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한국인에서 다발성 내분비선종 증후군의 초기 증상 및 임상 양상
김기호,구민영,허성모,이세경,최준호,이정언,김지수,정재훈<SUP>1<.SUP>,남석진,양정현,김정한,Ki-Ho Kim,M.D.,Min-Young Koo,M.D.,Sung-Mo Hur,M.D.,Se-Kyung Lee,M.D.,Jun-Ho Choe,M.D.,Jeong Eon Lee,M.D.,Jee Soo Kim,M.D.,Jae-Hoon Chung,M.D.<SU 대한갑상선-내분비외과학회 2010 The Koreran journal of Endocrine Surgery Vol.10 No.4
Purpose: Multiple endocrine neoplasia (MEN) syndrome is an inherited, autosomal dominant disease that presents as a combination of several endocrine tumors. Early diagnosis of this syndrome is difficult, because of the nonspecific symptoms and signs. This study analyzed early manifestations and clinical characteristics in patients with MEN syndrome. Methods: Medical records were retrospectively reviewed and telephone interviews were conducted with 35 patients diagnosed as MEN syndrome at Samsung Medical Center from December 1994 to December 2009. Results: The 35 patients had been diagnosed as MEN1 (n=14), MEN2A (n=19) and MEN2B (n=2). The early manifestations of the 14 MEN1 patients were related with hyperparathyroidism (n=5), pituitary tumor (n=3), and pancreatic endocrine tumor (n=2). There were tumors of the parathyroid gland in all 14 patients, anterior pituitary in eight patients, and pancreatic islet cells in seven patients. Four cases were incidentally detected during the screening examination. Six cases harbored a MEN1 gene mutation. The twenty-one patients diagnosed with MEN2 comprised medullary thyroid cancer (n=20), adrenal pheochromocytoma (n=15), and hyperparathyroidism (n=4). The MTC-related symptoms in the 21 MEN2 patients included neck mass or discomfort in 12 patients and pheochromocytoma-related symptoms in seven patients. Two cases were detected through familial genetic screening test. The RET gene mutationwas detected in 19 cases. Conclusion: Early manifestations of MEN syndrome were very different between the types of MEN and the types of its presenting tumor. The early diagnosis and proper management of MEN requires awareness of the clinical characteristics of each expressed tumor and is influenced by genetic screening methods. (Korean J Endocrine Surg 2010; 10:266-275)
김기호,한만욱,정상훈,유결,조용남,임진수,권호,이종건 대한성형외과학회 2002 Archives of Plastic Surgery Vol.29 No.2
The purpose of this study was to evaluate effects of chitin on open wound healing in rabbits. Using 15 rabbits, a round, full thickness defect of skin with 2cm in diameter was made on the ventral surface of the each ear. The experimental animals were divided into 3 groups:control group untreated group), base ointment group (group treated with base ointment), and chitin ointment group(group treated with water soluble chitin ointment). A total of 30 wounds were made and each subgroup was allocated 10. On the 7th day after initial wounding, each wound site including surrounding tissue was taken for macroscopic and histological observations. The amount of epithelialization and granulation tissue were measured by Image Analysis System.In macroscopic examination, larger amount of exudate and granulation tissue were observed in water soluble chitin ointment group compared to control and base ointment groups.In histological examination, water soluble chitin ointment group showed thick epithelium and larger amount of granulation tissue and fibroblast deposition. The areas of epithelialization and granulation tissue were significantly increased in water soluble chitin ointment group compared to control and base ointment groups.In conclusion, water soluble chitin accelerated open wound healing by accelerating reepithelization and granulation tissue formation.
김기호 택민국학연구원 2023 국학연구론총 Vol.- No.31
모든 아름다운 것은 심연의 악에 뿌리를 두고 있다. 이 명제를 전제로 하여 본 연구는 참된 효는 심연의 본능에 뿌리를 두고 있다는 주장을 하였다. 이러한 주장을 하는 데는 세 가지의 단계를 거쳤다. 첫째는 「손순매아」가 전설의 형식을 띠고 있다는 점이다. 이것은 이 텍스트가 효에 대한 문학적 설득과 주장을 하고 있다는 것을 의미한다. 둘째 「손순매아」 텍스트는 의지적인 효와 비의지적인 본능의 이항 대립적 구조로 이루어져 있다는 점이다. 의지적인 효는 손순의 판단과 행동, 그리고 동의에 따라서 구체화 된다. 비의지적인 본능은 손순 아이의 배고픔과 그의 생명을 통하여 구체화 된다. 의지적인 효의 목소리가 발생하는 순간 항상 비의지적인 본능의 목소리가 들려온다는 점에서 효와 본능은 언제나 이항 대립적으로 인식되는 관계이다. 셋째 「손순매아」의 효와 본능의 인식론적 구조는 그 자체로 정적이지 않고 ‘참된 효는 무엇인가’라는 매우 동적인 의미 생성에 참여한다. 동적인 의미 생성의 과정을 통하여 텍스트는 효와 본능 사이의 경계를 해체하며, 실존론적으로 참된 효의 의미를 생성한다. 마침내 독자는 생성된 참된 효의 앞에 선다. 「손순매아」의 문학적 가치는 독자를 위하여 일상으로 고정된 효의 인식을 해체하고 효와 본능의 관계 내에서 가능성의 효를 생성하는 데 있다.