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      • SCIESCOPUSKCI등재

        자궁경부암 조직에서 세포회로 조절인자 Cyclin Dependent Kinase(CDK) Inhibitors의 발현

        김영태,김재욱,박상원,조남훈 대한부인종양 콜포스코피학회 1998 Journal of Gynecologic Oncology Vol.9 No.3

        Recent studies have revealed a new family of tumor suppressor genes that directly implicate aberrant cell cycle regulation in tumorigenesis. The general function of these gene products is that they prevent cell cycle progression by directly interfering with cyclin/cyclin dependent kinase (CDK) activation. The importance of these genes is that they are potent inhibitors of CDK and are induced by p53. Among these cell cycle inhibitors, p21WAF1/CIP1 and p16 have been thoroughly studied. However, the role of p21WAF1/CIP1 and p16 in tumorigenesis of the uterine cervix has been poorly defined. We used immunohistochemical techniques to study the expression of these cell cycle inhibitors in formalin-fixed, paraffin-embedded cervical tissue to explore the relationship between cyclin/CDK inhibitors and cervical carcinoma. Cervical tissues were analyzed from 46 patients with cervical carcinoma, 30 cases with cervical intraepithelial neoplasia (CIN) and 22 control cases who underwent hysterectomy due to benign gynecologic disease at Yonsei University College of Medicine. All CDK inhibitors strongly expressed in the reverse cell hyperplasia and koilocytes, whereas they revealed significantly decreased expression in neoplastic tissues (p <0.05). Normal endocervical cells revealed focal and weak expression to all CDK inhibitors but p16 showed no expression in endocervical adenocarcinoma. P16 revealed higher expressions in cases associated with human papilloma virus (HPV) (t-test, p <0.05) than in cases lacking any type of HPV. Our results were consistent with the concept that underexpression of CDK inhibitors may play an important role in neoplastic transformation in cervical carcinoma.

      • KCI등재

        단기보호서비스 이용동기와 불만족 요인에 대한 인식 연구 -입소노인의 보호자를 중심으로

        김영태 한국노인복지학회 2018 노인복지연구 Vol.73 No.1

        본 연구는 노인장기요양보험제도의 단기보호시설 이용자 보호자들의 서비스 이용에 관한이용 동기와 불만족 요인에 대한 인식을 알아보고, 이에 관한 개선방안을 찾아보는 연구이다. 연구를 위해 표집은 서울시에서 운영되고 있는 단기보호시설에 3회 이상 이용한 입소보호자 8명을 유의표집하여 심층면접을 실시하였다. 면접조사는 두 개 그룹으로 나누어서 진행하였으며, 1차는 초점집단면접(Focus Group Interview)으로 진행하였으며, 2차는 개별면접(Individual Personal Interview)으로 진행하였다. 면접은 단기보호서비스에 대한 이용 동기와 불만족 요인에 대하여 집중하여 진행하였다. 연구결과, 이용 동기요인으로는 일시적인 개인적 사유의 해결과 수발부담의 완화, 시설입소 적응을 위한 전단계로서 단기보호시설을 이용하고 있었다. 그리고 서비스 이용에 대한불만족요인으로는 불안감과 이용에 대한 어려움, 프로그램 등의 문제를 가지고 있었다 The purpose of this study is to suggest improvement plan through the analysis of users’caregiver recognition for improving of service at short stay facilities in long term care insurance. For the study, sampling method did purposive sampling from the caregiver who uses the facilities for more than 3 times in Seoul. It selected 8 caregiver for the study. Interview went off divided into two groups. First stage, it went along the focus group interview from the each facilities. After that, it had an Individual personal interview for the second stage. Interview was running to find the usage motivation and the dissatisfaction factor to use at the short stay service. From the result, usage motivation of short stay facilities solved the personal reasons and issues, relief of care burden, adaptation to enter nursing facilities, and dissatisfaction factors at the short stay facilities had anxiety from economic burden, usage limit from busy schedule and lacking of weekend programs at the facilities.

