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      • KCI등재후보

        한국인에서 다발성 내분비선종 증후군의 초기 증상 및 임상 양상

        김기호,구민영,허성모,이세경,최준호,이정언,김지수,정재훈<SUP>1<.SUP>,남석진,양정현,김정한,Ki-Ho Kim,M.D.,Min-Young Koo,M.D.,Sung-Mo Hur,M.D.,Se-Kyung Lee,M.D.,Jun-Ho Choe,M.D.,Jeong Eon Lee,M.D.,Jee Soo Kim,M.D.,Jae-Hoon Chung,M.D.<SU 대한갑상선-내분비외과학회 2010 The Koreran journal of Endocrine Surgery Vol.10 No.4

        Purpose: Multiple endocrine neoplasia (MEN) syndrome is an inherited, autosomal dominant disease that presents as a combination of several endocrine tumors. Early diagnosis of this syndrome is difficult, because of the nonspecific symptoms and signs. This study analyzed early manifestations and clinical characteristics in patients with MEN syndrome. Methods: Medical records were retrospectively reviewed and telephone interviews were conducted with 35 patients diagnosed as MEN syndrome at Samsung Medical Center from December 1994 to December 2009. Results: The 35 patients had been diagnosed as MEN1 (n=14), MEN2A (n=19) and MEN2B (n=2). The early manifestations of the 14 MEN1 patients were related with hyperparathyroidism (n=5), pituitary tumor (n=3), and pancreatic endocrine tumor (n=2). There were tumors of the parathyroid gland in all 14 patients, anterior pituitary in eight patients, and pancreatic islet cells in seven patients. Four cases were incidentally detected during the screening examination. Six cases harbored a MEN1 gene mutation. The twenty-one patients diagnosed with MEN2 comprised medullary thyroid cancer (n=20), adrenal pheochromocytoma (n=15), and hyperparathyroidism (n=4). The MTC-related symptoms in the 21 MEN2 patients included neck mass or discomfort in 12 patients and pheochromocytoma-related symptoms in seven patients. Two cases were detected through familial genetic screening test. The RET gene mutationwas detected in 19 cases. Conclusion: Early manifestations of MEN syndrome were very different between the types of MEN and the types of its presenting tumor. The early diagnosis and proper management of MEN requires awareness of the clinical characteristics of each expressed tumor and is influenced by genetic screening methods. (Korean J Endocrine Surg 2010; 10:266-275)

      • KCI우수등재
      • KCI등재
      • KCI등재후보

        흉막액 Adenosine Deaminase 활성도의 진단적 가치에 관한 연구

        김기호,김경환,김성규,장준,장상호,손희영 대한내과학회 1986 대한내과학회지 Vol.31 No.2

        Adenosine deaminase(ADA) is an enzyme which irreversibly hydrolyzes adenosine into inosine and ammonia. Recently, as preventive medicine and chemotherapy have made remarkable progress. cases of pulmonary tuberculosis and tuberculous pleuritis have greatly decreased, but their incidence remain still high in Korea. At the same time, we have seen an increasing number of patients with malignant pleuritis. Therefore, we often have a problem on the differential diagnosis of pleuritis. We have investigated 67 cases of pleuroperitoneal effusions to see the specificity of ADA determination in their diagnosis. The pleural effusions were due to tuberculosis (41 cases), malignancy(17 cases), pneumonia(3 cases), and systemic lupus erythematosus(1 case). The peritoneal effusions were due to liver cirrhosis(5 cases). The results obtained are as follows: 1) In tuberculous effusions, the ADA activity in pleural fluid was clearly higher tban that in all other effusions. 2) In almostly a)1 patients with pleuroperitoneal effusions, serum ADA activity fell within the reference limits for ADA activity in normal humal serum. 3) In tuberculous effusions, total lymphocytes count in pleural fluid was significantly higher than that malignant effusions, but there was no statistical correlation between the ADA activity and the total lymphocytes count in both groups. 4) There was no statistical correlation between the ADA activity and the total protein in tuberculous and malignant pleural effusions respectively. It is suggested that measurement of ADA activity in pleural effusions is of value in the differential diagnosis of patients with tuberculous pleuritis from those with malignant pleuritis and others, paticularly when the results of other laboratory and clinical tests are negative, if the value is over 50 unit/L.

      • KCI등재
      • KCI등재후보

        수용성 키틴이 토끼 개방창의 창상치유에 미치는 영향

        김기호,한만욱,정상훈,유결,조용남,임진수,권호,이종건 대한성형외과학회 2002 Archives of Plastic Surgery Vol.29 No.2

        The purpose of this study was to evaluate effects of chitin on open wound healing in rabbits. Using 15 rabbits, a round, full thickness defect of skin with 2cm in diameter was made on the ventral surface of the each ear. The experimental animals were divided into 3 groups:control group untreated group), base ointment group (group treated with base ointment), and chitin ointment group(group treated with water soluble chitin ointment). A total of 30 wounds were made and each subgroup was allocated 10. On the 7th day after initial wounding, each wound site including surrounding tissue was taken for macroscopic and histological observations. The amount of epithelialization and granulation tissue were measured by Image Analysis System.In macroscopic examination, larger amount of exudate and granulation tissue were observed in water soluble chitin ointment group compared to control and base ointment groups.In histological examination, water soluble chitin ointment group showed thick epithelium and larger amount of granulation tissue and fibroblast deposition. The areas of epithelialization and granulation tissue were significantly increased in water soluble chitin ointment group compared to control and base ointment groups.In conclusion, water soluble chitin accelerated open wound healing by accelerating reepithelization and granulation tissue formation.

