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Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4
The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway
SPME와 GC/MS를 이용한 녹나무 향기성분 특성분석
원미미,차은주,윤옥경,김남선,김건,이동선 서울여자대학교 자연과학연구소 2007 자연과학연구논문집 Vol.19 No.-
Recently, land managers have come to realize that, outside Asia, camphor trees grow like street-tree or weeds, infesting forests and displacing native trees. This is because camphor trees are prolific seed producers that do not have serious predators or diseases outside their native range. The camphor tree (Cinnamomum camphora), belongs to lauraceae, is the aromatic evergreen tree from which camphor was derived. Headspace solid-phase microextraction (HS-SPME) and GC-MS were applied for the analysis of volatile fragrances emanated from camphor tree. Divinylbenzene / Carboxen / PDMS fiber was used for HS-SPME adsorption materials. (+)-Camphor (31.00%) and cineol (21.89%) were found as the major volatile aroma components from Chinese camphor tree, whereas (+)-camphor (62.06%) and β-caryophyllene (10.01%) from Japanese camphor tree. Camphor tree is a promising garden tree for well-being.
개에서 발생한 양파 섭취에 의한 하인즈 소체 용혈성 빈혈 증례
이미선,윤기영,서경원,최호정,정성목,송근호,조종기,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2012 動物醫科學硏究誌 Vol.19 No.1
A 10 month-old Yorkshire Terrier was referred to the Veterinary Medical Teaching Hospital of Chungnam National University with the history of lethargy, bile pigment in urine and anorexia. Blood smear showed Heinz body, polychromatocytosis, schistocytosis, anisocytosis, which were the results from the oxidative injury. Hematology demonstrated a moderate anemia(PCV 22.4%, reference rage 35-55%), which was regeneration based on the degree of RPI (4.03, reference rage > 1). Serum biochemistry demonstrated mild elevation in total bilrubin, and mild decrease in total protein and albumin concentration. A diagnosis of Heinz body hemolytic anemia secondary to onion ingestion was made and treated with fluid therapy, oxygen and antioxidant drugs. The dog recovered without any complication.
한지 쌈지 극미량 고체상 추출법을 이용한 레몬과 오렌지 향유 성분 분석
원미미,이동선 서울여자대학교 2010 자연과학연구논문집 Vol.22 No.-
In this study, headspace mulberry paper bag micro solid phase extraction (HS-MPB-μ-SPE) combined to gas chromatography/mass spectrometry has been applied for the analysis of volatile aromas of liquid essential oils from lemon and orange. The technique uses an adsorbent of Tenax TA contained in a mulberry paper bag, minimal amount of organic solvent and very small amount (10 μL) of sample size. Linearity for the calibration curve was excellent, the LOD value was 10.3 ng/mL. Precision and recovery were generally good. In addition, this method allowed combining extraction, enrichment, and clean-up in a single step. Analysis of aroma components in lemon and orange essential oils were performed successfully using this method.
박미향,정미선,박원혁 부산대학교 과학교육연구소 2007 교사교육연구 Vol.46 No.2
본 연구는 환경문제의 심각성을 학습자에게 알리고, 환경에 대한 인식 및 태도를 변화시키는 교육적 방안으로서 자기평가의 효과를 알아보고자 한다. 이를 위해 자기평가지를 개발하여 학습자에게 투입한 결과 자기평가 활동에 참여한 학습자들은 첫째 환경에 대해 의지, 실천, 정서적 측면에서 긍정적으로 변화하였으며, 둘째 환경일반, 환경오염, 재활용, 동물보호, 물 절약 등 주제별 환경 문제에 대해서도 그 심각성을 깊이 인식하며 이를 해결하기 위한 대안 구성에 적극적인 태도를 가지는 것으로 조사되었다. 셋째, 이러한 자기평가 활동은 환경에 대한 태도변화에 있어 남학생보다 여학생의 태도변화에 더 의미 있는 것으로 나타났다. 그러므로 환경문제에 대한 학습자의 자기평가 활동은 학습자의 환경에 대한 인식 및 태도변화에 긍정적인 효과를 나타내므로 환경교육에 있어 현장체험 중심의 프로그램이 가지는 활동적·단기적·장소 제한적 이라는 단점을 보완할 수 있을 것으로 기대된다 The purpose of this study is to find out the effectiveness of self-assessment on the elementary school students' attitude toward environment dealing with environmental issue. For this study, 63 participants in the 3rd grade were chosen and divided into two groups. The self-assessment was applied to the experimental group and the control group were taught by the traditional teaching method focused on the teacher's lecture for 10 lessons. To analyze the effectiveness of the self-assessment, the pre- and post-test for the attitude toward environment was applied to both the groups. As a result, the attitude toward environment including the awareness on environment and environmental issues was not significantly different(p>.05) between the experimental and control group in terms of the pre-test score. However, the post-test score of the experimental group turned out higher than that of the control group(p<.05). Especially the post-test score of the female experimental group was more significant than that of the male experimental group(p<.05). Therefore the self-assessment could make a positive effect on the elementary school students' environment attitude.
