Impedance를 이용한 전도성고분자 센서의 가스감응특성

이경문,유준부,이병수,전희권,이상태,이덕동,허증수 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

통합심리치료의 인지분화훈련이 정신분열병 환자의 기초 인지기능에 미치는 영향

이희상,현명호,조현상,이연희,김태용,장순아,노규식,정기립,이만홍,유계준 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

연구목적 : 정신분열별 환자들을 대상으로 통합심리치료의 소프로그램인 인지분화훈련을 실시하여 실행기능, 개념형성능력, 언어능력 및 추론력에 대한 훈련이 보다 더 하위단계의 인지기능인 주의력, 기억력, 반응시간 등을 호전시킬 수 있는 지를 알아보고자 하였다. 연구방법 : DSM-IV상 정신분열병으로 진단된 24명의 입원환자를 무작위로 양분하여 한 군은 인지분화훈련군으로 다른 한 군은 대조군으로 나누었다. 훈련군은 4주동안 1주일에 3회(매회 60분간)로 총 12회의 통합심리치료의 인지분화훈련을 받았으며 대조군은 동일한 시간동안 정신건강교육을 받았다. 훈련전후에 훈련군과 대조군을 대상으로 개정판 Wechsler 기억검사로 주의집중력, 장·단기 기억력을 측정하였고 Vienna test system중 결정반응시간검사로 반응시간, 반응결정시간, 반응운동시간을 평가하였다. 연구결과 : 1) 주의집중력에서는 훈련군과 대조군사이에 집단간 효과, 집단내 효과 및 상호작용 효과가 없었다. 2) 단기기억력에서는 훈련군과 대조군사이에 집단내 효과는 있었으나(F(1,24)=10.46. p〈.05). 집단간 효과, 상호작용 효과는 없었다. 3) 장기기억력에서는 훈련군과 대조군사이에 집단내 효과는 있었으나(F(1,24)=15.09. p〈.05). 집단간 효과, 상호작용 효과는 없었다. 4) 반응시간에서는 상호작용 효과(F(1,24)=5.18, p〈.05)가 있었다. 5) 반응운동시간에서는 집단간 효과, 집단내 효과 및 상호작용 효과가 없었다. 6) 반응결정시간에서는 상호작용 효과(F(1.24)=6.00, p〈.05)가 있었다. 결 론 : 통합심리치료의 인지분화훈련은 정신분열병 환자에서 하위단계의 인지기능 중 반응시간(특히 반응결정시간)을 단축시키는 효과가 있었다. Objectives : The purpose of this study was to investigate the effects of cognitive differentiation training of Integrated Psychological Therapy(a training program of executive function, concept formation, language, and abstraction) on micro-level cognitive function such as attention, memory and reaction time in patients time in patients with schizophrenia. Methods : Twenty-four inpatients diagnosed as schizophrenia using DSM-IV were randomly assigned to 2 groups. The training group went through a total of 12 sessions of cognitive differentiation training for 4 weeks. The control group received psychoeducation program during the same period. Wechsler Memory Scale-Revised and Decision-Reaction Timer of Vienna Test System were administered to all patients, both before and after the training program. Results : 1) In the attention and concentration scores of Wechsler Memory Scale-Revised, between group, within group and interaction effects of training were not significant. 2) In the short-term memory scores of Wechsler Memory Scale-Revised, within group effect of training was significant(F(1,24)=10.46, p〈0.05), but the between group and interaction effects did not reach significance. 3) In the long-term memory scores of Wechsler Memory Scale-Revised, within group effect of training was significant(F(1,24)=15.09, p〈0.05), but the between group and interaction effects did not reach significance. 4) In the reaction time scores of Decision-Reaction Timer, interaction effect of training was significant(F(1,24)=5.18, p〈0.05). 5) In the motor time scores of Decision-Reaction Timer, between group, within group and interaction effects of training were not significant. 6) In the decision time scores of Decision-Reaction Timer, interaction effect of training was significant(F(1,24)=6.00, p〈0.05). Conclusion : Our findings suggest that cognitive differentiation training of Integrated Psycho-logical Therapy is partly effective on improving micro-level cognitive functions such as reaction time(especially, decision time) in patents with schizophrenia.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Purge & Trap-GC를 이용한 의약품 필름코팅 정제 중 잔류용제에 관한 연구