      • SCOPUSKCI등재

        흉부대동맥의 동맥류 절제 치험례

        김영태 대한흉부심장혈관외과학회 1973 Journal of Chest Surgery (J Chest Surg) Vol.6 No.1

        This is one case report of successful resection of the aneurysm of the thoracic aorta, which det-ected by thoractomy unexpectedly, in the Department of Thoracic Surgery, Hanyang University Hospital. The patient was a 34 years old woman and subjective complaints was not related with the aneurysm. Chest film showed a small round hazy shadow in the left margin of the upper posterior mediastinum. A saccular aneurysm located on the descending thoracic aorta, 7cm distal to the left subclavian artery and arouse from the antero-lateral wall of the aorta. Excision of the saccular aneurysm was performed by cross clamping the descending aorta above and below the aneurysm, and then the defect of the aortic wall was closed by aortorrhaphy with continuous suture. Crossclamping time was required 15 minute. Histopathologically, the wall of the aneurysm consisted of all layers of the arterial wall, that is, intima, media and adventitia. Postoperative course was uneventful and aortogram showed good continuity of the blood flow of the entire aorta.

      • KCI등재

        침윤성 자궁경부암조직에서 c-erbB-2 암유전자 단백의 함량측정 및 예후인자와의 관련성

        김영태,김재욱 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.4

        1995년 7월부터 1996년 2월까지 연세대학교 의과대학 산부인과학교실에 내원한 환자중 침윤성 자궁경부암으로 진단 확진된 환자 40명, 자궁경부암 선별검사에서 이상소견을 보여 질확대경 조준하 자궁경부생검술에서 자궁경부 상피내종양으로 진단된 10명, 그리고 대조군으로는 조직학적으로 만성 자궁경부염으로 판명된 10명을 대상으로 c-erbB-2 암유전자 단백산물을 enzyme immunoassay법으로 정량적으로 측정하고 자궁경부암의 임상적 예후인자와의 상관관계를 분석하여 다음과 같은 결과를 얻었다. 1. c-erbB-2 암유전자 단백산물의 중위수(median)는 자궁경부암 환자군에서는 951 fmole/mg protein으로 나타났고 자궁경부 상피내종양 환자군에서는 484 fmole/mg protein으로 나타나 두 군사이에는 통계적으로 유의(p=0.02)한 차이를 보였다. 또한 대조군에서는 353 fmole/mg protein의 중앙값을 보여 침윤성 자궁겨우암 환자군 사이에 통계적으로 유의(p=0.01)한 차이를 나타내었다. 그러나 대조군과 자궁경부 상피내종양 환자군 사이에는 유의한 차이를 나타내지 않았다. 2.자궁경부암 환자군에서 c-erbB-2 암유전자 단백산물의 측정중앙값을 임상병기별로 살펴보면, 병기 I에서는 1,180 fmole/mg protein, 병기 II에서는 1,061 fmole/mg protein, 병기 III에서는 1,538 fmolr/mg protein으로 나타나 병기가 진행될 수록 중앙값은 증가하는 경향을 보였으나 통계적으로 유으한 차이를 나타내지 않았다(p=0.711). 3. 침윤성 자궁경부암 환자군에서 병소 크기별로 구분하여 c-erbB-2 암유전자 단백산물의 중앙값을 살펴보면 4 cm이상군(n=23)에서는 1,896 fmole/mg protein, 4 cm미만군(n=17)에서는 1,403 fmole/mg protein으로 나타나 두 군사이에 유의한 차이를 나타내지 않았다(p=0.093). 4. 자궁경부암 환자군에서 c-erbB-2 암유전자 단백산물의 발현도를 연령, 폐경유무 상태, 세포형태별로 구분하여 연구한 결과 통계적인 유의성은 나타나지 않았다. 결론적으로 본 연구에서는 c-erbB-2 암유전자 단백산물이 자궁경부암의 종양발생화 및 악성화에 중요한 역할을 하고 있음을 알 수 있었으나 침윤성 자궁경부암의 불량한 예후인자와의 상관관계가 명확하게 나타나지 않았으므로 예후적 임상지표로 사용되기 위해서는 이들 환자의지속적인 추적관찰로 생존율 및 치료실패율에 관한 연구가 뒷받침되어야 할 것으로 사료된다. c-erbB-2 oncogene is a gene that encodes a growth factor receptor-like molecule with tyrosine kinase activity and has a structure similar to that of the epidermal growth factor receptor. The oncoprotein endoded by this gene is a 185-kilodalton transmembrane glycoprotein. Overexpression of the c-erbB-2 oncoprotein is detected in human adenocarcinoma of the breast, ovary, and salivary gland, in which association between overexpression of the c-erbB-2 and poor prognosis of the disease has been reported. The role of c-erbB-2 oncoprotein in the tumorigenesis of the uterine cervix has been poorly understood and controversial. In order to explore the relationship beteen c-erbB-2 oncoprotein status and cervical carcinoma, tissues were analyzed from 40 patients, each of whom had invasive cervical carcinoma prior to treatment, 10 patients with cervical intraepithelial neoplasia(CIN) and 10 control cases who underwent hysterectomy due to benign gynecological disease at Yonsei University College of Medicine. We measured c-erbB-2 oncopretein with an enzyme-linked immunosorbent assay(ELISA) which was a sandwich type. Patients with invasive cervical cancer were found to have significantly higher median c-erbB-2 oncoprotein expression than patients with either the patients with CIN(P=0.02) or the control(P=0.001), respectively. However, there was no significant difference in c-erbB-2 oncoprotein status between CIN and the control groups. Overexpression of c-erbB-2 oncoprotein was found in 12 of 40(30%) invasive cervical cancers and in 1 of 10(10%) CIN patients. In invasive cervical cancer, no significant difference in c-erbB-2 oncoprotein levels was noted when stratified according to age, menopausal status, histological cell type, lesion size or clinical stage. Our results were consistent with the concept that c-erbB-2 oncoprotein may play an important role in malignant transformation and tumorigenesis in cervical cancer. But, further study based on larger numbers of cases with correlation to c-erbB-2 oncoprotein status and complete follow-up survival data will help to define the prognostic significance of c-erbB-2 oncoprotein in patients with cervical carcinoma.

