Clinical Significance of Classification of Graves` Disease According to the Characteristics of TSH receptor Antibodies

(Won Bae Kim),(Hyun Kyung Chung),(Young Joo Park),(Do Joon Park),(Hong Kyu Lee),(Bo Youn Cho) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.3

N/A Background:It has been widely accepted that the epitope (s) and/or functional characteristics of thyrotropin receptor antibodies (TSHRAb) from Graves` patients are heterogenous among patients. However, the clinical significance of such heterogeneity has not been systematically evaluatedyet. We were to elucidate and find the clinical significance of heterogeneity for TSH receptor antibodies in Graves` disease. Methods:We measured stimulating TSHRAb (TSAb) activities using CHO-hTSHR cells, FRTL-5 cells and chimeric receptor expressing cells (Mc1+2 and Mc2), specific blocking TSHRAb (TSBAb) activities using Mc2 cells and TBII activities using porcine thyroid membrane in 136 patients with untreated hyperthyroid Graves` disease. Results: Based on various TSHRAb activities from each patient, the patients could be categorized into 7 subgroups by cluster analysis; 1) Group 1 (n=41) was characterized by moderate TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, typical TSAb epitope, rare blocking antibodies and high TBII activities. 2) Group 2 (n=16) was characterized by the presence of blocking TSHRAb in most patients, albeit the other characteristics were the same as those in Group 1. 3) Group 3 (n=19) patients had low TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, seldom had blocking TSHRAb, but they had high TBII activities. 4) Group 4 (n=30) could be categorized as `mild disease` group, as they had low activities in all kinds of TSHRAb assay and had low antim icrosomal antibody activities. 5) Group 5 (n=14) was characterized by moderate TSAb activities with atypical epitope (s), rare blocking TSHRAb and moderate TBII activities. 6) Group 6 (n=10) patients had veryhigh TSAb activities with typical epitopes, seldom blocking TSHRAb and low TBII activities. 7) Group 7 (n=6) was characterized by very high TSAb activities with atypical epitopes and high TBII activities. Pretreatment serum thyroid hormone level was low only in group 4 patients compared to the other 6 groups (p<0.05). The size of goiter was significantly larger in those in group 1 and group 3 (p<0.05) compared to the other 5 groups. The prevalence of clinically significant ophthalmopathy was higher in group 2 patients than the other 6 groups (50%vs.27.5%,p=0.06). Among 6 kinds of TSHRAb activities, only the blocking TSHRAb activity was significantly associated with the presence of ophthalmopathy in multivariate analysis. Conclusion:These results suggest that the differences inepitopes for TSAb or the presence of blocking TSHRAb is not a major factor in determining the degree of thyrotoxicosis in Graves` disease. Although the pathogenic mechanism is not clearyet, we suggest that patients with ophthalmopathy have different TSHRAb repertoire from those without ophthalmopathy in Graves` disease.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

3분과 : 가선집재작업에서의 작업 생산성 및 비용 분석

한원성 ( Won Sung Han ),한한섭 ( Han Sup Han ),김남훈 ( Nam Hun Kim ),차두송 ( Du Song Chu ),조구현 ( Koo Hyun Cho ),민도홍 ( Do Hong Min ),권기철 ( Ki Cheol Kwon ) 한국임학회 2014 한국산림과학회지 Vol.103 No.1

본 연구에서는 임목수확작업에 사용되는 집재기계의 작업효율성을 분석하여 경사가 급한(20° 이상) 작업조건에 적합한 가선계 집재기계를 선정하는데 기초 정보를 제공하고자, 타워야더(RME-300T), 트랙터부착형 집재기(일명: 춘천집재기), 트랙터윈치(FARMI) 등에 의한 집재작업에서의 작업생산성 및 비용을 비교 분석하였다. 평균 흉고직경이 20 cm, 집재거리 60 m, 가로집재거리 10 m, 그리고 기계이용률이 70%인 동일한 작업 조건에서 작업이 이루어질 경우, 타워야더의 1일 집재작업 생산성은 33.04 m3/일, 트랙터부착형 집재기는 38.47 m3/일, 그리고 트랙터윈치는 14.17 m3/일으로 분석되었으며, 이에 따른 집재작업비용은 각각 25,105원/m3, 20,520원/m3, 37,835원/m3으로 나타났다. 동일한 작업조건에서 집재거리에 따른 각 집재기계별 작업효율성을 비교하였을 경우, 집재거리가 40 m 이내로 짧을 경우에는 트랙터윈치에 의한 집재작업이 효율적이며, 40~140 m의 집재거리에서는 춘천집재기가, 140 m 이상의 장거리 집재작업에서는 타워야더가 가장 효율적인 것으로 나타났다. This study was conducted to provide field-based harvesting study information which can be used to select an optimal cable system for certain work conditions on steep grounds (>20° ground slope) in Korea. Toaccomplish this study objectives, we evaluated three cable yarding systems (RME-300T tower-yarder, Chuncheontower-yarder, FARMI tractor winch) working in typical work conditions for their yarding productivity and operational efficiency. Those yarders are commonly used for removing logs or trees on steep grounds in Korea. Under the same work conditions (average DBH of tree to be cut, 20 cm; yarding distance, 60 m; lateral yardingdistance, 10 m; and machine utilization rate, 70%), the average productivities were 33.04 m3/day, 38.47 m3/day, and 14.17 m3/day for RME-300T, Chuncheon tower-yarder, and FARMI, respectively. Our standardized cost comparison study also showed that the yarding cost was highest at 37,835 won/m3 with FARMI, followed byRME-300T at 25,105 won/m3 for the same work conditions. We found the lowest yarding cost with the Chuncheon tower-yarder at 20,520 won/m3 which was resulted primarily from high yarding productivity at theyarding distance (60 m). Our analysis suggested that a small machine such as FARMI could be a low-costyarding machine option for a cable yarding job with a short yarding distance (40 m or less). The Chuncheontower-yarder is well suited for a mid-range yarding distance job in Korea, ranged between 40 to 140 m. Ifyarding distance were longer than 140 m, the RME-300T tower yarder appears to be most cost-effective.

