서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

신포동 젠트리피케이션 현상에 대한 연구

김준우(Kim Jun Woo),김용구(Kim Yong Gu),전동진(Jeon Dong Jin) 인천대학교 인천학연구원 2018 인천학연구 Vol.29 No.-

본 연구는 신포동 젠트리피케이션 현상에 관한 연구이다. 인천의 중심지였던 신포동 지역은 1985년 시청 및 공공시설이 구월동으로 이전하고 인천시의 대규모 도시개발정착에 따라 낙후된 지역으로 변해갔다. 그러나 2008년부터 교육서비스업종, 창작 및 예술, 협회 및 단체 업종의 종사자 수를 보면 신포동이 다른 주변지역(연안동, 동인천동, 북성동)보다 크게 증가하고 있다. 같은 시기 신포동의 인구의 수는 계속 감소하는 반면에 부동산업, 교육서비스업종, 창작예술업종, 문화예술인들이 카페 등으로 등록하는 휴게음식점 종사자는 증가하고 있다. 중구지역 지가변동은 2008년부터 2012년 까지 감소하다가 2013년부터 증가한다. 2013년부터 지가변동율이 증가하자 휴게음식점업종 및 창작예술업종이 감소하고 있다. 연구 결과를 종합해보면 신포동의 인구의 수는 계속 감소하는 반면에 부동산업, 교육서비스업종, 창작예술업종, 휴게음식점 종사자의 증가하고 있으며, 2013년부터 지가변동율이 증가하자 휴게음식점업종 및 창작예술업종이 감소한다. 신포동은 2013년을 기점으로 젠트리피케이션 단계로 진입한 것으로 파악된다. This study is a study on the phenomenon of gentrification phenomena in Shinpo - dong. The Shinpodong area, which was the center of Incheon, was moved to Guwol-dong in 1985 when the city and public facilities were moved to Incheon. However, since 2008, the number of employees in the education service industry, creative arts, arts, associations and organizations has increased sharply compared to other surrounding areas (coastal dong, Dongchun-dong, and north-east). At the same time, the number of population in Shinpo - dong continues to decline, while the number of resting restaurants that real estate, educational service, creative arts, and cultural artists are registered as cafes is increasing. The fluctuation of Jungang area land prices will decrease from 2008 to 2012, but it will increase from 2013. As the land price volatility has increased since 2013, the rest restaurants and creative arts industries are declining. According to the results of the study, the number of population in Shinpo - dong continues to decrease, while the number of real estate, educational service, creative arts and resting restaurants are increasing, and the rate of change in land prices has increased since 2013. Shinpodong appears to have entered the gentrification phase starting in 2013.

정상면역을 가진 성인에서 발생한 식도 방선균증

김현수 ( Hyun Soo Kim ),천종운 ( Jong Woon Cheon ),김민수 ( Min Su Kim ),정창길 ( Chang Kil Jung ),김경록 ( Kyung Rok Kim ),최재원 ( Jae Won Choi ),강동우 ( Dong Woo Kang ),김선영 ( Sun Young Kim ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2

Hyun Soo Kim, Jong Woon Cheon, Min Su Kim, Chang Kil Jung, Kyung Rok Kim, Jae Won Choi, Dong Woo Kang and Sun Young Kim1 Departments of Internal Medicine and Pathology1, DongKang Medical Center, Ulsan, Korea Actinomycosis is a chronic suppurative disease and caused by Actinomycosis species, principally Actinomyces israelii, which are part of the normal inhabitant on the mucous membrane of the oropharynx, gastrointestinal tract, and urogenital tract. It usually affects cervicofacial, thoracic and abdominal tissue. Cervicofacial type has the highest percentage of occurrence with 50%. Actinomycosis frequently occurs following dental extraction, jaw surgery, chronic infection or poor oral hygiene. It may also be considered as an opportunistic infection in immunocompromised patients such as malignancy, human immunodeficiency virus infection, diabetes mellitus, steroid usage or alcoholism. But, actinomycosis rarely occurs in adults with normal immunity and rare in the esophagus. We report an unusual case of esophageal actinomycosis which was developed in a patient with normal immunity and improved by therapy with intravenous penicillin G followed oral amoxicillin, and we also reviewed the associated literature.