      • KCI등재
      • KCI등재

        『朱子語類』 <독서법>에 나타난 新意論

        김기호 영남대학교 인문과학연구소 2010 人文硏究 Vol.- No.59

        This thesis is to analyze the inquiring method for Shin-ui, and to the contents of acceptance and practice of Shin-ui clarified by Juja in Reading method of Juja-eolyu(朱子語類). And also, this thesis is to discuss the effect of the Shin-ui theory of Juja on the history of Korean classical reading theory, based on the contents analyzed. The results are as follows. Firstly, Juja suggested three inquiring methods for Shin-ui in explaining the course of pursuit for Dori(道理), which are the inquiring method for Shin-ui through a careful perusal, through discussion, and through a lecturing explanation. Among the three methods, the first method itself shows an independent completeness, but the others do not. In this respect, it is possible to say that in the inquiring activity for Shin-ui for the identification of Dori, the inquiring activity for Shin-ui through a careful perusal should be followed first under any circumstances. And the inquiring activity for Shin-ui under the premise of the inquiring activity of Shin-ui through a careful perusal is possible in any cases. Secondly, Juja mentioned that, though the inquiring activity for Shin-ui is mainly for finding Dori, the activity is also a premise for the acceptance of Dori. He sorted the Dori found through the inquiring activity into two things: Hwaehwal Dori(會活 道理) which moves lively and Bulhwal Dori(不活 道理) which does not move lively. He also suggested that the Bulhwal Dori(不活 道理) found should be Hwaehwal Dori(會活 道理) in order that the Dori found may be accepted into the heart of reader. As he said that the inquiring activity for Shin-ui was in itself not only the course of finding Dori, but also an activity of making the Bulhwal Dori(不活 道理) as the Hwaehwal Dori(會活 道理), it is possible to say that the inquiring activity for Shin-ui becomes a premise for the acceptance of Dori. Thirdly, Juja mentioned that the inquiring activity for Shin-ui had a significance for the acceptance and practice of Dori, as the Dori was found by the inquiring activity for Shin-ui. Without the finding of Dori through the inquiring activity for Shin-ui, the internalization of Dori is not possible, and also the practice of Dori can not be performed. Additionally, the finding of Dori can not be accomplished without the inquiring activity for Shin-ui. It means that the inquiring activity for Shin-ui can be a cognitive foundation to accomplish the Juja's goal of reading. The historical significance of the Shin-ui theory in Korean classical reading theory is classified into two things. One is that Juja's Shin-ui theory provided a cognitive method and procedure for the finding of Dori for Korean classical reading theory, which can be identified in the reading theory of Toegye and Hyungam. The other is that the Shin-ui theory played a role of foundation for the blossom of new shin-ui theory, which can be identified in the reading theory of Dasan. 본고는 주자가 『주자어류』 <독서법>에서 밝힌 新意 탐색 방법, 新意의 수용과 실천의 내용을 분석하고, 분석의 내용을 토대로 주자의 新意論이 한국 고전 독서론사 전개에 기여한 역할을 논의하였다. 결과를 제시하면 첫째 주자는 도리를 탐색하는 과정을 설명하면서 세 가지 新意 탐색 방법을 제시하였다. ‘熟讀을 통한 신의 탐색 방법’, ‘討論을 통한 신의 탐색 방법’, 그리고 ‘講解를 통한 신의 탐색 방법’이 그것이다. 이 세 가지 방법 중 ‘熟讀을 통한 신의 탐색 방법’만 그 자체 독자적 완결성을 띠고 나머지는 독자성이 없다. 도리의 확인을 위한 신의 탐색 활동은 어떠한 경우에도 ‘熟讀을 통한 신의 탐색 활동’이 전제되어야 한다는 것을 의미한다. 그리고 ‘熟讀을 통한 신의 탐색’ 활동을 전제한 신의 탐색 활동은 어떠한 경우의 수라도 가능하다. 둘째 주자는 신의 탐색 활동 그 자체는 도리의 발견 과정이면서도 살아 움직이지 않는 도리[不活 道理]를 살아 움직이는 도리[會活 道理]로 만드는 활동도 된다고 보았다. 그렇기 때문에 신의 탐색 활동은 독자가 도리를 내면화하기 위한 전제 조건이 된다. 셋째 독서를 통해 신의를 왜 탐색하느냐는 물음에 대해 ‘신의 탐색 활동은 도리의 수용과 실천을 위해서이다’라고 할 수 있다. 신의가 없는 수용과 실천 그 자체는 성립할 수 없기 때문이다. 이를 통해 볼 때 신의 탐색을 통한 도리의 발견이 없으면, 도리의 내면화도 불가능하며, 도리의 실천도 이루어질 수 없다. 또한 도리의 발견이라는 것도 신의 탐색의 활동이 없으면 달성될 수 없는 것이다. 이것은 신의 탐색 활동이 주자의 독서 목적을 달성하기 위한 인식론적 토대가 된다는 것을 의미한다. 마지막으로 한국 고전 독서론에서 차지하는 주자 신의론의 의의는 두 가지로 대별된다. 하나는 계승의 면에서 주자의 신의론이 도리의 발견을 위한 인식론적 방법과 절차를 한국 고전 독서론에 제공했다는 점이다. 이 점은 퇴계와 형암의 독서론에서 확인되었다. 다른 하나는 창조적 변용의 면에서 주자의 신의론이 새로운 신의론의 꽃을 피우 데 토대 역할을 했다는 점이다. 이 점은 다산의 독서론에서 확인되었다. 그러므로 한국 고전 독서론 전개에서 주자의 신의론은 긍정적 영향의 면에서 그 의의가 인정된다.

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