國民學校兒童의 健康基準確立을 爲한 血液의 生化學的 및 血液學的 成分에 對한 調査硏究

金相仁,趙漢翊,朴明姬,金昇元,尹鍾求 대한의학협회 1979 대한의학협회지 Vol.22 No.8

Mo¨ssbauer Effect of the Lithium- and Cesium- nitrosylpentacyanoferrates(Ⅱ)

김일구,류상훈,김형상,홍치유,심동훈,김순구 동국대학교 자연과학연구원 2000 자연과학연구 논문집 Vol.5 No.-

We observed the 57Fe Mo¨ssbauer spectra and Fourier transformation infrared spectra & X-ray fluorescence spectra of lithium nitrosylpentacyanoferrates(Ⅱ) (Li₂[Fe(CN)5NO]·4H₂O, Li₂NP) and cesium nitrosylpentacyanoferrates(Ⅱ) (Cs₂[Fe(CN)5NO]·H₂O, Cs₂NP) samples which comprise nitrosylpentacyanoferrates(Ⅱ) anions with a Fe atom center. The Mo¨ssbauer parameters, values of isomer shift and quadrupole splitting have been measured at room temperature and liquid nitrogen temperature. Also the Mo¨ssbauer Lamb factors of all samples have been measured at room temperature. We have drawn the experimental line width of the Mo¨ssbauer lines normalized to natural line width Γn versus effective thickness of 57Fe.

부산지역 무균성 뇌막염 원인 바이러스의 분리 및 동정 : 1998년을 중심으로

김영희,정영기,김기순,지영미,윤재득,김병준,구평태,민상기,정구영,김만수,조경순 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1

The incidence of aseptic meningitis infection is ensuing and threatening the health of children. Enteroviruses are the major agents of aseptic meningitis and identification of virus has been a clue to diagnosis and epidemiology. The outbreak of aseptic meningitis occurred in Pusan, 1998. Patients were concentrated from April through November. Children were more susceptible than adults. Among 306 cases of specimens from stool, throat swab tested, only 7.2% were positive on virus isolation, 12 cases from stool and 10 from throat, respectively. All isolated 7 serotypes of viruses represented cytopathic effect on cultured cells. Three types of echovirus 6, 25, 30 and coxsackievirus B2, B3, B4, B6 were identified by neutralizing anti body test. Isolated coxsackievirus and echovirus were observed by an electron microscope with negative staining.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

상피세포 종양에서 bcl-2 표출에 관한 연구

김의한,정현,이종석,이성열,조명구 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Background : The bc1-2 protein, contrast to p53, has been shown to be suppress the apoptosis, and overexpression of the bc1-2 protein has been reported in several malignant tumors. Although how the bc1-2 protein takes part in tumorgenesis has not been proved, the bc1-2 positive tumors appeared to have good prognosis in some malignant tumors. The expression pattern of the bc1-2 in keratinocyte originated skin tumors have not been well known. The authors analyzed immunohistochemically expression of the bc1-2 protein to invastigate the role of the bc1-2 protein in developing skin tumors. Method : 21 squamous cell carcinoma, 19 basal cell carcinoma, 9 keratoacanthoma 11 seborrehic keratosis and 9 Bowen's disease were immunostained with anti-bc1-2 monoclonal antibody. Results : 1. The bc1-2 negative reactions were seen in all cases of sqaumous cell carcinoma, keratoacanthoma and Bowen's disease. The basal layer in keratoacanthoma and Bowen's disease shown to be intense positive reaction in bc1-2, whch suggested of the protected barrier function from tumor cell invasion into the dermis. 2. The bc1-2 were positive in all basal cell carcinoma. 3. In seborreheic keratosis, 9 cases were negative and 2 cases were positive. The positive cases appeared to be resulted from invagination of the basal cells in the epidermis. Conclusion : The bc1-2 protein did not appear to express in full matures cell, but positive reaction are seen in proliferating activity cells. The bc1-2 positive cells are rahter not abnormal cells than have function of protection of tumor cell proliferation by the prolongation of survival time normal cell.

Dicyanovinyl기를 포함하는 Polyurethane의 합성과 그들의 열적성질

김상태,김병구,공명선 단국대학교 신소재기술연구소 1992 신소재 Vol.2 No.-

주쇄에 enaminonitrile을 포함하는 polyurethane의 성질을 조사하기 위하여 먼저 p-bis-(1-chloro-2,2-dicyanovinyl)benzene(1)에 2-(N-methylamino)-ethanol과 4-piperidinol을 반응시켜 p-bis[1-[N-mthyl-N-(hydroxyethyl)amino]-2,2-dicyanovinyl]benzene(2)과 p-bis[α-[1-(4-hydroxypiperidinyl)-β,β-dicyanoviny]]benzene(3)을 합성하였다. 이들을 각각 hexamethylene diisocyanate(HDI), tolylene-2,4-diisocyanate(TDI), diphenylmethane-4,4'-diisocyanate(MDI)와 반응시켜 polyurethane을 얻었다. 또한 모델 화합물은 1과 phenylisocyanate의 반응에 의하여 얻었으며, 중합체의 화학적 구조는 모델 화합물과 비교에 의하여 분석하였다. 열적성질은 DSC와 TGA로 측정하였는데 2로부터 얻어진 polyurethane은 272-302℃에서 발열피크를, 3에서 얻어진 중합체는 315-323℃에서 큰 흡열피크를 보여주었다. 특히 2에서 얻어진 중합체들은 열경화후 불용성 중합체가 얻어졌으며, 3을 사용한 중합체는 큰 변화가 없었다. TGA 분석에서 500℃에서의 잔사량은 2의 중합체의 경우 55-68%이었으며 3의 중합체는 43-55%이었다. In order to investigate the properties of polyurethanes with enaminoitrile units in the main chain, p-bis[1-[N-methyl-N-(hydroxyethyl)amino)-2,2-dicyanovinyl]benzene(2) and p-bis[α-[1-(4-hydroxypiperidinyl)-β,β-dicyanovinyl]]benzene(3) were synthesized by reacting p-bis(1-chloro-2,2-dicyanovinyl) benzene (1) with 2-(N-methylamino)ethanol and 4-piperidinol. The polyurethanes were obtained from 2 and 3 with hexamethylene diisocyanate (HDI), tolylene-2,40diisocyanate (TDI), diphenylmethane-4,4'-diisocyanate (MDI), respectively. Before the polymer synthesis, model compound has been also obtained from phenylisocyanate with 1, and the chemical structure of polyurethane was analyzed by comparison with model compound. the thermal properties were measured by DSC and TGA, the polyurethanes obtained from 2 showed a large exothermic peak at 272-302℃, and those obtained from 3 was showed large endothermic peak at 315-323℃. Especially, polymer obtained from 2 gives insoluble polymer after heat curing, whereas the polymers derivied from 3 unchanged in their solubility. In the case of polymers from 2, residual weight is in the range of 55-68% at 500℃, and polymers from 3 were in 43-55%.