장준식,이명자,소유섭,문춘선,이주헌,박희라,김진숙,강경모,이선옥,방성연,유미자,유문균,금오성,이병욱 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

의약품은 약물을 생체에 적풋하기 위하여 유효성분의 효과가 언제나 일정하게 확보되고 사응에 편리하도록 만들어지는 것이므로 유효썽분 이외에 약효에 영향을 주지 않는 성분이 첨가되는 경운가 많다. 이 때 사용되는 용매들은 제피의 광택 및 건쪼시간의 단축 등을 위하여 휘발점이 낮을 용매들이 주로 사용되어진다. 본 연구는 의약품 필름코팅정제 중 잔류용매 4종(chlorofonr benzen, trichloro ethylen, 1,4-dioxane)에 대한 변형된 pirge & trap-GC 장치를 이용한 동시분석방법을 개발하였으며, 각 표준품의 RSD 값은 chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69% and 1,4-dioxane 3.41%였다. 또한 시중 유통중인 의약품 50종에 대하여 잔류웅매 양을 측정하였으며, 검출되는 잔류용매는 한 건도 없었다. This study nras carried out to develope the analytical method for the mixture of chlorefonn, benzen, trichloroethylen and 1,4-dioxane simultaneously and determine the remainingorgauic solvents in coating tablets by Purge & Trap-GC. The results were as follouFs ; 1. Chloroform, benzen, trio:tloroethylen and 1,4-dioxane separated by tenax #5 trap by HP-624GC column by terrlperature programming. The peaks were separated completely at retentiontime of 6.88min for chloroform, 8.21min for benzen, 10.38miu for trichloroethylen and 11.95minfor 1,4-dioxane. 2. Standard RSD were individually chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69%and 1,4-diorane 3.41%. 3. 60 samples were not detrcted chloroform, benzen, trichloroethylen and 1,4-dioxane.

전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

7075 Al 합금의 T9처리후 미세조직 및 인장강도 분석

이준희,송요승,김효열,이윤복 한국항공대학교 항공우주산업기술연구소 2002 航空宇宙産業技術硏究所 硏究誌 Vol.12 No.-

본 실험에서는 기존 텐트용 pole 로 사용되어 온 7075 AI의 T6처리 제품보다 더 우수한 인장강도 및 표면 특성을 갖는 제품 개발을 목적으로 T6처리에 냉간가공을 가미한 T9처리를 하여 그 특성을 알아보았다. 각 시편은 직경이 8.5㎜, 8.7㎜, 8.9㎜ 9.1㎜이고, 두께 t는 0.7 ㎜∼0.72㎜ 인 것을 사용하여 표면 조도, 경도 측정, 인장강도측정 및 조직관찰을 행하였다. 조도 측정 결과 T9시편이 T6시편에 비해 약 0.02㎛정도 작게 나왔으며 이것은 냉간가공에 의해 조직이 치밀해졌기 때문이라 여겨진다. 경도 측정과 최대인장강도 측정 결과 T9시편에 T6보다 큰 경도값과 최대인장강도 값을 가졌으며 이것은 냉간가공에 의한 grain의 심한 변형으로 인한 영향이라 여겨진다. 조직관찰 결과 T9시편이 T6시편보다 더 많은 변형이 일어난 것을 알 수 있었다. grain의 크기 차이가 많지 않았는데 이것은 열간가공과는 달리 냉간가공에서는 재결점 없이 단순히 grain의 변형에 따른 찌그러짐이나 분열에 의한 것이므로 grain의 크기에는 크게 영향을 주지 않았다고 사료된다. The properties of the samples after T9 treatment on 7075 aluminum which has been used as tent pole were studied in this paper. The T9 treatment is the process to be added a cold work after T6 treatment for improving the tensile strength and the properties of a surface roughness. The tests of surface roughness, hardness, tensile strength and micro structure on T9 treatment samples were conducted. The diameters of samples are 8.5㎜, 8.7㎜, 8.9㎜ and 9.1㎜. The thicknesses of samples are 0.7㎜ and 0.72 ㎜. The average surface roughness of samples after T9 treatment was less 0.02㎛ than that of T6 treatment The average values of hardness and tensile strength were increased after T9 treatment because of grain deformation.