서초동(서울시 서초구)의 거미상

김주필(Joo Pil Kim),정혜리(Hye ri Jeong),김대희(Dae Hee Kim),박동우(Dong Woo Park),서재웅(Jae Woong Seo),이현우(Hyun woo Lee) 한국거미연구소 2017 한국거미 Vol.33 No.1

2016년 3월 31일부터 7월 31일까지 서울특별시 서초구 서초동에 위치한 서울고등학교 교정 일대를 서울고등학교 환경생물부 부원들이 채집 조사한 결과 20과 43속 53종의 거미가 조사 연구되어 이에 보고하는 바이다. From March 31st to July 31st in 2016, members of an environmental biology club at Seoul High School located in Seocho-gu, Seoul, Dae-Hee Kim, Dong-Woo Park, Jae-Woong Seo and Hyun-woo Lee, collected 20 families 43 genera 53 species of spiders and report the result of the study here.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

Dong-Chun Lecture : Cell-based High Content Screening (HCS) for action modes of drug targets by using systematic deletion mutants of Schizosaccharomyces pombe

( Dong Uk Kim ),( Im Seon Woo ),( Mi Sun Won ),( Young Joo Jang ),( Kyung Sook Chung ),( Han Oh Park ),( Hyang Sook Yoo ),( Kwang Lae Hoe ),( Doo Sik Kim ) 한국생화학분자생물학회 (구 한국생화학회) 2005 생화학분자생물학회 춘계학술발표논문집 Vol.2005 No.-

각종 난치성 혈액 질환에서의 비혈연간 골수이식

김동욱,한훈,김정아,김희제,민창기,엄현석,최정현,이종욱,한치화,홍영선,최일봉,신완식,민우성,김학기,김춘추,김원일,김동집 대한조혈모세포이식학회 1997 대한조혈모세포이식학회지 Vol.2 No.1

