원발성 후복막 점액낭샘암종 1예

지준호,이화정,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Primary retroperitoneal mucinous cystadenocarcinoma is a very rare malignancy, and little is known concerning its Pathogenesis, optimal treatment, and prognosis. A 29-year-o1d pregnant woman (21 weeks) Presented with abdominal discomfort CA 19-9, CA 125, and CEA were normal Abdominal CT scanning revealed a 19x15x13 cm retropentoneal tumor Exploratory laparotomy and tumor excision were performed. Mucinous retropentoneal implants were removed as completely as possible Histologically, the tumor showed focal areas of capsular invasion, but free resection margins The uterus and both ovaries were normal in appearance No adjuvant therapy was pursued. Six months later, Peritoneal and bilateral ovarian metastases were discovered. Hence, we report the details of this case of primary retroperitoneal mucinous Cystadeno-carcinoma and present a review of the literature.

만성 승모판 패쇄부전증 환자에서의 안지오텐신 전환효소 억제제의 장기 투여 효과

김대희,이명묵,이해영,조현재,박승정,서재빈,서정원,양한모,윤창환,조상호,이준희,김용진,김명아,손대원,오병희,박영배 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.2

췌장 선방세포암 1예

이화정,지준호,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Acinar cell carcinoma is a rare tumor that represents 1~2% of al1 pancreatic cancers. Clinical and radiologic findings are inconclusive in this disease Acinar cell carcinoma is characterized by rapid progression and early metastasis, which lead to its poor prognosis. A 41-year-o1d man was admitted to our hospital for abdominal pain. Abdominal computed tomography (CT) and positron emission tomography-computed tomography (PET-CT) showed a splenic mass, which was being invaded by a pancreatic tail mass and which had increased ^(18)F-fluorodeoxyglucose (FDG) uptake Primary radical distal pancreatectomy and splenectomy were performed. Pathologic findings revealed an acinar cell carcinoma of the Pancreas The patient underwent a total gastrectomy three months later because of gastric recurrence Four months later, multiple hepatic metastases were discovered, and the patient underwent a left hepatectomy During treatment with capecitabine, there was no evidence of tumor progression for 14 months. We report a case of metastatic pancreatic acinar cell carcinoma, which did not progress for an extended period while the patient was being treated with capecitabme.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

흰쥐 뇌줄기에 분포하는 Nitric Oxide Synthase 신경세포에 관한 면역조직화학적 연구

나준희,허영범,박찬,김정혜,유진화,안희경,이원규 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.2

스트레인 게이지 브리지 종류에 따른 탄성계수의 실험적 연구

鄭熺孝,李承烈,朴泳珏,朴峻熙 경상대학교 생산기술연구소 2001 工學硏究院論文集 Vol.1 No.-

Strain gauges are widely used for physical force measurements in mechanical, marine, aircraft and civil engineering as well as the fields of architecture, automobiles, and medical science. Strain is measured to determine the degree and behavior of forces such as stress or load. Strain gauges are easy to use and offer a high degree of accuracy and stability. This paper is shown the accuracy of experimental elastic modulus in the tension test according to the strain gauges connections and bridge circuits which are Quarter Bridge(single active uni-axial gauge), Half Bridge(two active on possion gauge), Full Bridge(four active two possion gauge).

開斷面 캔틸레버 보의 휨-비틂 擧動에 關한 實驗的 硏究

鄭熺孝,金洪俊 경상대학교 생산기술연구소 2001 工學硏究院論文集 Vol.1 No.-

The analysis on flexural-torsional behavior is fundamental and significant in the analysis and design of structural members. In fact, as most structures are affected by flexure and torsion at the same time, the stress analysis can be performed by superimposing the effects caused by the bending and twisting loads acting seperately as far as the stress-strain relationships maintain linearly elastic. In this paper, cantilever channels for this analysis was considered and the flexural-torsional behaviors of these channel specimens was analytically investigated by superimposing the influence of bending, pure torsion and warping torsion. To conduct an experiment, three cantilever channel specimens were made and tested with strain gauges, Also, these results of theory and experiment were compared with analysis program, SAP2000.