新羅 高塚의 특성과 의의

李熙濬 嶺南考古學會 1997 嶺南考古學 Vol.- No.20

언어학에서 바라본 화자

이준희 고려대학교 민족문화연구원 한국문학연구소 2001 한국문학연구 Vol.- No.2

Currently, the study of Language is moved speaker's utterance to hearer's utterance. This currency is made by the change of understanding about speaker. That is, the studies of production in utterance are progressive to the interpretation in utterance. The speaker in structural linguistics play only on role in judging right or wrong sentence. But the speaker in pragmatics play an important role in the subject of speech-acts. The changes of roles with speaker is changed to linguistics but also the study of korean-the treatment.

라켓스포츠소비자의 구매행동에 관한 연구

이준희,최정도 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.1

The purpose of this study was to investigate customers purchasing behavior in racquet sports (table tennis, badminton, tennis and squash) based on their demographics including age, sex and occupation. This study also examined differences in purchasing motives, sources for the product information, a period of searching for the production information, main factors affecting purchasing behavior, and people influencing purchasing behavior. One hundred ninety-eight individuals who engaged in racquet sports voluntarily participated in this study. The program of statistics process was used with SPSS 10.0. The statistical techniques used for analysis were reliability, frequency, and Chi-square. Statistical significance was accepted at an alpha level of p<.05. The major findings of this study were as follows: 1. There were statistical significance differences in consumers purchasing motives based on their age and occupation(p<.05). The main purchasing motive for older respondents was to maintain or improve their health and fitness while younger consumers motive was to improve their sport skills. Respondents who were administrators and managers were more interested in learning sport skills than the other respondents. 2. There were statistical significance differences in consumers sources for the product information based on their gender(p<.05) and occupation(p<.01). Male respondents were more likely to receive the information from their club members and the expert while female respondents were more likely to get it from their family. 3. There were statistical significance differences in a period of searching for the production information based on their age(p<.01) and occupation(p<.001). Respondents who were administrators and managers spent much more time(8-13 days) than the other respondents (3 days or less). 4. There were statistical significance differences in main factors affecting purchasing behavior based on their age(p<.05) and occupation(p<.001). Older respondents were more likely to select the product based on its fee and facilities while younger respondents were more likely to view services as the most important factor. 5. There were statistical significance differences in people influencing on consumer purchasing behavior based on their gender(p<.01) and occupation(p<.001). Male respondents were more likely to be influenced by their friends and co-workers while female respondents were more likely to be affected by their spouse. 6. There were statistical significance differences in consumers willingness to recommend the product to others based on their gender(p<.01) and occupation(p<.001). Older respondents were more likely to recommend the product to the others than younger respondents.

스쿠버다이빙장비 구매결정요인에 관한 연구

이준희,최정도 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4

The purpose of this study was to investigate opportunities in the scuba diving market and examine the factors influencing the customer's purchase decision in scuba diving equipment in order to provide guidelines for planning effective marketing strategies to enhance customer satisfaction and maintain customer loyalty, The subjects were scuba diving customers at scuba diving resorts or scuba diving pro shops in the Republic of Korea Eight hundred forty-three customers voluntarily participated in this study by completing a survey. The statistical analyses were performed by using the SPSS 10.0 software, The statistical techniques used for analysis were factor analysis, reliability analysis, frequency, t-test, One-way ANOVA, and Scheffe's post hoc test, Statistical significance was accepted at an alpha Level of p<.05. The major findings of this study were as follows: First, female customers in the study indicated that its quality was the most important element of their purchase decision when considering equipment, followed by design, price, brand name, rarity, and fashion. The females ranked these factors significantly higher than their male counterparts. Second, people in their 20s thought that quality was the most important factor that influenced their purchase decision, followed by price, design, rarity, brand name, and fashion, They rated these factors significantly higher than the rest of the subjects, Third, people with high incomes (monthly income l,500,000won) felt that price and rarity were the most important factors for their purchase decision, while people with high incomes (monthly income 3,500,000won) indicated that quality was the most important factor. Forth, people with high education (bachelor degree) thought that function was the most important factor for their purchase decision, followed by quality, convenience, price, and design, Fifth, people who participated in scuba diving between one and three times a week believed that design was the most important factor for their purchase decision making, followed by rarity, brand name, advertisement, fashion, and the location of the store, Sixth, people with less than three years of scuba diving experience indicated that price was the most important factor for their purchase decision, followed by the design, brand name, rarity, fashion, and advertisement, Seventh, scuba diving beginners tended to believe that design was the most important factor for their purchase decision followed by brand name, and fashion.