정순민,김미경,이정빈,최진환,정봉주,변원탄 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.3
Objectives : Psychotic Symptom Rating Scale (PSYRATS) is an assessment tool to measure the seventy of different dimen-sions of auditory hallucinations and delusions. The reliability and validity of the Korean version of PSYRATS (K-PSYRATS)were examined in Korean patients with major psychosis. Methods : The inter-rater reliability of the K-PSYRATS was determined from the videotaped interviews of the five Schizoph-renic patients. To measure validity and internal consistency reliability, the 109 patients with auditory hallucinations or delusions were assessed using the K-PSYRATS, Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression-Se-verity (CGI-S) scale. Results : K-PSYRATS was found to have excellent inter-rater reliability (intra-class correlation coefficient of auditory haliu-cination=0.81, P<.001, intm-class correlation coefficient ofde1usion=0.97, P<.001) and internal consistency reliability (Cron-bach's a of auditory hallucination =0.77, Cronbach's α of delusion =0.76). Significant correlation was found between K-PSY-RATS and positive syndrome subscale of PANSS and CGI. Conclusion : K-PSYRATS is a useful assessment instrument for psychotic symptoms in Korea.
악성흑색점흑색종 19예에 대한 임상 및 병리 조직학적 연구
홍원진 ( Won Jin Hong ),장홍선 ( Hong Sun Jang ),이상희 ( Sang Hee Lee ),이상은 ( Sang Eun Lee ),정기양 ( Kee Yang Chung ),노미령 ( Mi Ryung Roh ) 대한피부과학회 2016 大韓皮膚科學會誌 Vol.54 No.10
Background: Lentigo maligna melanoma (LMM) is a subtype of melanoma that typically develops on sun-damaged skin. LMM is estimated to comprise 4∼15% of melanomas, but the prevalence is known to be relatively lower in the Korean population than in the Caucasian population. Objective: To review the clinico-pathologic features and treatment outcomes of Korean patients with LMM. Methods: Nineteen patients diagnosed with LMM during 2003∼2015, in the Yonsei University Health System, were included in this study. The age and sex of the patients, lesion location, thickness (Breslow), stage, treatment methods, BRAF, NRAS, and KIT mutation status, and survival rates were analyzed. Results: Among the 19 Korean patients, 11 were male and 8 were female. The median age was 59.2 years. The most common site was the cheek (47.4%), followed by the scalp, eyelid, nose, forehead, lip, and neck. At the time of diagnosis, 13 patients were in localized stages (5 patients, stage 0; 3 patients, stage I; and 5 patients, stage II) and 6 patients were in advanced stages (3 patients, stage III; and 3 patients, stage IV). Patients in the localized stages showed better overall survival (OS) than those in the advanced stages (p=0.012). Nine patients were treated with a wide excision, and 6 using Mohs micrographic surgery. Three patients received high-dose interferon-α therapy; 6, chemotherapy; and 4, radiotherapy. Two patients in stage 0 were treated with topical ingenol mebutate. Two patients had BRAF V600E mutation; 1, NRAS G12R mutation; and 1, KIT mutation. Median OS of the patients was 40.8 months. Conclusion: Our analysis provides additional information about clinical characteristics, treatment, and prognosis of LMM in Korean patients. (Korean J Dermatol 2016;54(10):769∼775)
차미선,소원욱,박인준,이수복 한국공업화학회 2004 응용화학 Vol.8 No.1
We describe the synthesis and characterization of amphoteric poly(acrylate), consisting of the F-marcromer and a 2-(dimethyl amino)ethyl methacrylate (2-DMAEMS) The amphoteric polymer were prepared by marcromonomer technique and radical copolymerization. After copolymerization, the resultant rection solution was purified by silica column. In this study, separation of resultant reaction sloution was purified by silica column. In this study, separation of amphoteric poly(acrylate)s and characterization by InfraRed Spectroscopy, Gel Permeation Charomatography. The IR traces showed that the amphoteric poly(acrylate) was separated successfully polymr of p(2-DMAEMA). The amphoteric poly(acrylate) have number average molecular weights(Mw) about 38,000 by GPC.