목적: 비혈연간 골수이식은 혈연내에 적절한 골수공여자가 없는 만성골수성백혈병, 고위험군의 급성별혁병, 면역억제치료에 실패한 재생불량성빈혈 및 각종 난치성 조혈모세포질환의 완치를 위한 표준적인 치료방법으로 정착되고 있다. 혈연간 표준적인 동종 이식에 비하여 비혈연간 이식시에는 생착부전, 이식편대숙주반응과 감염이 더 빈번하게 발생하며, 국내에서는 아직까지 체계적인 임상연구결과가 보고된 바 없었다. 이에 본 센터에서는 1995년 10월 이후로 약 20개월간 26예의 비혈연간 골수이식을 시행하였으며 3개월 이상의 추적관찰이 가능하여 이식초기 합병증의 관찰 및 분석이 가능하였던 20예의 환자를 대상으로 이식성적 및 문제점을 보고함으로써 새롭게 확대되고 있는 이 분야의 임상연구 및 진료의 활성화를 꾀하고자 한다. 방법: 각종 혈액 종양질환으로 비혈연간 이식을 시행한 총 26예의 환자중 3개월이상의 추적관찰이 가능하였던 20예를 대상으로 후향적으로 임상경과를 분석한 후 생존 분석을 시행하였고, 환자의 연령, 성별, 질병의 상태, 조식 적합 항원의 일치정도, 이식편대 숙주 반응의 유무와 생존기간과의 상관관계를 살펴보았다. 또한 표준위험군과 고위험군으로 나누어 생존율을 비교하였고 이식과 관계된 생착 부전, 이식편대숙주반응, 감염의 발생과 양상 그리고 그 합병증을 관찰하였다. 결과: 1. 환자와 공여자간에 HLA 불일치가 20예 중 4예에서 있었으며, 생착여부의 확인이 가능했던 17예 중 16예에서 생착이 확인되어 94.1%의 생착율을 보였다. 2. 급성이식편대숙주반응은 62.5%(10/16예)에서 발생하였으며 111도 이상의 급성의 이식편대숙주 반응은 25%(4/16예)에서 발생하였다. 만성이식편대숙주반응은 40%(2/5예)의 환자에서 발생하였으며 이들 모두 국소형으로 중증의 진행형 만성이식편대숙주반응이 관찰된 환자는 없었다. 3. 호흡기 합병증은 10예(50%)에서 발생하였으며 감염성 폐렴을 포함한 호흡기 합병증이 가장 흔한 일차적인 사망 원인이었다. 호흡기 합병증이 발생했던 10예중 6예가 감염에 의한 폐렴이 의심되었고 나머지 4예는 특발성 간질성 폐렴이었다. 4. 8.5개월의 중앙추적기간 중 35%의 생존율을 관찰할 수 있었고, 생존기간은0.5개월에서 15개월 (중앙치:4개월)이었다. 한편 고위험군은 25%(3/12예), 표준위험군은 50%(4/8)의 생존율을 관찰할 수 있었다. 5. 가장 흔한 사망 원인은 감염성 폐렴을 포함한 호흡기 합병증(6예)이었고, 이외의 사망 원인으로는 급성 이식편대숙주반응과 다장기부전이 각각 2예, 생착 부전, 간정맥 폐쇄, 그리고 재발이 각각 1예였다. Unrelated bone marrow transplantation(UBMT) has been increasingly recognized as the standard treatment for cure of chronic myelogenous leukemia, high risk acute leukemia, aplastic failed on immunotherapy, and the variety of refractory hematologic diseases in patients lacking a related donor. However, as compared to HLA identical sibing transplantation, UBMT carries higher incidence of graft failure, graft versus host disease(GVHD), and infection. In our center, 26 patients underwent UMBT between October 1995 and June 1997. The minimum follow-up of 3 months was possible in 20 patients, for whom early complications and clinical outcomes were assessed. The median age of the 20 patients was 24 years. 8 patients had standard risk disease and 12 patients had high risk disease. All patients received various preparative regimens including total body irradiation according to disease and disease status. 19 patients received CsA + short course MTX for GVHD prophylaxis. One patient received marrow that was depleted of T cells ex vivo using avidinbiotin column. The class I loci were typed by serological methods and HLA-A, HLA-B and HLA-DRB1. 3 additional pairs were one minor mismatched at the HLA-B locus. Another one patients was one major mismatched at the DRBI alleles. 17 patients were evaluable for engraftment. Successful enfraftment was confirmed in 16 patients(94.1%). Only one patient who was performed one major DRBI mismatched transplants experienced graft rejection. 16 patients were evaluable for acute GVHD. The overall incidence of acute GVHD developed in 4 patients(25%). Five patients were evaluable for the development of Ⅳ acute GVHD developed in 4 patients (25%). Five patients were evaluanle for the development of chronic GVHD. 2 patients(40%) developed limited chronic GVHD. Respiratory complications including pulmonary infection developed in 10 patients(50%) and these complications were the most common primary cause of death. Of these 10patients, 6 had pneumonia due to fungus(4 patients), pacterial (1 patient), and CMV infection (1 patient) and 4(20%) had idiopathic interstitial pneumonitis and/or adult respiratory distress syndrome. The duration of median follow- up was 8.5 months and 7 of 20 patients(35%) are alive at the time of this analysis with survival duration of 0.5 to 15 months(median survival duration: 4 months). The overall survival was 25% (3/12 patients) in high risk group and 50%(4/8 patients) in standard group. From these results, we can predict that the incidence and severity of GVHD in Korea are lesser than multiracial countries and the long-term survival of patients with standard risk disease can approach that of HLA matched sibling transplants. For the past two years, the performance of UBMT has been rapidly increasing and it will be possible to analyze much larger number of patients soon in Korea. In the future the problems of graft failure, GVHD, and infection due to long lasting immunocompromised status will need to be overcome by continued medical research. In addition, the volunteer donor pool will have to be expanded by the promotion of the national awareness of its need.