환율, 금리, 주가사이의 동적연관성 연구

조혜원(hye-won cho),홍정효(Chung-Hyo Hong) 한국산업경제학회 2009 한국산업경제학회 정기학술발표대회 논문집 Vol.- No.추계

환율, 금리, 주가사이의 동적연관성 연구

홍정효(Chung-Hyo Hong),조혜원(Hae-Won Cho) 전북대학교 산업경제연구소 2010 아태경상저널 Vol.2 No.1

본 연구는 2000년 1월부터 2008년 말까지 콜금리, 3년물 국채금리, 원달러 외환시장 및 KOSPI자료를 이용하여 원달러 환율 및 장단기 금리 변화량, KOSPI수익률사이의 동적연관성을 실증적으로 분석하였다. 실증분석결과 첫째, 콜금리와 원달러 외환시장사이에는 장기적인 균형관계가 존재하고 있으나, 콜금리와 KOSPI, 원달러와 KOSPI사이에는 장기적인 균형관계가 존재하지 않는 것으로 나타났다. 3년물 국채금리는 콜금리와 공적분관계가 있으나 원달러, KOSPI와는 공적분관계가 존재하지 않는 것으로 나타났다. 둘째, 3년물 국채금리는 KOSPI 및 원달러 환율간에는 피드백적인 관계가 존재하고 있으나, 3년물 국채금리의 KOSPI 및 원달러에 대한 영향력이 그 반대의 경우보다 상대적으로 더 강한 것으로 나타났다. 세째, KOSPI와 원달러 환율사이에도 피드백적인 영향력이 존재하고 있으나 KOSPI의 원달러 환율변화에 대한 영향력이 그 반대의 경우 보다 더 강한 것으로 나타났다. 다섯째, 콜금리는 원달러 외환시장에만 영향력을 미치고 있으며, 장단기 금리사이에는 3년물 국채금리가 콜금리에 대한 영향력을 미치고 있으나 그 반대의 경우는 존재하지 않는 것으로 나타났다. 여섯째, 전반적으로 4가지 금융시계열모두 호재보다는 악재에 더 민감하게 반응하는 정보의 비대칭적인 특성이 존재하는 것으로 나타났다. 이러한 실증분석결과는 투자자들의 투자 및 위험관리전략 수립 뿐 아니라 정책당국자들의 통화 및 금융정책수립에 다소 나마 기여를 할 수 있을 것으로 보여 진다. We try to examine on the short term lead-lag relationship between call, KOSPI and won dollar spot markets with a vector error correction model, Granger causality test and impulse response analysis. This paper uses daily return data covering from January 2000 to December 2008. The major results are as follows; First, according to empirical test based on the Granger causality, the returns of won/dollar spot market Granger causes call market but vice versa. Second, we find a bilateral influence between won/dollar and KOSPI spot markets but the impact of KOSPI is relatively more dominant than of that of won/dollar market. Third, we also find that there is no influence between call and KOSPI markets in a statistically significant level. We hope these kinds of empirical results might be helpful for the investors to set up a asset portfolio and risk management system.