烏貝散이 HCI-aspirin 으로 유발된 십이지장궤양에 미치는 조직학적 영향

구세광,이형식,김종대,한상원,김상찬,이재현 慶山大學校 基礎科學硏究所 1999 基礎科學 Vol.3 No.-

오패산이 HCI-aspirin tm으로 유발된 rat 십이지장궤양에 미치는 조직학적 영향을 관찰하기 위하여, 오패산을 1,3 및 5일 동안 경구투여하고 십이지장의 조직학적 변화를 관찰하였던 바 다음과 같은 결과를 얻었다. 실험 전 기간동안 대조군에서는 십이지장 융모의 위축과 붕괴가 관찰되었으며, 조직학적으로는 점막상피의 변성 및 탈락이 관찰되었고 점막고유층에서는 염증세포의 침윤(infilteration)의 소견이 관찰된 반면 오패산 투여군의 투여 1일에서는 대조군과 유사하게 관찰되었으나, 투여 3일후부터 점막상피의 첨부에서 경미한 카타르성 물질이 관찰된 이외에 정상군과 유사한 소견을 나타내었다. 이상에서 오패산이 십이지장궤양의 치유를 촉진시키는 것으로 관찰되었다. In order to study, the histological effects of Opeaesan on the duodenal ulcer induced by HCI-aspirin tm in rate, experiments were done by oral administration and observed histological profiles of the ulcerative lesions. Ulcerative lesions were unmerously detected in control groups especially in pylorus-duodenal junctions. Histologically, very severe injury to duodenal epithelium wer observed in control groups and these injuries were increased with time intervals. But in the Opaesan-administration groups, no gross lesion of ulcer were demonstrated and histologically minor injury to the mucosal epithelium were observed. Among the Opaesan treatment groups, most slight injuries to duodenal mucosa were detected in 5 days after administration when the histological profiles were similar to that of normal groups. According to these result, it is suggested that Opaesan should be used in treatment of the duodenal ulcer but the funcitonal mechanisms were unknown.

심리적 연습이 아동의 폐쇄기능 수행 및 학습에 미치는 영향

김상규,김성문,류상구,조주란 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.3

The purpose of this thesis is, through the positive study, to clarify the effects of mental practice on performance and learning to the closed skill of children, what differences there are between mental practice and physical practice, whether or not the mental practice is effective in case it is performed simultaneously with physical practice, and when the effects of mental practice come out. The subjects are all right-handed elementary school students who are in the fifth grade and divided into four groups through four-step preliminary test. The subjects throw balls toward the five-meter apart target whose center is one meter high from the ground with their feet stuck on the ground. The points are treated 'ANOVA with repeated measured'-practice conditions(four variables) times practice periods(four variables)- making use of PC-SAS. If meaningful differences are found, they are put under the afterward identification - 'Turkey's HSD.' The material analysis brought the following conclusions. First, the skill performance effects are not found according to the practice conditions, but the practice performance effects are found according to the practice period. Second, the learning effects are not found according to the practice conditions, but the skill learning effects are found according to the practice period. Third, in the latter part of the practice period are the learning effects of the mental practice found.

Symbols in Truman Capote's Other Voices, Other Rooms

金相九 釜山大學校 1981 人文論叢 Vol.20 No.1

<Abstract>In Truman Capote's first novel, Other Voices, Other Rooms(1948), called a psychological-supernatural story, can some feminizing Faulknerian qualities be found like in such southern novelists as K. Anne Porter, E. Welty, and C. McCullers.In this nover the juxtaposition and harmony between Southern Gothic setting or atmosphere and grotesque characters are properly established. The boy-hero, Joel Knox has feministic qualities in his attitude and behavior. Whereas Joel's so-called counterpart, girl-heroine, Idabel Thompkins, has masculine characteristics. In other words, Joel is represented as girlishness, while Idabel tomboyishness.On the other hans, Randolph Lee, whose look is both boyish and feminine, living in a self-contained world, is a homosexual and transvestite.Referring to symbols of images of nonguman or living things in the novel, symbols or images of death, darkness, decay, loss, desertion, deception, fear, and loneliness are rich. Capote deals with them in the mystic, grotesque legends and through his poetical style of writing. Capote's things, as common in Southrn novelists, bound up with place and character, also induce unique, grotesque, and mysterious atmosphere, image, and sense. This novel remains, as Ihab Hasasn indicates, "a tour de force of the dark, mythic sensibility."