좌심실 기능부전을 동반한 만성 관상동맥질환에서 Dobutamine 심초음파의 역할

정보영,임세중,최승혁,고충원,하종원,정남식,유경종,강면식 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

필리핀 여행 후 발생한 쯔쯔가무시병 1예

김계형,김낙현,김문석,김충종,전재현,박완범,장원종,박상원,김익상,오명돈,최강원 대한감염학회 2008 감염과 화학요법 Vol.40 No.6

Infectious diseases imported from other countries have increased as more and more Koreans are going abroad for various purposes. Tsutsugamushi disease from other endemic area such as Southeast Asia is important, because it can occur in any season and eschar may be absent. We report a case of imported tsutsugamushi disease acquired in the Philippines. A patient presented with fever, headache, and maculopapular skin rash. However, eschar was absent. Polymerase chain reaction (PCR) for 56-kDa gene of Orientia tsutsugamushi using buffy coat was positive. Serum indirect immunofluorescent antibody assay was initially negative but became positive with a titer of 1:320 at follow-up, Sequencing analysis revealed the strain to be 100% identical to the TW73R strain identified in Taiwan. After the patient received doxycycline, body temperature normalized in 12 hours. Tsutsugamushi disease is one of the differential diagnoses that should be included for patients with fever who have recently returned from Southeast Asian countries. PCR for O. tsutsugamushi using patient's buffy coat was useful for early diagnosis.

한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

맥주맥 F_1세대의 조합능력 검정

정원복,오주성,황필성,김수동,서세정,현종내,김대호 東亞大學校 2002 東亞論叢 Vol.39 No.-

맥주맥의 이면교잡에 의한 F_1세대에 대한 조합능력을 검정한 결과를 요약하면 다음과 같다. 8개 형질에 대한 GCA, SCA, RCA효과를 검정한 바 조합능력은 전 형질에서 GCA, SCA, RCA가 모두 유의하였는데 간장, 수장, 망장, 간직경, 곡핍폭, 1수립수 1000립중은 GCA가 SCA보다 크고, 품종간 GCA효과는 진양보리가 간장에서 부(-)이고, 삼도보리가 수장·망장·간직경·1000립중에서, 사천6호가 망장과 간직경에서, 진광보리가 곡립장에서, 두산29호가 곡립폭·1수립수·1000립중에서 각각 정(+)으로 높았다. SCA효과에서 수장은 두산29호×두산8호 조합이, 망장은 진양보리×두산29호 조합이, 간직경은 사천6호×진광보리 조합이, 곡립장은 진양보리×두산8호 조합이, 곡립폭은 진광보리×두산8호 조합이, 1수립수는 진양보리×삼도보리 조합이, 1000립중은 사천6호×두산8호 조합 및 두산29호×두산8호 조합이 각각 정으로 높았고, 간장은 삼도보리×진광보리 조합이 부로서 높았다. RCA효과에서 수장은 두산8호×남향보리 조합이, 망장은 진양보리×삼도보리 조합이, 간직겨은 사천6호×진양보리 조합이, 곡립장은 사천6호×진광보리 조합이, 곡립폭은 진양보리×삼도보리 조합이, 1수립수는 사천6호×두산29호 조합이, 1000립중은 진양보리×두산29호 조합이 각각 정으로 높았고, 간장은 사천6호×두산29호 조합이 부로서 높았다. Seven barley varieties in F_1 generation of the possible crosses among them were used to estimate the combining ability for eight characters, i.e., culm length, spike length, awn length, culm diameter, grain length, grain width, number of grains per spike and 1000 grains weight. Data for F_1 hybrid and parents were subjected to the analysis method proposed by Griffing. The results obtained were summarized as follows. mean squares of general combining ability(GCA), specific combining ability(SCA) and reciprocal combining ability(RCA) were significant for all characters observed. Mean squares of GCA were higher than those of SCA and RCA in culm length, spike length, awn length, culm diameter, grain width, number of grains per spike and 1000 grains weight. Variety Dusan#29 showed the highest GCA effect for number of grains per spike and positively high effects of GCA were observed from variety Samdo bori in spike length, awn length, culm diameter, 1000 grains weight, and from variety Jinkwang bori I grain length, from Dusan#29 in grain width, umber of grains per spike, 1000 grains weight. Also Jinyang bori showed negatively high GCA effect in culm length. In SCA effects, hybrids in Jinyang bori × Samdo bori were exhibited positively high for number of grains per spike and high SCA effects for 1000 grins weight were found positively in Sacheun#6×Dusan#8 and Dusan#29×Dusan#. In RCA effects, hybrids in Sacheun#6×Dusan#29 were exhibited positively high for number of grains per spike and high RCA effects for 1000 grains weight were found positively in Jinyang bori×Dusan#29.