권역심뇌혈관질환센터 사업의 비용-편익 분석

김병호 ( Byung Ho Kim ),감신 ( Sin Kam ),배상근 ( Sang Geun Bae ),김건엽 ( Keon-yeop Kim ),이원기 ( Won Kee Lee ),홍남수 ( Nam-soo Hong ),박형근 ( Hyeung-keun Park ),이혜진 ( Heyjean Lee ),조은정 ( Eun-jung Cho ),채성철 ( Shung C 한국보건정보통계학회(구 한국보건통계학회) 2017 보건정보통계학회지 Vol.42 No.1

Objectives: This study was conducted to investigate economic feasibility of operating Regional Cardiocerebrovascular Centers using cost-benefit analysis. Methods: The current study assessed cost and benefit data collected from nine hospitals which were designated as Regional Cardiocerebrovascular Centers between 2008 and 2010. Results: The operation of Regional Cardiocerebrovascular Centers reduced mortality rate and length of stay due to acute myocardial infarction and stroke and also decreased disability occurred after stroke. The total calculated cost of operating nine Regional Cardiocerebrovascular Centers was 19.85-22.30 billion won and the minimum benefit calculated was 23.98 billion won. Applying the maximum cost and the minimum benefit, the net benefit was 1.68 billion won, which is estimated to 190 million won per Regional Cardiocerebrovascular Center. Conclusions: The present study revealed that the operation of Regional Cardiocerebrovascular Centers was economically beneficial. The benefit would be larger if intangible benefit such as the long-term effects to community hospitals and enhancement of quality of life of patients and their families are considered.

청신경종의 크기에 따른 어지러움의 양상 및 전정기능 검사의 특징

정원호,홍성화,조양선,김성민,장병찬,최재연,이승진 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.1

신경회로망을 이용한 원공 결함 패턴 인식에 관한 연구

홍순혁,이동우,허건,조석수,주원식 동아대학교 생산기술연구소 2000 生産技術硏究所硏究論文集 Vol.5 No.1

Ultrasonic inspection of defects has been focused on the existence of defect in structural material and need has much time and expenses in inspecting all the coordinates (x, y) on material surface. Neural networks is information processing system modeling human brain and can have an application to coordinates (x, y) of defects by multi-point inspection method. Ultrasonic inspection modeling is optimized by neural networks which makes defect echo, back-wall echo and ultrasonic transducer units of input layer and absolute and relative coordinates of defects and defect pattern units of output layer. This method can predict coordinates (x, y) of defects within engineering estimated mean error Ψ.

분광색채계측기를 이용한 Vita Shade 광중합형 복합레진의 색상 비교

조경이,황인남,최홍란,오원만 大韓齒科保存學會 1998 Restorative Dentistry & Endodontics Vol.23 No.1

To get a satisfactory result in the composite resin restorations, it is necessary to choose correct shade. At present, most of the commercial composite resins are based on the Vita Lumin shade guide or Bioform shade guide. but color differences might be expected even using the same shade in various materials. In this study, five kinds of light cured composite resins with A2 and B3 shade were used to measure and compare the color each other while one porcelain served as a control. All composite resins (Spectrum TPH (SP), VeridonFil-Photo (VE), Z100 (Z100), Charisma (CH), Prodigy (PRO)) were filled in to the metal mold (12 mm diameter, 2 mm depth), followed by compression, polymerization and polishing with wet sandpaper. The specimens of porcelain were fabricated by using the refractory mold for porcelain. After 24 hours, the specimens were placed on the spectrocolorimeter and spectral reflectance were measured under CIE illuminant D65. After measuring the values of L*, a*, b* and ΔE*, following results were obtained; 1, The L*, a* and b* values of both shade of porcelain specimens showed significantly higher than those of resin specimens(p<0.05). 2. In comparing the resin specimens of the A2 shade, differences were significant except L* values of SP-CH and PRO-VE, a* values of the VE-SP and b* values of the VE-Z100 and SP-PRO(p<0.05). 3. In comparing the resin specimens of the B3 shade, differences were significant except L* values of PRO-SP(p<0.05). 4. In comparing the resin specimens of the A2 shade, color differences between materials(ΔE*) showed the lowest value of 1.66. and the highest was 5.16. ΔE* values of the materials of VE-PRO, CH-PRO, SP-PRO, SP-Z100 and SP-CH were lower than 3.3. 5. In com0paring the resin specimens of the B3 shade, the lowest value of the ΔE* was 0.57 and the highest was 5.92. ΔE* values of Z100-CH and SP-PRO were lower than 3.3. The present study revealed there was perceptible color difference between materials even if they have the same designated shade based on Vita shade guide. The results of the present study suggested that it would be necessary to establish the reproducible and constant color specification system for an esthetic restoration.

개에서 관찰된 모기질세포종의 증례보고

조성환,손화영,김혜성,최종윤,류시윤,박배근,윤원기,홍성혁,김덕환 충남대학교 수의과대학 동물의과학연구소 2002 動物醫科學硏究誌 Vol.10 No.-

Pilomatricoma was histopathologically diagnosed in a 2.5-year-old male Alaskan malamute. The patient was referred to Chungnam National University, Veterinary Medical Teaching Hospital with solitary, firm and well-circumscribed mass at shoulder. Grossly, the mass was dome shaped to tumor like and 10 x 8 x 5㎝ in size. Some lesions had gritty or bony consistency and was chalky when sectioned Histopathologic feature included mumerous clusters of tightly arranged, basaloid cells with evenly distributed chromatin and ghost cells were characterized by a central unstained zone. The ghost cells often become calcified and osseous metaplasia was also present.