vol.42 No.-

In this paper, a CMOS fully-differential complementary current-mode integrator adequate to design low-voltage, low-power and high frequency application circuit. The designed fully-differential complementary current-mode integrator has a new architecture. When the improved integrator is compared with proposed current-mode integrator, the new integrator has lower power dissipation and higher frequency range. The small signal analysis results are showed in table.1 with several improved characteristics. And the results of PSPICE simulation using ORBIT company's 1.2㎛ CMOS n-well processing parameter shows fig. 3.

운동부하양식에 따른 심폐 능력의 비교분석

전태원,우재홍,신창호,이기봉,이광희,박익렬,박성태,강현주 서울대학교 체육연구소 2000 서울大學校 體育硏究所論集 Vol.21 No.1

The purpose of this study this study was to comparative analysis the V02max and HR through arm ergometer exercise, bicycle ergometer exercise, and treadmill exercise and to propose correct data of aerobic ability according to GXT. Subjects for study were 8 healthy male students. The process of the test were performed maximal GXT on arm ergometer exercise, bicycle ergometer exercise, and treadmill exercise and measured V02max, max heart rate and recovery time of 3 VO2 and heart rate respectively. The conclusions were supported by the findings of this study: 1.There were significant differences between test style and V02/kg/min(p<.05). 2.There were significant differences between test style and test stage at heart rate(p<.05) There were no effect of reciprocal action. Therefore, V02/kg/min should be on individual exercise prescription guiedlines for health promotion should be provided proper GXT which are arm ergometer exercise, bicycle ergometer exercise, and treadmill exercise.

보존적 치료 및 수술적 치료에 의한 상위 경추 골절 및 탈구의 안정성

이준규,안재성,양준영,이장익 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

In general, hangman's fracture, odontoid Type III fractures, and most miscellaneous axis fractures are effectively managed with nonoperative methods (typically, the halo vest with its rigid external immobilization). Halo apparatus is a reliable instrument for the management of cervical spine injury, including that of odontoid fractures and other C1-2 injuries. Surgical fusion is the usual alternative to the halo device. Posterior wiring with or without fusion using autogenous iliac bone graft is probably the most common surgical treatment of cervical spine fracture and dislocation. The purpose of this study was to compare with stability of each others and to estimate the atlanto-dental interval and space for available in patients who were received conservative treatment and operative treatment due to upper cervical spine fracture and/or dislocation. 25 patients who were recieved conservative and operative management due to fracture and/or dislocation of the upper cervical spine (Cl and C2) during 1990. Jan. to 1997. May. were defined as a patient group. 12 patients were received conservative treatment. 13 patients were received operative treatment. In patient group who were received conservative treatment, the average of ADI and SAC was within normal range. In patient group who were received operative treatment, the average of ADI and SAC was within normal range. The patient group with the ADI and SAC of normal range were stable with good bone union at the last follow-up examination. Also the patient group was received fusion as their initial treatment for injuries incurred 1 month to 8 month prior to hospitalization were stable with good bone union.

경부 청소술 후의 승모근기능

박준명,박동식,정광익,이언석,노영수 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.2

콘크리트 지하철 구조물의 비선형 지진응답해석

이종세,최준성,박균익 漢陽大學校 工學技術硏究所 2001 工學技術論文集 Vol.10 No.-

1995년 Hyogoken-Nanbu 지진은 RC 지중 지하철 구조물에 지난 과거 전혀 경험치 못했던 심각한 피해를 일으켰다. 이같은 지진피해의 정확한 평가를 위하여, 주파수영역상에서의 지반-구조물 상호작용효과를 고려한 지하 구조물에 대한 선형지진응답해석이 수행되어왔으나, 보다 정확한 지진피해를 예측하기 위해서는 시간영역상에서 지반과 구조물의 이력감쇠와 강성변화를 고려한 비선형지진응답해석을 수행하는 것이 반드시 필요하다. 본 논문에서는 지반-구조물 상호작용을 고려한 비선형 지진응답해석을 시간영역상에서 수행하기 위하여 주파수영역상에서 지반-구조물 상호작용효과를 고려하기위해 개발된 KIESSI-2D와 유한요소 범용해석프로그램 ANSYS를 연계한 복합법을 사용하여 Hyogoken-Nanbu 지진시 피해가 많았던 고베의 가미사와 지하철역을 대상으로 비선형 지진응답해석을 수행하고 실제 발생한 피해상황과 비교 ·분석하였다. 해석시 등가 선형화기법에 근거한 대표적인 자유장 해석프로그램인 SHAKE를 사용하여 지반의 비선형성을 고려하였고, 콘크리트의 비선형성을 고려하기위해서 Hognestad 모델을 사용하였다. 해석결과 실제 발생한 중간기둥의 전단파괴를 매우 유사하게 예측할 수 있음을 보여주었다. During the 1995 Hyogoken-Nanbu earthquake, underground RC structures experienced significant damages which had never been experienced before. To evaluate these damages, a linear earthquake response analysis in frequency domain has often been used. For more accurate evaluation of the damages, however, a nonlinear earthquake response analysis in time domain must be employed by incorporating she continuous change of stiffness and hysteresis damping of soil-structure interaction systems. In this study, a hybrid method which combines a soil-structure interaction program, KIESSI-2D with a general purpose FEM package, ANSYS is developed to perform nonlinear earthquake response analysis of soil-structure interaction in time domain. As a verification of the hybrid method, nonlinear earthquake response analyses are performed on the Kamisawa subway station which was damaged severely during the Kobe earthquake and analytical results are compared with the real damages. In order to consider the nonlinearity of soil, SHAKE program is used, whereas Hognestad model is used to consider the nonlinearity of concrete. It is shown that the analytical prediction agrees fairly well with the actual damages which were caused by the shear failure of the center column of the station.

열대 지역에서 통일형 초다수성 벼 품종의 생육 및 수량성 비교

이지윤,준현,성환,손영보,송유천,한상익,박동수,권영업,이철원,이종희 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2