Two New Records of Sepia (Doratosepion) kobiensis Holye, 1885 and S. tokioensis Ortmann, 1888

Kim, Yeong-Hye,Lee, Dong-Woo,Choi, Kwang-Ho,Yeon, In-Ja,Kim, Young-Seop The Malacological Society of Korea 2004 The Korean Journal of Malacology Vol.20 No.2

The true cuttlefishes genus Sepia (Doratosepion) Linne, 1758, characterized by shell thick, entirely calcareous, shell almost as long as mantle, was collected from the coastal of Dong-Am, Busan, Korea in April, 2004. The specimen agreed closely with description of Sepia (Doratosepion) kobiensis Hoyle, 1885 and S. tokioensis Ortmann, 1888. We herein described the species, being as the first record of S. kobiensis and tokioensis from the region. New Korean names are also provided.

복 공진형 고주파 인버터의 특성해석 및 설계

김종해,이동헌,이철우,김중기,김동희,조규판 嶺南大學校 工業技術硏究所 1998 工業技術硏究所論文集 Vol.26 No.2

This paper proposes a double resonant high frequency inverter which reduces the distribution of the switching current. The analysis of the proposed circuit is generally described by using the normalized parameters. Also, the principle of the basic operation and the characteristics of driving were estimated by the switching frequency and the load parameters. And the data for the design were got by the characteristic values obtained from the characteristic estimation. At the same time the example of the design method was proposed. In addition, Comparing the theoretical waveforms to the experimental waveforms certified the operating characteristics of the proposed Inverter. It is certain that the proposed circuit will be used and expanded in the high frequency power supplies like induction heating systems.

설사와 산혈증에 의한 신생아 메트헤모글로빈혈증 2례

김두권,김영진,김기호,고희신,김우택,최성민,이동석,권경배 東國大學校 醫學硏究所 1995 東國醫學 Vol.3 No.-

메트헤모글로빈혈증은 환원 효소계 결핍이나 환원되지 않은 비정상 메트헤모글로빈을 가지는 선천성 질환 및 후천성 산화성 물질이나 약제에 노출될 때 생기게 되나, 신생아에서는 산화성 물질에의 감수성이 높은 동시에 환원효소의 활성이 낮으므로 산화성 물질에의 노출이 없이 설사, 산혈증 및 감염증 등에 의해서 일시적 메트헤모글로빈혈증이 일어날 수 있다. 저자들은 발열과 심한 설사 및 청색증을 주소로 내원한 생후 18일, 생후 19일된 남아 2례에서 메트헤모글로빈 혈증을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Methemoglobinemia is characterized by generalized cyanosis without cardiac and pulmonary diseases. Methemoglobin, yielded by oxidation of hemoglobin iron to the ferric state, is nonfunctional and imparts a chocolate hue to the blood. The blood of normal healthy persons contains methemoglobin, but the intraerythrocytic methemoglobin-reducing system maintains its concentration less than 2% of the total hemoglobin. Methemoglobinemia is caused by the inherited disorders of methemoglobin metabolism and the accidental ingestion of oxidizing agents and infection. Fetal hemoglobin has increased susceptability to oxidation NADH diaphorase activity is reduced to 60% of adult levels in newborn erythrocytes. Acute diarrhea and acidosis further reduce the activity of the enzyme. We experienced two cases of methemoglobinemia due to acute diarrhea and metabolic acidosis who were admitted to the department of pediatrics at Dong-Guk University Hospital. No history of toxin exposure could be elicited. Case 1 concerns a 19-day-old male neonate who had irritability, fever, cyanosis, tachypnea, severe diarrhea, mild metabolic acidosis and grunting without cardiac and pulmonary diseases. On the day of admission, methemoglobin level was 52.3% of the total hemoglobin. After the treatment with methylene blue which was purified by 0.45㎛ of Nalgene syringe filter(Nalge Co.), its level was decreased to 6% of the total hemoglobin, and then it reached a normal level at the 5th day after admission. Case 2 concerns a 18-day-old male neonate who had fever, diarrhea, mild metabolic acidosis and cyanosis around lips without cardiac and pulmonary diseases. At admission, his level of methemoglobin was 25.3% of the total hemoglobin. After twice injection of methylene blue its level was decreased to 4.4% of the total hemoglobin, and then it reached 1.3% of the total hemoglobin at the 7th day after admission. So, we report it with a brief review of relevant literatures.