주요 국산수종의 휨가공성 평가

정인석,이원희,장준복,배현미 한국목재공학회 2002 목재공학 Vol.30 No.2

본 연구는 고주파 가열에 의한 산벚나무, 소태나무, 서어나무, 굴참나무, 박달나무, 고로쇠나무, 피나무, 소나무, 리기다 소나무, 참오동나무의 휨가공성을 평가해 보기 위하여 실시하였다. 본 연구에서 휨가공을 위한 곡율반경은 휨틀의 곡율반경에 의해 4 ㎝, 6 ㎝, 10 ㎝으로 구분하고, 대철의 두께는 0.6 ㎜과 0.8 ㎜로 구분하였다. 본 연구결과, 소태나무, 서어나무, 박달나무 고로쇠나무는 모든 곡율반경에서 100% 성공율을 나타내었다. 산벚나무와 굴참나무의 경우 58%와 83%의 성공율을 각각 나타내었다. 피나무와 오동나무의 경우 총 29%와 8%로 매우 불량하게 나타났고, 곡율반경 4 ㎝에서는 모두 실패로 나타났다. 침엽수재인 소나무와 리기다 소나무는 각각 44%와 56%의 성공율을 나타내었다. 대철의 두께는 휨가공성의 쉽고 어려움보다는, 건조시 건조속도에 더 많은 영항을 주는 것으로 나타났다. 건조과정에서 대철두께가 얇을수록 휨가공부재의 건조 속도가 빠른 경향을 나타내었다. This study was carried out to evaluate bending property on principal domestic species such as sargent cherry(Prunus sargentii), bitter wood(Picrasma quassioides), horn beam(Carpinus laxflora), cork oak(Quercus variabilis), birch(Betula schmidtii), painted maple(Acer mono), basswood(Tilia amurensis), red pine(Pinus densiflora), pitch pine(Pinus rigida), royal pawtonia(Paulownia tomentosa) by microwave heating. In this study, radius of curvature(ROC) for bending process was classified by radius of curvature(ROC) of bending plate such as 4 ㎝, 6 ㎝, and 10 ㎝, and thickness of metal-strap(TMS) was 0.6 ㎜ and 0.8 ㎜. Bending process was successfully operated for 100 percent in bitter wood, horn beam, birch and painted maple. On the other hand, there was a success rate of 58 percent in sargent cherry and 83 percent in cork oak and 29 percent in hasswood and 8 percent in royal pawlonia which is the worst bending property. All specimens of basswood and royal pawlonia were broken at 4 ㎝ of ROC. Success rate of bending property was shown 44 percent in red pine and 56 percent in pitch pine. TMS has an effect on only drying speed in drying process than difficulty and facility of bending property. It was considered that the thinner TMS in drying process is the faster in drying speed of bent wood.

흰쥐의 횡복직근 피판술에서 Lipo-PGE1의 투여 시기가 피판 생존에 미치는 효과

정성노,백혜원,조성필,변준희 大韓成形外科學會 2004 Archives of Plastic Surgery Vol.31 No.3

상자형의 전단지연 현상과 유효폭에 관한 연구

鄭熺孝,金洪俊,李承烈,朴峻熙 경상대학교 생산기술연구소 2002 工學硏究院論文集 Vol.2 No.-

In a box girder, it is an accepted practice in structural engineering to represent the effect of 'shear lag' by adopting an 'effective width' concept. The actual width of flange plate (b) is replaced by a reduced width (b_e) over which the longitudinal stresses may be considered uniformly distributed and the application of the elementary theory of bending to the transformed girder cross section gives the correct value of maximum longitudinal stress (σ_max). This paper provides how to determine the magnitude of 'shear lag' and 'effective width ratio' in case of orthotropic box girder which is simply supported, symmetrically loaded only.