      • KCI등재
      • SCOPUSKCI등재

        자연기흉에 대한 Thoracoscopy 의 임상적의의

        김영태,김근호,Kim, Young-Toe,Kim, Kun-Ho 대한흉부심장혈관외과학회 1975 Journal of Chest Surgery (J Chest Surg) Vol.8 No.1

        The thoracoscopic study was reported on 21 cases of spontaneous pneumothorax requiring surgical management, and clinical values of thoracoscopic examination on spontaneous pneumothorax were also discussed. patients were treated in the Department of .Thoracic Surgery, Hanyang University Hospital for the period of two Years from May 1972 to April 1974. For exact detection of etiologic factors on spontaneous pneumothorax, the thoracoscopic examination in the intrapleural space was performed in parallel with X-ray study. this study, the difference of diagnostic and therapeutic significance between radiological and thoracoscopic findings were observed and compared simultaneously. The results are summerized as follows: Patients age was distributed between 3 and 70 years old with highest incidence in the age group of sixty decade [33. 3%], and sex ratio of male to female was 5:2. The tuberculous processes which developed superficial subpleural layer in the lung parenchyme, on the pulmonary surface could be observed by thoracoscopic examination in a characteristic picture. detection ratio of pulmonary tuberculosis by the radiologic study to that by thoracoscopy was 8:2. The adhesion between the visceral and the parietal pleura which could possibly make a rupture of the alveola and the visceral pleura was found to be localized in a small area of the lung surface. The other part of the lung surface was free of the adhesion and, therefore, the movement of the lung took place completely without any difficulty. The ruptured orifice of the pleura and pathological changes surrounding the orifice can be detected by thoracoscopy, but not by other means such as radiologic examination. A single tuberculous bleb and multiple emphysematous blebs were found on 6 cases out of 21 cases of spontaneous pneumothorax. Among these cases, radiologic Study revealed the bleb only in one patient. On the other hand, the blebs were found in all the six patients by means of thoracoscopic examination. It gives the detection ratio of bleb by radiologic study to that by thoracoscopy was 1:6. By thoracoscopy, the rupture on the lung surface were visualized on the 10 patients out of a total of 21 patients [10 patients of visual rupture]. However, the rupture of the pleura was not observed on the rest of 11 patients even by thoracoscopic examination [11 patients of non visual rupture]. Five patients [50%] out of ten who had the visual rupture on the lung surface was required a surgical operation to remove pneumothorax. For the patients who were detected to have the visual rupture of the pleura by thoracoscopy, be considered in the early stage of closed thoracostomy. of 21 patients, 16 patients [11 patients of non visual rupture of the pleura and 5 patients of visual rupture of the pleura] who received no surgical management, were treated with closed thoracostomy with continuous suction, and the` pneumothorax was healed completely up in each cases. Therapeutic measures for the remaining 5 patients of visual rupture of the pleura who were subjected to surgical approach for radical treatment of spontaneous pneumothorax were accordingly complicated, and the following different procedures were properly indicated case by case, that is, rib resection thoracostomy, simple closure of ruptured visceral pleura, wedged resection of the lung, and lobectomy.

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