대장암 환자에서의 담즙 암태아성 항원(CEA)

김종우,박용태,정철운,권성원,장항석,손석우,안대호,이경포 대한대장항문학회 2000 Annals of Coloproctolgy Vol.16 No.6

선천성 양측성 폐정맥 협착증의 심초음파 및 심도자 및 혈관조영술 소견

정남식,하종원,윤정한,김병옥,장양수,조승연,조범구 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.4

大豆未熟子葉祖織의 營養培地條件에 따른 器官分化

元鍾樂,權貞淑,鄭圭和,張權烈 慶尙大學校 1987 論文集 Vol.26 No.1

大豆의 末熟子葉組織을 사용하여 여러가니 營養培地에서 칼루스와 胚狀體로부터 器官을 分化시키고자 하였던 바 얻어진 결과를 要約하면 다음과 같다. 1. 칼루스誘起는 MS 基本培地에 1.0mg/12,4-D,와 2.0mg/1kinetin을 첨가하거나 (M5培地) 하였을 때 가장 효과적이었다. 2. M4培地에 培養한 칼루스로부터 生長點모양의 완전한 구조를 갖춘 細胞群을 組織學的으로 관찰할 수 있었다. 3.칼루스를 器官分化를 위한 培地에 ?代培養하였을때 根分化, 칼루스로부터胚狀體의 形成, 胚狀體로부터 싹이나 잎의 分化는 供試한 大豆系統이나 使用한 營養培地에 따라 약간의 差異는 있으나 비교적 용이할 것으로 여겨졌다. 4. 供試한大豆系統인 뱀콩의 末熟子葉組織을 M4培地에서 칼루스를 誘起시킨 후 MS基本培地에 0.005mg/1 picloram 과 2.0 mg/1 BAP를 첨가한 培地(OM2培地)에 ?代培養하였을 때 칼루스로부터 胚狀體의 形成이 잘 되었고 胚狀體들로 부터 잎이 分化되었다. The experiments were conducted to investigate organ differentatin rom calls and embryoid under various media using immature ctyledon of soybeam. The results obtained were as followings: 1. 1. Omg 2,4-D plus 0.2mg kinetin or 0.2 mg BAP perr litre on MS basal mediu were efective growth regulators for callus induction. 2. Meristematic structure was observed from the callus induced by 1.0mg 2,4-D plus 0.2mg kinetin per litre in MS basal medium in which callus growth showed best response. 3. Root and embryoid from callus and shoot or leaflet from embryoid were differentiated on the medium subcultured for organ different on the soybean lines and media applied. 4. Embryoid from callus and leaflet from the embryoid were differentiated on the nutritional condition subscultured with 0.005mg picloram plus 2.0mg kinetin per litre on MS in immature cotyledon of spybean line Baemkong.

慶山鑛山附近의 地質과 鑛化作用에 對하여

鄭遠佑,李倫鐘 경북대학교 과학교육연구소 1981 科學敎育硏究誌 Vol.5 No.-

The geology and minerliaztion of Gyeongsan mine and its vicinity were studied mainly from petrochemical and geochemical point of view. The mineral composition of ores and the content variations of trace elements in carbonate veins investigated in relation to the origin of ore deposits. From field observation, microscopic study and chemical analysis of major and trace elements it may be summarized and concluded as followings: 1) Mineralization is assumed to have been formed from carbonate-rich hydrothermal solution passing through the fissures developed in the granitic rocks. The major strike and dip of the fissures are NS to N10˚E and nearly vertical. 2) The characteristic variation trends of several oxides of bulk chemical analysis and modal analysis of the granitic rocks indicate that the rocks belong to adamellite to granite and have some similarity to the granite of G group in southern Gyeongsang basin (Lee, 1978) and the younger granite of Ogcheon geosynclinal zone(Lee, 1971). 3. Ore minerals in the carbonate vein are mainly arsenopyrite, molybdenite, pyrite and sphalerite. Sphalerite associates occasionaly with small amounts of bismuthinite and chalcopyrite. Gangue minerals found in this ore deposits composed of calcite, dolomite, ankerite, quartz, K-feldspar etc.. 4) The distribution pattern of trace elements show that Co content is mostly low and t tends to decrease, like Cu and As, with depth, and that Mo content is high in drill holes of No. 5 to 7 and tends to increase with depth. It seems that the variation trends of Co fairly show similarity with As and Cu, but dissimilarity with Mo and the others. 5) The raw ores of the past might be cobalt-bearing arsenopyrite, that was much enriched in Co, considering the ratio of Fe/Co based on the past analytical results of arsenopyrite.