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        Plasma CRABP2 as a Novel Biomarker in Patients with Non-Small Cell Lung Cancer

        김도준,김우진,임명남,홍윤기,이승준,홍석호,허정원,이희영,한선숙 대한의학회 2018 Journal of Korean medical science Vol.33 No.26

        Background: Lung cancer is the most common cause of cancer-related mortality worldwide. We previously reported the identification of a new genetic marker, cellular retinoic acid binding protein 2 (CRABP2), in lung cancer tissues. The aim of this study was to assess plasma levels of CRABP2 from patients with non-small cell lung cancer (NSCLC). Methods: Blood samples that were collected from 122 patients with NSCLC between September 2009 and September 2013 were selected for the analysis, along with samples from age- (± 5 years), sex-, and cigarette smoking history (± 10 pack-years [PY])-matched controls from the Korea Biobank Network. The control specimens were from patients who were without malignancies or pulmonary diseases. We measured plasma levels of CRABP2 using commercially available enzyme-linked immunosorbent assay kits. Results: The mean age of the NSCLC patients was 71.8 ± 8.9 years, and the median cigarette smoking history was 32 PY (range, 0–150 PY). Plasma CRABP2 levels were significantly higher in patients with NSCLC than in the matched controls (37.63 ± 28.71 ng/mL vs. 24.09 ± 21.09 ng/mL, P < 0.001). Higher plasma CRABP2 levels were also correlated with lower survival rates in NSCLC patients (P = 0.014). Conclusion: Plasma CRABP2 levels might be a novel diagnostic and prognostic marker in NSCLC.

      • 청소년의 유도수련 참가유형이 사회적 지지와 자기효능감에 미치는 영향

        김도준,김경수 龍仁大學校 武道硏究所 2010 武道硏究所誌 Vol.21 No.1

        이 연구의 목적은 청소년의 유도수련 참가유형이 사회적 지지와 자기효능감에 미치는 영향을 규명하는데 있다. 이 연구에서 얻은 결론은 다음과 같다. 첫째, 인구통계학적 특성 변인에 따른 사회적 지지와 자기효능감은 부분적으로 차이가 있었다. 사회적 지지는 성별, 학년, 부모의 학력수준, 부모의 소득수준 등에 따라서 차이가 있었지만, 자기효능감은 성별과 부모님의 학력수준에 따라서는 차이가 있었지만, 학년과 부모님의 소득수준에 따라서는 차이가 없었다. 둘째, 유도수련 참가유무에 따른 사회적 지지와 자기효능감은 수련자가 비수련자보다 높다 사회적 지지는 유도 수련기간이 오래될수록, 수련 빈도가 잦을수록, 수련강도가 높을수록 향상되어지고, 자기효능감은 수련기간이 오래될수록, 수련빈도가 잦을수록 높아진다. 셋째, 청소년의 사회적 지지가 향상 될수록 자기효능감의 하위요인인 자신감, 자기조절 효능감, 과제난이도선호를 높게 인지시킨다.

      • 유도선수의 경기력 향상을 위한 운동 프로그램 : 훈련주기 중 단련기를 중심으로 Laying Stress on Drilling-Stage of All Training Periods

        金道俊,南在和 龍仁大學校 1995 용인대학교 논문집 Vol.11 No.-

        The training method which drill physical strength equally should be planned to achieve the exact and perfect Judo skill. The following shows its summary of this study, the contents and expectation effect of drilling stage in the training paired. 1. Contents (1) This Study was planned, stressing muscular strength, expeditiousness, endurance, pliancy, balancing strength, which is necessary along with skill. (2) Stressed on the lower limbs muscular strength, and controlling strength improvement, which is needed for motion operation and center movement skill training. (3) Divided the physical strength factors, considering the importance of physical strength. That is necessary to give full play to skills. (4) Correlated principle & practice with target skill training and physical strength training. 2. expectation Effect In the Judo training, the additional training factors are mental strength training and psychological trait should be considerate. This study contented on skill aspect rather than theory. Especially courage and fighting spirit training would be very important. So, mental-strength training and physical-strength training should go side by side by adding following training into the exercise program, such as a parachute high-altitude training a clift-climbing rope training, a hilly-area training, self-command training(enduring thirsty, night-climbing training).

      • 동작 분석을 위한 인체의 그래픽 모델 프로그램에 관한 연구

        김도준,강상학 龍仁大學校 1997 용인대학교 논문집 Vol.13 No.-

        The purpose of this study is making computer program which is putting the muscle to the linked wire frame of known segment endpoints, just like human body's structure. The first model is making wire frame using c-language which provides sufficient graphic functions and next is making hidden line removing model, and the third model is developing computer program which paints to the divided human body to help visual analysis of three dimensional image. The only way of representing the graphic by three dimensional coordinates data which come foam three dimensional image analysis is the wire frame of simple linked line. Then this study added simuliar thickness muscle to the single line human body segment, and made that each segment as octagonal Prism and removed hidden line, and another is painting model which using wornock's screen dividing algorithm. As result of this study, displaying the wire frame and the human body's segment which represinted by octagonal prism is not complex process, but to display the surface model which removed the hidden line from viewpoint and painted model, it need much of memory space and need time consuming process, this model used the method of saving calculated coordinates to the file and displayed again from reading this file. The motion screen of this three dimensional solid figure which drawn by c-language function of this study is possible to analize from any viewpoint we want and size adjust and animation also exactly performed, so this study found the base of more exact analisys by visualizing the moving motion variously applying this program to the analysis of moving motion of three dimensional space.

      • 운동과 활성 산소ㆍ황산화물의 관계에 관한 고찰

        김도준,오봉석,전형권 龍仁大學校 1999 용인대학교 논문집 Vol.17 No.-

        The purpose of this study was to review for further understanding of the possible mechanisms of free radical formation during exercise and the relation of exercise and exercise induced oxidative stress and the antioxidant system. Acute or chronic strenuous exercise results in excessive production of reactive oxygen species(ROS). This ROS production may lead to lipid peroxidation and protein oxidation in the exercising muscle. Now, the results of study on the role of non-enzymatic defense system was not clear. Further study is necessary to get clear results of antioxidants. But, exercise induced oxidative stress may be reduced by antioxidant ingestion. Therefore, it is necessary to study on proper exercise for reduction of oxidative injury and for efficient practice of intensive exercise by antioxidant administration.

      • 中學校 柔道 選手의 體重減量에 따른 等速性 運動 變化에 관한 硏究

        김도준 龍仁大學校 2000 용인대학교 논문집 Vol.18 No.-

        In order to see the middle school Judo athletes' change in physical strength by the weight reduction, 13 athletes in each weight have been divided into 3 classes, lightweight, middleweight and heavyweight, and participated the test for muscular strength(Isomeric, Isokinetic Strength) and anaerobic fitness (Peak AnP, AnC) among the facts of physical strength most necessary for Judo before the weight reduction(at normal condition) and after it(the day before formal match), in which the following results have been produced from the comparison and analysis of those data : 1. There was no difference in isomeric strength(grip, muscular strength of arms and legs, abdominal muscle strength) by the weight reduction. 2. Isokinetic strength of the knee joint has been found, after the weight reduction, to be lower in the absolute value than before it(P<0.05), and to be lower in the unit weight sugar, however, there was no significant difference. As for the main joint, the absolute value and the unit weight sugar have been checked to be lower after the weight reduction(P<0.01). 3. The anaerobic fitnesses, i.e. the peak anaerobic power(Peak AnP) and the anaerobic capability (AnC) all have been found to be lower after the weight reduction(P<0.01). 4. In relation to the weight classes, the muscular strength and anaerobic capability has been resulted, in general, to be higher at the heavy classes, however, the abdominal muscle strength and anaerobic capability of the middleweight athletes has been found to be same with or rather higher than that of the heavyweight athletes. 5. The ratio of the strength of extensor and flexor generally has been arisen to be a problem as it was lower than 60%.

      • 포지션별 排求選手들의 競技中 傷害에 관한 硏究

        金道俊,金孝哲 龍仁大學校 1993 용인대학교 논문집 Vol.9 No.-

        The purpose of this study is to survey injury and tretment in volleyball players. The subjects are 986 numbers who belonged to tigh school, university, industry teams all over the nation. The results were as follows ; 1.The parts of injury are shown highly in the lower parts(23.58%), followed by hands (20.5%), upper parts(16.99%), trunk(12.28%)etc. 2.The forms of injury are shown highly in the joint and tendons(48.20%), followed by muscles and tendons (27.46%), bones (15.94%), skin(6.44)% etc. 3.The motions of injury time are shown highly in spiking(29.79%), followed by blocking (28.97% ), receive (13.92% ) , slipping (10.33% ) , collision(9.96% ) etc. 4.The currence cause of injury are shown the highest percentage in excessive motion (43.19%), followed by unable condition beyond man power (15.27%), bad conditions (11.23%), physical fitness lowering(8.76%) etc. 5.The times of injury are shown the highest percentage in P.M (55.99%), followed by A.M(37.65%), night during(6.36%) etc. 6.The seasons of injury are shown the highest percentage in winter(54.12%) followed by spring(19.91%), autumn(14.90%), summer(11.08%), Industury teams were shown lower then other teams in spring 7.The Yes or No of first aid after injury are shown the highest percentage in Yes(62.28%), followed by No(31.36%), Dont know(6.36%), Industry teams wree shown higher than other teams in Yes. 8.The first arid persons after injury are shown the highest percentage in the person concerned(34.88%), followed by special doctor(20.96%), team doctor(15.87%) etc. Men were shown higher than women in the person concerned. 9.The treatment methods after injury are shown the highest percentage in physical theraphy (31.35%), followed by oriental medicine theraphy(27.08%), manipulation and sports massage (14.68%) etc. Women were shown higher than men in manipulation and sports massage, university teams were shown lower than other teams in manipulation and sports massage. 10.The protect mothods after injury are shown highly in the taping(31.81%), followed by protecting pad(31.21%), don't(19.54%), bandage(8.76%) etc. 11.The recovery conditions after treatment are shown the highest percentage in more favorable turn (31.96%), followed by complete treatment(26.7%), Less favorable turn(24.55%) etc. Industey teams were shown higher than other teams in more favorable turn. Setter was shown higher than other position players in complete treatment.

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